Splenic Subcapsular Hematoma from Commercial Air Travel: Case Report of a Unique Incident of Altitude-Associated Splenic Syndrome
We present a case of a 41-year-old man with a history of SCT who developed severe epigastric pain and nearly lost consciousness while traveling on a commercial airplane. His twin brother, who also has SCT, had a similar episode in the past and required a splenectomy. A splenic subcapsular hematoma was found in a computed tomography scan of the abdomen and pelvis with intravenous contrast. He was admitted and managed conservatively until his symptoms resolved. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Though SCT is prevalent in our population, the complications that can arise, such as altitude-associated splenic ...
Source: Pain Physician - March 9, 2024 Category: Anesthesiology Authors: Lauren Santucci Anthony Almeida Source Type: research
Mirtazapine and Vitamin B6 May Be Best Options for Antipsychotic-Induced Akathisia
APA ’s Good Faith Estimates Survey: Please Respond TodayThe No Surprises Actrequires clinicians to provide patients who are uninsured or are insured but choose not to submit claims through their health plan with a Good Faith Estimate of the cost of care. The Centers for Medicare and Medicaid Services has asked APA for your feedback on efforts to comply with these requirements and any educational support you may need from CMS. The deadline istoday, March 8.TAKE SURVEYAkathisia —a feeling of restlessness that is often accompanied by movements like rocking or pacing—is a common side effect of antipsychotic medications. ...
Source: Psychiatr News - March 8, 2024 Category: Psychiatry Tags: akathisia antipsychotic JAMA Network Open meta-analysis mirtazapine restlessness trazodone vitamin B6 Source Type: research
Renal medullary carcinoma: the zebra amongst the horses
A 13-year old Latino male who presented with recurrent gross hematuria, 5-cm right sided poorly defined heterogeneous mass, enlarged retrocaval lymph nodes and 1.2 cm paratracheal lymph node. Given the need for multiple blood transfusions, robot-assisted radical nephrectomy with lymph node dissection was performed. Pathology revealed pT3a high-grade tumor, clear margins, and positive lymph node. Additionally, with multiple sickled RBCs and loss of staining of SMARCB1 in tumor specimen, and hemoglobin electrophoresis suggesting sickle cell trait, diagnosis of metastatic renal medullary carcinoma was confirmed. (Source: Urology)
Source: Urology - March 8, 2024 Category: Urology & Nephrology Authors: Deepansh Dalela, Shane Batie, Alexandra Carolan, Bruce Schlomer, Rebecca Collins, Micah Jacobs Source Type: research
Renal Medullary Carcinoma: The Zebra Amongst the Horses
A 13-year old Latino male presented with recurrent gross hematuria, 5cm right-sided poorly defined heterogeneous mass, enlarged retrocaval lymph nodes, and 1.2 cm paratracheal lymph node. Given the need for multiple blood transfusions, robot-assisted radical nephrectomy with lymph node dissection was performed. Pathology revealed pT3a high-grade tumor, clear margins, and positiv e lymph node. Additionally, with multiple sickled RBCs and loss of staining of SMARCB1 in tumor specimen, and hemoglobin electrophoresis suggesting sickle cell trait, diagnosis of metastatic renal medullary carcinoma was confirmed. (Source: Urology)
Source: Urology - March 8, 2024 Category: Urology & Nephrology Authors: Deepansh Dalela, Shane Batie, Alexandra Carolan, Bruce Schlomer, Rebecca Collins, Micah Jacobs Tags: Pediatric Case Report Source Type: research
Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease
Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284831. Online ahead of print.ABSTRACTMitapivat, a pyruvate kinase (PK) activator, shows great potential as a sickle cell disease (SCD)- modifying therapy. Safety and efficacy of mitapivat as a long-term maintenance therapy is currently being evaluated in two open-label studies. Here we apply a comprehensive multi-omics approach to investigate the impact of activating PK on red blood cells (RBCs) from 15 SCD patients. HbSS patients were enrolled in one of the open label, extended studies (NCT04610866). Leuko-depleted RBCs obtained from fresh whole blood at baseline (vis...
Source: Haematologica - March 7, 2024 Category: Hematology Authors: Angelo D'Alessandro Kang Le Maureen Lundt Quan Li Emily B Dunkelberger Troy Cellmer Andrew J Worth Spurthi Patil Chris Huston Abby Grier Monika Dzieciatkowska Daniel Stephenson William A Eaton Swee Lay Thein Source Type: research
