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A Novel Mechanistic Model for Future Research in the Elements of the ERAS Program in Patients With Sickle Cell Disease
AANA J. 2024 Apr;92(2):87-92.ABSTRACTEnhanced recovery after surgery (ERAS) is a patient-centered, evidence-based, multidisciplinary team-developed approach to a surgical stress response that is implemented to optimize physiological function and facilitate recovery for the best possible outcomes from surgery. Although there are currently well-known published guidelines for the perioperative management of patients with sickle cell disease, there are currently no specific and evidencebased ERAS protocols that address the needs of these patients. A novel mechanistic model has recently been found that could change ERAS protoco...
Source: AANA Journal - April 2, 2024 Category: Anesthesiology Authors: Marcy Purnell Michong Rayborn Source Type: research

Prevention of Potential Delayed Hemolytic Transfusion Reaction in Two Sickle Cell Patients Using Intravenous Immunoglobulins and Steroids Before and After Red Blood Cell Exchange with Antigen Positive Units and Review Literature
Emergent Red Blood Cell (RBC) exchange is indicated in sickle cell disease (SCD) patients with severe acute chest syndrome. However, fully matched RBC units may not be available for patients with multiple RBC antibodies. Intravenous immunoglobulin (IVIG) and steroids were reported for preventing potential delayed hemolytic transfusion reaction (HTR) in simple transfusion of antigen-positive RBCs. We investigated the efficacy and safety of IVIG and steroids in two SCD patients presented with acute chest syndrome receiving RBC exchange with multiple incompatible units. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 1, 2024 Category: Hematology Authors: Janna Shold, Amitava Dasgupta, Zhan Ye Source Type: research

40. Dysmenorrhea and Chronic Pelvic Pain amongst Adolescents with Sickle Cell Disease: A Scoping Review
While the potential relationship between menstruation, vaso-occlusive pain crisis, and dysmenorrhea in patients with Sickle Cell Disease (SCD) has been studied periodically, findings have been inconsistent. There are scarce treatment recommendations, particularly for adolescent populations. This rapid scoping review seeks to 1) examine the existing literature regarding dysmenorrhea and pelvic pain in adolescents with Sickle Cell Disease 2) understand current provider practices and 3) identify areas in need of further research to better serve the unique needs of this population in adolescent gynecology. (Source: Journal of ...
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Brooke Upchurch, Rabab Isa, Erin Kovar, Nima Rahman, Akua Afriyie-Gray Source Type: research

Probiotic Treatment Alleviates Chronic Pain in Sickle Cell Disease Mice
Chronic pain is a primary complication for those suffering from sickle cell disease, a genetic blood disorder. The basis of chronic sickle cell disease pain is not completely resolved, and thus, analgesic offerings have limited efficacy. Using transgenic mice, our lab recently determined that the gut microbiota contributes to chronic sickle cell disease pain. Fecal material transplant from sickle cell disease mice into pseudo-germfree animals induced persistent mechanical and cold allodynia in recipients, phenotypes that mirrored donor behaviors. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: McKenna L. Pratt, Mandee K. Schaub, Gregory Dussor, Katelyn E. Sadler Source Type: research

Frequent Vaso-occlusive Crises Alter Brain Network Connectivity in Patients with Sickle Cell Disease
Sickle cell disease (SCD) is an inherited hemolytic disorder complicated by acute vaso-occlusive crises (VOCs) that are associated with extremely painful episodes that frequently require hospitalization and opioids for pain control. We previously reported significant correlations between resting state functional connectivity (fs-rc) and number of hospitalizations associated with VOCs (Darbari, 2015). Eight-minute rs-fc and high-resolution T1w structural scans were collected from 22 patients aged 14-73 yrs old. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Eric Ichesco, Andrew Q. Pucka, Richard E. Harris, Ying Wang Source Type: research

Keratinocyte Sensitization Contributes to Sickle Cell Disease Pain
Individuals with sickle cell disease (SCD) experience debilitating, chronic pain. Additionally, vaso-occlusive events (VOEs) trigger acute pain episodes, resulting in hospitalization and negatively affecting quality of life. Current SCD pain therapeutics have limited efficacy and are accompanied by deleterious side effects. Therefore, a better understanding of SCD pain is necessary for the development of novel therapeutics. Keratinocytes in the epidermis form synaptic-like contact with sensory axons and contribute to innocuous and noxious sensory transduction. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Dianise M. Rodr íguez García, Anvitha Sriram, Jonathan D Enders, Vanessa L. Ehlers, Cheryl L. Stucky Source Type: research

Peripheral TNF α Inhibition Alleviates Acute Vaso-occlusive Hypersensitivity in a Mouse Model of Sickle Cell Disease
Debilitating pain is the prevailing complication for individuals with sickle cell disease (SCD). Opioid therapy is the mainstay of SCD pain treatment but is often accompanied by adverse side-effects. To improve patient outcomes, novel peripheral targets that alleviate acute SCD pain need to be identified. The monoclonal antibody Infliximab binds tumor necrosis factor alpha (TNF α) and can treat other painful conditions sharing inflammatory and neuropathic hallmarks of SCD. But whether and how TNFα inhibition might alleviate SCD acute pain remains unknown. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Vanessa L. Ehlers, Meghan Konda, Samuel J. Zorn, Anvitha Sriram, Anthony D. Menzel, Cheryl L. Stucky Source Type: research

Clinically Important Changes and Agreement Among Pain Measurements During Sickle Cell Disease Vaso-occlusive Episodes in The Emergency Department
We aimed to determine minimally clinically important difference (MCID) in pain severity and agreement between the visual analog scale (VAS) and the verbal numeric rating scale (NRS) in people with sickle cell disease experiencing an acute vaso-occlusive episode in the emergency department (ED). In the COMPARE-VOE trial (NCT03933397), participants were administered the VAS (0-100), NRS (0-100), and verbal categorical rating of pain scale (a lot better, a little better, same, a little worse, much worse) every 30 minutes while in the ED. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Mitchell R. Knisely, Huiman Barnhart, Stephanie Ibemere, Paula Tanabe Source Type: research

Mediators and Moderators of Cognitive-Behavioral Digital Health Intervention for Youth with Sickle Cell Disease Pain
Pain is the hallmark symptom of sickle cell disease (SCD). By adolescence, 20% of youth are experiencing chronic SCD pain, a concern that extends into adulthood. Our recent trial evaluated the effectiveness of digital cognitive-behavioral therapy (CBT) in managing adolescent SCD pain, revealing significant reductions in pain in those receiving CBT versus Education Control. However, little is known about factors that moderate or mediate the effects of CBT in individuals with SCD. This secondary data analysis aims to identify adolescent and family characteristics that moderated or mediated treatment effects on pain intensity...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kavin Srinakarin, Shwetha Sanpoori, Chitra Lalloo, Chuan Zhou, Carlton Dampier, William Zempsky, Sherif M. Badawy, Nitya Bakshi, Yeon Joo Ko, Fareha Nishat, Jennifer N. Stinson, Tonya M. Palermo Source Type: research

Development of an interactive mapping tool to estimate where resources for people living with sickle cell disease may be needed most
Transfusion. 2024 Mar 28. doi: 10.1111/trf.17802. Online ahead of print.NO ABSTRACTPMID:38549364 | DOI:10.1111/trf.17802 (Source: Transfusion)
Source: Transfusion - March 29, 2024 Category: Hematology Authors: Kendall Werneiwski Eric A Gehrie Source Type: research