Prevention of Potential Delayed Hemolytic Transfusion Reaction in Two Sickle Cell Patients Using Intravenous Immunoglobulins and Steroids Before and After Red Blood Cell Exchange with Antigen Positive Units and Review Literature

Emergent Red Blood Cell (RBC) exchange is indicated in sickle cell disease (SCD) patients with severe acute chest syndrome. However, fully matched RBC units may not be available for patients with multiple RBC antibodies. Intravenous immunoglobulin (IVIG) and steroids were reported for preventing potential delayed hemolytic transfusion reaction (HTR) in simple transfusion of antigen-positive RBCs. We investigated the efficacy and safety of IVIG and steroids in two SCD patients presented with acute chest syndrome receiving RBC exchange with multiple incompatible units.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research