Aerobic physical capacity and health-related quality of life in children with sickle cell disease

CONCLUSION: Aerobic capacity is poor in children with sickle cell disease. VO2max decrease is associated with the level of anemia, the existence of a homozygote HbS/S mutation, lung function, and health-related quality of life. These results represent a signal in favor of early initiation of cardiac rehabilitation in patients with sickle cell disease.CLINICAL TRIALS: NCT05995743.IMPACT: Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. Aerobic capacity (VO2max) is poor in children with sickle cell disease, despite the absence of any pattern of heart failure. VO2max decrease was associated with the level of anemia, the existence of a homozygote HbS/S mutation, restrictive lung disease, and health-related quality of life. These results are in favor of early initiation of cardiac rehabilitation in children with sickle cell disease.PMID:38491141 | DOI:10.1038/s41390-024-03143-1

Source: Cell Research - March 16, 2024 Category: Cytology Authors: Corentin Laurent-Lacroix Marie Vincenti Stefan Matecki Perrine Mah é Lionel Moulis Gregoire De La Villeon Sophie Guillaumont Anne Requirand Johan Moreau Muriel Lalande Marie-Christine Picot Pascal Amedro Arthur Gavotto Source Type: research