Performance of serum procalcitonin as a biochemical predictor of death in hematology patients with febrile neutropenia
CONCLUSION: In conclusion, in our trial a single PCT on admission at a cut-off value of 0.46 ng/mL was able to predict the occurrence of septic shock and death in FN patients.PMID:34126299 | DOI:10.1016/j.bcmd.2021.102586 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - June 14, 2021 Category: Hematology Authors: Alan Ledif Reyes Mondrag ón Olga Graciela Cant ú-Rodríguez Andrea Cecilia Garza-Acosta C ésar Homero Gutiérrez-Aguirre Perla Roc ío Colunga Pedraza Luz Del Carmen Tar ín-Arzaga Jos é Carlos Jaime-Pérez Jos é Angel Hawing Zárate Graciela Alejand Source Type: research

Performance of serum procalcitonin as a biochemical predictor of death in hematology patients with febrile neutropenia
CONCLUSION: In conclusion, in our trial a single PCT on admission at a cut-off value of 0.46 ng/mL was able to predict the occurrence of septic shock and death in FN patients.PMID:34126299 | DOI:10.1016/j.bcmd.2021.102586 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - June 14, 2021 Category: Hematology Authors: Alan Ledif Reyes Mondrag ón Olga Graciela Cant ú-Rodríguez Andrea Cecilia Garza-Acosta C ésar Homero Gutiérrez-Aguirre Perla Roc ío Colunga Pedraza Luz Del Carmen Tar ín-Arzaga Jos é Carlos Jaime-Pérez Jos é Angel Hawing Zárate Graciela Alejand Source Type: research

Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia
In this study, the expression of a panel of 16 human imprinted genes was investigated using real-time quantitative polymerase chain reaction and 8 of them were further validated in 114 patients newly diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects. Our results demonstrated upregulated expression of 8 imprinted genes (C15orf2, COPG2, H19, IGF2, PEG3-AS1, PRIM2, SLC22A3 and ZNF215) was observed in patients with CA-AML (p
Source: Blood Cells, Molecules and Diseases - June 6, 2021 Category: Hematology Authors: Ming-Yu Yang Pai-Mei Lin Chao-Hui Yang Ming-Luen Hu I-Ya Chen Sheng-Fung Lin Cheng-Ming Hsu Source Type: research

Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia
In this study, the expression of a panel of 16 human imprinted genes was investigated using real-time quantitative polymerase chain reaction and 8 of them were further validated in 114 patients newly diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects. Our results demonstrated upregulated expression of 8 imprinted genes (C15orf2, COPG2, H19, IGF2, PEG3-AS1, PRIM2, SLC22A3 and ZNF215) was observed in patients with CA-AML (p
Source: Blood Cells, Molecules and Diseases - June 6, 2021 Category: Hematology Authors: Ming-Yu Yang Pai-Mei Lin Chao-Hui Yang Ming-Luen Hu I-Ya Chen Sheng-Fung Lin Cheng-Ming Hsu Source Type: research

Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia
In this study, the expression of a panel of 16 human imprinted genes was investigated using real-time quantitative polymerase chain reaction and 8 of them were further validated in 114 patients newly diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects. Our results demonstrated upregulated expression of 8 imprinted genes (C15orf2, COPG2, H19, IGF2, PEG3-AS1, PRIM2, SLC22A3 and ZNF215) was observed in patients with CA-AML (p
Source: Blood Cells, Molecules and Diseases - June 6, 2021 Category: Hematology Authors: Ming-Yu Yang Pai-Mei Lin Chao-Hui Yang Ming-Luen Hu I-Ya Chen Sheng-Fung Lin Cheng-Ming Hsu Source Type: research

Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia
In this study, the expression of a panel of 16 human imprinted genes was investigated using real-time quantitative polymerase chain reaction and 8 of them were further validated in 114 patients newly diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects. Our results demonstrated upregulated expression of 8 imprinted genes (C15orf2, COPG2, H19, IGF2, PEG3-AS1, PRIM2, SLC22A3 and ZNF215) was observed in patients with CA-AML (p
Source: Blood Cells, Molecules and Diseases - June 6, 2021 Category: Hematology Authors: Ming-Yu Yang Pai-Mei Lin Chao-Hui Yang Ming-Luen Hu I-Ya Chen Sheng-Fung Lin Cheng-Ming Hsu Source Type: research

Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia
In this study, the expression of a panel of 16 human imprinted genes was investigated using real-time quantitative polymerase chain reaction and 8 of them were further validated in 114 patients newly diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects. Our results demonstrated upregulated expression of 8 imprinted genes (C15orf2, COPG2, H19, IGF2, PEG3-AS1, PRIM2, SLC22A3 and ZNF215) was observed in patients with CA-AML (p
Source: Blood Cells, Molecules and Diseases - June 6, 2021 Category: Hematology Authors: Ming-Yu Yang Pai-Mei Lin Chao-Hui Yang Ming-Luen Hu I-Ya Chen Sheng-Fung Lin Cheng-Ming Hsu Source Type: research

Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia
In this study, the expression of a panel of 16 human imprinted genes was investigated using real-time quantitative polymerase chain reaction and 8 of them were further validated in 114 patients newly diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects. Our results demonstrated upregulated expression of 8 imprinted genes (C15orf2, COPG2, H19, IGF2, PEG3-AS1, PRIM2, SLC22A3 and ZNF215) was observed in patients with CA-AML (p
Source: Blood Cells, Molecules and Diseases - June 6, 2021 Category: Hematology Authors: Ming-Yu Yang Pai-Mei Lin Chao-Hui Yang Ming-Luen Hu I-Ya Chen Sheng-Fung Lin Cheng-Ming Hsu Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response
Blood Cells Mol Dis. 2021 May 11;90:102576. doi: 10.1016/j.bcmd.2021.102576. Online ahead of print.NO ABSTRACTPMID:34020272 | DOI:10.1016/j.bcmd.2021.102576 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 21, 2021 Category: Hematology Authors: Alina Sadaf Charles T Quinn Jennifer B Korpik Amanda Pfeiffer Mary Reynaud Omar Niss Punam Malik Russell E Ware Theodosia A Kalfa Patrick T McGann Source Type: research

Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells
Blood Cells Mol Dis. 2021 Apr 30;90:102574. doi: 10.1016/j.bcmd.2021.102574. Online ahead of print.ABSTRACTGamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone ma...
Source: Blood Cells, Molecules and Diseases - May 20, 2021 Category: Hematology Authors: Hal E Broxmeyer Scott Cooper Janice S Blum Source Type: research

Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells
Blood Cells Mol Dis. 2021 Apr 30;90:102574. doi: 10.1016/j.bcmd.2021.102574. Online ahead of print.ABSTRACTGamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone ma...
Source: Blood Cells, Molecules and Diseases - May 20, 2021 Category: Hematology Authors: Hal E Broxmeyer Scott Cooper Janice S Blum Source Type: research

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency
Blood Cells Mol Dis. 2021 May 6;90:102575. doi: 10.1016/j.bcmd.2021.102575. Online ahead of print.ABSTRACTIn order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk in...
Source: Blood Cells, Molecules and Diseases - May 14, 2021 Category: Hematology Authors: Timothy M Bahr Nicholas R Carr Thomas R Christensen Jacob Wilkes Elizabeth A O'Brien Kendell R German Robin K Ohls Diane M Ward Robert D Christensen Source Type: research

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency
Blood Cells Mol Dis. 2021 May 6;90:102575. doi: 10.1016/j.bcmd.2021.102575. Online ahead of print.ABSTRACTIn order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk in...
Source: Blood Cells, Molecules and Diseases - May 14, 2021 Category: Hematology Authors: Timothy M Bahr Nicholas R Carr Thomas R Christensen Jacob Wilkes Elizabeth A O'Brien Kendell R German Robin K Ohls Diane M Ward Robert D Christensen Source Type: research

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency
Blood Cells Mol Dis. 2021 May 6;90:102575. doi: 10.1016/j.bcmd.2021.102575. Online ahead of print.ABSTRACTIn order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk in...
Source: Blood Cells, Molecules and Diseases - May 14, 2021 Category: Hematology Authors: Timothy M Bahr Nicholas R Carr Thomas R Christensen Jacob Wilkes Elizabeth A O'Brien Kendell R German Robin K Ohls Diane M Ward Robert D Christensen Source Type: research

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency
Blood Cells Mol Dis. 2021 May 6;90:102575. doi: 10.1016/j.bcmd.2021.102575. Online ahead of print.ABSTRACTIn order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk in...
Source: Blood Cells, Molecules and Diseases - May 14, 2021 Category: Hematology Authors: Timothy M Bahr Nicholas R Carr Thomas R Christensen Jacob Wilkes Elizabeth A O'Brien Kendell R German Robin K Ohls Diane M Ward Robert D Christensen Source Type: research

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency
Blood Cells Mol Dis. 2021 May 6;90:102575. doi: 10.1016/j.bcmd.2021.102575. Online ahead of print.ABSTRACTIn order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk in...
Source: Blood Cells, Molecules and Diseases - May 14, 2021 Category: Hematology Authors: Timothy M Bahr Nicholas R Carr Thomas R Christensen Jacob Wilkes Elizabeth A O'Brien Kendell R German Robin K Ohls Diane M Ward Robert D Christensen Source Type: research

Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent
In conclusion, these data suggest that the factor X variant described here could potentially serve as a bypassing agent independent of the inhibitor status of hemophilia patients. However, more research is needed to further investigate the potential of this molecule.PMID:33962291 | DOI:10.1016/j.bcmd.2021.102570 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 7, 2021 Category: Hematology Authors: Mariana Ebert Elmar Raquet Sabine Schweisgut Peter M Schmidt Thomas Weimer Source Type: research

Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent
In conclusion, these data suggest that the factor X variant described here could potentially serve as a bypassing agent independent of the inhibitor status of hemophilia patients. However, more research is needed to further investigate the potential of this molecule.PMID:33962291 | DOI:10.1016/j.bcmd.2021.102570 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 7, 2021 Category: Hematology Authors: Mariana Ebert Elmar Raquet Sabine Schweisgut Peter M Schmidt Thomas Weimer Source Type: research

Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent
In conclusion, these data suggest that the factor X variant described here could potentially serve as a bypassing agent independent of the inhibitor status of hemophilia patients. However, more research is needed to further investigate the potential of this molecule.PMID:33962291 | DOI:10.1016/j.bcmd.2021.102570 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 7, 2021 Category: Hematology Authors: Mariana Ebert Elmar Raquet Sabine Schweisgut Peter M Schmidt Thomas Weimer Source Type: research

Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent
In conclusion, these data suggest that the factor X variant described here could potentially serve as a bypassing agent independent of the inhibitor status of hemophilia patients. However, more research is needed to further investigate the potential of this molecule.PMID:33962291 | DOI:10.1016/j.bcmd.2021.102570 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 7, 2021 Category: Hematology Authors: Mariana Ebert Elmar Raquet Sabine Schweisgut Peter M Schmidt Thomas Weimer Source Type: research

Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent
In conclusion, these data suggest that the factor X variant described here could potentially serve as a bypassing agent independent of the inhibitor status of hemophilia patients. However, more research is needed to further investigate the potential of this molecule.PMID:33962291 | DOI:10.1016/j.bcmd.2021.102570 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - May 7, 2021 Category: Hematology Authors: Mariana Ebert Elmar Raquet Sabine Schweisgut Peter M Schmidt Thomas Weimer Source Type: research

Good treatment-free survival of monoclonal gammopathy of undetermined significance associated pure red cell aplasia after bortezomib plus dexamethasone
In this report, for the first time, we demonstrated two patients with MGUS associated PRCA obtained rapid remission and maintained TFS after accepting intensive short-term bortezomib plus dexamethasone. The first case was refractory to cyclosporine and prednisone, but achieved complete remission after ten doses of bortezomib. Moreover, he has kept TFS for 12 months. The other case initiated bortezomib plus dexamethasone as soon as making a definite diagnosis. She obtained complete remission after twelve doses of bortezomib and she has maintained a normal level of haemoglobin for 8 months.PMID:33957358 | DOI:10.1016/j.bcmd....
Source: Blood Cells, Molecules and Diseases - May 6, 2021 Category: Hematology Authors: Lele Zhang Nafei Chen Zhipeng Xu Qian Liang Hong Pan Jingyu Zhao Liwei Fang Jun Shi Source Type: research

A computational study of structural differences of binding of NADP < sup > + < /sup > and G6P substrates to G6PD Mediterranean < sup > c.563T < /sup > , G6PD A- < sup > c.202A/c.376G < /sup > , G6PD Cairo < sup > c.404C < /sup > and G6PD Gaza < sup > c.536A < /sup > mutations
We reported on three G6PD variants in the Gaza Strip Palestinian population with differing clinical impacts and frequencies: G6PD Mediterraneanc.563T, African G6PD A-c.202A/c.376G, and G6PD Cairoc.404C. We also identified a novel G6PD missense (Ser179Asn) mutation c.536G> A "G6PD Gaza". In this work we explore the effect of these four genetic variants on the structural and substrate (NADP+ and G6P) binding characteristics of the G6PD enzyme using the Monte Carlo (MC) flexible docking and molecular dynamics (MD) simulation approaches. We report that G6PD A-c.202A/c.376G, G6PD Mediterraneanc.563T, G6PD Cairoc.40...
Source: Blood Cells, Molecules and Diseases - May 6, 2021 Category: Hematology Authors: Mahmoud Sirdah N Scott Reading Hariprasad Vankayalapati Josef T Prchal Source Type: research

Good treatment-free survival of monoclonal gammopathy of undetermined significance associated pure red cell aplasia after bortezomib plus dexamethasone
In this report, for the first time, we demonstrated two patients with MGUS associated PRCA obtained rapid remission and maintained TFS after accepting intensive short-term bortezomib plus dexamethasone. The first case was refractory to cyclosporine and prednisone, but achieved complete remission after ten doses of bortezomib. Moreover, he has kept TFS for 12 months. The other case initiated bortezomib plus dexamethasone as soon as making a definite diagnosis. She obtained complete remission after twelve doses of bortezomib and she has maintained a normal level of haemoglobin for 8 months.PMID:33957358 | DOI:10.1016/j.bcmd....
Source: Blood Cells, Molecules and Diseases - May 6, 2021 Category: Hematology Authors: Lele Zhang Nafei Chen Zhipeng Xu Qian Liang Hong Pan Jingyu Zhao Liwei Fang Jun Shi Source Type: research

A computational study of structural differences of binding of NADP < sup > + < /sup > and G6P substrates to G6PD Mediterranean < sup > c.563T < /sup > , G6PD A- < sup > c.202A/c.376G < /sup > , G6PD Cairo < sup > c.404C < /sup > and G6PD Gaza < sup > c.536A < /sup > mutations
We reported on three G6PD variants in the Gaza Strip Palestinian population with differing clinical impacts and frequencies: G6PD Mediterraneanc.563T, African G6PD A-c.202A/c.376G, and G6PD Cairoc.404C. We also identified a novel G6PD missense (Ser179Asn) mutation c.536G> A "G6PD Gaza". In this work we explore the effect of these four genetic variants on the structural and substrate (NADP+ and G6P) binding characteristics of the G6PD enzyme using the Monte Carlo (MC) flexible docking and molecular dynamics (MD) simulation approaches. We report that G6PD A-c.202A/c.376G, G6PD Mediterraneanc.563T, G6PD Cairoc.40...
Source: Blood Cells, Molecules and Diseases - May 6, 2021 Category: Hematology Authors: Mahmoud Sirdah N Scott Reading Hariprasad Vankayalapati Josef T Prchal Source Type: research

A case series highlighting structured hematological, biochemical and molecular approach to clinical oral iron refractoriness in children: A pressing need for a 3-tier system for classification of variants in TMPRSS6 gene
Blood Cells Mol Dis. 2021 Apr 16;89:102569. doi: 10.1016/j.bcmd.2021.102569. Online ahead of print.ABSTRACTIn current study, we discuss clinical oral iron refractoriness cases and highlight need for a classification system to define TMPRSS6 gene variants. Out of 231 cases of microcytic hypochromic anemia screened (Sept 2019-Dec 2020), 17 cases (7.35%) with unexplained iron refractoriness (URIDA) phenotype were enrolled after ruling out secondary causes and compliance related issues. 11 (65%) had absent/negligible response (0-0.4 g/dl Hb rise) while 6 (35%) partial (0.5-0.9 g/dl Hb rise) response to initial iron trial at 4-...
Source: Blood Cells, Molecules and Diseases - April 30, 2021 Category: Hematology Authors: Pankaj Sharma Prateek Bhatia Minu Singh Reena Das Richa Jain Deepak Bansal Savita Verma Attri Amita Trehan Source Type: research

A case series highlighting structured hematological, biochemical and molecular approach to clinical oral iron refractoriness in children: A pressing need for a 3-tier system for classification of variants in TMPRSS6 gene
Blood Cells Mol Dis. 2021 Apr 16;89:102569. doi: 10.1016/j.bcmd.2021.102569. Online ahead of print.ABSTRACTIn current study, we discuss clinical oral iron refractoriness cases and highlight need for a classification system to define TMPRSS6 gene variants. Out of 231 cases of microcytic hypochromic anemia screened (Sept 2019-Dec 2020), 17 cases (7.35%) with unexplained iron refractoriness (URIDA) phenotype were enrolled after ruling out secondary causes and compliance related issues. 11 (65%) had absent/negligible response (0-0.4 g/dl Hb rise) while 6 (35%) partial (0.5-0.9 g/dl Hb rise) response to initial iron trial at 4-...
Source: Blood Cells, Molecules and Diseases - April 30, 2021 Category: Hematology Authors: Pankaj Sharma Prateek Bhatia Minu Singh Reena Das Richa Jain Deepak Bansal Savita Verma Attri Amita Trehan Source Type: research

A case series highlighting structured hematological, biochemical and molecular approach to clinical oral iron refractoriness in children: A pressing need for a 3-tier system for classification of variants in TMPRSS6 gene
Blood Cells Mol Dis. 2021 Apr 16;89:102569. doi: 10.1016/j.bcmd.2021.102569. Online ahead of print.ABSTRACTIn current study, we discuss clinical oral iron refractoriness cases and highlight need for a classification system to define TMPRSS6 gene variants. Out of 231 cases of microcytic hypochromic anemia screened (Sept 2019-Dec 2020), 17 cases (7.35%) with unexplained iron refractoriness (URIDA) phenotype were enrolled after ruling out secondary causes and compliance related issues. 11 (65%) had absent/negligible response (0-0.4 g/dl Hb rise) while 6 (35%) partial (0.5-0.9 g/dl Hb rise) response to initial iron trial at 4-...
Source: Blood Cells, Molecules and Diseases - April 30, 2021 Category: Hematology Authors: Pankaj Sharma Prateek Bhatia Minu Singh Reena Das Richa Jain Deepak Bansal Savita Verma Attri Amita Trehan Source Type: research

A case series highlighting structured hematological, biochemical and molecular approach to clinical oral iron refractoriness in children: A pressing need for a 3-tier system for classification of variants in TMPRSS6 gene
Blood Cells Mol Dis. 2021 Apr 16;89:102569. doi: 10.1016/j.bcmd.2021.102569. Online ahead of print.ABSTRACTIn current study, we discuss clinical oral iron refractoriness cases and highlight need for a classification system to define TMPRSS6 gene variants. Out of 231 cases of microcytic hypochromic anemia screened (Sept 2019-Dec 2020), 17 cases (7.35%) with unexplained iron refractoriness (URIDA) phenotype were enrolled after ruling out secondary causes and compliance related issues. 11 (65%) had absent/negligible response (0-0.4 g/dl Hb rise) while 6 (35%) partial (0.5-0.9 g/dl Hb rise) response to initial iron trial at 4-...
Source: Blood Cells, Molecules and Diseases - April 30, 2021 Category: Hematology Authors: Pankaj Sharma Prateek Bhatia Minu Singh Reena Das Richa Jain Deepak Bansal Savita Verma Attri Amita Trehan Source Type: research

ABO blood groups, COVID-19 infection and mortality
CONCLUSION: We were not able to confirm that ABO blood group influences risk of COVID-19 infection or outcome.PMID:33894687 | PMC:PMC8059281 | DOI:10.1016/j.bcmd.2021.102571 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - April 24, 2021 Category: Hematology Authors: Steven Lehrer Peter H Rheinstein Source Type: research

ABO blood groups, COVID-19 infection and mortality
CONCLUSION: We were not able to confirm that ABO blood group influences risk of COVID-19 infection or outcome.PMID:33894687 | PMC:PMC8059281 | DOI:10.1016/j.bcmd.2021.102571 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - April 24, 2021 Category: Hematology Authors: Steven Lehrer Peter H Rheinstein Source Type: research

ABO blood groups, COVID-19 infection and mortality
CONCLUSION: We were not able to confirm that ABO blood group influences risk of COVID-19 infection or outcome.PMID:33894687 | PMC:PMC8059281 | DOI:10.1016/j.bcmd.2021.102571 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - April 24, 2021 Category: Hematology Authors: Steven Lehrer Peter H Rheinstein Source Type: research

ABO blood groups, COVID-19 infection and mortality
CONCLUSION: We were not able to confirm that ABO blood group influences risk of COVID-19 infection or outcome.PMID:33894687 | PMC:PMC8059281 | DOI:10.1016/j.bcmd.2021.102571 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - April 24, 2021 Category: Hematology Authors: Steven Lehrer Peter H Rheinstein Source Type: research

ABO blood groups, COVID-19 infection and mortality
CONCLUSION: We were not able to confirm that ABO blood group influences risk of COVID-19 infection or outcome.PMID:33894687 | DOI:10.1016/j.bcmd.2021.102571 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - April 24, 2021 Category: Hematology Authors: Steven Lehrer Peter H Rheinstein Source Type: research

Co-morbidities and mortality in patients with sickle cell disease in England: A 10-year cohort analysis using hospital episodes statistics (HES) data
Blood Cells Mol Dis. 2021 Apr 1;89:102567. doi: 10.1016/j.bcmd.2021.102567. Online ahead of print.ABSTRACTPatients with a primary diagnosis of sickle cell disease (SCD) with or without crisis during the 10-year period January 2009 to December 2018 were identified in the HES Admitted Patient Care (APC) dataset and matched with the Office for National Statistics (ONS) mortality dataset. Three sub-cohorts were defined: 'crises', 'transfusions' and 'other SCD'. APC records were examined for co-morbidities commonly associated with SCD and 10-year mortality rates compared with the general population. After data cleaning and excl...
Source: Blood Cells, Molecules and Diseases - April 16, 2021 Category: Hematology Authors: Fr édéric B Piel Minesh Jobanputra Meghan Gallagher Jon Weber Sandra G Laird Michael McGahan Source Type: research

LXR β is involved in the control of platelet production from megakaryocytes
Blood Cells Mol Dis. 2021 Apr 13;89:102568. doi: 10.1016/j.bcmd.2021.102568. Online ahead of print.ABSTRACTLiver X receptor β (LXRβ), a nuclear receptor involved in important cellular processes such as cholesterol, glucose and fatty acid metabolism, was suggested to be involved in platelet aggregation but its detailed roles are not clear. In the present study, we evaluated the contribution of LXRβ to platelet functions and production. In the systemic collagen-epinephrine thrombosis mouse model, LXRβ-deficient mice showed increased area of blood clots compared with control wide-type littermates. The aggr...
Source: Blood Cells, Molecules and Diseases - April 16, 2021 Category: Hematology Authors: Yu-Wei Wan Wang Liu Mu-Ting Feng Jun Pu Shao-Wei Zhuang Ben He Xuan Liu Source Type: research

Whole exome sequencing of a breast tumor in a patient with Diamond Blackfan anemia
Blood Cells Mol Dis. 2021 Apr 1;89:102566. doi: 10.1016/j.bcmd.2021.102566. Online ahead of print.NO ABSTRACTPMID:33862369 | DOI:10.1016/j.bcmd.2021.102566 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - April 16, 2021 Category: Hematology Authors: Anupama Narla Kathryn J Ruddy Benjamin L Ebert Brenton Mar Source Type: research

Co-morbidities and mortality in patients with sickle cell disease in England: A 10-year cohort analysis using hospital episodes statistics (HES) data
Blood Cells Mol Dis. 2021 Apr 1;89:102567. doi: 10.1016/j.bcmd.2021.102567. Online ahead of print.ABSTRACTPatients with a primary diagnosis of sickle cell disease (SCD) with or without crisis during the 10-year period January 2009 to December 2018 were identified in the HES Admitted Patient Care (APC) dataset and matched with the Office for National Statistics (ONS) mortality dataset. Three sub-cohorts were defined: 'crises', 'transfusions' and 'other SCD'. APC records were examined for co-morbidities commonly associated with SCD and 10-year mortality rates compared with the general population. After data cleaning and excl...
Source: Blood Cells, Molecules and Diseases - April 16, 2021 Category: Hematology Authors: Fr édéric B Piel Minesh Jobanputra Meghan Gallagher Jon Weber Sandra G Laird Michael McGahan Source Type: research

LXR β is involved in the control of platelet production from megakaryocytes
Blood Cells Mol Dis. 2021 Apr 13;89:102568. doi: 10.1016/j.bcmd.2021.102568. Online ahead of print.ABSTRACTLiver X receptor β (LXRβ), a nuclear receptor involved in important cellular processes such as cholesterol, glucose and fatty acid metabolism, was suggested to be involved in platelet aggregation but its detailed roles are not clear. In the present study, we evaluated the contribution of LXRβ to platelet functions and production. In the systemic collagen-epinephrine thrombosis mouse model, LXRβ-deficient mice showed increased area of blood clots compared with control wide-type littermates. The aggr...
Source: Blood Cells, Molecules and Diseases - April 16, 2021 Category: Hematology Authors: Yu-Wei Wan Wang Liu Mu-Ting Feng Jun Pu Shao-Wei Zhuang Ben He Xuan Liu Source Type: research