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Therapy: Corticosteroid Therapy

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Total 342 results found since Jan 2013.

Late Breaking Abstract - Inhaled corticosteroids (ICS), blood eosinophils (EOS), and FEV1 decline in patients with Chronic Obstructive Pulmonary Disease in a large UK primary healthcare setting
Conclusions: Regardless of blood EOS level, ICS-containing medication is associated with slower rates of FEV1 decline in COPD patients.Funding: GSK study 208602
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Whittaker, H., Mullerova, H., Jarvis, D., Barnes, N., Jones, P., Compton, C., Kiddle, S., Quint, J. Tags: Epidemiology Source Type: research

Functional Neurochemistry of the Ventral and Dorsal Hippocampus: Stress, Depression, Dementia and Remote Hippocampal Damage.
Abstract The hippocampus is not a homogeneous brain area, and the complex organization of this structure underlies its relevance and functional pleiotropism. The new data related to the involvement of the ventral hippocampus in the cognitive function, behavior, stress response and its association with brain pathology, in particular, depression, are analyzed with a focus on neuroplasticity, specializations of the intrinsic neuronal network, corticosteroid signaling through mineralocorticoid and glucocorticoid receptors and neuroinflammation in the hippocampus. The data on the septo-temporal hippicampal gradient are...
Source: Neurochemical Research - October 24, 2018 Category: Neuroscience Authors: Gulyaeva NV Tags: Neurochem Res Source Type: research

Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation.
CONCLUSIONS: This review suggested that an expectant approach to the management of women with severe early onset pre-eclampsia may be associated with decreased morbidity for the baby. However, this evidence was based on data from only six trials. Further large, high-quality trials are needed to confirm or refute these findings, and establish if this approach is safe for the mother. PMID: 30289565 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 5, 2018 Category: General Medicine Authors: Churchill D, Duley L, Thornton JG, Moussa M, Ali HS, Walker KF Tags: Cochrane Database Syst Rev Source Type: research

The role of plasmalemma vesicle-associated protein in pathological breakdown of blood –brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema
AbstractBreakdown of the blood –brain barrier (BBB) or inner blood–retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality, or vision loss. Restoratio n of the barrier function with corticosteroids in the brain, or by blocking VEGF in the eye are currently the predominant treatment options for brain edema and diabetic macular edema, respectively. However, corticosteroids have side effects, and VEGF has important neuroprotective, vascular protect...
Source: Fluids and Barriers of the CNS - September 20, 2018 Category: Neuroscience Source Type: research

Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors.
CONCLUSION: SUR1 is a putative therapeutic target to reduce neuroinflammation in adult and pediatric brain tumors. Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma.
. PMID: 30079884 [PubMed - as supplied by publisher]
Source: Clinical Neuropathology - August 6, 2018 Category: Pathology Authors: Thompson EM, Halvorson K, McLendon R Tags: Clin Neuropathol Source Type: research

Inhaled corticosteroids may prevent lung cancer in asthma patients
CONCLUSIONS: For patients with asthma, regular ICS use might have a protective effect against LC. Further studies are required to assess this potential association from both immunohistopathological and clinical aspects.
Source: Annals of Thoracic Medicine - July 18, 2018 Category: Respiratory Medicine Authors: I-Jen Wang Wen-Miin Liang Trong-Neng Wu Wilfried J.J. Karmaus Jiin-Chyr Hsu Source Type: research

Listerial myocarditis as a complication of Listerial meningoencephalitis
Publication date: June 2018Source: Cor et Vasa, Volume 60, Issue 3Author(s): M. Strnadel, T. Hnátek, R. Havlíček, E. Krčová, M. Malý, M. ZavoralAbstractHere, we present a case report of a 53-year-old patient who was admitted for an acute ischaemic stroke. During the hospitalization period, the patient developed meningoencephalitis and acute myocarditis with recurrent episodes of ventricular fibrillation that required defibrillation repeatedly. Listeria monocytogenes was isolated from blood culture samples. The patient was treated with antibiotic therapy and showed a good clinical response. The diagnosis of myocarditi...
Source: Cor et Vasa - July 10, 2018 Category: Cardiology Source Type: research

Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report
We describe a case of an Italian child. Diagnoses: we diagnosed early a Tuberculous meningitis complicated by the occurrence of hydrocephalus, stroke, and paradoxical reaction with brain pseudo-abscesses. Interventions: The child started readily a specific therapy associated with steroids and thalidomide was introduced few month later. Outcomes: the patient had a favorable outcome without neurologic sequelae. Lessons: Despite the prompt specific anti-tubercular and adjuvant corticosteroid therapies, only the addition of thalidomide to the treatment allow to a favorable clinical outcome.
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Association of non-invasive hemodynamics with arterial stiffness in rheumatoid arthritis.
CONCLUSIONS: Among patients with RA, arterial stiffness appears as the composite of cardiovascular risk factors and inflammation, while corticosteroid use emerges as an additional adverse factor. PMID: 29560750 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - March 27, 2018 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study.
Conclusions: The ACOS cohort had a higher risk of the neurodegenerative diseases. The lower dose of the inhaler corticosteroids with cumulative dose ≧0.13 gram have the less risk of stroke and dementia. PMID: 29552322 [PubMed]
Source: Oncotarget - March 20, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Idiopathic Intracranial Hypertension Progressing to Venous Sinus Thrombosis, Subarachnoid Hemorrhage, and Stroke
We describe a young woman with typical IIH who underwent lumbar puncture and was treated with a short course of high-dose corticosteroids followed by acetazolamide. She subsequently developed CVST, subarachnoid hemorrhage, and stroke. Risk factors that may have resulted in CVST are discussed.
Source: Journal of Neuro-Ophthalmology - February 21, 2018 Category: Opthalmology Tags: Clinical Observation Source Type: research

Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events: A Cohort Analysis.
CONCLUSIONS: In COPD patients with CVD or risk factors for CVD, exacerbations confer an increased risk of subsequent CVD events, especially in hospitalized patients and within the first 30 days post-exacerbation. Patients and clinicians should have heightened vigilance for early CVD events following AECOPD. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01313676. PMID: 29442524 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2018 Category: Respiratory Medicine Authors: Kunisaki KM, Dransfield MT, Anderson JA, Brook RD, Calverley PMA, Celli BR, Crim C, Hartley BF, Martinez FJ, Newby DE, Pragman AA, Vestbo J, Yates JC, Niewoehner DE, SUMMIT Investigators Tags: Am J Respir Crit Care Med Source Type: research

Multiple Cerebral Infarctions Due to Patent Foramen Ovale in a Patient with Eosinophilic Granulomatosis with Polyangiitis
A 51-year-old man was diagnosed with eosinophilic granulomatosis with polyangiitis 6 years ago due to asthma, sinusitis, hypereosinophilia, and peripheral neuropathy based on the diagnostic criteria of American College of Rheumatology, and corticosteroid therapy achieved a remission. One year ago, he was hospitalized due to deep venous thrombosis (DVT) and pulmonary embolism, and rivaroxaban was administrated. He was admitted to our hospital for acute onset of diplopia and right hemiparesis. Peripheral blood examinations disclosed leukocytosis with hypereosinophilia.
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2018 Category: Neurology Authors: Kota Maekawa, Masunari Shibata, Masaru Seguchi, Kazuto Kobayashi, Yutaka Naito, Fumitaka Miya Tags: Case Studies Source Type: research