Checkerboard Visual Field Defect in Occipital Stroke
Abstract: A 74-year-old man with vasculopathic risk factors presented to the emergency room with a chief complaint of peripheral vision loss resulting from an intracranial hemorrhage in his right parietal and occipital lobes. Urgent craniotomy and ventriculostomy led to a stable clinical condition with subsequent development of a crossed quadrant homonymous hemianopsia (checkerboard visual field) due to a new right parieto-occipital infarct superimposed on a prior left occipital infarct. This uncommon visual field defect represents juxtaposed homonymous quadrantanopias that produce a striking checkerboard appearance that...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Trainees' Corner Source Type: research

Corneal Neurotization: A Surgical Treatment for Neurotrophic Keratopathy
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Surgeons' Corner Source Type: research

European Neuro-Ophthalmology Society Meeting, June 16–19, 2019, Porto, Portugal
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Neuro-Ophthalmology News Source Type: research

Klara Landau's Retirement From University Chair and European Neuro-Ophthalmology Society 2018 Course Both Occur in Switzerland
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Neuro-Ophthalmology News Source Type: research

The Eyes Give Warning
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Historical Note Source Type: research

Literature Commentary
In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, ND and Mark L. Moster, MD will discuss the following 6 articles: (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Literature Commentary Source Type: research

Aspirin Should Not Be Recommended to Prevent Second Eye Involvement in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Point Counter-Point Source Type: research

Episodic Visual Distortions and Stroke-Like Symptoms in a 56-Year-Old Man With Intravascular Lymphoma
Abstract: A healthy 56-year-old man presented with vision changes and left upper extremity motor and sensory changes. MRI of the brain without contrast was significant for multifocal areas of restricted diffusion in multiple vascular territories. Neuro-Ophthalmic evaluation revealed an inferonasal visual field defect in the left eye, thickened choroid on optical coherence tomography, and bilateral delayed arteriovenous and choroidal filling on fluorescein angiogram. Repeat MRI demonstrated interval enlargement of many of the same foci of abnormal diffusion-weighted imaging signal. Computed tomography of the abdomen and p...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Familial Cavernous Hemangioma
Abstract: A 30-year-old woman presented with diplopia after resection of an intracranial cavernous malformation. Fundus examination showed an asymptomatic intraocular cavernous hemangioma of the retina. Clinicians should be aware of the potential coexistence of intraocular and intracranial cavernous malformations; the presence of both should suggest familial etiology. As with other intracranial and intraocular vascular lesions (e.g., arteriovenous malformation in Wyburn-Mason syndrome, retinal hemangioblastoma in von Hippel Lindau disease, and choroidal hemangioma in Sturge–Weber syndrome), the presence of a vascul...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Photo Essay Source Type: research

Toxic Optic Neuropathy From Quinine Overdose
We present a patient with the stereotypical findings and natural history of quinine toxicity, a rare and not widely known cause of toxic optic neuropathy and retinopathy. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Photo Essay Source Type: research

Isolated Optic Perineuritis as the Presenting Sign of Sarcoidosis
Abstract: A 35-year-old healthy African-American woman presented with a 4-month history of gradual loss of vision in the right eye from an optic neuropathy. MRI of the orbits with gadolinium showed isolated thickening and enhancement of the right optic nerve sheath. Chest x-ray and CT-scan of the chest were performed and showed bilateral hilar and mediastinal lymphadenopathy. This was suggestive of sarcoidosis, and the diagnosis was confirmed with histopathology. The patient promptly recovered vision with high-dose corticosteroids; the thickening of the optic nerve sheath also regressed. Isolated optic nerve sheath thick...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Photo Essay Source Type: research

Jugular Paraganglioma and Bilateral Vestibular Schwannoma Presenting to an Acute Ophthalmology Service
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Paroxysmal Adduction After Internuclear Ophthalmoplegia
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Fulminant Pseudotumor Cerebri Syndrome Secondary to Over-the-Counter Topical Retinoids
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Recurrent Bilateral Myelin Oligodendrocyte Glycoprotein Antibody Optic Neuritis in a Leber Hereditary Optic Neuropathy Carrier
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Acute Solar Retinopathy and the Autosomal Dominant Compelling Helio-Ophthalmic Outburst Syndrome
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Optic Nerve Regeneration: How Will We Get There?
Conclusions: As neuro-regenerative and cell-transplantation based strategies for optic nerve regeneration continue to be refined, researchers and clinicians will need to work together to determine who will be a good candidate for such therapies. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

“Leaky” and “Unstable” Neural Integrator Can Coexist—Paradox Observed in Multiple Sclerosis
Abstract: The mechanism for stable gaze-holding requires a neural integrator that converts pulse of neural discharge to steady firing rate. The integrator is feedback-dependent, impaired feedback manifests as either “unstable” integration when it is too much or “leaky” when it is too little. The “unstable” integrator is known to cause sinusoidal oscillations of the eyes called pendular nystagmus, whereas the “leaky” integrator causes jerky eye oscillations called gaze-evoked nystagmus. We hypothesized that integrator can be simultaneously leaky and unstable. Mechanistically...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Basic and Translational Research Source Type: research

Central Venous Obstruction–Induced Intracranial Hypertension in Hemodialysis Patients: An Underrecognized Cause of Elevated Intracranial Pressure
Conclusions: Central venous obstruction–induced IH is likely underrecognized by clinicians and mimics idiopathic IH. Hemodialysis patients with IH should be screened with computed tomography venography of the chest. Optimal treatment is with vascular intervention or a CSF diversion procedure and can help prevent vision loss from papilledema or nervous system damage. Medical management may be appropriate in mild cases or as a bridge to definitive interventional treatment. Increased awareness among clinicians has potential to facilitate the timely diagnosis of this treatable condition with potential for good neurolog...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Disease of the Year: Cerebrovascular Disorders Source Type: research

Correlation of Visual Quality of Life With Clinical and Visual Status in Friedreich Ataxia
Conclusions: The NEI-VFQ-25 captures the subjective component of visual function in patients with FRDA. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

A Reliability and Comparative Analysis of the New Randomized King-Devick Test
Objective: The King-Devick (K-D) test is a rapid visual screening tool that can assess underlying brain trauma such as concussion via impairments in saccadic rhythm. A new tablet version of the K-D test using randomized numbers is now available, but reliability for this new version and comparison to the traditional K-D test has not yet been reported. Known for learning effects in the test, the aim of this study was to determine test–retest reliability and to compare performance of the new “randomized” version to the “traditional” K-D test version. We hypothesized that the “traditional&...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

Gabapentin and Memantine for Treatment of Acquired Pendular Nystagmus: Effects on Visual Outcomes
Conclusions: This study demonstrated that both memantine and gabapentin reduce APN, improving functional visual outcomes. Gabapentin showed a better tolerability, suggesting that this agent should be used as a first-line agent for APN. Data from our investigation emphasize the importance of visual functional outcome evaluations in clinical trials for APN. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

Orbicularis Oculi Morphological Alterations in Affected and Nonaffected Sides in Hemifacial Spasm
Conclusions: Significant morphological differences in the orbicularis oculi muscle in patients with HFS were observed on both the affected and nonaffected sides. Our findings suggest a potential role for muscle homeostasis disturbances on both sides for patients with HFS. Affected sides in patients with HFS did, however, demonstrate muscle degeneration that was not present on the nonaffected sides. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

Transcranial Magnetic Stimulation in Adults With Amblyopia
Conclusions: Visual acuity, suppressive imbalance, and stereoacuity had significant enhancements compared with baseline after cTBS over the right occipital lobe in an ambliopic population. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

Deep Learning and Transfer Learning for Optic Disc Laterality Detection: Implications for Machine Learning in Neuro-Ophthalmology
Conclusions: Small data sets can be used to develop high-performing DL systems for semantic labeling of neuro-ophthalmology images, specifically in distinguishing between right and left optic discs, even in the presence of neuro-ophthalmological pathologies. Although this may seem like an elementary task, this study demonstrates the power of transfer learning and provides an example of a DCNN that can help curate large medical image databases for machine-learning purposes and facilitate ophthalmologist workflow by automatically labeling images according to laterality. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

Spontaneous Venous Pulsations Detected With Infrared Videography
Conclusions: Infrared video is widely available in eye clinics by the use of OCT imaging systems and is substantially more sensitive in detecting SVP than traditional assessments using ophthalmoscopy. SVP is absent in as few as 1% of people with presumed normal ICP. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

Strain and Shear Wave Elastography in Diagnosis of Retrobulbar Neuritis
In this study, we investigated the diagnostic performance of strain elastography (SE) and shear wave elastography (SWE) in patients with RN. Elastography is a new sonographic technique and a noninvasive ultrasound method for evaluating the elastic properties of tissues based on static compression: the elastographic techniques of SE compress the tissues axially, and SWE uses waves that are generated by transducers and interact with the tissue. Methods: The study included 40 eyes of 20 patients with sudden visual loss, who were diagnosed with RN. The eyes of the patients were divided into 2 groups: the eye with a diagnosi...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Original Contribution Source Type: research

Idiopathic Intracranial Hypertension and Anemia: A Matched Case–Control Study
Conclusions: In this retrospective, matched case–control study, no significant association was found between IIH and anemia when comparing standardized CBC values. In accordance with previous studies, the prevalence of anemia may be relatively higher in the IIH population due to a prominent demographic overlap of females of child-bearing age. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Research: Epidemiology Meets Neuro-Ophthalmology Source Type: research

Self-Reported Weight and Height Among Idiopathic Intracranial Hypertension Patients
Background: Idiopathic intracranial hypertension (IIH) mostly affects overweight and obese women. Severe obesity is associated with poorer visual outcomes in IIH, and weight gain can precipitate IIH and increase the risk of recurrence. Conversely, weight loss can decrease intracranial pressure and is an effective IIH treatment. Therefore, accurate monitoring of weight and body mass index (BMI) is important to help guide the management of IIH patients. Our goal was to compare estimated and measured BMI among patients with presumed IIH and non-IIH controls to determine whether these vital signs should be systematically mea...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Research: Epidemiology Meets Neuro-Ophthalmology Source Type: research

High- and Low-Contrast Letter Acuity Perception Matures With Age in Normally Sighted Children
Background: High-contrast visual acuity (HCVA) changes with age, yet little is known about pediatric-specific age- and sex-normative values for low-contrast letter acuity (LCLA). We define maturational changes in monocular and binocular HCVA and LCLA in childhood and adolescence. Methods: Normally sighted youth (ages 5–20 years, without neurologic or ophthalmologic disease and best-corrected HCVA of 20/25 or better in each eye) were recruited. Mean monocular and binocular scores using Early Treatment Diabetic Retinopathy Study (for HCVA) and 2.5% and 1.25% Sloan (for LCLA) charts and the magnitude of binocular s...
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Clinical Research: Epidemiology Meets Neuro-Ophthalmology Source Type: research

The Case–Control Study in Neuro-Ophthalmology
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Editorial Source Type: research

Evolution of the Journal of Neuro-Ophthalmology and the Clinical Ophthalmology Literature: A 20-Year Retrospective
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 19, 2020 Category: Opthalmology Tags: Editorial Source Type: research

Vertical Meridian Sparing Homonymous Hemianopia due to an Occipital Infarct
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Trainees' Corner Source Type: research

Perineural Spread of Squamous Cell Carcinoma Without Enlargement or Enhancement of Involved Nerves
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Surgeons' Corner Source Type: research

American Academy of Ophthalmology and Neuro-Ophthalmology Subspecialty Day 2019 Summary
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Neuro-Ophthalmology News Source Type: research

Effect of Positioning on Intracranial Pressure: Response
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Effect of Positioning on Intracranial Pressure
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Literature Commentary
In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD will discuss the following 6 articles: Lambru G, Rantell K, Levy A, Matharu MS. A prospective comparative study and analysis of predictors of SUNA and SUNCT. Neurology. 2019;93:e1127–e1137.Gruener AM, Poostchi A, Carey AR, Eberhart CG, Henderson AD, Chang JR, McCulley TJ. Association of giant cell arteritis with race. JAMA Ophthalmol. [published ahead of print August 8, 2019] doi: 10.1001/jamaophthalmol.2019.2919.Ferro JM, Coutinho JM, Dentali F, Kobayashi A, Alasheev A, Canhão P, Karpov D, Nagel S, Posthuma L, Roriz J...
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Literature Commentary: Double Feature - Take Two! Source Type: research

Should Tocilizumab Be Used Routinely in New Patients With a Diagnosis of Giant Cell Arteritis?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Point Counter-Point Source Type: research

Intracranial Pure Germinoma With Optic Nerve Infiltration
Abstract: A 19-year-old man presented with a 3-year history of episodic headaches, right hemiparesis, and progressive vision loss in both eyes. Initially, extensive laboratory testing was unrevealing. MRI later demonstrated progressive enlargement and enhancement of the left optic nerve poorly correlated with the timing of his clinical manifestations. There was no clinical or radiological response to treatment with corticosteroids, mycophenolate mofetil, or rituximab administered empirically for possible inflammatory processes. Later in the disease course, he developed diabetes insipidus (DI), worsening vision to light p...
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Binocular Diplopia Caused by an Epiretinal Membrane With Foveal Displacement
Abstract: A 73-year-old woman presented with 3 years of monocular visual distortion and progressive binocular diplopia. She was found to have a comitant left hypertropia due to an epiretinal membrane causing inferior foveal drag. Displacement of the fovea from an epiretinal membrane is a likely under-recognized cause ocular cause of a comitant binocular diplopia. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Photo Essay Source Type: research

Isolated Abducens Nerve Palsy as Manifestation of Diffuse Intracranial Dolichoectasia
Abstract: An 83-year-old man presented with a 1-year history of abducens palsy. Brain MRA revealed arterial dolichoectasia of most cerebral vessels, including the basilar, internal carotid, and middle cerebral arteries. Abducens nerve palsy as a sole manifestation of diffuse intracranial dolichoectasia is unusual but may occur in diffuse intracranial dolichoectasia. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Photo Essay Source Type: research

Asymmetric Inferior Predilection of Lisch Nodules With Unilateral Ptosis
Abstract: Lisch nodules are melanocytic hamartomas that have been hypothesized to grow larger in the presence of sunlight. A 17-year-old boy with neurofibromatosis Type 1 and congenital ptosis in one eye presented and was found to have a distinct asymmetry of Lisch nodules between eyes with less under the ptotic lid. This case supports the theory that Lisch nodules form at least partially due to a direct trophic effect of sunlight. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Photo Essay Source Type: research

Multicolor Imaging of Myelinated Nerve Fibers Contiguous to the Optic Disc
Abstract: Myelinated nerve fibers (MNF) are characterized as whitish, relatively sharply demarcated, feather-like structures located in the retinal nerve fiber layer. MNF are located quite frequently in contiguity with the optic nerve head. This may lead to a diagnostic dilemma by preventing clear visualization of the optic disc margins. We herein describe the utility of multicolor imaging (MCI) in identifying optic disc anatomy in a case of MNF contiguous to the disc. MCI and infrared reflectance were superior to color fundus photography in delineating disc margins. Our pilot study describes the efficacy of MCI in delin...
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Photo Essay Source Type: research

Third Nerve Palsy Due to a Malignant Oculomotor Nerve Sheath Tumor
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Oculopalatal Tremor With Dissociated Pendular Nystagmus in Bilateral Inferior Olivary Hypertrophy
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Treatment of Ptosis Using Brimonidine Tartrate for Anterior Laminectomy-Induced Horner Syndrome
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Internuclear Ophthalmoplegia as the Presenting Sign of Giant Cell Arteritis
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Origins of Cerebral Edema: Implications for Spaceflight-Associated Neuro-Ocular Syndrome
Conclusions: Using the pathophysiology of cerebral edema as a model, hypotheses can be inferred as to the etiology of ODE in SANS. Further studies are needed to determine the presence and contribution of local vascular stasis and resulting inflammation and oxidative stress to the pathophysiology of SANS. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Teprotumumab in Thyroid-Associated Ophthalmopathy: Rationale for Therapeutic Insulin-Like Growth Factor–I Receptor Inhibition
Abstract: Thyroid-associated ophthalmopathy (TAO) is an autoimmune component of Graves' disease for which no currently available medical therapy provides reliable and safe benefit. Based on insights generated experimentally over the past several decades, the insulin-like growth factor–I receptor (IGF-IR) has been implicated in the pathogenesis of TAO. Furthermore, an IGF-IR inhibitor, teprotumumab, has emerged from 2 clinical trials as a promising treatment for active, moderate to severe TAO. This brief review intends to provide an overview of the rationale underlying the development of teprotumumab for this diseas...
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Basic and Translational Research Source Type: research