On Behalf of the North American Neuro-Ophthalmology Society, the Editorial Office of the Journal of Neuro-Ophthalmology Acknowledges With Gratitude Our Reviewers Who Dedicated Their Time and Effort Between January 1 and December 31, 2018
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Acknowledgment of Reviewers Source Type: research

Aditya Vikram Mishra, MD, FRCC (1961–2017)
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: In Memorium Source Type: research

Anterior Ischemic Optic Neuropathy After Dental Extraction: Comment
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

An Ancient Case of Horner Syndrome?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Historical Note Source Type: research

Anterior Ischemic Optic Neuropathy After Dental Extraction: Response
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Literature Commentary: Take Two!
In this section of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD will discuss the following 6 articles: 1. Brownlee WJ, Miszkiel KA, Tur C, Barkhof F, Miller DH, Ciccarelli O. Inclusion of optic nerve involvement in dissemination in space criteria for multiple sclerosis. Neurology. 2018;91:e1130–e1134. 2. Cossack M, Nabrinsky E, Turner H, Abraham A, Gratton S. Timolol eyedrops in the treatment of acute migraine attacks: a randomized crossover study. JAMA Neurol. 2018;75:1024–1025. 3. Rotenstein LS, Torre M, Ramos MA, Rosales RC, Guille C, Sen S, Mata DA. Prevalence of burnout amo...
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Literature Commentary: June Issue Double Feature Source Type: research

Literature Commentary
In this section of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD will discuss the following 6 articles: 1. Gallina P, Savastano A, Becattini E, Orlandini S, Scollato A, Rizzo S, Carreras G, Di Lorenzo N, Porfirio B. Glaucoma in patients with shunt-treated normal pressure hydrocephalus. J Neurosurg. 2018;129:1078–1084. 2. Pagovich OE, Vo ML, Zhao ZZ, Petropoulos IN, Yuan M, Lertsuwanroj B, Ciralsky J, Lai E, Kiss S, D'Amico DJ, Mezey JG, Malik RA, Crystal RG. Corneal confocal microscopy: neurologic disease biomarker in Friedreich ataxia. Ann Neurol. 2018;84:893–904. 3. Albrecht P,...
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Literature Commentary: June Issue Double Feature Source Type: research

Is Positioning During Lumbar Puncture Clinically Significant?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Point Counter-Point Source Type: research

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Complicated by Fatal Cerebral Vasculitis
Abstract: A 21-year-old man experienced unilateral vision loss associated with multiple atrophic chorioretinal lesions. He was treated for a presumptive diagnosis of acute retinal necrosis, but his vision did not improve with antiviral therapy. Over the course of several weeks, his symptoms progressed to involve both eyes. The fellow eye showed characteristic yellow-white placoid lesions, prompting treatment with oral corticosteroids for acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Despite high-dose therapy with prednisone 80 mg daily, the patient developed the acute onset of mental status changes ...
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Optic Perineuritis Due to Tuberculosis
Abstract: A 30-year-old man experienced subacute peripheral visual field loss with preserved central vision in his right eye. He was diagnosed with optic perineuritis due to tuberculosis. Optic perineuritis is an uncommon disorder and, at times, can be difficult to distinguish from optic neuritis. The differentiation can have significant impact on diagnostic testing and patient management. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

Retinal Nerve Fiber Layer and Peripapillary Capillary Density Reduction Detected Using Optical Coherence Tomography Enface Images and Angiography in Optic Tract Syndrome
Abstract: In a patient with an optic tract syndrome, we describe the loss of retinal nerve fiber layer and retinal microvasculature using enface and optical coherence tomography angiography image analyses. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

Infantile Presentation of Leber Hereditary Optic Neuropathy “Plus” Disease
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Endovascular Stenting in a Transgender Patient With Idiopathic Intracranial Hypertension
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Ocular Tilt Reaction in Compensated Vestibular Schwannoma
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Myasthenia Gravis Associated With Orbital Marginal Zone Lymphoma
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Minocycline-Induced Vasculitis Presenting as a Third Nerve Palsy
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Monocular Single Saccadic Pulses
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Neurofibromatosis Type 1 Vasculopathy Presenting as Impending Central Retinal Artery Occlusion
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Intracranial Hypertension in Transgender Patients
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Neurological and Ophthalmological Manifestations of Varicella Zoster Virus
Conclusions: HZ produces a spectrum of potentially blinding and life-threatening complications that adversely affect quality of life and increase health care costs. Individuals at risk for HZ, such as the elderly and immunocompromised, should be encouraged to receive the highly effective VZV vaccine to prevent HZ and its complications. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Vestibular Migraine: How to Sort it Out and What to Do About it
Conclusions: The keys to correctly diagnosing VM is identifying a relationship between vestibular symptoms and migrainous features and being aware of the heterogeneity of manifestations of this enigmatic, but treatable, condition. The principles of treatment of VM include rescue therapy, lifestyle modification, nonpharmacologic migraine preventives, pharmacologic migraine prophylaxis, and treatment of comorbidities. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Disease of the Year: Migraine Source Type: research

Neuro-Ophthalmic Symptoms of Primary Headache Disorders: Why the Patient With Headache May Present to Neuro-Ophthalmology
Conclusions: Patients with primary headache disorders may experience a wide range of visual and ophthalmic symptoms. An understanding of the typical features of these disorders allows providers to help patients find appropriate treatment without unnecessary testing and to recognize when atypical presentations require additional evaluation. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Disease of the Year: Migraine Source Type: research

Effects of Varying Intranasal Treatment Regimens in ST266-Mediated Retinal Ganglion Cell Neuroprotection
Conclusions: ST266 is a potential neuroprotective therapy to prevent RGC damage, and intranasal delivery warrants further study as a novel mechanism to deliver protein therapies for optic neuropathies. Results suggest that once daily ST266 treatment is sufficient to sustain maximal benefits and demonstrate that neuroprotective effects promoted by ST266 are specific to the combination of factors present in this complex biologic therapy. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Basic and Translational Research: Bench to Bedside Source Type: research

Visual Field Mean Deviation at Diagnosis of Idiopathic Intracranial Hypertension Predicts Visual Outcome
Conclusions: Based on this retrospective study, patients with IIH who have relatively mild visual dysfunction at diagnosis are likely to have a favorable visual outcome, provided they are adherent to recommended treatment. Many of those with poor visual function at diagnosis will have unfavorable visual outcomes despite aggressive treatment. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Original Contribution Source Type: research

Visual and Positional Modulation of Pendular Seesaw Nystagmus: Implications for the Mechanism
Conclusions: The similar patterns of nystagmus modulation observed in our patients with a different etiology indicate a common role of both visual and otolithic inputs in generating pendular SSN. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Original Contribution Source Type: research

Radiation-Induced Optic Neuropathy: Clinical and Imaging Profile of Twelve Patients
Conclusions: This study further delineates the profile of RON. Visual loss is often acute, profound, and monocular but may decline slowly after acute onset and later affect both optic nerves. High-resolution MRI of the optic nerves usually will display enhancement of a discrete segment of the intracranial prechiasmatic optic nerve, often with accompanying expansion and T2 hyperintensity. In some cases, these imaging features may precede vision loss. They may be subtle or appear after vision loss. Enhancement lingers for a wide interval, ranging in this study from 2 to at least 17 months. Recognition of these imaging char...
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Original Contribution Source Type: research

Aquaporin-4 Serostatus and Visual Outcomes in Clinically Isolated Acute Optic Neuritis
Conclusions: At 6 months, positive AQP4-Ab vs negative AQP4-Ab patients no evidence of poorer visual acuity. Lower visual acuity at baseline was associated with poor visual recovery at 6 months. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Original Contribution Source Type: research

Identifying Incidence of and Risk Factors for Fluoroscopy-Guided Lumbar Puncture and Subsequent Persistent Low-Pressure Syndrome in Patients With Idiopathic Intracranial Hypertension
Conclusions: The incidence of low-pressure syndrome, as measured by blood patches, is similar in IIH patients and MS controls. This suggests that having elevated intracranial pressure before an LP is not protective against developing postpuncture low-pressure syndrome, contrary to common assumptions. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Research: Epidemiology Meets Neuro-Ophthalmology Source Type: research

Initial Impairment and Recovery of Vision-Related Functioning in Participants With Acute Optic Neuritis From the RENEW Trial of Opicinumab
Conclusions: Most participants in the RENEW PP population demonstrated substantial recovery from baseline in patient-reported vision-related functioning and HCVA, regardless of treatment and structural damage. Average scores after recovery remained lower than those of published disease-free control groups. These results provide important information on visual function recovery in patients with AON, as measured by NEI-VFQ-25 and NOS-10. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Research: Epidemiology Meets Neuro-Ophthalmology Source Type: research

Risk Factors for Fellow Eye Involvement in Nonarteritic Anterior Ischemic Optic Neuropathy
Conclusions: Bilateral ODD and noncompliance with CPAP when indicated are associated with increased risk of NAION in the fellow eye. Patients with these risk factors should be counseled on the potentially devastating visual consequences of bilateral NAION, and compliance with CPAP should be stressed when appropriate. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 21, 2019 Category: Opthalmology Tags: Clinical Research: Epidemiology Meets Neuro-Ophthalmology Source Type: research

Neuro-Ophthalmology Virtual Education Library (NOVEL) 2019 Update: North American Neuro-Ophthalmology Society's Neuro-Ophthalmology Examination Techniques (NExT) and Illustrated Curriculum are Online
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Neuro-Ophthalmology News Source Type: research

Neuro-Ophthalmology in Canada
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Worldwide Neuro-Ophthalmology Source Type: research

Neuro-Ophthalmology in South India
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Optic Nerve Head Drusen: The Relationship Between Intraocular Pressure and Optic Nerve Structure and Function: Response
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Optic Nerve Head Drusen: The Relationship Between Intraocular Pressure and Optic Nerve Structure and Function: Comment
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Leber Hereditary Optic Neuropathy in a Mother and Daughter Associated With m.10197G>A Mutation
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Should Antiviral/Anti-Varicella Zoster Virus Treatment Be Used in Patients With Giant Cell Arteritis?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Point Counter-Point Source Type: research

A Tough NUT to Crack: A 47-Year-Old With Diplopia From a Rare Malignancy
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Congenital Oculonasal Synkinesis
Abstract: A 4-year-old girl with maxillary hypoplasia, intermittent exotropia, and high myopia displayed congenital oculonasal synkinesis. We examine the implications for pathogenesis of these disparate craniofacial findings. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

Central Retinal Artery Occlusion Due to Intraorbital Ophthalmic Artery Aneurysm
Abstract: A 60-year-old woman experienced sudden onset of vision loss in her right eye. Neuroimaging studies initially were interpreted as tumorous compression of the right optic nerve. On referral to our institution, examination findings were that of a right central retinal artery occlusion (CRAO). Review of the previous imaging studies was consistent with an aneurysm of the intraorbital ophthalmic artery at the origin of the central retinal artery, which was believed to be the cause of the CRAO. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

Isolated Fourth Nerve Palsy in Nontraumatic Tentorial Hemorrhage
Abstract: A 46-year-old woman being treated with warfarin for antiphospholipid antibody syndrome experienced a rise in international normalized ratio (INR) to 5.4 and developed sudden headache and diplopia. Neuro-ophthalmologic examination disclosed a right fourth nerve palsy. Noncontrast computed tomography revealed a subdural hematoma layered along the right tentorium cerebelli, directly in the path of the nerve. With normalization of the INR, the palsy markedly improved over subsequent weeks. This is a unique case of a nontraumatic subdural hematoma causing a fourth nerve palsy. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Photo Essay Source Type: research

Actinomyces Orbital Osteomyelitis in the Setting of Multiple Myeloma and Bisphosphonate-Related Osteonecrosis
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Positional Ocular Flutter Associated With Middle Cerebellar Peduncle Demyelination
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Finger Extension Weakness and Downbeat Nystagmus Motor Neuron Disease Syndrome: A Series of Two Cases
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Radiation-Induced Multiphasic Demyelination
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Intracranial Hypertension Induced by Megestrol Acetate Withdrawal
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Acute Retinal Necrosis Presenting With Optic Disc Edema
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Optical Coherence Tomography Angiography Findings in Superior Segmental Optic Nerve Hypoplasia
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Clinical Correspondence Source Type: research

Neurobiology of Photophobia
Background: Photophobia is commonly associated with migraine, meningitis, concussion, and a variety of ocular diseases. Advances in our ability to trace multiple brain pathways through which light information is processed have paved the way to a better understanding of the neurobiology of photophobia and the complexity of the symptoms triggered by light. Purpose: The purpose of this review is to summarize recent anatomical and physiological studies on the neurobiology of photophobia with emphasis on migraine. Recent Findings: Observations made in blind and seeing migraine patients, and in a variety of animal models...
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Disease of the Year: Migraine Source Type: research

Headaches in Idiopathic Intracranial Hypertension
Conclusions: Treatments used to manage primary headache disorders may be effective in the management of IIH-associated headache, although none have been specifically studied in this condition. Results: Recommendations provided consider a holistic approach to the problem based on existing guidelines and clinical experience. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 23, 2019 Category: Opthalmology Tags: Disease of the Year: Migraine Source Type: research