Hemoptysis in COVID-19: Observation
Sora Yasri, Viroj WiwanitkitAnnals of Thoracic Medicine 2020 15(2):102-102 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Sora Yasri Viroj Wiwanitkit Source Type: research

Intrapulmonary location of benign solitary fibrous tumor
Zeead M Alghamdi, Sharifah A Othman, Mohammed J Al-Yousef, Bader Z AlFadelAnnals of Thoracic Medicine 2020 15(2):98-101Intrapulmonary solitary fibrous tumors (SFTs) are sporadic mesenchymal neoplasms that typically arise from visceral or parietal pleura. While accounting for <5% of all pleural tumors, SFTs are known to occur in nearly all bodily organs, including nasopharynx, bladder, prostate, soft tissue of neck, buttocks, extremities, and abdominal wall. Such tumors have been previously designated localized fibrous mesothelioma or pleural fibroma. SFTs have no genetic basis and are unrelated to environmental fac...
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Zeead M Alghamdi Sharifah A Othman Mohammed J Al-Yousef Bader Z AlFadel Source Type: research

Mediastinal cyst infection followed by bacteremia due to Streptococcus anginosus after endobronchial ultrasound-guided transbronchial needle aspiration
Takehiko Hashimoto, Masaru Ando, Erina Watanabe, Jun-ichi KadotaAnnals of Thoracic Medicine 2020 15(2):95-97We herein report a case of recurrent mediastinal cyst infection followed by bacteremia after endobronchial ultrasound-guide transbronchial needle aspiration (EBUS-TBNA). A 65-year-old Japanese male with sarcoidosis presented with 4 L progressive lymph node adenopathy and was diagnosed with mediastinal cyst by EBUS-TBNA. After bronchoscopy, he suffered from a high fever. Chest computed tomography showed enlargement of the 4 L lymph node with low attenuation areas, the elevation of mediastinal fat concentration. Blood ...
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Takehiko Hashimoto Masaru Ando Erina Watanabe Jun-ichi Kadota Source Type: research

Thymoma diagnosis and categorization in the current scenario: Morphological analysis based on interobserver variability
CONCLUSION: The new WHO classification has good reproducibility among pathologists in thymoma reporting. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Meetu Agrawal Megha S Uppin Shantveer G Uppin Sundaram Challa Sumeet Agrawal AK Dharmrakshak Source Type: research

A comparison between warfarin and apixaban: A patient & #39;s perspective
CONCLUSIONS: Future studies should explore why patients using apixaban showed lower QOL scores and improve health-care providers' awareness of these issues. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Abdullah U Althemery Abdullah A Alfaifi Abdulrahman Alturaiki Maha A. L. Ammari Khizra Sultana Leanne Lai Source Type: research

Clinical and pathological differences between polymorphonuclear-rich and lymphocyte-rich tuberculous pleural effusion
CONCLUSION: The TB pleurisy patients dominated by neutrophils show strong inflammatory reactions and higher ADA levels in pleural effusion. These findings can significantly improve the positive rate of Mycobacterium tuberculosis in neutrophil-predominant TPE under thoracoscopy. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Tingting Zhao Bing Chen Yurong Xu Yiqing Qu Source Type: research

The correlation between oxygen saturation indices and the standard obstructive sleep apnea severity
CONCLUSION: Our findings support the clinical reliability of the currently used standard classification of OSA severity based on the AHI. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Siraj Omar Wali Bahaa Abaalkhail Ibrahim AlQassas Faris Alhejaili David W Spence Seithikurippu R Pandi-Perumal Source Type: research

Correlating computed tomography pulmonary angiography signs of right ventricular strain in pulmonary embolisms to clinical outcomes
CONCLUSION: Only IVC contrast reflux was associated with increased mortality, and no other sign of RVS on CTPA correlated with clinical outcomes. This suggests that most signs of RVS on CTPA do not reliably predict PE severity. Therefore, RVS seen by CTPA should be used cautiously in weighing the decision to initiate thrombolytics. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Jay Karri Tiffany Truong Joseph Hasapes Daniel Ocazionez Trujillo Steven Chua Kaustubh Shiralkar Gabriel Aisenberg Source Type: research

An overview of exacerbations of chronic obstructive pulmonary disease: Can tests of small airways & #39; function guide diagnosis and management ?
Nowaf Y Alobaidi, James A Stockley, Robert A Stockley, Elizabeth SapeyAnnals of Thoracic Medicine 2020 15(2):54-63 Chronic obstructive pulmonary disease (COPD) is common and debilitating. Most patients with COPD experience intermittent, acute deterioration in symptoms which require additional therapy, termed exacerbations. Exacerbations are prevalent in COPD and are associated with poor clinical outcomes including death, a faster decline in lung health, and a reduced quality of life. Current guidelines highlight the need to treat exacerbations promptly and then mitigate future risk. However, exacerbations are self-reporte...
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Nowaf Y Alobaidi James A Stockley Robert A Stockley Elizabeth Sapey Source Type: research

Spectrum of histopathological findings in coronavirus disease-19, Middle East respiratory syndrome and severe acute respiratory syndrome
Khaled O Alsaad, Yaseen M Arabi, Ali H HajeerAnnals of Thoracic Medicine 2020 15(2):52-53 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Khaled O Alsaad Yaseen M Arabi Ali H Hajeer Source Type: research

Clinical trials for coronavirus disease 2019: What is being evaluated and what is not
Yaseen M Arabi, Ayed Asseri, Steve Webb, John Marshall, Mohamed S Al MoamaryAnnals of Thoracic Medicine 2020 15(2):49-51 Since the report of the first case of coronavirus disease 2019 (COVID-19) in China in late December 2019, there have been 204 610 cases worldwide as of 18 March, 2020. As part of the response to this outbreak, there has been an impressive amount of research undertaken to better characterize the disease and to evaluate therapeutic options. By March 12, 2020, there are more than 382 studies registered in the clinical trials databases addressing COVID-19 including more than 80 randomized controlled trials....
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Yaseen M Arabi Ayed Asseri Steve Webb John Marshall Mohamed S Al Moamary Source Type: research

Role of long-term azithromycin therapy for severe bronchial asthma
Mohamed S Al-Hajjaj, Mohamed S Al MoamaryAnnals of Thoracic Medicine 2020 15(2):47-48 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 3, 2020 Category: Respiratory Medicine Authors: Mohamed S Al-Hajjaj Mohamed S Al Moamary Source Type: research

Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
Mahmood Dhahir Al-MendalawiAnnals of Thoracic Medicine 2020 15(1):45-45 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Mahmood Dhahir Al-Mendalawi Source Type: research

Treatment-related toxicity in lung cancer: Radiation induced or radiation attributed ?
Efstathios Kamperis, Chionia Kodona, Vasileios GiannouzakosAnnals of Thoracic Medicine 2020 15(1):44-44 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Efstathios Kamperis Chionia Kodona Vasileios Giannouzakos Source Type: research

Organizing pneumonia in a carrier of human T-cell lymphotropic virus type-1
We present a case of an 82-year-old woman with OP as a HABA. This patient responded to corticosteroid therapy; however, the patient required the continuation of oral corticosteroid therapy to avoid OP relapse. In cases of OP as a HABA that are not stabilized by treatment with corticosteroids, continuation of oral corticosteroid therapy might be considered. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Masahiro Yamasaki Masaya Taniwaki Kunihiko Funaishi Noboru Hattori Source Type: research

Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
Nguk Chai Diong, Benedict Dharmaraj, Cindy Thomas Joseph, Narasimman SathiamurthyAnnals of Thoracic Medicine 2020 15(1):38-40Mediastinal nonseminomatous germ cell tumor (NSGCT) is rare. NSGCT shows excellent response to cisplatin-based chemotherapy. However, some tumors continue to enlarge despite normal tumor markers after chemotherapy, a rare condition called growing teratoma syndrome (GTS). Recognition of this condition is imperative for prompt surgical resection to prevent further cardiopulmonary compression and to improve survival. Multidisciplinary team meeting is important for perioperative preparation and care to i...
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Nguk Chai Diong Benedict Dharmaraj Cindy Thomas Joseph Narasimman Sathiamurthy Source Type: research

Incidence of latent tuberculosis infection among health science students during clinical training
CONCLUSIONs: The risk of acquiring LTBI during clinical training in health science colleges is 10%. Students in the college of medicine are at significantly higher risk of LTBI than students of other health science specialties. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Mada H Alsharif Atheer A Alsulami Malikah Alsharef Amr S Albanna Siraj O Wali Source Type: research

The effect of the presence and severity of bronchiectasis on the respiratory functions, exercise capacity, dyspnea perception, and quality of life in patients with chronic obstructive pulmonary disease
CONCLUSIONS: In patients with Stage 3 and 4 COPD, the presence of bronchiectasis adversely affects the clinical status of the patients, decreases their exercise capacity, deteriorates their quality of life, and disrupts their psychological status. Investigating the presence of bronchiectasis in COPD patients is crucial for early diagnosis and proper treatment. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Hulya Sahin Ilknur Naz Seher Susam Ahmet Emin Erbaycu Serhan Olcay Source Type: research

Congenital lobar emphysema: Thoracotomy versus minimally invasive surgery
CONCLUSIONS: CLE is a rare malformation with variable presentation. Infants presenting with respiratory distress or recurrent chest infection should be evaluated for the possibility of CLE. Lobectomy is the treatment of choice, and rarely, the patients may be managed conservatively. Thoracoscopic lobectomy is a safe procedure with the possibility of air leak and conversion to open lobectomy. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Osama Abdullah Bawazir Source Type: research

A retrospective clinical research of relapsed organizing pneumonia
CONCLUSIONS: When treating cases of OP with high serum concentrations of SP-D, attention should be paid to the possibility of relapse. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Toru Yamagishi Norio Kodaka Kayo Watanabe Chihiro Nakano Takeshi Oshio Kumiko Niitsuma Nagashige Shimada Hiroto Matsuse Source Type: research

Prevalence of restless legs syndrome among pregnant women: A case & #8211;control study
CONCLUSION: RLS is common, but underdiagnosed, among Saudi pregnant women and nonpregnant women of childbearing age. The study revealed that RLS during pregnancy is linked to parity, anemia, diabetes mellitus, Vitamin D deficiency, and smoking. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Aljohara S Almeneessie Nada Alyousefi Maha Alzahrani Aisha Alsafi Raneem Alotaibi Awad H Olaish Yasser Sabr Ahmed S Bahammam Source Type: research

Ventilator- and interface-related factors influencing patient-ventilator asynchrony during noninvasive ventilation
Hadil A Al Otair, Ahmed S BaHammamAnnals of Thoracic Medicine 2020 15(1):1-8 Patient-ventilator asynchrony (PVA) is common in patients receiving noninvasive ventilation (NIV). This occurs primarily when the triggering and cycling-off of ventilatory assistance are not synchronized with the patient's inspiratory efforts and could result in increased work of breathing and niv failure. In general, five types of asynchrony can occur during NIV: ineffective inspiratory efforts, double-triggering, auto-triggering, short-ventilatory cycling, and long-ventilatory cycling. Many factors that affect PVA are mostly related to the ...
Source: Annals of Thoracic Medicine - January 2, 2020 Category: Respiratory Medicine Authors: Hadil A Al Otair Ahmed S BaHammam Source Type: research

A novel diagnostic approach for Pneumocystis jirovecii pneumonia using fine-needle aspiration, electromagnetic navigational bronchoscopy and rapid on-site evaluation
We present a unique presentation of Pneumocystis jirovecii pneumonia and discuss the utility of electromagnetic navigational bronchoscopy in the evaluation of immunocompromised patients with peripheral cavitary lung lesion. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Farnaz Houshmand Fatima Zahra Aly Mark Rollin Bowling Source Type: research

Prevalence and factors associated with adult bronchial asthma in Aseer region, Southwestern Saudi Arabia
CONCLUSION: The prevalence of BA was high, affecting one-fifth of adults in Aseer region. The study revealed some modifiable factors significantly associated with BA in adults. There is a need to improve asthma control programs at the primary health-care level, particularly at rural and at low-altitude areas, and more focus should address the elders. In addition, enhancing community-based health promotion programs tackling the identified modifiable factors of BA are required. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Badr Rashed Al Ghamdi Emad Abdulkadir Koshak Hussein Mohammad Ageely Fakhreldin Mohamed Omer Nabil Joseph Awadalla Ahmed A Mahfouz Source Type: research

Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
CONCLUSION: There is a high burden of pulmonary dysfunction in SCD among Nigerians which may be related to the severity of disease. There is a need for further research to explore the effectiveness of potential interventions so as to harness the benefits from monitoring and early detection. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Obianuju B Ozoh Olufunto O Kalejaiye Ojiebun E Eromesele Yusuf A Adelabu Sandra K Dede Folasade O Ogunlesi Source Type: research

Repositioning of endotracheal tube and risk of ventilator-associated pneumonia among adult patients: A matched case-control study
CONCLUSION: Reposition of ETT considers as a risk factor for VAP in ICU patients, and appropriate measures should be applied to reduce movements of the ETT tube. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Taha Ismaeil Latifah Alfunaysan Nouf Alotaibi Shatha Alkadi Fatmah Othman Source Type: research

Diagnosis of infectious pleural effusion using predictive models based on pleural fluid biomarkers
CONCLUSIONS: The two predictive models developed for IPE showed a good diagnostic performance, superior to that of any of the markers when used separately. Although IL-6 contributes a slight greater capacity of discrimination to the model that includes it, its routine determination does not seem justified. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Luc & #237;a Ferreiro & #211;scar Lado-Baleato Juan Su & #225;rez-Antelo Mar & #237;a Elena Toubes Mar & #237;a Esther San Jos & #233; Adriana Lama Nuria Rodr & #237;guez-N & #250; & #241;ez Jos & #233; Manuel & #193;lvarez-Doba & #241;o Francisco J Gonz Source Type: research

Prognostic value of blood biomarkers in patients with unprovoked acute pulmonary embolism
CONCLUSIONS: The biomarker model including hemoglobin, uric acid, and glucose has good prognostic performance comparable to the ESC risk classification while PESI or simplified PESI score was not useful in unprovoked PE. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Joo Hee Lee Jin Won Huh Sang-Bum Hong Yeon-Mok Oh Tae Sun Shim Chae-Man Lim Sang-Do Lee Younsuck Koh Woo Sung Kim Jae Seung Lee Source Type: research

Thoracoscopy in pediatrics: Surgical perspectives
Osama A BawazirAnnals of Thoracic Medicine 2019 14(4):239-247 Thoracoscopic surgery and other minimally invasive approaches in children achieved marked advancement and expanded to include several disciplines in the last decade. The new armamentarium of the minimally invasive surgery including the smaller instruments and better magnification led to the application of this technology in the small infants and neonates. Currently, thoracoscopy is considered the preferred surgical approach for various conditions in neonates and infants over the standard thoracotomy, and thoracoscopic training is included in the surgical traini...
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Osama A Bawazir Source Type: research

Lung nodules: A comprehensive review on current approach and management
This article reviews current knowledge on nodule definition, diagnostic evaluation, and management based on literature data and mainly recent guidelines. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Konstantinos Loverdos Andreas Fotiadis Chrysoula Kontogianni Marianthi Iliopoulou Mina Gaga Source Type: research

The journey to zero deep-vein thrombosis in critically ill patients
Yaseen M Arabi, Sami J Alsolamy, Abdulaziz Al-DawoodAnnals of Thoracic Medicine 2019 14(4):223-225 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 27, 2019 Category: Respiratory Medicine Authors: Yaseen M Arabi Sami J Alsolamy Abdulaziz Al-Dawood Source Type: research

Trends of critical care research in Saudi Arabia
Musharaf Sadat, Yaseen ArabiAnnals of Thoracic Medicine 2019 14(3):220-221 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Musharaf Sadat Yaseen Arabi Source Type: research

Successful management for repeated bar displacements after Nuss method by two bars connected by a stabilizer
Kotoku Yoshida, Tsutomu Kashimura, Yuji Kikuchi, Hiroaki NakazawaAnnals of Thoracic Medicine 2019 14(3):216-219The Nuss method has become the standard surgery for the treatment of funnel chest, and good therapeutic results have been reported. Among the complications of the Nuss method, displacement of the bar is the most frequent, and there are cases in which reoperation is necessary. In this case report, we have devised a new stabilizer that connects and fixes two bars as bar displacement occurred following each of the two prior Nuss procedures, and the outcome of our procedure was evaluated. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Kotoku Yoshida Tsutomu Kashimura Yuji Kikuchi Hiroaki Nakazawa Source Type: research

Two rare complications in a single patient of lung cancer: Radiation-induced spontaneous esophageal perforation and aortic rupture and their successful management
This report also highlights the use of above mentioned novel therapeutic methods for successful management of these complications in these frail patients. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Mohan Venkatesh Pulle Harsh Vardhan Puri Belal Bin Asaf Arvind Kumar Source Type: research

Computed tomography-guided percutaneous hook wire localization of pulmonary nodular lesions before video-assisted thoracoscopic surgery: Highlighting technical aspects
CONCLUSIONS: Preoperative percutaneous hook wire localization is a dependable and useful technique to facilitate positioning small and deep pulmonary nodules for thoracoscopic complete excision and accurate diagnosis. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Jae Bum Park Song Am Lee Woo Surng Lee Yo Han Kim Inyoung Song Jeong Geun Lee Jae Joon Hwang Source Type: research

Level and predictors of anxiety in patients undergoing diagnostic bronchoscopy
CONCLUSION: Diagnostic bronchoscopy can cause high anxiety in many patients. Prebronchoscopy anxiety assessment can help bronchoscopists to anticipate the anxiety levels of patients, and then further use it to tailor sedation requirements. Special attention should be given to older patients, patients with high BMI, and the ones undergoing bronchoscopy in outpatient settings. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Ahmed A Aljohaney Source Type: research

Comparison of arterial and venous blood gases in patients with obesity hypoventilation syndrome and neuromuscular disease
CONCLUSIONS: There was a correlation between ABG and VBG values (pH, pCO2, and HCO3). VBG parameters (pH, pCO2, and HCO3) can be used safely instead of ABG parameters which have many risks, during treatment and follow-up of patients with OHS and NMD. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Hicran Orucova Tulin Cagatay Zuleyha Bingol Penbe Cagatay Gulfer Okumus Esen Kiyan Source Type: research

Low early posttransplant serum tacrolimus levels are associated with poor patient survival in lung transplant patients
CONCLUSIONS: These finding suggest that tacrolimus levels ≥10 ng/ml within 1 month after lung transplantation appear to be associated with better patient survival. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Jung-Hwa Ryu Sunmi Choi Hyun Joo Lee Young Tae Kim Young Whan Kim Jaeseok Yang Source Type: research

Characteristics and outcome of viral pneumonia caused by influenza and Middle East respiratory syndrome-coronavirus infections: A 4-year experience from a tertiary care center
CONCLUSION: Viral pneumonia caused by influenza and MERS-CoV carries a high mortality rate, particularly among MERS-CoV infected cases. Old age, male gender, and comorbid illnesses are predictors of poor outcome. Routine testing for newly emergent viruses is warranted for adults who have been hospitalized with pneumonia. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Abeer M Al-Baadani Fatehi E Elzein Salwa A Alhemyadi Osama A Khan Ali H Albenmousa Majdy M Idrees Source Type: research

Prevalence of the epidermal growth factor receptor mutations in lung adenocarcinoma patients from the Middle East region
Arafat Hussein Tfayli, Ghina Bassam Fakhri, Majd Sassine Al AssaadAnnals of Thoracic Medicine 2019 14(3):173-178 Lung cancer remains a major cause of cancer mortality with a 5-year survival in advanced stages around 4%. Platinum-based chemotherapy was routinely used as the standard of care in patients with advanced nonsmall cell lung cancer, but it is being progressively replaced by targeted molecular therapy. One of the molecular aberrations harbored by lung adenocarcinoma is the epidermal growth factor receptor (EGFR). A large ethnic variation has been reported in the prevalence of EGFR mutations in patients with lu...
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Arafat Hussein Tfayli Ghina Bassam Fakhri Majd Sassine Al Assaad Source Type: research

Biomarkers and clinical scoring systems in community-acquired pneumonia
Meropi Karakioulaki, Daiana StolzAnnals of Thoracic Medicine 2019 14(3):165-172 Community-acquired pneumonia (CAP) is the third most common cause of death globally. Due to the complexity of CAP, it is widely accepted that, currently, clinical prognosis and diagnosis is inadequate for the assessment of the severity of the disease. With the aim to determining the initial treatment and the appropriate level of intervention, several clinical scores of severity and biomarkers have been developed. Both biomarkers and clinical scoring systems are expected to determine the different aspects of the host factor and the response to ...
Source: Annals of Thoracic Medicine - June 26, 2019 Category: Respiratory Medicine Authors: Meropi Karakioulaki Daiana Stolz Source Type: research

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: Unusual presentation
Nuha Nasser Alrajhi, Muthurajan P Paramasivam, Ahmad Amer Alboukai, Ammar C Alrikabi, Esam Hamad AlhamadAnnals of Thoracic Medicine 2019 14(2):161-163Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNEC) is an abnormal proliferation of pulmonary neuroendocrine cells that occur without underlying etiology. Here, we report a unique case of 55-year-old female with unusual presentation of DIPNECH and thymoma and on the background history of Crohn's disease that might point toward an autoimmune phenomenon. To the best of our knowledge, there were no previous reports of DIPNECH with either thymoma or Crohn...
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Nuha Nasser Alrajhi Muthurajan P Paramasivam Ahmad Amer Alboukai Ammar C Alrikabi Esam Hamad Alhamad Source Type: research

Fatal and near-fatal thunderstorm asthma epidemic in a desert country
CONCLUSION: The study is the first to report on a thunderstorm-associated asthma epidemic in Kuwait and emphasizes the potential dangers associated with this entity. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Fatima Ali Naser Behbehani Noura Alomair Assad Taher Source Type: research

Asthma control and predictive factors among adults in Saudi Arabia: Results from the Epidemiological Study on the Management of Asthma in Asthmatic Middle East Adult Population study
CONCLUSIONS: Asthma control remains suboptimal among Saudi population. This needs huge efforts to achieve acceptable levels of control and better QoL for asthma patients. Further studies are still needed in Saudi Arabia and the Middle East region. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Hamdan AL-Jahdali Siraj Wali Gamal Salem Fahad Al-Hameed Abdullah Almotair Mohammed Zeitouni Hassan Aref Rufai Nadama Mohammed M Algethami Ahmed Al Ghamdy Tarek Dihan Source Type: research

Association of preoperative systemic corticosteroid therapy with surgical outcomes in chronic obstructive pulmonary disease patients
CONCLUSIONS: This study suggests that preoperative administration of systemic corticosteroids in stable COPD patients is associated with an increased risk of postoperative wound complications but may not reduce PPCs. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Samer Abou Arbid Habib El-Khoury Faek Jamali Hani Tamim Hassan Chami Source Type: research

Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases
CONCLUSION: Medical thoracoscopy is effective for diagnosing tuberculous pleurisy. Younger patients with tuberculous pleurisy have a higher number of positive TB tests in the pleural cavity, are more likely to have granuloma in pleural biopsy specimens, and have higher ADA levels in the pleural fluid. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Tingting Zhao Yurong Xu Qian Song Xinjie Wang Minghua Jin Dianjie Lin Source Type: research

Prospective study of dual use of e-cigarettes and other tobacco products among school-going youth in rural Appalachian Tennessee
CONCLUSION: The increasing trend in dual use of e-cigarettes and other tobacco products among youth in Appalachia Tennessee suggests a critical need for comprehensive tobacco control programs to avert exacerbating disparities in tobacco use and tobacco-related diseases in the US. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Hadii M Mamudu Liang Wang Daniel Owusu Crystal Robertson Candice Collins Mary A Littleton Source Type: research

2018 Year in Review in Critical Care
Yaseen M Arabi, Alaa Gouda, Youssuf A AliAnnals of Thoracic Medicine 2019 14(2):122-126 (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Yaseen M Arabi Alaa Gouda Youssuf A Ali Source Type: research

Asthma and obesity in the Middle East region: An overview
Samer Hammoudeh, Wessam Gadelhak, Ibrahim A JanahiAnnals of Thoracic Medicine 2019 14(2):116-121This paper aims to cover the current status of asthma and obesity in the Middle East, as well as to introduce the various studies tying the two diseases; further expanding on the proposed mechanisms. Finally, the paper covers recent literature related to sphingolipids and its role in asthma, followed by recommendations and future directions. In preparation of this paper, we searched PubMed and Google Scholar, with no restrictions, using the following terms; asthma, obesity, Middle East, sphingolipids. We also used the reference ...
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: Samer Hammoudeh Wessam Gadelhak Ibrahim A Janahi Source Type: research

Sarcoidosis in the Middle East
B Jayakrishnan, Nasser Al-Busaidi, Saif Al-Mubaihsi, Omar A Al-RawasAnnals of Thoracic Medicine 2019 14(2):106-115Sarcoidosis, a systemic granulomatous disease of unknown cause, has been described worldwide and in all populations with notable differences in clinical characteristics, organ involvement, disease severity, and prognosis among different ethnic and racial groups. While the exact prevalence of sarcoidosis in the Middle East is unknown, studies from various countries in the region have reported the clinical characteristics of affected patients, along with a few anecdotal reports. A search of the MEDLINE and Google...
Source: Annals of Thoracic Medicine - April 5, 2019 Category: Respiratory Medicine Authors: B Jayakrishnan Nasser Al-Busaidi Saif Al-Mubaihsi Omar A Al-Rawas Source Type: research