Teaching case 2-2020: Lhermitte-Duclos disease in a female patient with Cowden syndrome.
PMID: 32049624 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - February 12, 2020 Category: Pathology Authors: Hametner S, Hainfellner JA, Ortler M, Haberler C Tags: Clin Neuropathol Source Type: research

High mitotic activity in a capillary hemangioma of the cauda equina: Case report and review of the literature.
CONCLUSION: Natural history and post-operative follow-up for patients with spinal intradural capillary hemangioma are uncertain. This is the sole case to have not recurred at 12 months which underwent gross total resection and had a high proliferative index.
. PMID: 32049625 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - February 12, 2020 Category: Pathology Authors: Fish C, Sy J, Wong J Tags: Clin Neuropathol Source Type: research

TSC2 alterations in anaplastic ependymoma progression to ependymosarcoma.
We report the case of a 38-year-old male with anaplastic ependymoma (WHO grade III) that progressed to ependymosarcoma in less than 2 years after multiple resections, chemoradiotherapy, and anti-PD1 immunotherapy. Next-generation sequencing was performed on both high-grade anaplastic ependymoma and ependymosarcoma samples to detect small base changes, insertions, and deletions in exons and splice junctions from a panel of over 400 genes. We identify genetic variants in the tumor suppressors RB1, TP53, and TSC2 in these samples and discuss the potential significance of an additional TSC2 genetic variant in the progression t...
Source: Clinical Neuropathology - February 4, 2020 Category: Pathology Authors: Pujadas E, Chen L, Weingart JD, Orr B, Ozer BH, Holdhoff M, Rodriguez FJ Tags: Clin Neuropathol Source Type: research

MicroRNAs and HDAC4 protein expression in the skeletal muscle of ALS patients.
CONCLUSION: The different expression of miRNAs and HDAC4 in genetic ALS vs. SALS and UMN cases is likely to be correlated to different pathogenic mechanisms.
. PMID: 32000889 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - January 31, 2020 Category: Pathology Authors: Pegoraro V, Marozzo R, Angelini C Tags: Clin Neuropathol Source Type: research

History of Pick's disease.
Abstract After a short summary of Arnold Pick's biography, the history of how Pick's disease (PiD) was reported is presented, from its clinical symptoms to its molecular characterization. The macroscopic description of frontotemporal atrophy by Pick is recounted followed by a description of the histological lesions observed by Alzheimer and the progressive characterization of the disease. The subsequent diagnosis has since relied on ultrastructural findings as well as immunohistochemical and biochemical techniques. The discovery of the role of the microtubule-associated τ-protein, encoded by chromosome 17, mor...
Source: Clinical Neuropathology - January 31, 2020 Category: Pathology Authors: Mikol J Tags: Clin Neuropathol Source Type: research

Clinicopathological concordance in cognitive disease diagnostics.
In this study, a full concordance between clinical diagnoses and neuropathological morphology was found in 61% of individuals, with marked variations between subgroups, including the lowest (31%) in the group of VaD. Vigilance in clinicopathological concordance is important for quality maintenance as well as the improvement of skills in diagnostic work. In light of the previous study, VaD one decade later remains elusive. The unmasking of this complicated and multifaceted disorder may be beneficial to the overall diagnostic accuracy in cognitive disease investigations.
. PMID: 31983385 [PubMed - as supplied by publi...
Source: Clinical Neuropathology - January 27, 2020 Category: Pathology Authors: Möller Andersson E, Johansson Hoff E, Landqvist Waldö M, Englund E Tags: Clin Neuropathol Source Type: research

Intracranial chondromas: A histopathologic and molecular study of three cases.
CONCLUSION: Meningeal chondroma is rare. It affects predominantly young adults and has a good outcome. No molecular alterations have currently been described in this entity.
. PMID: 31983386 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - January 27, 2020 Category: Pathology Authors: Tauziède-Espariat A, Burel-Vandenbos F, Pedeutour F, Gareton A, Saffroy R, Andreiuolo F, Blauwblomme T, Dangouloff-Ros V, Boddaert N, Lechapt E, Chrétien F, Varlet P Tags: Clin Neuropathol Source Type: research

How frequent is double pathology in Rasmussen encephalitis?
Abstract Rasmussen encephalitis (RE) is an uncommon, medically refractory cause of seizures that usually presents in childhood or adolescence resulting in unilateral hemispheric atrophy in most cases. The purported immune-mediated cause of the disease is supported by the characteristic histopathologic features of diffuse perivascular and intraparenchymal T-cell-predominant infiltrates, microglial activation with microglial nodules, and neuronophagia. A small number of reports have emerged, however, suggesting that double pathology (such as focal cortical dysplasia (FCD) or hippocampal sclerosis) may be present. We...
Source: Clinical Neuropathology - December 19, 2019 Category: Pathology Authors: Gilani A, Kleinschmidt-DeMasters BK Tags: Clin Neuropathol Source Type: research

Clinical Neuropathology 1-2020.
PMID: 31847952 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 18, 2019 Category: Pathology Authors: Hainfellner JA Tags: Clin Neuropathol Source Type: research

Cystic sellar salivary gland-like lesions.
CONCLUSION: Few pathologists or neuropathologists have encountered CSSLs in their practices; case 1 produced recurrence and significant infundibular stalk damage, and case 3 originally manifested apoplexy, features not previously reported.
. PMID: 31845864 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 17, 2019 Category: Pathology Authors: Kleinschmidt-DeMasters BK, Rosenblum MK, Kerr JM, Lillehei KO Tags: Clin Neuropathol Source Type: research

A high-grade glioma with SOS1 amplification.
We present a case of a 56-year-old male with an enhancing left temporal lobe tumor. Histology revealed a high-grade glioma adjacent to a low-grade glioneuronal component with abundant Rosenthal fibers, focal eosinophilic granular bodies, and CD34-positive neurons. The tumor was negative for IDH1 (R132H), BRAF-V600E, and the KIAA1549-BRAF fusion. Comparative genomic hybridization detected a large amplification (> 15 copies) of the Son of Sevenless 1 (SOS1) gene, a component of the MAPK pathway. Although activating mutations in the MAPK pathway occur frequently in gliomas and glioneuronal tumors, SOS1 gene amplificat...
Source: Clinical Neuropathology - December 16, 2019 Category: Pathology Authors: Vidal B, Bryke C, Hsu N, Alterman R, Yeo AT, Charest A, Varma H Tags: Clin Neuropathol Source Type: research

Neuropathological findings in a South Korean patient with Perry syndrome.
CONCLUSION: The neuropathology, including TDP-43 proteinopathy, is comparable to that reported previously in Caucasian populations. In addition to the stereotypic features of PS, our patient had NFTs in the parahippocampal gyrus, the pathology similar to that is described as primary age-related tauopathy (PART). These observations suggest that comorbid age-related neuropathologic change may also contribute to cognitive impairment in PS.
. PMID: 31829926 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 12, 2019 Category: Pathology Authors: Chung EJ, Kim SJ, Kim EJ, Ahn JW, Huh GY, Cho HJ, Cairns NJ Tags: Clin Neuropathol Source Type: research

Teaching case 1-2020: Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia - An unusual cause of dementia.
PMID: 31793869 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 3, 2019 Category: Pathology Authors: Klotz S, Riederer F, Hergovich N, Schlager T, Steinkellner L, Fertl E, Baumgartner C, Zimprich A, Gelpi E Tags: Clin Neuropathol Source Type: research

Intracranial venous myxoma - An incidental finding.
Abstract Myxomas are the commonest type of benign cardiac tumors, however, myxomas of an extracardiac origin are rare. This case report presents the postmortem finding of a myxoma arising in the superior sagittal sinus of a 76-year-old woman in the absence of a cardiac primary tumor. PMID: 31793870 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - December 3, 2019 Category: Pathology Authors: Rekathati N, Englund E Tags: Clin Neuropathol Source Type: research

Predicting short-term recurrence in pituitary adenomas: Phosphohistone-H3 (Ser 10) proves an effective biomarker.
Abstract AIMS: This research sought to assess the effectiveness of the phosphohistone-H3 (PHH3) mitotic index (MI) as a biomarker to predict early recurrence and inform treatment options and follow-up intervals. MATERIALS AND METHODS: Quantitative immunohistochemical analysis was performed to assess H & E, PHH3, and MIB-1/Ki-67 expression in samples of 141 PAs. Next, the correlation between mitotic figures on H & E (mitotic figures), PHH3 MI, Ki-67 labeling index (LI) and clinical variables was analyzed. The difference among primary- and repeated-surgery groups, nonrecurrent and recurrent groups, and ...
Source: Clinical Neuropathology - November 14, 2019 Category: Pathology Authors: Li C, Wei L, Li L, Wang J, Li R, Zhang Q, Zhou D Tags: Clin Neuropathol Source Type: research

Intraventricular Cladophialophora bantiana fungal ball.
PMID: 31670647 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - October 31, 2019 Category: Pathology Authors: Offerman EJ, Prayson RA Tags: Clin Neuropathol Source Type: research

Recurrent solitary fibrous tumor of the spinal cord: A case report and literature review.
Abstract Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm occurring anywhere in the body, such as the visceral pleura, while it is extremely rare in the central nervous system, especially within the spinal cord. Here, we present a case of recurrent spinal SFT in a 44-year-old woman who had the tumor resected 5 years before. This time, her magnetic resonance imaging revealed an intradural tumor at the level of C6-7. A secondary resection was performed completely, and the patient's neurological conditions recovered fully after resection. Histological and immunohistochemical findings revealed an SFT. Alt...
Source: Clinical Neuropathology - October 31, 2019 Category: Pathology Authors: Chen Y, Xu Z, Liu M, Xu H Tags: Clin Neuropathol Source Type: research

Multicentric malignant glioma with striking morphologic heterogeneity and early and extensive metastatic spread to the bone.
Abstract We document the case of a young adult female patient who presented with multiple intracerebral and extracerebral bone lesions, the latter most prominently along the vertebral column. The spatially distinct intracerebral lesions included a superficial frontal tumor nodule as well as diffuse enlargement of the pons. Differential diagnoses ranged from neoplastic to inflammatory conditions. Repeated bone biopsies yielded uncharacteristic reactive changes whereas cerebrospinal fluid cytology pointed towards a neoplastic disease. Resection of the superficial frontal tumor nodule prompted the diagnosis of an unu...
Source: Clinical Neuropathology - October 29, 2019 Category: Pathology Authors: Peter N, Roetzer T, Furtner J, Kiesel B, Herac M, Susani M, Capper D, Zimprich F, Hainfellner JA, Marosi C, Woehrer A Tags: Clin Neuropathol Source Type: research

Brain tumor disparities: From biology to social determinants - The 2019 Brain Tumor Epidemiology Consortium meeting report.
Abstract The Brain Tumor Epidemiology Consortium (BTEC) is an international consortium that fosters international and interdisciplinary collaborations focusing on research related to the etiology, outcomes, and prevention of brain tumors. The 20th annual BTEC meeting with the theme "Brain tumor Disparities: From Biology to Social Determinants" was held in Los Angeles, CA, USA, on June 6 - 8, 2019. Scientists from the United States and Europe representing a broad range of brain tumor research disciplines presented their research findings at the meeting. The scientific content of the meeting is s...
Source: Clinical Neuropathology - October 29, 2019 Category: Pathology Authors: Johnson KJ, Bauchet L, Hainfellner JA, Kruchko C, Scheurer ME, Wiemels J, Schwartzbaum J Tags: Clin Neuropathol Source Type: research

Clinical Neuropathology 6-2019.
PMID: 31661067 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - October 29, 2019 Category: Pathology Authors: Hainfellner JA Tags: Clin Neuropathol Source Type: research

Histopathological features of malignant craniopharyngioma: Case report and literature review.
CONCLUSION: We concluded that SCC represented only half of the malignant cases, while the morphology of ~ 11% of them was comparable with ameloblastic or odontogenic ghost cell carcinomas and 28% lacked a specific histological diagnosis. Most cases were fatal, which makes it necessary to include the entity of malignant craniopharyngioma in the WHO Classification of Tumors of the CNS as a high-grade tumor defining its histological variability.
. PMID: 31661068 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - October 29, 2019 Category: Pathology Authors: Mezmezian MB, Fernandez Ugazio G, Paparella ML Tags: Clin Neuropathol Source Type: research

Diagnostic indicators for adult-onset neuronal intranuclear inclusion disease.
In this study, we summarized 9 patients with NIID from multiple centers. The mean age was 60.0 ± 6.2 years. The mean duration of disease was 4.4 ± 3.2 years. The most common symptoms included cognitive impairment, episodic encephalopathy, and bladder dysfunction. Among the 6 patients with bladder dysfunction, 3 patients had the symptom prior to the development of other neurological symptoms; 5 patients needed permanent cystostomy. Isolated high DWI signals on the splenium of corpus callosum were observed in 2 patients at the early stage. The characteristic intranuclear inclusions in the skin were identified i...
Source: Clinical Neuropathology - October 29, 2019 Category: Pathology Authors: Wang Y, Wang B, Wang L, Yao S, Zhao J, Zhong S, Cong L, Liu L, Zhang J, Zhang J, Hong D Tags: Clin Neuropathol Source Type: research

BRAF-mutated histiocytosis of the skull lacking the expression of Langerhans cell markers.
We report the case of a 55-year-old adult who presented with a single lytic self-healing lesion of the skull, invading adjacent soft tissues. The histology and cytology were also typical of LCH, and tumor cells contained the BRAFV600E mutation. However, histiocytes were negative for CD1a and CD207. We suggest that this case might be considered as LCH, despite its abnormal phenotype.
. PMID: 31661070 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - October 29, 2019 Category: Pathology Authors: El Sissy FN, Lorillon G, Mandonnet E, Polivka M, Addle-Biassette H, Emile JF Tags: Clin Neuropathol Source Type: research

CLIPPERS: A case report with radiology, three serial biopsies and a literature review.
We report a case of CLIPPERS in a 45-year-old man presenting with left facial numbness and dizziness. Imaging studies were conducted repeatedly over an 8-year follow-up period. Given diagnostic uncertainty in the early stages of the disease, three serial biopsies were obtained, which together with the clinical and radiological findings, led to the diagnosis. This case highlights the diagnostic challenges regarding the rare entity of CLIPPERS and discusses the main differential diagnoses that are necessary to consider. Additionally, some of the atypical features of this case, including the presenting finding of a large, sol...
Source: Clinical Neuropathology - October 29, 2019 Category: Pathology Authors: Turnquist C, Pretorius PM, DeLuca GC, Halliday J, Kerr R, Hofer M Tags: Clin Neuropathol Source Type: research

Multiple recurrences of spindle cell oncocytoma: A case report and literature review.
We report a case of SCO in a patient who underwent multiple surgical resections for recurrence. The aim of this case report and literature review is to provide an overview of what is currently known about SCO as well as raise the awareness of this entity to endocrinologists, neurologists, neurosurgeons, and neuropathologists. Our case is also unusual in that the tumor displayed immunoreactivity for neuronal markers, which is a very rare occurrence.
. PMID: 31496509 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - September 9, 2019 Category: Pathology Authors: Chainey J, Chan VK, Au K, Das S Tags: Clin Neuropathol Source Type: research

Clinical Neuropathology 5-2019.
PMID: 31426905 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - August 20, 2019 Category: Pathology Authors: Hainfellner JA Tags: Clin Neuropathol Source Type: research

Hemorrhagic giant cerebral capillary telangiectasia resulting in death: Case report and literature review.
This report emphasizes the existence and complications of giant CCTs and stresses the importance of their investigation to ensure patients receive optimal treatment and follow-up.
. PMID: 31397264 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - August 9, 2019 Category: Pathology Authors: Kesserwan MA, Shakil H, Fong C, Provias JP Tags: Clin Neuropathol Source Type: research

Imaging and clinicopathologic features of myxoid meningiomas.
CONCLUSION: Myxoid meningiomas present with atypical imaging and histologic characteristics but are not truly metaplastic, i.e., are not differentiated to a different cell type.
. PMID: 31347490 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 26, 2019 Category: Pathology Authors: Johnson MD, Hussain A Tags: Clin Neuropathol Source Type: research

Cerebral pleomorphic liposarcoma: Clinicopathologic findings.
We present a 62-year-old woman with an intraparenchymal mass involving the left frontoparietal lobes. Histologic examination demonstrated a mesenchymal neoplasm with a dense reticulin network and pleomorphic lipoblasts. Immunohistochemical stain for adipophilin highlighted intracytoplasmic vacuoles. MDM2 immunostain was negative. A diagnosis of pleomorphic liposarcoma was made. There was no evidence of an extracranial primary neoplasm by imaging or physical exam. Pleomorphic liposarcoma may rarely present as a solitary intracranial mass, an entity that must be entertained in the differential diagnosis of pleomorphic tumors...
Source: Clinical Neuropathology - July 26, 2019 Category: Pathology Authors: Verdugo D, Voltaggio L, Hoot A, Rodriguez FJ Tags: Clin Neuropathol Source Type: research

Pathophysiology of neurodevelopmental mTOR pathway-associated epileptic conditions: Current status of biomedical research.
eucht M Abstract Epilepsy is one of the most common and serious neurological disorders worldwide. It has no identifiable cause in approximately 50% of patients; in the other 50%, the condition may be due to a variety of etiologies and pathomechanisms. In this review, special focus is put on the prototypes of "mTORpathies": tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type IIb. We review recent research data on mTORpathies, with emphasis on cortical tubers and FCD-like lesions (neuronal migration lines (NML)). A major pathologic aspect in the network of drug-resistant epilepsy progr...
Source: Clinical Neuropathology - July 26, 2019 Category: Pathology Authors: Gruber V, Scholl T, Samueli S, Gröppel G, Mühlebner A, Hainfellner JA, Feucht M Tags: Clin Neuropathol Source Type: research

A family with limb girdle muscular dystrophy type 1B and multiple exostoses.
DISCUSSION: The clinical, genetic, and muscle biopsy findings suggest that both mutations are pathogenic. The EXT2 mutation was most likely responsible for the multiple exostoses phenotype in mother and son, whereas the myopathy was probably caused by a combined effect of the LMNA and EXT2 mutations.
. PMID: 31296281 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 12, 2019 Category: Pathology Authors: Romeike BFM, Becker K, Großkreutz J, Schulz S, Weis J, Cirak S Tags: Clin Neuropathol Source Type: research

Metastatic gastrointestinal stromal tumor to the thoracic spine.
PMID: 31296282 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 12, 2019 Category: Pathology Authors: Prayson RA Tags: Clin Neuropathol Source Type: research

Duplication of chromosome 1q23.2 in congenital craniopharyngioma.
PMID: 31296283 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 12, 2019 Category: Pathology Authors: Kumar N, Prayson RA Tags: Clin Neuropathol Source Type: research

Focal cerebral accumulation of corpora amylacea.
te; M PMID: 31296284 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 12, 2019 Category: Pathology Authors: Pimentel J, Roque R, Cunha E Sá M Tags: Clin Neuropathol Source Type: research

Melanocytic colonization of choroid plexus papilloma: A previously undocumented source of pigment storage in the plexogenic epithelium.
PMID: 31296285 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 12, 2019 Category: Pathology Authors: Egervari K, Lobrinus JA, Merkler D, Vajtai I Tags: Clin Neuropathol Source Type: research

Buzz groups facilitate collaborative learning and improve histopathological competencies of students.
DISCUSSION: Collaborative BGs improve the learning of histopathological competencies. They motivate and activate students to learn. The course also increased the appreciation of students for histopathology. For BGs, digital microscopy was better suited than traditional analog microscopy. The application of BGs in the context of analyzing microscopic images should be disseminated and studied on larger cohorts.
. PMID: 31296286 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 12, 2019 Category: Pathology Authors: Romeike BFM, Fischer M Tags: Clin Neuropathol Source Type: research

Synchronous identification of a dysembryoplastic neuroepithelial tumor (DNET) and an oligodendroglioma in a patient: A case report.
We present a case of synchronous gliomas, one dysembryoplastic neuroepithelial tumor (DNET) and the other oligodendroglioma.
. PMID: 31262396 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 2, 2019 Category: Pathology Authors: Ravanpay AC, Gabikian P, Marshall D, Williams JR, Huber B, Silbergeld DL Tags: Clin Neuropathol Source Type: research

Clinical Neuropathology 4-2019.
PMID: 31234964 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - June 25, 2019 Category: Pathology Authors: Hainfellner JA Tags: Clin Neuropathol Source Type: research

Pineal apoplexy due to pleomorphic variant pineocytoma.
PMID: 31232273 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - June 24, 2019 Category: Pathology Authors: O'Connell K, Crimmins D, Power S, Ligon KL, Cryan J, Beausang A Tags: Clin Neuropathol Source Type: research

ALDH1 - A new immunohistochemical diagnostic marker for Schwann cell-derived tumors.
In this study, we present aldehyde dehydrogenase 1 (ALDH1) as a new, viable diagnostic marker for Schwann cell tumors. Protein expression was examined by immunohistochemistry in schwannomas, neurofibromas, and malignant peripheral nerve sheath tumors (MPNST) as well as in non-neoplastic peripheral nerve sheath specimens. Meningiomas and other spindle cell-like tumors served as control tissue. ALDH1 immunohistochemistry was performed on human FFPE samples. Staining evaluation was performed according to a defined immunoreactive score. All schwannomas and neurofibromas were strongly positive for ALDH1. MPNST were positive too...
Source: Clinical Neuropathology - May 27, 2019 Category: Pathology Authors: Liesche F, Griessmair M, Barz M, Gempt J, Schlegel J Tags: Clin Neuropathol Source Type: research

Joint meeting: 55th Congress of the Italian Association of Neuropathology and Clinical Neurobiology (AINPeNC) / 45th Congress of the Italian Association for Cerebral Aging Research (AIRIC).
PMID: 31057145 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - May 6, 2019 Category: Pathology Authors: Cenacchi PG Tags: Clin Neuropathol Source Type: research

Clinical Neuropathology 3-2019.
PMID: 31057146 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - May 6, 2019 Category: Pathology Authors: Hainfellner JA Tags: Clin Neuropathol Source Type: research

Teaching case 3-2019: Are nuclear clefts or invaginations the niche of intranuclear inclusions in FTLD-TDP?
M, Gelpi E PMID: 31023421 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - April 26, 2019 Category: Pathology Authors: Molina-Porcel L, Pérez-Navarro E, García-Forn M, Westaway D, Colom-Cadena M, Gelpi E Tags: Clin Neuropathol Source Type: research

A case of childhood intracerebral angiomatoid fibrous histiocytoma radiologically mimicking infection and with unusual immunopositivity for placental alkaline phosphatase.
PMID: 30990406 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - April 16, 2019 Category: Pathology Authors: Aizpurua M, Zebian B, Minichini V, Sanghvi H, Dudau C, Fisher C, King A Tags: Clin Neuropathol Source Type: research

Corticosteroid-induced immunodeficiency in a patient with gliomatosis cerebri: Are corticosteroids indicated in all brain tumors?
ić M Abstract An elderly male was admitted to the Department of Neurology for slowly progressive dysarthria and right-sided atactic hemiparesis. Magnetic resonance imaging (MRI) revealed a small contrast-enhanced focus of malignant glioma in the left parietal lobe - with the growth pattern of cerebral gliomatosis - involving the whole left cerebral hemisphere, the corpus callosum, and spreading into the right frontal hemisphere. Diagnostic biopsy was deferred until the exclusion of other possible causes of the brain lesion. A follow-up brain MRI was planned in 6 weeks. In the interim, the patient was treated with...
Source: Clinical Neuropathology - April 9, 2019 Category: Pathology Authors: Car M, Šteblaj S, Mitrovič G, Dolenc-Stražar Z, Popović M Tags: Clin Neuropathol Source Type: research

Missense mutations in LAMA2 causing a new phenotype of mild cognitive impairment, proximal myopathy, seizure, and severe leukoencephalopathy: A case report and protein analysis.
Abstract Congenital muscular dystrophy with laminin-α2 deficiency, also known as MDC1A, displays an extensive phenotypic and genetic heterogeneity. The combination of clinical, biochemical, and genetic findings must be considered to obtain the precise diagnosis and provide appropriate genetic counseling. Here we report one individual from a family presenting with clinical features including seizure attack, slight weakness of proximal leg muscles, and mild cognitive impairment with increased small angular fibers, decreased expression of α-DG and β-DG, normal expression of laminin-α2, and seve...
Source: Clinical Neuropathology - March 22, 2019 Category: Pathology Authors: Ding M, Wang X, Zeng Y, Lu Z, Cai S, Gao M, Zhu W, Luo S, Zhao C, Xiao Z Tags: Clin Neuropathol Source Type: research

Metastasis of papillary thyroid carcinoma to the thoracic spine.
We present the case of a patient in whom thoracic spinal cord compression was the first presentation of metastatic PTC. CASE REPORT: A 65-year-old woman presented with deteriorating mobility over a 2-month period. Her past history was significant for a right hemithyroidectomy 10 years prior. Examination revealed bilateral lower limb weakness, worse on the right side. Investigations showed a large extradural contrast-enhancing mass at the T7 spinal level. Laminectomy and debulking of this lesion was undertaken. Histopathological examination revealed PTC. The patient proceeded to further treatment with external beam rad...
Source: Clinical Neuropathology - March 22, 2019 Category: Pathology Authors: Dablouk MO, O'Halloran PJ, Faul C, Beausang A, Rawluk D Tags: Clin Neuropathol Source Type: research

Endometrial glial polyp and peritoneal gliomatosis: Neuropathological lesions in gynecological biopsy.
This article presents a short review of such entities in gynecological pathology and reports on two rare cases. The first described lesion is an endometrial glial polyp in a young woman. The second is a mature cystic teratoma accompanied by a peritoneal gliomatosis in an adolescent girl. Both presented entities posed diagnostic difficulties from the clinical and pathological perspective. They demanded careful sampling, immunophenotyping, as well as neuropathological consultation.
. PMID: 30900986 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - March 22, 2019 Category: Pathology Authors: Czarnota K, Goertz S, Gulczyński J, Hermann-Okoniewska B, Czauderna P, Adamkiewicz-Drożyńska E, Iżycka-Świeszewska E Tags: Clin Neuropathol Source Type: research

Rosette-forming and papillary glioneuronal tumors - A clinicopathological and molecular analysis.
Abstract INTRODUCTION: Rosette-forming glioneuronal tumors (RGNT) and papillary glioneuronal tumors (PGNT) account for
Source: Clinical Neuropathology - March 22, 2019 Category: Pathology Authors: Singh V, Gupta K, Salunke P, Kumar S, Radotra BD, Vasishta RK Tags: Clin Neuropathol Source Type: research

Clinical Neuropathology 2-2019.
Abstract PMID: 30771805 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - February 17, 2019 Category: Pathology Authors: Hainfellner JA Tags: Clin Neuropathol Source Type: research