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Specialty: Cardiology
Condition: Cardiomyopathy

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Total 533 results found since Jan 2013.

Detection of mutations in symptomatic patients with hypertrophic cardiomyopathy in Taiwan.
CONCLUSIONS: We identified 13 HCM pedigrees, including 5 carrying novel mutations and 1 with a double mutation. The three most commonly mutated genes were MYH7, MYBPC3, and TNNT2. These results, together with genetic counseling, could lead to earlier diagnosis and better management of family members at risk of HCM. PMID: 25086479 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - July 30, 2014 Category: Cardiology Authors: Chiou KR, Chu CT, Charng MJ Tags: J Cardiol Source Type: research

Genotype-Positive Status in Patients With Hypertrophic Cardiomyopathy Is Associated With Higher Rates of Heart Failure Events Original Articles
Conclusions— The presence of a pathogenic sarcomere mutation in patients with hypertrophic cardiomyopathy was associated with an increase in heart failure events, with no differences in event rates seen between myosin heavy chain and myosin-binding protein C genotype-positive patients. The presence of a disease-causing mutation seems more clinically relevant than the specific mutation itself.
Source: Circulation: Cardiovascular Genetics - August 19, 2014 Category: Cardiology Authors: Li, Q., Gruner, C., Chan, R. H., Care, M., Siminovitch, K., Williams, L., Woo, A., Rakowski, H. Tags: Other heart failure, Myocardial cardiomyopathy disease, Genetics of cardiovascular disease Original Articles Source Type: research

CNS disease triggering Takotsubo stress cardiomyopathy
There are a number of hereditary and non-hereditary central nervous system (CNS) disorders, which directly or indirectly affect the heart (brain-heart disorders). The most well-known of these CNS disorders are epilepsy, stroke, infectious or immunological encephalitis/meningitis, migraine, and traumatic brain injury. In addition, a number of hereditary and non-hereditary neurodegenerative disorders may impair cardiac functions. Affection of the heart may manifest not only as arrhythmias, myocardial infarction, autonomic impairment, systolic dysfunction/heart failure, arterial hypertension, or pulmonary hypertension, but al...
Source: International Journal of Cardiology - August 26, 2014 Category: Cardiology Authors: Josef Finsterer, Karim Wahbi Source Type: research

The burnout stage of an apical hypertrophic cardiomyopathy
A 66years-old female with a previous medical history of hypertension and ischemic stroke was admitted in the Emergency Room with persistent regular palpitations. In the admission the patient had normal blood pressure and tachycardia. The remaining physical examination was unremarkable.
Source: International Journal of Cardiology - August 23, 2014 Category: Cardiology Authors: Daniel Caldeira, Luis R. Lopes, Inês Cruz, Ana Rita Almeida, Gonçalo Morgado, Catarina Gomes, Bruno Stuart, Sofia Almeida, Luis Brandão Alves, Hélder Pereira Source Type: research

CNS disease triggering Takotsubo stress cardiomyopathy
There are a number of hereditary and non-hereditary central nervous system (CNS) disorders, which directly or indirectly affect the heart (brain–heart disorders). The most well-known of these CNS disorders are epilepsy, stroke, infectious or immunological encephalitis/meningitis, migraine, and traumatic brain injury. In addition, a number of hereditary and non-hereditary neurodegenerative disorders may impair cardiac functions. Affection of the heart may manifest not only as arrhythmias, myocardial infarction, autonomic impairment, systolic dysfunction/heart failure, arterial hypertension, or pulmonary hypertension, but ...
Source: International Journal of Cardiology - August 26, 2014 Category: Cardiology Authors: Josef Finsterer, Karim Wahbi Tags: Review Source Type: research

The burnout stage of an apical hypertrophic cardiomyopathy
A 66year-old female with a previous medical history of hypertension and ischemic stroke was admitted in the Emergency Room with persistent regular palpitations. In the admission the patient had normal blood pressure and tachycardia. The remaining physical examination was unremarkable.
Source: International Journal of Cardiology - August 23, 2014 Category: Cardiology Authors: Daniel Caldeira, Luís R. Lopes, Inês Cruz, Ana Rita Almeida, Gonçalo Morgado, Catarina Gomes, Bruno Stuart, Sofia Almeida, Luís Brandão, Hélder Pereira Tags: Letter to the Editor Source Type: research

Home Blood Pressure and Cardiovascular Outcomes in Patients During Antihypertensive Therapy: Primary Results of HONEST, a Large-Scale Prospective, Real-World Observational Study Epidemiology/Population
In conclusion, it is essential to control morning HBP to <145 mm Hg, even in patients with controlled clinic blood pressure. Clinical Trial Registration— URL: http://www.umin.ac.jp/ctr/index.htm. UMIN Clinical Trials Registry, trial No. UMIN000002567.
Source: Hypertension - October 8, 2014 Category: Cardiology Authors: Kario, K., Saito, I., Kushiro, T., Teramukai, S., Ishikawa, Y., Mori, Y., Kobayashi, F., Shimada, K. Tags: Cerebrovascular disease/stroke, Myocardial cardiomyopathy disease, Clinical Studies Epidemiology/Population Source Type: research

The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure
Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80% (60). Unfortunately, many long-term survivors of pediatric cancer develop chemotherapy-related health effects; 25% are afflicted with a severe or life-threatening medical condition, with cardiovascular disease being a primary risk (96). Childhood cancer survivors have markedly elevated incidences of stroke, congestive heart failure (CHF), coronary artery disease, and valvular disease (96). Their cardiac mortality is 8.2 times higher tha...
Source: AJP: Heart and Circulatory Physiology - November 15, 2014 Category: Cardiology Authors: Lindsey, M. L., Lange, R. A., Parsons, H., Andrews, T., Aune, G. J. Tags: REVIEW Source Type: research

Clinical Outcomes After Continuous-Flow Left Ventricular Assist Device: A Systematic Review Original Articles
Conclusions— The totality of data for continuous-flow left ventricular assist devices show consistent improvements in survival and quality of life counterbalanced by a range of common complications. Although this summary should provide a practical resource for healthcare provider-led discussions with patients, it highlights the critical need for high-quality patient-centered data collected with standard definitions.
Source: Circulation: Heart Failure - November 18, 2014 Category: Cardiology Authors: McIlvennan, C. K., Magid, K. H., Ambardekar, A. V., Thompson, J. S., Matlock, D. D., Allen, L. A. Tags: Congestive, CV surgery: transplantation, ventricular assistance, cardiomyopathy Original Articles Source Type: research

A decade of cardiac transplantation in Coimbra: The value of experience
Conclusion This 10-year series yielded results equivalent or superior to those of centers with wider and longer experience, and have progressively improved following the introduction of changes prompted by experience. This program has made it possible to raise and maintain the rate of heart transplantation to values above the European average.
Source: Revista Portuguesa de Cardiologia - November 21, 2014 Category: Cardiology Source Type: research

Stem Cell Factor Gene Transfer Improves Cardiac Function After Myocardial Infarction in Swine Original Articles
Conclusions— Local overexpression of SCF post-MI induces the recruitment of c-kit+ cells at the infarct border area acutely. In the chronic stages, SCF gene transfer was associated with improved cardiac function in a preclinical model of ischemic cardiomyopathy.
Source: Circulation: Heart Failure - January 20, 2015 Category: Cardiology Authors: Ishikawa, K., Fish, K., Aguero, J., Yaniz-Galende, E., Jeong, D., Kho, C., Tilemann, L., Fish, L., Liang, L., Eltoukhy, A. A., Anderson, D. G., Zsebo, K., Costa, K. D., Hajjar, R. J. Tags: Angiogenesis, Myogenesis, Other Treatment, Acute myocardial infarction Original Articles Source Type: research

Right Ventricular Hypertrophy is Associated With Cardiovascular Events in Hypertrophic Cardiomyopathy: Evidence From Study With Magnetic Resonance
Conclusions These results suggest that HCM patients with RVH on CMR have a higher incidence of cardiovascular events than non-RVH patients. Further work is needed to confirm this observation and assess its clinical importance. Teaser Right ventricular hypertrophy (RVH) was found in 28.3% of patients with hypertrophic cardiomyopathy (HCM). Because the extent of RVH significantly correlated with left ventricular mass index, not with systolic pulmonary artery pressure, the RV wall could be hypertrophied in a similar manner of left ventricle irrespective of any increase in RV afterload. RVH was an independent predictor of the ...
Source: Canadian Journal of Cardiology - January 24, 2015 Category: Cardiology Source Type: research

Predictors of long-term outcomes in hypertrophic cardiomyopathy patients undergoing cardiopulmonary stress testing and echocardiography
Conclusions In HCM patients undergoing CPT, a higher % of achieved age-gender predicted V02 and surgical relief of LVOT obstruction were associated with better outcomes, while abnormal HRR, atrial fibrillation and lower LVEF were associated with worse outcomes.
Source: American Heart Journal - February 25, 2015 Category: Cardiology Source Type: research

Heart failure in patients with atrial fibrillation in Europe: a report from the EURObservational Research Programme Pilot survey on Atrial Fibrillation
ConclusionWe provide insights into the clinical characteristics and outcomes in AF patients with HF, who were managed by European cardiologists. Despite a high prevalence of oral anticoagulant use, 1‐year mortality and morbidity remained high in AF patients with HF, whether HFrEF or HFpEF. Such patients require a holistic approach to cardiovascular risk management.
Source: European Journal of Heart Failure - March 2, 2015 Category: Cardiology Authors: Gregory Y.H. Lip, Cécile Laroche, Mircea I. Popescu, Lars H. Rasmussen, Laura Vitali‐Serdoz, Gheorghe‐Andrei Dan, Zbigniew Kalarus, Harry J.G.M. Crijns, Mario M. Oliveira, Luigi Tavazzi, Aldo P. Maggioni, Giuseppe Boriani Tags: Original Article Source Type: research

Predictors of long-term outcomes in patients with hypertrophic cardiomyopathy undergoing cardiopulmonary stress testing and echocardiography
Conclusions In HCM patients undergoing CPT, a higher % of achieved age-gender predicted VO2 and surgical relief of LVOT obstruction were associated with better outcomes, whereas abnormal HRR, atrial fibrillation, and lower LVEF were associated with worse outcomes.
Source: American Heart Journal - March 10, 2015 Category: Cardiology Source Type: research