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Specialty: Cardiology
Condition: Cardiomyopathy

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Total 533 results found since Jan 2013.

Heartbeat: Highlights from the issue
This issue of Heart has a group of articles about hypertrophic cardiomyopathy with two of these studies addressing exercise capacity. In a study from The Heart Hospital in London (See page 644 and figure 1) cardiopulmonary exercise testing showed a reduced peak oxygen consumption and cardiac index in 70 patients with hypertrophic cardiomyopathy compared to normal volunteers. Left ventricular outflow tract obstruction was present in 31% of patients at rest and an additional 14% had obstruction provoked by exercise. Compared to patients without obstruction, outflow obstruction at all levels of exercise was associated with an...
Source: Heart - March 21, 2014 Category: Cardiology Authors: Otto, C. M. Tags: Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Echocardiography, Interventional cardiology, Clinical diagnostic tests Heartbeat Source Type: research

Cardiac output response and peripheral oxygen extraction during exercise among symptomatic hypertrophic cardiomyopathy patients with and without left ventricular outflow tract obstruction
Conclusions Cardiac reserve is reduced in HCM because of failure of SV augmentation. LVOTO exacerbates this abnormal response, but haemodynamic responses vary significantly. Non-invasive exercise haemodynamic assessment may improve understanding of symptoms and help tailor therapy.
Source: Heart - March 21, 2014 Category: Cardiology Authors: Critoph, C. H., Patel, V., Mist, B., Elliott, P. M. Tags: Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Hypertension Heart failure and cardiomyopathies Source Type: research

Scar tissue–guided left ventricular lead placement for cardiac resynchronization therapy in patients with ischemic cardiomyopathy: An acute pressure-volume loop study
Background: Response to cardiac resynchronization therapy (CRT) is hampered by the extent and location of left ventricular (LV) scar tissue. It is commonly advised to avoid scar tissue while placing the LV lead. However, whether individual patients benefit from this strategy remains unclear.Methods: Thirty-two CRT candidates with ischemic cardiomyopathy were enrolled from 2 successive clinical trials (TBS and E-pot study). Magnetic resonance imaging with late contrast enhancement was performed to assess location, degree and transmurality of LV scar tissue. Patients underwent invasive pressure-volume loop measurements to as...
Source: American Heart Journal - January 16, 2014 Category: Cardiology Authors: Gerben Jan de Roest, LiNa Wu, Carel C. de Cock, Matthijs L. Hendriks, Peter Paul H.M. Delnoy, Albert C. van Rossum, Cornelis P. Allaart Tags: Heart Failure Source Type: research

Left Atrial Remodeling in Hypertrophic Cardiomyopathy and Susceptibility Markers for Atrial Fibrillation Identified by Cardiovascular Magnetic Resonance
This study characterizes left atrial (LA) structural and functional parameters to establish markers predictive of AF risk, using cardiovascular magnetic resonance (CMR) imaging. We studied 427 consecutive patients with HC in sinus rhythm with CMR (age 44 ± 18 years), including 41 who developed clinically overt AF after study entry (2.6 ± 2.1 years), 49 patients with AF before CMR, 337 patients with HC but without AF, and 244 normal controls. LA chamber was assessed for absolute and indexed end-diastolic volume (LAEDV), end-systolic volume, and percent ejection fraction (LAEF). In the 41 prospectively studied patients w...
Source: The American Journal of Cardiology - February 3, 2014 Category: Cardiology Authors: Barry J. Maron, Tammy S. Haas, Martin S. Maron, John R. Lesser, Joseph A. Browning, Raymond H. Chan, Iacopo Olivotto, Ross F. Garberich, Robert S. Schwartz Tags: Cardiomyopathy Source Type: research

Cardiac Sarcoidosis Detected by Late Gadolinium Enhancement and Prevalence of Atrial Arrhythmias
In conclusion, atrial arrhythmias were documented more frequently than ventricular arrhythmias in patients with sarcoidosis with cardiac involvement and were 3 times more prevalent than in patients with sarcoidosis without cardiac involvement. Risk-benefit assessment of anticoagulation for primary prevention of stroke should be performed for patients with CS. In patients receiving implantable defibrillators, programing to minimize inappropriate ICD shocks for atrial arrhythmias must be considered.
Source: The American Journal of Cardiology - February 14, 2014 Category: Cardiology Authors: Matthew A. Cain, Mark D. Metzl, Amit R. Patel, Karima Addetia, Kirk T. Spencer, Nadera J. Sweiss, John F. Beshai Tags: Cardiomyopathy Source Type: research

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms.
Abstract Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%-26%). The aim of this article is to review the clinical epidemiological features of AF and to relate them to underlying mechanisms. Long-established risk factors for AF include aging, male sex, hypertension, valve disease, left ventricular dysfunction, obesity, and alcohol consumption. Emerging risk factors include prehypertension, increased pulse pressure, obstructive sleep apnea, high-level physical training, diastolic dysfunction, predisposing gene variants, hypertrophic cardiomyopathy, and congenital heart disease. Po...
Source: Circulation Research - April 25, 2014 Category: Cardiology Authors: Andrade J, Khairy P, Dobrev D, Nattel S Tags: Circ Res Source Type: research

Relation of Interatrial Block to New-Onset Atrial Fibrillation in Patients With Chagas Cardiomyopathy and Implantable Cardioverter-Defibrillators
Chagas cardiomyopathy is an endemic disease in Latin America. A significant proportion of patients develop atrial fibrillation (AF), which may result in stroke and increased morbidity or mortality. Interatrial block (IAB) has been associated with the development of AF in different clinical scenarios. The aim of our study was to determine whether IAB can predict new-onset AF in patients with Chagas cardiomyopathy and implantable cardioverter-defibrillators (ICDs). We conducted a retrospective study of patients with Chagas cardiomyopathy and ICDs from 14 centers in Latin America. Demographics, clinical, and device follow-up ...
Source: The American Journal of Cardiology - March 3, 2014 Category: Cardiology Authors: Andres Enriquez, Diego Conde, Francisco Femenia, Antoni Bayés de Luna, Antonio Ribeiro, Claudio Muratore, Mariana Valentino, Enrique Retyk, Nestor Galizio, Wilma M. Hopman, Adrian Baranchuk Tags: Cardiomyopathy Source Type: research

CardioPulse Articles * The European Society of Cardiology in Arabia * Health in the Arab world * Guidelines for a successful European Society of Cardiology grant application * Tako-Tsubo cardiomyopathy * Does aetiology matter in secondary prevention of stroke?
Source: European Heart Journal - May 14, 2014 Category: Cardiology Tags: CardioPulse Source Type: research

Positron Emission Tomography-Computed Tomography for Imaging of Inflammatory Cardiovascular Diseases.
Abstract Inflammation is a determinant of atherosclerotic plaque rupture, the event usually responsible for myocardial infarction and stroke. Possible causes of inflammatory cardiomyopathy include myocarditis, eosinophilic disease, and sarcoidosis. Although conventional imaging techniques can identify the site and severity of luminal stenosis, they do not provide information regarding inflammatory status. (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for imaging of inflammatory cardiovascular diseases has been rapidly evolving. Integrated PET/computed tomography (CT) is becoming the method of c...
Source: Circulation Journal - May 9, 2014 Category: Cardiology Authors: Miyagawa M, Yokoyama R, Nishiyama Y, Ogimoto A, Higaki J, Mochizuki T Tags: Circ J Source Type: research

Left ventricular hypertrabeculation/noncompaction in an Eritrean war invalid with neuromuscular disease
Left ventricular hypertrabeculation/noncompaction (LVHT) is categorized as an unclassified cardiomyopathy and is characterized by a two-layered left ventricular myocardium distal to the papillary muscles with a thicker noncompacted inner (endocardial) layer and a compacted thinner outer (pericardial) layer . LVHT is complicated by ventricular arrhythmias, stroke/embolism, or heart failure, which is why these patients require close cardiologic surveillance . In more than half of the patients LVHT is associated with a neuromuscular disorder (NMD) or a chromosomal aberration . LVHT has been occasionally reported in African pa...
Source: International Journal of Cardiology - April 28, 2014 Category: Cardiology Authors: Josef Finsterer, Claudia Stöllberger, Maria Motamen Tags: Online Letters to the Editor Source Type: research

Atorvastatin improves systolic function, but does not prevent the development of dilated cardiomyopathy in streptozotocin-induced diabetic rats
Conclusions: Whereas atorvastatin does not reverse ventricular dilatation, it does have a positive hemodynamic effect on the CV system of diabetic rats. This hemodynamic benefit is independent of cholesterol levels, and is observed concomitantly with reduced oxidative stress, vascular remodeling, and improved endothelial function. Together, these results suggest that atorvastatin decreases the workload on the heart and improves systolic performance in type 1 diabetic rats by reducing oxidative stress, vascular tone, and systemic vascular resistance.
Source: Therapeutic Advances in Cardiovascular Disease - June 11, 2014 Category: Cardiology Authors: Quidgley, J., Cruz, N., Crespo, M. J. Tags: Original Research Source Type: research

Reversible De Novo Left Ventricular Trabeculations in Pregnant Women: Implications for the Diagnosis of Left Ventricular Non-Compaction in Low Risk Populations.
CONCLUSIONS: -Pregnancy induces de novo LV trabeculations in a significant proportion of women. The results suggest that left ventricular trabeculations occur in response to increased LV loading conditions or other physiologic responses to pregnancy and are not specific for LVNC. These factors should be considered when assessing individuals with LV trabeculations outside the context of symptoms of heart failure or familial cardiomyopathy. PMID: 25006201 [PubMed - as supplied by publisher]
Source: Circulation - July 8, 2014 Category: Cardiology Authors: Gati S, Papadakis M, Papamichael ND, Zaidi A, Sheikh N, Reed M, Sharma R, Thilaganathan B, Sharma S Tags: Circulation Source Type: research

Lipid lowering in patients with treatment-resistant hypertension: an analysis from the Treating to New Targets (TNT) trial
Conclusion In subjects with TRH, intensive lipid lowering with atorvastatin 80 mg is associated with a significant reduction in cardiovascular events.
Source: European Heart Journal - July 15, 2014 Category: Cardiology Authors: Bangalore, S., Fayyad, R., Laskey, R., DeMicco, D., Deedwania, P., Kostis, J. B., Messerli, F. H., Treating to New Targets Steering Committee and Investigators Tags: Heart failure/cardiomyopathy Source Type: research

Abstract 236: Obstructive Sleep Apnea in Hypertrophic Cardiomyopathy: Comparing Exercise Tolerance, Cardiac Remodeling, Clinical and Genetic Data Session Title: Poster Session II
Conclusions: OSA occurs frequently in HCM and is associated with decreased exercise tolerance, worse hemodynamics, poor outcome as well as increased LV mass, which may be attenuated by therapy. OSA is an important and modifiable risk factor in HCM. Prospective evaluation utilizing PSG based diagnosis and positive pressure therapy is warranted.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Kumar, S., Ebner, B., Bragg-Gresham, J., Farrehi, P., Day, S. Tags: Session Title: Poster Session II Source Type: research

Abstract 351: Optimizing the Frequency of Surveillance Echocardiography in Clinically Stable Patients With Hypertrophic Cardiomyopathy Session Title: Poster Session III
Conclusions: In select clinically stable patients with HCM, repeat echo may be unlikely to identify significant changes or impact practice. In these patients, a decreased frequency of echocardiography could decrease resource utilization without compromising care. Ongoing data collection and better risk stratification tools may allow more targeted surveillance strategies in the future.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Carr, C. W., Conner, L. M., McCarthy, C. A., Greenberg, J. O., Laskowski, K. R., Parambi, R. J., Graham, D. A., Szent-Gyorgyi, L. E., Cirino, A. L., Ho, C. Y., MacRae, C. A., Seidman, C. E., Ghazinouri, R., Lakdawala, N. K. Tags: Session Title: Poster Session III Source Type: research