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Specialty: Neurology
Condition: Alzheimer's

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Total 647 results found since Jan 2013.

Poststroke cognitive impairment: a longitudinal follow-up and pre/poststroke mini-mental state examination comparison
CONCLUSION: Ischemic stroke substantially affects cognition with an average six-point drop in MMSE. The rate of cognitive decline in PSCI was similar to AD, and those with white matter or basal ganglia infarct were at greater risk of PSCI.PMID:35927922 | DOI:10.2174/1567205019666220802151945
Source: Current Alzheimer Research - August 5, 2022 Category: Neurology Authors: Chien-Tai Hong Hsun-Hua Lee Chen-Chih Chung Wei-Ting Chiu Ting-Yi Lee David Yen-Ting Chen Li-Kai Huang Chaur-Jong Hu Lung Chan Source Type: research

Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model
AbstractTransient ischemic attack (TIA) presents a high risk for subsequent stroke, Alzheimer ’s disease (AD), and related dementia (ADRD). However, the neuropathophysiology of TIA has been rarely studied. By evaluating recurrent TIA-induced neuropathological changes, our study aimed to explore the potential mechanisms underlying the contribution of TIA to ADRD. In the current study, we es tablished a recurrent TIA model by three times 10-min middle cerebral artery occlusion within a week in rat. Neither permanent neurological deficit nor apoptosis was observed following recurrent TIA. No increase of AD-related biomarker...
Source: Translational Stroke Research - July 22, 2022 Category: Neurology Source Type: research

The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review
AbstractNeurodegenerative diseases (NDs), including chronic disease such as Alzheimer ’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis, and acute diseases like traumatic brain injury and ischemic stroke are characterized by progressive degeneration, brain tissue damage and loss of neurons, accompanied by behavioral and cognitive dysfunctions. So far , there are no complete cures for NDs; thus, early and timely diagnoses are essential and beneficial to patients’ treatment. Magnetic resonance imaging (MRI) has become one of the advanced medical imaging techniques widely used in the clinic...
Source: Molecular Neurobiology - July 12, 2022 Category: Neurology Source Type: research

Associations between primary care electrocardiography and non-Alzheimer dementia
To determine whether electrocardiogram (ECG) markers are associated with incident non-Alzheimer's dementia (non-AD) and whether these markers also improve risk prediction for non-AD.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2022 Category: Neurology Authors: Jonas L. Isaksen, Jonas Ghouse, Morten W. Skov, Morten S. Olesen, Anders G. Holst, Adrian Pietersen, Jonas B. Nielsen, Anja Maier, Claus Graff, Ruth Frikke-Schmidt, J ørgen K. Kanters Source Type: research

Direct AT2R Stimulation Slows Post-stroke Cognitive Decline in the 5XFAD Alzheimer ’s Disease Mice
AbstractAlzheimer ’s disease (AD), currently the single leading cause of death still on the rise, almost always coexists alongside vascular cognitive impairment (VCI). In fact, the ischemic disease affects up to 90% of AD patients, with strokes and major infarctions representing over a third of vascular lesions. St udies also confirmed that amyloid plaques, typical of AD, are much more likely to cause dementia if strokes or cerebrovascular damage also exist, leading to the term “mixed pathology” cognitive impairment. Although its incidence is expected to grow, there are no satisfactory treatments. There is hence an u...
Source: Molecular Neurobiology - June 5, 2022 Category: Neurology Source Type: research

Recent Synergy of Nanodiamonds: Role in Brain-Targeted Drug Delivery for the Management of Neurological Disorders
AbstractThe aim of the present review article is to summarize the role of nanodiamonds in various neurological diseases. We have taken related literature of making this review article from ScienceDirect, springer, Research gate, PubMed, Sci-finder, etc. The current approaches for treating neurological conditions such as glioblastoma includes chemotherapy or combination anti-retro viral therapy for HIV (human immunodeficiency virus) or use of anti-Alzheimer drugs during cognitive impairment. These approaches can provide only symptomatic relief as they do not target the cause of the disease due to their inability to penetrat...
Source: Molecular Neurobiology - May 27, 2022 Category: Neurology Source Type: research

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases
Transcranial Magnetic Stimulation (TMS) has widespread use in research and clinical application. For psychiatric applications, such as depression or OCD, repetitive TMS protocols (rTMS) are an established and globally applied treatment option. While promising, rTMS is not yet as common in treating neurological diseases, except for neurorehabilitation after (motor) stroke and neuropathic pain treatment. This may soon change. New clinical studies testing the potential of rTMS in various other neurological conditions appear at a rapid pace. This can prove challenging for both practitioners and clinical researchers. Although m...
Source: Frontiers in Neurology - May 20, 2022 Category: Neurology Source Type: research

Aerobic Physical Exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond
Brain disorders, including stroke, Alzheimer's disease, depression, and chronic pain, are difficult to effectively treat. These major brain disorders have high incidence and mortality rates in the general population, and seriously affect not only the patient's quality of life, but also increases the burden of social medical care. Aerobic physical exercise is considered an effective adjuvant therapy for preventing and treating major brain disorders. Although the underlying regulatory mechanisms are still unknown, systemic processes may be involved. Here, this review aimed to reveal that aerobic physical exercise improved de...
Source: Frontiers in Neurology - May 13, 2022 Category: Neurology Source Type: research

Improvement of poststroke cognitive impairment by intermittent theta bursts: A double ‐blind randomized controlled trial
ConclusioniTBS can effectively and safely improve overall cognitive impairment in stroke patients, including semantic understanding and executive function, and it also has a positive impact on memory function. Future randomized controlled studies with large samples and long-term follow-up should be conducted to further validate the results of the present study
Source: Brain and Behavior - April 29, 2022 Category: Neurology Authors: Wen Li, Qian Wen, Yu ‐Han Xie, An‐Li Hu, Qing Wu, Yin‐Xu Wang Tags: ORIGINAL ARTICLE Source Type: research

Current Trends in the Animal Models for Screening of Nootropic Agents
CONCLUSION: Since a variety of etiologies can affect the cognitive processes, hence a nootropic agent may be screened in a variety of disease models. The most widely used and appropriate method to assess cognition would be by combining the behavioral and biochemical assays so that a more comprehensive profile about the nootropic effects of a drug can be elicited.PMID:35469584 | DOI:10.2174/2772432817666220425121323
Source: Epilepsy Curr - April 26, 2022 Category: Neurology Authors: Shubhima Grover Seema Jain Source Type: research