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Specialty: Neurology
Condition: Alzheimer's
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Total 647 results found since Jan 2013.
Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers
AbstractBlood pressure variability is an emerging risk factor for dementia but relationships with markers of neurodegeneration and Alzheimer ’s disease risk are understudied. We investigated blood pressure variability over one year and follow-up medial temporal brain volume change in apolipoprotein ϵ4 carriers and non-carriers, and in those with and without Alzheimer’s disease biomarker abnormality. 1051 Alzheimer’s Disease Neuroi maging Initiative participants without history of dementia or stroke underwent 3–4 blood pressure measurements over 12 months and ≥ 1 MRI thereafter. A subset (n = 252) underw...
Source: Brain Imaging and Behavior - September 28, 2021 Category: Neurology Source Type: research
Preliminary validation of the apraxia battery for adults-second edition (ABA-2) in Greek patients with dementia
ConclusionABA-2 is a valid, reliable and sensitive battery to differentiate demented patients from healthy individuals in the Greek population. We propose the modification of ABA-2 to a 5-subtest tool, to be administered as a bed-side test.
Source: Acta Neurologica Belgica - September 1, 2021 Category: Neurology Source Type: research
Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study
CONCLUSION: Strictly lobar CMBs, as well as WMH volume in anterior and posterior regions, were associated with cognitive decline. Future research focuses are warranted to evaluate interventions that may prevent cognitive decline related to SVD.PMID:34420506 | DOI:10.2174/1567205018666210820125543
Source: Current Alzheimer Research - August 23, 2021 Category: Neurology Authors: Bibek Gyanwali Benedict Lui Chuen Seng Tang Eddie Jun Yi Chong Henri Vrooman Christopher Chen Saima Hilal Source Type: research
Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke
In this study, we observed the accumulation of 17-kDa tau fragment in cultured primary neurons and media after oxygen-glucose deprivation/reperfusion (OGD/R) treatment that could be diminished by the presence of a calpain inhibitor. This calpa in-mediated proteolytic tau fragment was also detected in brain tissues from middle cerebral artery occlusion–injured rats and acute ischemic stroke patients receiving strokectomy, and human plasma samples collected within 48 h after the onset of stroke. The mass spectrometry analysis of this 17-k Da fragment identified 2 peptide sequences containing 195–224 amino acids of tau, w...
Source: Molecular Neurobiology - August 19, 2021 Category: Neurology Source Type: research
Air Pollution: A Neglected Risk Factor for Dementia in Latin America and the Caribbean
The risk of dementia and Alzheimer's disease in Latin America and the Caribbean (LAC) rises with increasing age and polluted air. Currently, at least 172 million people breathe unhealthy levels of air pollution in LAC countries. Several cohort studies have indicated that air pollution increases the risk of developing dementia and neurodegenerative diseases, but the mechanisms underlying the association are still not clear. Air pollution causes and aggravates five established risk factors for dementia (obesity, hypertension, stroke, diabetes mellitus, and heart diseases) and is linked to three other risk factors (physical i...
Source: Frontiers in Neurology - July 22, 2021 Category: Neurology Source Type: research
Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: a snapshot of their underlying mechanisms
Brain Res Bull. 2021 Jun 30:S0361-9230(21)00194-5. doi: 10.1016/j.brainresbull.2021.06.020. Online ahead of print.ABSTRACTRehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & Mey., and Gardenia, the fruit of Gardenia jasminoides Ellis from Rubiaceae, both are famous traditional Chinese medicines that have been traditionally used in China. Catalpol and geniposide, as two kinds of iridoid glycosides with high activities, are the main bioactive components in Rehmannia glutinosa and Gardenia jasminoides Ellis, respectively. Over the past few decades, catalpol and geniposide hav...
Source: Brain Research - July 3, 2021 Category: Neurology Authors: Xumin Zhang Kai Liu Mingyi Shi Long Xie Mao Deng Huijuan Chen Xiaofang Li Source Type: research
COVID-19 Infection and Circulating Microparticles —Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel Disease
AbstractSevere acute respiratory syndrome corona virus-2 (SARS-CoV-2) due to novel coronavirus disease 2019 (COVID-19) has affected the global society in numerous unprecedented ways, with considerable morbidity and mortality. Both direct and indirect consequences from COVID-19 infection are recognized to give rise to cardio- and cerebrovascular complications. Despite current limited knowledge on COVID-19 pathogenesis, inflammation, endothelial dysfunction, and coagulopathy appear to play critical roles in COVID-19-associated cerebrovascular disease (CVD). One of the major subtypes of CVD is cerebral small vessel disease (C...
Source: Molecular Neurobiology - June 26, 2021 Category: Neurology Source Type: research
Protective effect of alpha-linoleic acid on A β-induced oxidative stress, neuroinflammation, and memory impairment by alteration of α7 nAChR and NMDAR gene expression in the hippocampus of rats
Neurotoxicology. 2021 Jun 7;85:245-253. doi: 10.1016/j.neuro.2021.06.002. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder that affects many older people around the world. Numerous studies are underway to evaluate the protective effects of natural products in AD. Alpha-linoleic acid (ALA) is an essential unsaturated fatty acid that exhibits neuroprotective outcomes in rat models of ischemic stroke and Parkinson's disease. This research aimed to investigate the effect of ALA on oxidative stress, neuroinflammation, neuronal death, and memory deficit induced by amyloid-beta (A...
Source: Neurotoxicology - June 10, 2021 Category: Neurology Authors: Nahaleh Tofighi Masoumeh Asle-Rousta Mehdi Rahnema Rahim Amini Source Type: research
