Filtered By:
Specialty: Neurology
Condition: Alzheimer's
This page shows you your search results in order of date.
Order by Relevance | Date
Total 647 results found since Jan 2013.
NOTCH3 C201R variant causes cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) that can be confused with early-onset Alzheimer's disease
NOTCH3 is the causative gene for autosomal dominant cerebral arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) which is associated with both stroke and dementia. When CADASIL presents primarily as dementia it can be difficult to distinguish from Alzheimer's disease (AD) at both the clinical and neuropathological levels.
Source: Journal of the Neurological Sciences - August 7, 2023 Category: Neurology Authors: Olena Korvatska, Stephanie A. Bucks, Rebecca A. Yoda, Amber Nolan, Michael O. Dorschner, Debby Tsuang, Suman Jayadev, Wendy H. Raskind, Thomas D. Bird Source Type: research
Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer ’s disease
Stroke and late-onset Alzheimer ’s disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a significant challenge in basic research and clinical p...
Source: Molecular Neurodegeneration - July 3, 2023 Category: Neurology Authors: Shan P. Yu, Michael Q. Jiang, Seong S. Shim, Soheila Pourkhodadad and Ling Wei Tags: Review Source Type: research
Turning the Spotlight to Cholinergic Pharmacotherapy of the Human Language System
AbstractEven though language is essential in human communication, research on pharmacological therapies for language deficits in highly prevalent neurodegenerative and vascular brain diseases has received little attention. Emerging scientific evidence suggests that disruption of the cholinergic system may play an essential role in language deficits associated with Alzheimer ’s disease and vascular cognitive impairment, including post-stroke aphasia. Therefore, current models of cognitive processing are beginning to appraise the implications of the brain modulator acetylcholine in human language functions. Future work sho...
Source: CNS Drugs - June 21, 2023 Category: Neurology Source Type: research
Are Periodontitis, Stroke, and Alzheimer ' s Disease Linked? Are Periodontitis, Stroke, and Alzheimer ' s Disease Linked?
A new report provides the latest scientific evidence for the association between these outcomes, as well as practical recommendations.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - June 15, 2023 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Natural killer cells in aging and age-related diseases
Neurobiol Dis. 2023 May 18:106156. doi: 10.1016/j.nbd.2023.106156. Online ahead of print.ABSTRACTAging leads to escalated systemic inflammation. As the sentinel of immune system, natural killer (NK) cells are early responders that sense cues and signals from target organs and swiftly orchestrate local inflammation upon their arrival. Emerging evidence indicates a profound role of NK cells in the initiation and evolution of neuroinflammation in aging and age-related diseases. Here we discuss recent advances in NK cell biology and the organ-specific features of NK cells in normal brain aging, Alzheimer's disease, Parkinson's...
Source: Neurobiology of Disease - May 20, 2023 Category: Neurology Authors: Caiyun Qi Qiang Liu Source Type: research
Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee
Clin Neurophysiol. 2023 Mar 29;150:131-175. doi: 10.1016/j.clinph.2023.03.010. Online ahead of print.ABSTRACTThe review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on clinical diagnostic utility of transcranial magnetic stimulation (TMS) in neurological diseases. Most TMS measures rely on stimulation of motor cortex and recording of motor evoked potentials. Paired-pulse TMS techniques, incorporating conventio...
Source: Clinical Neurophysiology - April 17, 2023 Category: Neurology Authors: Steve Vucic Kai-Hsiang Stanley Chen Matthew C Kiernan Mark Hallett David H Benninger Vincenzo Di Lazzaro Paolo M Rossini Alberto Benussi Alfredo Berardelli Antonio Curr à Sandro M Krieg Jean-Pascal Lefaucheur Yew Long Lo Richard A Macdonell Marcello Mass Source Type: research
Role of tRNA-Derived Fragments in Neurological Disorders: a Review
AbstracttRFs are small tRNA derived fragments that are emerging as novel therapeutic targets and regulatory molecules in the pathophysiology of various neurological disorders. These are derived from precursor or mature tRNA, forming different subtypes that have been reported to be involved in neurological disorders like stroke, Alzheimer ’s, epilepsy, Parkinson’s, MELAS, autism, and Huntington’s disorder. tRFs were earlier believed to be random degradation debris of tRNAs. The significant variation in the expression level of tRFs in disease conditions indicates their salient role as key players in regulation of these...
Source: Molecular Neurobiology - January 19, 2023 Category: Neurology Source Type: research
An analysis of neurovascular disease markers in the hippocampus of Tupaia chinensis at different growth stages
DiscussionIt was suggested that when the hippocampus of T. chinensis developed from day 15 to 3 months, the expression of oxidatively phosphorylated proteins and RPs would vary over time. Meanwhile, the hippocamppal protein expression profile of T. chinensis after 3 months had become stable. Moreover, the study underlines that, during the early development of the hippocampus of T. chinensis, energy demand increases while protein synthesis decreases. The mitochondria of T. chinensis changes with age, and the oxidative phosphorylation metabolic pathway of mitochondria is closely related to neurovascular diseases, such as str...
Source: Frontiers in Neurology - January 17, 2023 Category: Neurology Source Type: research
