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Protective effect of alpha-linoleic acid on A β-induced oxidative stress, neuroinflammation, and memory impairment by alteration of α7 nAChR and NMDAR gene expression in the hippocampus of rats
Neurotoxicology. 2021 Jun 7;85:245-253. doi: 10.1016/j.neuro.2021.06.002. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder that affects many older people around the world. Numerous studies are underway to evaluate the protective effects of natural products in AD. Alpha-linoleic acid (ALA) is an essential unsaturated fatty acid that exhibits neuroprotective outcomes in rat models of ischemic stroke and Parkinson's disease. This research aimed to investigate the effect of ALA on oxidative stress, neuroinflammation, neuronal death, and memory deficit induced by amyloid-beta (A...
Source: Neurotoxicology - June 10, 2021 Category: Neurology Authors: Nahaleh Tofighi Masoumeh Asle-Rousta Mehdi Rahnema Rahim Amini Source Type: research

Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
Curr Neuropharmacol. 2021 Jun 8. doi: 10.2174/1570159X19666210608165509. Online ahead of print.ABSTRACTNeurological disorders like Alzheimer's disease (AD), Parkinson's disease (PD), stroke, amyotrophic lateral sclerosis, Huntington's disease (HD), epilepsy, traumatic brain injury (TBI), depression and anxiety are responsible for thousands of deaths worldwide every year. With the increase in life expectancy, there has been a rise in the prevalence of these disorders. Age is one of the major risk factors for these neurological disorders and with the aged population is set to rise to 1.25 billion by 2050. There is a growing ...
Source: Epilepsy Curr - June 9, 2021 Category: Neurology Authors: Namrata Pramod Kulkarni Bhupesh Vaidya Acharan Narula Shyam Sunder Sharma Source Type: research

Cognitive–motor Interference in Individuals With a Neurologic Disorder: A Systematic Review of Neural Correlates
Conclusion: Despite large heterogeneity in study methodologies, some recurrent patterns were noted. Particularly, in neurologic patients, an already higher brain activation during single tasks was seen compared with healthy controls, perhaps compromising the patients’ ability to further adapt brain activation with increasing load during dual tasking and resulting in reduced behavioral dual task performance.
Source: Cognitive and Behavioral Neurology - June 1, 2021 Category: Neurology Tags: Review Source Type: research

The circadian rhythm of arterial blood pressure in Alzheimer ’s disease and vascular dementia
This study aimed to evaluate blood pressure using ABPM, in 30 Alzheimer ’s disease (AD) patients and 30 vascular dementia (VaD) patients in comparison with 30 healthy controls. BP was recorded every 15 min from 6 AM to 10 PM, and every 30 min from 10 PM to 6 AM. Mean systolic (SBP) and diastolic (DBP) blood pressure during daytime, nighttime, diurnal index, pulse pr essure, and heart rate were extracted from the ABPM recordings. VaD patients presented higher SBP values compared to AD patients and healthy controls. DBP values in the AD group were the lowest, while VaD patients presented the highest DBP values, includin...
Source: Acta Neurologica Belgica - May 27, 2021 Category: Neurology Source Type: research

GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF- κB pathway in neuropathic pain mice
Neurobiol Learn Mem. 2021 May 17:107463. doi: 10.1016/j.nlm.2021.107463. Online ahead of print.ABSTRACTGrowing evidences indicate that neuropathic pain is frequently accompanied with cognitive impairments, which aggravate the decrease in the quality of life of chronic pain patients. Furthermore, it has been shown that the activation of Glucagon-like-peptide-1receptor (GLP-1R) improved memory deficit in multiple diseases, including Alzheimer's disease (AD), stroke. However, whether GLP-1R activation could improve memory impairment induced by neuropathic pain and the mechanisms underlying the effect of the activation of GLP-...
Source: Neurobiology of Learning and Memory - May 20, 2021 Category: Neurology Authors: Long-Qing Zhang Wen Zhang Ting Li Ting Yang Xiaoman Yuan Yaqun Zhou Qian Zou Hui Yang Feng Gao YuKe Tian Wei Mei Xue-Bi Tian Source Type: research

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