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Specialty: Neurology
Condition: Alzheimer's
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Total 647 results found since Jan 2013.
A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders
Curr Drug Targets. 2022 Jan 17. doi: 10.2174/1389450123666220117104038. Online ahead of print.ABSTRACTNeurological disorders are disease conditions related to the neurons and central nervous system (CNS). Any kind of structural, electrical, biochemical and functional abnormalities in neurons can lead to various types of disorders like Alzheimer's disease (AD), depression, Parkinson's disease (PD), epilepsy, stroke, etc. Currently available medicines are symptomatic and do not treat the disease state. Thus, novel CNS active agents with the potential of complete treatment of an illness are highly desired. A range of small or...
Source: Epilepsy Curr - March 21, 2022 Category: Neurology Authors: Bhupinder Kumar Naveen Kumar Amandeep Thakur Vijay Kumar Rakesh Kumar Vinod Kumar Source Type: research
Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00077-6. doi: 10.1016/j.brainresbull.2022.03.008. Online ahead of print.ABSTRACTIschemic stroke in rodents is usually induced by intraluminal occlusion of the middle cerebral artery (MCA) via the external carotid artery (ECA) or the common carotid artery (CCA). The latter route requires permanent CCA occlusion after ischemia, and here, we assess its effects on long-term outcomes. Transient occlusion of MCA and CCA was performed at normal body temperature. After 90minutes of ischemia, mice were randomized to permanent CCA occlusion or no occlusion (control group). Body weight, and m...
Source: Brain Research Bulletin - March 19, 2022 Category: Neurology Authors: Zhong Yang Xuan Li Zhipeng Cao Peng Wang David S Warner Huaxin Sheng Source Type: research
Neuroprotective Mechanisms of Glucagon-Like Peptide-1-Based Therapies in Ischemic Stroke: An Update Based on Preclinical Research
The public and social health burdens of ischemic stroke have been increasing worldwide. Hyperglycemia leads to a greater risk of stroke. This increased risk is commonly seen among patients with diabetes and is in connection with worsened clinical conditions and higher mortality in patients with acute ischemic stroke (AIS). Therapy for stroke focuses mainly on restoring cerebral blood flow (CBF) and ameliorating neurological impairment caused by stroke. Although choices of stroke treatment remain limited, much advance have been achieved in assisting patients in recovering from ischemic stroke, along with progress of recanal...
Source: Frontiers in Neurology - March 15, 2022 Category: Neurology Source Type: research
Complement C3a Receptor (C3aR) Mediates Vascular Dysfunction, Hippocampal Pathology, and Cognitive Impairment in a Mouse Model of VCID
AbstractVascular contributions to cognitive impairment and dementia (VCID) secondary to chronic mild-moderate cerebral ischemia underlie a significant percentage of cases of dementia. We previously reported that either genetic deficiency of the complement C3a receptor (C3aR) or its pharmacological inhibition protects against cerebral ischemia in rodents, while others have implicated C3aR in the pathogenesis seen in rodent transgenic models of Alzheimer ’s disease. In the present study, we evaluated the role of complement C3a-C3aR signaling in the onset and progression of VCID. We utilized the bilateral common carotid art...
Source: Translational Stroke Research - March 8, 2022 Category: Neurology Source Type: research
Clinical and Instrumental Characterization of Patients With Late-Onset Epilepsy
Epilepsy is classically considered a childhood disease. However, it represents the third most frequent neurological condition in the elderly, following stroke, and dementia. With the progressive aging of the general population, the number of patients with Late-Onset Epilepsy (LOE) is constantly growing, with important economic and social consequences, in particular for the more developed countries where the percentage of elderly people is higher. The most common causes of LOE are structural, mainly secondary to cerebrovascular or infectious diseases, brain tumors, trauma, and metabolic or toxic conditions. Moreover, there ...
Source: Frontiers in Neurology - February 25, 2022 Category: Neurology Source Type: research
Volumetric White Matter Hyperintensity Ranges Correspond to Fazekas Scores on Brain MRI
Leukoaraiosis presents as white matter hyperintensities (WMH) on magnetic resonance (MR) imaging. It is thought to originate from decreased vascular supply to axons with an accompanying loss of axonal integrity. WMH have been found to be more prevalent in older patients, especially in those with neurodegeneration from Alzheimer's disease (AD) or stroke.1-6A visual categorization method named the Fazekas scale was developed in order to compare white matter disease burden on computed tomography scans between patients experiencing normal aging and those with AD.
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2022 Category: Neurology Authors: Ariana Andere, Gaurav Jindal, Janine Molino, Scott Collins, Derek Merck, Tina Burton, Christoph Stretz, Shadi Yaghi, Daniel C. Sacchetti, Sleiman El Jamal, Michael E. Reznik, Karen Furie, Shawna Cutting Tags: Short Communication Source Type: research
