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Specialty: Neurology
Condition: Alzheimer's

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Total 647 results found since Jan 2013.

Blood GFAP as an emerging biomarker in brain and spinal cord disorders
Nature Reviews Neurology, Published online: 03 February 2022; doi:10.1038/s41582-021-00616-3In this Review, the authors provide an overview of the evidence regarding the use of blood levels of glial fibrillary acidic protein as a biomarker in a range of neurological diseases, including traumatic brain injury, stroke, multiple sclerosis and Alzheimer disease.
Source: Nature Reviews Neurology - February 3, 2022 Category: Neurology Authors: Ahmed Abdelhak Matteo Foschi Samir Abu-Rumeileh John K. Yue Lucio D ’Anna Andre Huss Patrick Oeckl Albert C. Ludolph Jens Kuhle Axel Petzold Geoffrey T. Manley Ari J. Green Markus Otto Hayrettin Tumani Source Type: research

Bacopa monnieri for disorders affecting brain: Current perspectives
Curr Top Med Chem. 2022 Jan 19. doi: 10.2174/1568026622666220119111538. Online ahead of print.ABSTRACTBacopa monnieri (BM) is of immense therapeutic potential in today's world. This review is aimed to project the beneficial role of BM in disorders affecting the brain, including Alzheimer's disease, Parkinson's disease, stroke, epilepsy and depression. The active constituents and metabolites responsible for the effects of BM could be bacoside A and B, bacopaside I and II, bacopasaponin C, betulinic acid, asiatic acid, loliolide, ebelin lactone and quercetin. The mechanistic role of BM in brain disorders might be related to ...
Source: Epilepsy Curr - January 19, 2022 Category: Neurology Authors: Adithya Vinod S Sathianarayanan Anju Elizabath Babu Prashant Sadanandan None Athira K V Baskar Venkidasamy Source Type: research

Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement
AbstractRetinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While research has identified the biochemical roles of several nuclear receptor family members, the roles of RXRs in various neurological disorders remain relatively under-investigated . RXR acts as ligand-regulated transcription factor, modulating the expression of genes that plays a critical role in mediating several deve...
Source: Molecular Neurobiology - January 11, 2022 Category: Neurology Source Type: research

Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
Neurobiol Dis. 2022 Feb;163:105607. doi: 10.1016/j.nbd.2021.105607. Epub 2021 Dec 31.ABSTRACTBrain disorders are characterized by the progressive loss of structure and function of the brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a major risk factor for brain disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and stroke. Various cellular and molecular events have been shown to play a role in the progress of neurodegenerative diseases. Emerging studies suggest that primary cilia could be a key regulator in brain diseases. The ...
Source: Neurobiology of Disease - January 3, 2022 Category: Neurology Authors: Rong Ma Naseer A Kutchy Liang Chen Douglas D Meigs Guoku Hu Source Type: research

Vascular Cognitive Impairment (VCI)
AbstractVascular cognitive impairment (VCI) is predominately caused by vascular risk factors and cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild cognitive impairment to vascular dementia caused by ischemic or hemorrhagic stroke, and vascular factors alone or in a combination with neurodegeneration including Alzheimer ’s disease (AD) and AD-related dementia. VCI accounts for at least 20–40% of all dementia diagnosis. Growing evidence indicates that cerebrovascular pathology is the most important contributor to dementia, with additive or synergistic interactions with neurodegenera...
Source: Neurotherapeutics - December 22, 2021 Category: Neurology Source Type: research

Ictogenesis of viral pneumonia: A comparison between SARS-CoV-2 and H1N1/H3N2
Epilepsy Behav. 2021 Dec 10;126:108470. doi: 10.1016/j.yebeh.2021.108470. Online ahead of print.ABSTRACTSeveral studies reported acute symptomatic seizures as a possible neurological complication of COVID-19 pneumonia. Apart from metabolic imbalances, hypoxia, and fever, other ictogenic mechanisms are likely related to an immune-mediated damage. The same mechanisms are shared by other respiratory viruses. Since neurotropic properties of SARS-CoV-2 have been questioned, we investigated whether SARS-CoV-2 has a similar ictogenic potential to other respiratory non-neurotropic viruses. We conducted a retrospective study identi...
Source: Epilepsy and Behaviour - December 13, 2021 Category: Neurology Authors: Chiara Milano Francesco Turco Chiara Pizzanelli Alessia Pascazio Enrico Tagliaferri Lorenzo Nesti Mauro Pistello Anna Lisa Capria Francesco Menichetti Francesco Forfori Enrica Bonanni Gabriele Siciliano Source Type: research

Repurposing Vorinostat for the Treatment of Disorders Affecting Brain
AbstractBased on the findings in recent years, we summarize the therapeutic potential of vorinostat (VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and strategies to improve drug efficacy and reduce side effects. Scientific evidences provide a strong case for the therapeutic utility of VOR in various disorders affecting brain, including stroke, Alzheimer ’s disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, X‐linked adrenoleukodystrophy, epilepsy, Niemann-Pick type C disease, and neuropsychiatric dis...
Source: NeuroMolecular Medicine - December 1, 2021 Category: Neurology Source Type: research

Targeted RNA Sequencing of VZV-Infected Brain Vascular Adventitial Fibroblasts Indicates That Amyloid May Be Involved in VZV Vasculopathy
Discussion Gene expression profiles and pathway enrichment analysis of VZV-infected HBVAFs, as well as phenotypic studies, reveal features of pathologic vascular remodeling (e.g., increased cell migration and changes in the extracellular matrix) that can contribute to cerebrovascular disease. Furthermore, the discovery of amyloid-associated transcriptional pathways and intracellular amyloid deposition in HBVAFs raise the possibility that VZV vasculopathy is an amyloid disease. Amyloid deposition may contribute to cell death and loss of vascular wall integrity, as well as potentiate chronic inflammation in VZV vasculopathy,...
Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Bubak, A. N., Como, C. N., Hassell, J. E., Mescher, T., Frietze, S. E., Niemeyer, C. S., Cohrs, R. J., Nagel, M. A. Tags: Vasculitis, Viral infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, Gene expression studies Article Source Type: research

Evaluating 68GaGa-p14-032 as a Novel PET Tracer for Diagnosis Cerebral Amyloid Angiopathy
Conclusions: Our results provide early evidence that the [68Ga] Ga-p14-032 PET probe binds preferentially to vascular amyloid and may be a useful tracer for diagnosing CAA.
Source: Frontiers in Neurology - October 27, 2021 Category: Neurology Source Type: research

Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases
This article mainly focu ses on the delivering modes of genetic materials in the CNS, which includes viral and non-viral vectors and their application in gene therapy. Despite the many clinical trials conducted so far, data have shown disappointing outcomes. The efforts done to improve outcomes, efficacy, and safety in the identification of targets in various neurological disorders are also discussed here. Adapting gene therapy as a new therapeutic approach for treating neurological disorders seems to be promising, with early detection and delivery of therapy before the neuron is lost, helping a lot the development of new ...
Source: Molecular Neurobiology - October 15, 2021 Category: Neurology Source Type: research

Dietary Insights in Neurological Diseases
This article describes the most common and impactful dietary regimens for commonly encountered neurological disorders.RECENT FINDINGS: Plant-based, low-fat, high-fiber diets, rich in antioxidants and other lifestyle interventions may reduce the burden and disability of common neurological disorders. The ketogenic diet, the diet of choice for the treatment of refractory epilepsy, is such an example. Diverse neurological disorders demonstrate several common pathophysiological mechanisms including increased oxidative stress, neuroinflammation, and disrupted metabolism. Dietary interventions can potentially influence these pat...
Source: Epilepsy Curr - September 29, 2021 Category: Neurology Authors: Sergio A Ram írez-Salazar Cherie Herren Jessica McCartney Jorge G Ortiz Garc ía Source Type: research