Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results ...
Source: Neurobiology of Learning and Memory - May 2, 2021 Category: Neurology Authors: Cid-Fern ández Susana Lind ín Mónica D íaz Fernando Source Type: research

It's all about who you know: Memory retention of a rat's cagemates during infancy negatively predicts adulthood hippocampal FGF2
Neurobiol Learn Mem. 2021 Apr 26:107448. doi: 10.1016/j.nlm.2021.107448. Online ahead of print.ABSTRACTRecent research has demonstrated that individual differences in infant fear memory positively predict adulthood anxiety-like behavior and conditioned fear expression. However, the physiological mechanisms underlying this relationship and the effect of environmental (e.g., social) influences on the stability of this relationship have not been explored. In the present study, we examined whether individual differences in infant fear memory predict levels of endogenous fibroblast growth factor-2 (FGF2; a biomarker of fear/anx...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Sylvia K Harmon-Jones Bronwyn M Graham Gabrielle King Rick Richardson Source Type: research

Dorsal striatum and the temporal expectancy of an aversive event in Pavlovian odor fear learning
Neurobiol Learn Mem. 2021 Apr 26:107446. doi: 10.1016/j.nlm.2021.107446. Online ahead of print.ABSTRACTInterval timing, the ability to encode and retrieve the memory of intervals from seconds to minutes, guides fundamental animal behaviors across the phylogenetic tree. In Pavlovian fear conditioning, an initially neutral stimulus (conditioned stimulus, CS) predicts the arrival of an aversive unconditioned stimulus (US, generally a mild foot-shock) at a fixed time interval. Although some studies showed that temporal relations between CS and US events are learned from the outset of conditioning, the question of the memory of...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Julie Boulanger-Bertolus Sandrine Parrot Val érie Doyère Anne-Marie Mouly Source Type: research

Metaplastic regulation of neocortical long-term depression in vivo is sensitive to distinct phases of conditioned taste aversion
Neurobiol Learn Mem. 2021 Apr 26:107449. doi: 10.1016/j.nlm.2021.107449. Online ahead of print.ABSTRACTMetaplasticity refers to the persistent modification, by previous activity, in the ability to induce synaptic plasticity. Accumulated evidence has proposed that metaplasticity contributes to network function and cognitive processes such as learning and memory. In this regard, it has been observed that training in several behavioral tasks modifies the possibility to induce subsequent synaptic plasticity, such as long-term potentiation (LTP) and long-term depression (LTD). For instance, our previous studies have shown that ...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Esteban Urrietam Martha L Escobar Source Type: research

Epinephrine Modulates Memory of Latent Learning in an Inhibitory Avoidance Task
Neurobiol Learn Mem. 2021 Apr 26:107447. doi: 10.1016/j.nlm.2021.107447. Online ahead of print.ABSTRACTThe present study examined the memory modulatory effect of epinephrine on latent learning of an inhibitory avoidance task. Male Sprague-Dawley rats on the first day were subjected to one of three conditions (no, short or long) in pre-exposure to the task apparatus. One day or several days later, they received the typical inhibitory avoidance training with a 0.5 mA/0.5 s foot shock. Memory of the inhibitory avoidance response was tested one day after the foot-shock training. The long pre-exposure group showed better memory...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: K C Liang Der-Yow Chen Source Type: research

It's all about who you know: Memory retention of a rat's cagemates during infancy negatively predicts adulthood hippocampal FGF2
Neurobiol Learn Mem. 2021 Apr 26:107448. doi: 10.1016/j.nlm.2021.107448. Online ahead of print.ABSTRACTRecent research has demonstrated that individual differences in infant fear memory positively predict adulthood anxiety-like behavior and conditioned fear expression. However, the physiological mechanisms underlying this relationship and the effect of environmental (e.g., social) influences on the stability of this relationship have not been explored. In the present study, we examined whether individual differences in infant fear memory predict levels of endogenous fibroblast growth factor-2 (FGF2; a biomarker of fear/anx...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Sylvia K Harmon-Jones Bronwyn M Graham Gabrielle King Rick Richardson Source Type: research

Dorsal striatum and the temporal expectancy of an aversive event in Pavlovian odor fear learning
Neurobiol Learn Mem. 2021 Apr 26:107446. doi: 10.1016/j.nlm.2021.107446. Online ahead of print.ABSTRACTInterval timing, the ability to encode and retrieve the memory of intervals from seconds to minutes, guides fundamental animal behaviors across the phylogenetic tree. In Pavlovian fear conditioning, an initially neutral stimulus (conditioned stimulus, CS) predicts the arrival of an aversive unconditioned stimulus (US, generally a mild foot-shock) at a fixed time interval. Although some studies showed that temporal relations between CS and US events are learned from the outset of conditioning, the question of the memory of...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Julie Boulanger-Bertolus Sandrine Parrot Val érie Doyère Anne-Marie Mouly Source Type: research

Metaplastic regulation of neocortical long-term depression in vivo is sensitive to distinct phases of conditioned taste aversion
Neurobiol Learn Mem. 2021 Apr 26:107449. doi: 10.1016/j.nlm.2021.107449. Online ahead of print.ABSTRACTMetaplasticity refers to the persistent modification, by previous activity, in the ability to induce synaptic plasticity. Accumulated evidence has proposed that metaplasticity contributes to network function and cognitive processes such as learning and memory. In this regard, it has been observed that training in several behavioral tasks modifies the possibility to induce subsequent synaptic plasticity, such as long-term potentiation (LTP) and long-term depression (LTD). For instance, our previous studies have shown that ...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Esteban Urrietam Martha L Escobar Source Type: research

Epinephrine Modulates Memory of Latent Learning in an Inhibitory Avoidance Task
Neurobiol Learn Mem. 2021 Apr 26:107447. doi: 10.1016/j.nlm.2021.107447. Online ahead of print.ABSTRACTThe present study examined the memory modulatory effect of epinephrine on latent learning of an inhibitory avoidance task. Male Sprague-Dawley rats on the first day were subjected to one of three conditions (no, short or long) in pre-exposure to the task apparatus. One day or several days later, they received the typical inhibitory avoidance training with a 0.5 mA/0.5 s foot shock. Memory of the inhibitory avoidance response was tested one day after the foot-shock training. The long pre-exposure group showed better memory...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: K C Liang Der-Yow Chen Source Type: research

It's all about who you know: Memory retention of a rat's cagemates during infancy negatively predicts adulthood hippocampal FGF2
Neurobiol Learn Mem. 2021 Apr 26:107448. doi: 10.1016/j.nlm.2021.107448. Online ahead of print.ABSTRACTRecent research has demonstrated that individual differences in infant fear memory positively predict adulthood anxiety-like behavior and conditioned fear expression. However, the physiological mechanisms underlying this relationship and the effect of environmental (e.g., social) influences on the stability of this relationship have not been explored. In the present study, we examined whether individual differences in infant fear memory predict levels of endogenous fibroblast growth factor-2 (FGF2; a biomarker of fear/anx...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Sylvia K Harmon-Jones Bronwyn M Graham Gabrielle King Rick Richardson Source Type: research

Dorsal striatum and the temporal expectancy of an aversive event in Pavlovian odor fear learning
Neurobiol Learn Mem. 2021 Apr 26:107446. doi: 10.1016/j.nlm.2021.107446. Online ahead of print.ABSTRACTInterval timing, the ability to encode and retrieve the memory of intervals from seconds to minutes, guides fundamental animal behaviors across the phylogenetic tree. In Pavlovian fear conditioning, an initially neutral stimulus (conditioned stimulus, CS) predicts the arrival of an aversive unconditioned stimulus (US, generally a mild foot-shock) at a fixed time interval. Although some studies showed that temporal relations between CS and US events are learned from the outset of conditioning, the question of the memory of...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Julie Boulanger-Bertolus Sandrine Parrot Val érie Doyère Anne-Marie Mouly Source Type: research

Metaplastic regulation of neocortical long-term depression in vivo is sensitive to distinct phases of conditioned taste aversion
Neurobiol Learn Mem. 2021 Apr 26:107449. doi: 10.1016/j.nlm.2021.107449. Online ahead of print.ABSTRACTMetaplasticity refers to the persistent modification, by previous activity, in the ability to induce synaptic plasticity. Accumulated evidence has proposed that metaplasticity contributes to network function and cognitive processes such as learning and memory. In this regard, it has been observed that training in several behavioral tasks modifies the possibility to induce subsequent synaptic plasticity, such as long-term potentiation (LTP) and long-term depression (LTD). For instance, our previous studies have shown that ...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: Esteban Urrietam Martha L Escobar Source Type: research

Epinephrine Modulates Memory of Latent Learning in an Inhibitory Avoidance Task
Neurobiol Learn Mem. 2021 Apr 26:107447. doi: 10.1016/j.nlm.2021.107447. Online ahead of print.ABSTRACTThe present study examined the memory modulatory effect of epinephrine on latent learning of an inhibitory avoidance task. Male Sprague-Dawley rats on the first day were subjected to one of three conditions (no, short or long) in pre-exposure to the task apparatus. One day or several days later, they received the typical inhibitory avoidance training with a 0.5 mA/0.5 s foot shock. Memory of the inhibitory avoidance response was tested one day after the foot-shock training. The long pre-exposure group showed better memory...
Source: Neurobiology of Learning and Memory - April 29, 2021 Category: Neurology Authors: K C Liang Der-Yow Chen Source Type: research

Long-term effects of early postnatal nicotine exposure on cholinergic function in the mouse hippocampal CA1 region
Neurobiol Learn Mem. 2021 Apr 22:107445. doi: 10.1016/j.nlm.2021.107445. Online ahead of print.ABSTRACTIn rodent models of smoking during pregnancy, early postnatal nicotine exposure results in impaired hippocampus-dependent memory, but the underlying mechanism remains elusive. Given that hippocampal cholinergic systems modulate memory and rapid development of hippocampal cholinergic systems occurs during nicotine exposure, here we investigated its impacts on cholinergic function. Both nicotinic and muscarinic activation produce transient or long-lasting depression of excitatory synaptic transmission in the hippocampal CA1...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Sakura Nakauchi Hailing Su Ivan Trang Katumi Sumikawa Source Type: research

Transcranial alternating current stimulation at theta frequency to left parietal cortex impairs associative, but not perceptual, memory encoding
Neurobiol Learn Mem. 2021 Apr 22:107444. doi: 10.1016/j.nlm.2021.107444. Online ahead of print.ABSTRACTNeural oscillations in the theta range (4-8 Hz) are thought to underlie associative memory function in the hippocampal-cortical network. While there is ample evidence supporting a role of theta oscillations in animal and human memory, most evidence is correlational. Non-invasive brain stimulation (NIBS) can be employed to modulate cortical oscillatory activity to influence brain activity, and possibly modulate deeper brain regions, such as hippocampus, through strong and reliable cortico-hippocampal functional connections...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Alyssa Meng Max Kaiser Tom de Graaf Felix Duecker Alexander T Sack Peter de Weerd Vincent van de Ven Source Type: research

Touchscreen Cognitive testing: Cross-Species Translation and Co-Clinical Trials in Neurodegenerative and Neuropsychiatric Disease
Neurobiol Learn Mem. 2021 Apr 22:107443. doi: 10.1016/j.nlm.2021.107443. Online ahead of print.ABSTRACTTranslating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are central contributors to this challenge. Computer-automated cognitive test batteries have the potential to substantially improve translation between pre-clinical studies and clinical trials...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Daniel Palmer Julie R Dumont Tyler D Dexter Marco A M Prado Elizabeth Finger Timothy J Bussey Lisa M Saksida Source Type: research

Long-term effects of early postnatal nicotine exposure on cholinergic function in the mouse hippocampal CA1 region
Neurobiol Learn Mem. 2021 Apr 22:107445. doi: 10.1016/j.nlm.2021.107445. Online ahead of print.ABSTRACTIn rodent models of smoking during pregnancy, early postnatal nicotine exposure results in impaired hippocampus-dependent memory, but the underlying mechanism remains elusive. Given that hippocampal cholinergic systems modulate memory and rapid development of hippocampal cholinergic systems occurs during nicotine exposure, here we investigated its impacts on cholinergic function. Both nicotinic and muscarinic activation produce transient or long-lasting depression of excitatory synaptic transmission in the hippocampal CA1...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Sakura Nakauchi Hailing Su Ivan Trang Katumi Sumikawa Source Type: research

Transcranial alternating current stimulation at theta frequency to left parietal cortex impairs associative, but not perceptual, memory encoding
Neurobiol Learn Mem. 2021 Apr 22:107444. doi: 10.1016/j.nlm.2021.107444. Online ahead of print.ABSTRACTNeural oscillations in the theta range (4-8 Hz) are thought to underlie associative memory function in the hippocampal-cortical network. While there is ample evidence supporting a role of theta oscillations in animal and human memory, most evidence is correlational. Non-invasive brain stimulation (NIBS) can be employed to modulate cortical oscillatory activity to influence brain activity, and possibly modulate deeper brain regions, such as hippocampus, through strong and reliable cortico-hippocampal functional connections...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Alyssa Meng Max Kaiser Tom de Graaf Felix Duecker Alexander T Sack Peter de Weerd Vincent van de Ven Source Type: research

Touchscreen Cognitive testing: Cross-Species Translation and Co-Clinical Trials in Neurodegenerative and Neuropsychiatric Disease
Neurobiol Learn Mem. 2021 Apr 22:107443. doi: 10.1016/j.nlm.2021.107443. Online ahead of print.ABSTRACTTranslating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are central contributors to this challenge. Computer-automated cognitive test batteries have the potential to substantially improve translation between pre-clinical studies and clinical trials...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Daniel Palmer Julie R Dumont Tyler D Dexter Marco A M Prado Elizabeth Finger Timothy J Bussey Lisa M Saksida Source Type: research

Long-term effects of early postnatal nicotine exposure on cholinergic function in the mouse hippocampal CA1 region
Neurobiol Learn Mem. 2021 Apr 22:107445. doi: 10.1016/j.nlm.2021.107445. Online ahead of print.ABSTRACTIn rodent models of smoking during pregnancy, early postnatal nicotine exposure results in impaired hippocampus-dependent memory, but the underlying mechanism remains elusive. Given that hippocampal cholinergic systems modulate memory and rapid development of hippocampal cholinergic systems occurs during nicotine exposure, here we investigated its impacts on cholinergic function. Both nicotinic and muscarinic activation produce transient or long-lasting depression of excitatory synaptic transmission in the hippocampal CA1...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Sakura Nakauchi Hailing Su Ivan Trang Katumi Sumikawa Source Type: research

Transcranial alternating current stimulation at theta frequency to left parietal cortex impairs associative, but not perceptual, memory encoding
Neurobiol Learn Mem. 2021 Apr 22:107444. doi: 10.1016/j.nlm.2021.107444. Online ahead of print.ABSTRACTNeural oscillations in the theta range (4-8 Hz) are thought to underlie associative memory function in the hippocampal-cortical network. While there is ample evidence supporting a role of theta oscillations in animal and human memory, most evidence is correlational. Non-invasive brain stimulation (NIBS) can be employed to modulate cortical oscillatory activity to influence brain activity, and possibly modulate deeper brain regions, such as hippocampus, through strong and reliable cortico-hippocampal functional connections...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Alyssa Meng Max Kaiser Tom de Graaf Felix Duecker Alexander T Sack Peter de Weerd Vincent van de Ven Source Type: research

Touchscreen Cognitive testing: Cross-Species Translation and Co-Clinical Trials in Neurodegenerative and Neuropsychiatric Disease
Neurobiol Learn Mem. 2021 Apr 22:107443. doi: 10.1016/j.nlm.2021.107443. Online ahead of print.ABSTRACTTranslating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are central contributors to this challenge. Computer-automated cognitive test batteries have the potential to substantially improve translation between pre-clinical studies and clinical trials...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Daniel Palmer Julie R Dumont Tyler D Dexter Marco A M Prado Elizabeth Finger Timothy J Bussey Lisa M Saksida Source Type: research

Long-term effects of early postnatal nicotine exposure on cholinergic function in the mouse hippocampal CA1 region
Neurobiol Learn Mem. 2021 Apr 22:107445. doi: 10.1016/j.nlm.2021.107445. Online ahead of print.ABSTRACTIn rodent models of smoking during pregnancy, early postnatal nicotine exposure results in impaired hippocampus-dependent memory, but the underlying mechanism remains elusive. Given that hippocampal cholinergic systems modulate memory and rapid development of hippocampal cholinergic systems occurs during nicotine exposure, here we investigated its impacts on cholinergic function. Both nicotinic and muscarinic activation produce transient or long-lasting depression of excitatory synaptic transmission in the hippocampal CA1...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Sakura Nakauchi Hailing Su Ivan Trang Katumi Sumikawa Source Type: research

Transcranial alternating current stimulation at theta frequency to left parietal cortex impairs associative, but not perceptual, memory encoding
Neurobiol Learn Mem. 2021 Apr 22:107444. doi: 10.1016/j.nlm.2021.107444. Online ahead of print.ABSTRACTNeural oscillations in the theta range (4-8 Hz) are thought to underlie associative memory function in the hippocampal-cortical network. While there is ample evidence supporting a role of theta oscillations in animal and human memory, most evidence is correlational. Non-invasive brain stimulation (NIBS) can be employed to modulate cortical oscillatory activity to influence brain activity, and possibly modulate deeper brain regions, such as hippocampus, through strong and reliable cortico-hippocampal functional connections...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Alyssa Meng Max Kaiser Tom de Graaf Felix Duecker Alexander T Sack Peter de Weerd Vincent van de Ven Source Type: research

Touchscreen Cognitive testing: Cross-Species Translation and Co-Clinical Trials in Neurodegenerative and Neuropsychiatric Disease
Neurobiol Learn Mem. 2021 Apr 22:107443. doi: 10.1016/j.nlm.2021.107443. Online ahead of print.ABSTRACTTranslating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poor translational validity of many paradigms used to assess cognition in animal models are central contributors to this challenge. Computer-automated cognitive test batteries have the potential to substantially improve translation between pre-clinical studies and clinical trials...
Source: Neurobiology of Learning and Memory - April 25, 2021 Category: Neurology Authors: Daniel Palmer Julie R Dumont Tyler D Dexter Marco A M Prado Elizabeth Finger Timothy J Bussey Lisa M Saksida Source Type: research

Does memory reactivation during sleep support generalization at the cost of memory specifics?
Neurobiol Learn Mem. 2021 Apr 20:107442. doi: 10.1016/j.nlm.2021.107442. Online ahead of print.ABSTRACTSleep is important for memory, but does it favor consolidation of specific details or extraction of generalized information? Both may occur together when memories are reactivated during sleep, or a loss of certain memory details may facilitate generalization. To examine these issues, we tested memory in participants who viewed landscape paintings by six artists. Paintings were cropped to show only a section of the scene. During a learning phase, each painting section was presented with the artist's name and with a nonverb...
Source: Neurobiology of Learning and Memory - April 23, 2021 Category: Neurology Authors: Sarah Witkowski Sharon Noh Victoria Lee Daniela Grimaldi Alison R Preston Ken A Paller Source Type: research

Does memory reactivation during sleep support generalization at the cost of memory specifics?
Neurobiol Learn Mem. 2021 Apr 20:107442. doi: 10.1016/j.nlm.2021.107442. Online ahead of print.ABSTRACTSleep is important for memory, but does it favor consolidation of specific details or extraction of generalized information? Both may occur together when memories are reactivated during sleep, or a loss of certain memory details may facilitate generalization. To examine these issues, we tested memory in participants who viewed landscape paintings by six artists. Paintings were cropped to show only a section of the scene. During a learning phase, each painting section was presented with the artist's name and with a nonverb...
Source: Neurobiology of Learning and Memory - April 23, 2021 Category: Neurology Authors: Sarah Witkowski Sharon Noh Victoria Lee Daniela Grimaldi Alison R Preston Ken A Paller Source Type: research

Perirhinal cortex and the recognition of relative familiarity
We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object...
Source: Neurobiology of Learning and Memory - April 16, 2021 Category: Neurology Authors: Kamar E Ameen-Ali Magali H Sivakumaran Madeline J Eacott Akira R O'Connor James A Ainge Alexander Easton Source Type: research

Perirhinal cortex and the recognition of relative familiarity
We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object...
Source: Neurobiology of Learning and Memory - April 16, 2021 Category: Neurology Authors: Kamar E Ameen-Ali Magali H Sivakumaran Madeline J Eacott Akira R O'Connor James A Ainge Alexander Easton Source Type: research

Perirhinal cortex and the recognition of relative familiarity
We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object...
Source: Neurobiology of Learning and Memory - April 16, 2021 Category: Neurology Authors: Kamar E Ameen-Ali Magali H Sivakumaran Madeline J Eacott Akira R O'Connor James A Ainge Alexander Easton Source Type: research

Perirhinal cortex and the recognition of relative familiarity
We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object...
Source: Neurobiology of Learning and Memory - April 16, 2021 Category: Neurology Authors: Kamar E Ameen-Ali Magali H Sivakumaran Madeline J Eacott Akira R O'Connor James A Ainge Alexander Easton Source Type: research

Perirhinal cortex and the recognition of relative familiarity
We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object...
Source: Neurobiology of Learning and Memory - April 16, 2021 Category: Neurology Authors: Kamar E Ameen-Ali Magali H Sivakumaran Madeline J Eacott Akira R O'Connor James A Ainge Alexander Easton Source Type: research

Perirhinal cortex and the recognition of relative familiarity
We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object...
Source: Neurobiology of Learning and Memory - April 16, 2021 Category: Neurology Authors: Kamar E Ameen-Ali Magali H Sivakumaran Madeline J Eacott Akira R O'Connor James A Ainge Alexander Easton Source Type: research

Chromatin accessibility in neuropsychiatric disorders
Neurobiol Learn Mem. 2021 Apr 9:107438. doi: 10.1016/j.nlm.2021.107438. Online ahead of print.ABSTRACTEpigenetic mechanisms have recently emerged as critical regulators of brain function in health and disease. By controlling the accessibility and the expression of specific genes, these pathways can mediate transient and long-lasting changes in neuronal function in both physiological and pathological contexts. Due to the extreme complexity of the epigenetic regulatory landscape, emerging methods that directly assay chromatin accessibility are of particular interest. Here, I review recent insights gained on open and closed c...
Source: Neurobiology of Learning and Memory - April 12, 2021 Category: Neurology Authors: Gabor Egervari Source Type: research

Chromatin accessibility in neuropsychiatric disorders
Neurobiol Learn Mem. 2021 Apr 9:107438. doi: 10.1016/j.nlm.2021.107438. Online ahead of print.ABSTRACTEpigenetic mechanisms have recently emerged as critical regulators of brain function in health and disease. By controlling the accessibility and the expression of specific genes, these pathways can mediate transient and long-lasting changes in neuronal function in both physiological and pathological contexts. Due to the extreme complexity of the epigenetic regulatory landscape, emerging methods that directly assay chromatin accessibility are of particular interest. Here, I review recent insights gained on open and closed c...
Source: Neurobiology of Learning and Memory - April 12, 2021 Category: Neurology Authors: Gabor Egervari Source Type: research

Chromatin accessibility in neuropsychiatric disorders
Neurobiol Learn Mem. 2021 Apr 9:107438. doi: 10.1016/j.nlm.2021.107438. Online ahead of print.ABSTRACTEpigenetic mechanisms have recently emerged as critical regulators of brain function in health and disease. By controlling the accessibility and the expression of specific genes, these pathways can mediate transient and long-lasting changes in neuronal function in both physiological and pathological contexts. Due to the extreme complexity of the epigenetic regulatory landscape, emerging methods that directly assay chromatin accessibility are of particular interest. Here, I review recent insights gained on open and closed c...
Source: Neurobiology of Learning and Memory - April 12, 2021 Category: Neurology Authors: Gabor Egervari Source Type: research

Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent
Neurobiol Learn Mem. 2021 Apr 5:107435. doi: 10.1016/j.nlm.2021.107435. Online ahead of print.ABSTRACTRas/Raf/MEK/ERK (Ras-ERK) signaling has been shown to play an important role in fear acquisition. However, little information is known regarding the mechanisms that contribute to the regulation of this pathway in terms of the learning of conditioned fears. Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) is one of two guanine nucleotide exchange factors (GEF) that regulates the Ras-ERK signaling pathway in a Ca2+-dependent manner via control of the cycling of Ras isoforms between an inactive and active state. Here we so...
Source: Neurobiology of Learning and Memory - April 8, 2021 Category: Neurology Authors: Anastasia Olevska Rainer Spanagel Rick E Bernardi Source Type: research

Cortical neurochemical signaling of gustatory stimuli and their visceral consequences during the acquisition and consolidation of taste aversion memory
Neurobiol Learn Mem. 2021 Apr 5:107437. doi: 10.1016/j.nlm.2021.107437. Online ahead of print.ABSTRACTThe insular cortex (IC) has a crucial role in taste recognition memory, including conditioned taste aversion (CTA). CTA is a learning paradigm in which a novel taste stimulus (CS) is associated with gastric malaise (US), inducing aversion to the CS in future encounters. The role of the IC in CTA memory formation has been extensively studied. However, the functional significance of neurotransmitter release during the presentation of taste stimuli and gastric malaise-inducing agents remains unclear. Using microdialysis in fr...
Source: Neurobiology of Learning and Memory - April 8, 2021 Category: Neurology Authors: Daniel Osorio-G ómez Federico Berm údez-Rattoni Kioko R Guzm án-Ramos Source Type: research

Enhancement of prefrontal area excitability induced by a cognitive task: Impact on subsequence visuomotor task performance
Neurobiol Learn Mem. 2021 Apr 5:107436. doi: 10.1016/j.nlm.2021.107436. Online ahead of print.ABSTRACTCognitive tasks may have the potential to improve visuomotor task performance; however, the reason for this is unclear. If this can be clarified, it may be possible to develop clinically valuable outcomes, such as promotion of motor learning though cognitive tasks. The present study aimed to investigate whether changes in prefrontal area excitability induced by cognitive tasks, especially within the dorsolateral prefrontal cortex (DLPFC), influenced the speed of improvement during visuomotor task performance. Twenty young ...
Source: Neurobiology of Learning and Memory - April 8, 2021 Category: Neurology Authors: Takehide Kimura Wataru Nakano Source Type: research

Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent
Neurobiol Learn Mem. 2021 Apr 5:107435. doi: 10.1016/j.nlm.2021.107435. Online ahead of print.ABSTRACTRas/Raf/MEK/ERK (Ras-ERK) signaling has been shown to play an important role in fear acquisition. However, little information is known regarding the mechanisms that contribute to the regulation of this pathway in terms of the learning of conditioned fears. Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) is one of two guanine nucleotide exchange factors (GEF) that regulates the Ras-ERK signaling pathway in a Ca2+-dependent manner via control of the cycling of Ras isoforms between an inactive and active state. Here we so...
Source: Neurobiology of Learning and Memory - April 8, 2021 Category: Neurology Authors: Anastasia Olevska Rainer Spanagel Rick E Bernardi Source Type: research

Cortical neurochemical signaling of gustatory stimuli and their visceral consequences during the acquisition and consolidation of taste aversion memory
Neurobiol Learn Mem. 2021 Apr 5:107437. doi: 10.1016/j.nlm.2021.107437. Online ahead of print.ABSTRACTThe insular cortex (IC) has a crucial role in taste recognition memory, including conditioned taste aversion (CTA). CTA is a learning paradigm in which a novel taste stimulus (CS) is associated with gastric malaise (US), inducing aversion to the CS in future encounters. The role of the IC in CTA memory formation has been extensively studied. However, the functional significance of neurotransmitter release during the presentation of taste stimuli and gastric malaise-inducing agents remains unclear. Using microdialysis in fr...
Source: Neurobiology of Learning and Memory - April 8, 2021 Category: Neurology Authors: Daniel Osorio-G ómez Federico Berm údez-Rattoni Kioko R Guzm án-Ramos Source Type: research