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Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial
Neurobiol Learn Mem. 2023 Sep 10;205:107825. doi: 10.1016/j.nlm.2023.107825. Online ahead of print.ABSTRACTExposure-based therapies for anxiety and related disorders are believed to depend on fear extinction learning and corresponding changes in extinction circuitry. Frontopolar multifocal transcranial direct current stimulation (tDCS) has been shown to improve therapeutic safety learning during in vivo exposure and may modulate functional connectivity of networks implicated in fear processing and inhibition. A pilot randomized controlled trial was completed to determine the effects of frontopolar tDCS on extinction learni...
Source: Neurobiology of Learning and Memory - September 12, 2023 Category: Neurology Authors: Thomas G Adams Benjamin Kelmendi Jamilah R George Jennifer Forte Troy J J Hubert Hannah Wild Colton S Rippey Christopher Pittenger Source Type: research

Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial
Neurobiol Learn Mem. 2023 Sep 10:107825. doi: 10.1016/j.nlm.2023.107825. Online ahead of print.ABSTRACTExposure-based therapies for anxiety and related disorders are believed to depend on fear extinction learning and corresponding changes in extinction circuitry. Frontopolar multifocal transcranial direct current stimulation (tDCS) has been shown to improve therapeutic safety learning during in vivo exposure and may modulate functional connectivity of networks implicated in fear processing and inhibition. A pilot randomized controlled trial was completed to determine the effects of frontopolar tDCS on extinction learning a...
Source: Neurobiology of Learning and Memory - September 12, 2023 Category: Neurology Authors: Thomas G Adams Benjamin Kelmendi Jamilah R George Jennifer Forte Troy Hubert Hannah Wild Colton Rippey Christopher Pittenger Source Type: research

Predictive learning by a burst-dependent learning rule
Neurobiol Learn Mem. 2023 Sep 9:107826. doi: 10.1016/j.nlm.2023.107826. Online ahead of print.ABSTRACTHumans and other animals are able to quickly generalize latent dynamics of spatiotemporal sequences, often from a minimal number of previous experiences. Additionally, internal representations of external stimuli must remain stable, even in the presence of sensory noise, in order to be useful for informing behavior. In contrast, typical machine learning approaches require many thousands of samples, and generalize poorly to unexperienced examples, or fail completely to predict at long timescales. Here, we propose a novel ne...
Source: Neurobiology of Learning and Memory - September 11, 2023 Category: Neurology Authors: G William Chapman Michael E Hasselmo Source Type: research

The contextual fear conditioning consolidation depends on the functional interaction of the dorsal subiculum and basolateral amygdala in rats
Neurobiol Learn Mem. 2023 Sep 8;205:107827. doi: 10.1016/j.nlm.2023.107827. Online ahead of print.ABSTRACTFear conditioning tasks enable us to explore the neural basis of adaptative and maladaptive behaviors related to aversive memories. Recently, we provided the first evidence of the dorsal subiculum (DSub) involvement in contextual fear conditioning (CFC) consolidation by showing that the post-training bilateral NMDA (N-methyl-D-aspartate) receptor blockade in DSub impaired the performance of animals in the test session. As the memory consolidation process depends on the coordinated engagement of different brain regions,...
Source: Neurobiology of Learning and Memory - September 7, 2023 Category: Neurology Authors: M árcio Braga de Melo Vanessa Manchim Favaro Maria Gabriela Menezes Oliveira Source Type: research

The contextual fear conditioning consolidation depends on the functional interaction of the dorsal subiculum and basolateral amygdala in rats
Neurobiol Learn Mem. 2023 Sep 5:107827. doi: 10.1016/j.nlm.2023.107827. Online ahead of print.ABSTRACTFear conditioning tasks enable us to explore the neural basis of adaptative and maladaptive behaviors related to aversive memories. Recently, we provided the first evidence of the dorsal subiculum (DSub) involvement in contextual fear conditioning (CFC) consolidation by showing that the post-training bilateral NMDA (N-methyl-D-aspartate) receptor blockade in DSub impaired the performance of animals in the test session. As the memory consolidation process depends on the coordinated engagement of different brain regions, and...
Source: Neurobiology of Learning and Memory - September 7, 2023 Category: Neurology Authors: M árcio Braga de Melo Vanessa Manchim Favaro Maria Gabriela Menezes Oliveira Source Type: research

Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms
Neurobiol Learn Mem. 2023 Sep 4:107824. doi: 10.1016/j.nlm.2023.107824. Online ahead of print.ABSTRACTIndividuals with depression exhibit dysfunctional emotion regulation, general episodic memory deficits, and a negativity bias, where negative experiences are better remembered. Recent work suggests that the negativity bias in depression may be driven by enhanced mnemonic discrimination, a memory measure that relies on hippocampal pattern separation - a computation that processes experiences with overlapping features as unique. Previously, we found that individuals with depressive symptoms show enhanced negative and impaire...
Source: Neurobiology of Learning and Memory - September 6, 2023 Category: Neurology Authors: Brandon K Hayes Amritha Harikumar Lorena A Ferguson Eva E Dicker Bryan T Denny Stephanie L Leal Source Type: research

Activating M1 muscarinic cholinergic receptors induces destabilization of resistant contextual fear memories in rats
Neurobiol Learn Mem. 2023 Sep 2:107821. doi: 10.1016/j.nlm.2023.107821. Online ahead of print.ABSTRACTDestabilization of previously consolidated memories places them in a labile state in which they are open to modification. However, strongly encoded fear memories tend to be destabilization-resistant and the conditions required to destabilize such memories remain poorly understood. Our lab has previously shown that exposure to salient novel contextual cues during memory reactivation can destabilize strongly encoded object location memories and that activity at muscarinic cholinergic receptors is critical for this effect. In...
Source: Neurobiology of Learning and Memory - September 4, 2023 Category: Neurology Authors: Karim H Abouelnaga Andrew E Huff Olivia S O'Neill William S Messer Boyer D Winters Source Type: research