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Systemic corticosterone administration impairs the late fear memory reconsolidation via basolateral amygdala glucocorticoid receptors: dependence on the time window and memory age
Neurobiol Learn Mem. 2023 Jun 27:107797. doi: 10.1016/j.nlm.2023.107797. Online ahead of print.ABSTRACTGlucocorticoid receptors (GRs) of the basolateral amygdala (BLA) play an important role in memory reconsolidation. The present study investigated the role of the BLA GRs in the late reconsolidation of fear memory using an inhibitory avoidance (IA) task in male Wistar rats. Stainless steel cannulae were implanted bilaterally into the BLA of the rats. After 7 days of recovery, the animals were trained in a one-trial IA task (1mA, 3s). In Experiment one, 48h after the training session, the animals received 3 systemic doses o...
Source: Neurobiology of Learning and Memory - June 29, 2023 Category: Neurology Authors: Maryam Nazari Ali Rashidy-Pour Abbas Ali Vafaei Payman Raise-Abdullahi Source Type: research

Effects of exercise intensity on spatial memory performance and hippocampal synaptic function in SAMP8 mice
In conclusion, the positive effect of treadmill exercise is closely related to exercise intensity, with moderate-intensity exercise showing the most optimal effects.PMID:37380098 | DOI:10.1016/j.nlm.2023.107791 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - June 28, 2023 Category: Neurology Authors: Linlin Guo Sha Li Yizhou Zhang Xinxin Yang Yuanyuan Zhang Huixian Cui Yan Li Source Type: research

The functional heterogeneity of PACAP: Stress, learning, and pathology
Neurobiol Learn Mem. 2023 Jun 25:107792. doi: 10.1016/j.nlm.2023.107792. Online ahead of print.ABSTRACTPituitary adenylate cyclase-activating peptide (PACAP) is a highly conserved and widely expressed neuropeptide that has emerged as a key regulator of multiple neural and behavioral processes. PACAP systems, including the various PACAP receptor subtypes, have been implicated in neural circuits of learning and memory, stress, emotion, feeding, and pain. Dysregulation within these PACAP systems may play key roles in the etiology of pathological states associated with these circuits, and PACAP function has been implicated in ...
Source: Neurobiology of Learning and Memory - June 27, 2023 Category: Neurology Authors: Abha K Rajbhandari Jessica R Barson Marieke R Gilmartin Sayamwong E Hammack Briana K Chen Source Type: research

Overshadowing, but not Relative Validity, Between the Elements of an Outcome During Human Associative Learning
Neurobiol Learn Mem. 2023 Jun 21:107790. doi: 10.1016/j.nlm.2023.107790. Online ahead of print.ABSTRACTOvershadowing and relative validity constitute two phenomena that inspired the development of the Rescorla-Wagner model in 1972. They demonstrate that cues will interact with one another for an association with the presence or absence of an outcome. Here, three experiments sought to explore whether these two effects extended to outcomes using a food allergist paradigm with human participants. In Experiment 1 (overshadowing) participants received trials in which a cue was followed by a compound of two outcomes (A-O1O2). Te...
Source: Neurobiology of Learning and Memory - June 23, 2023 Category: Neurology Authors: Martyn Quigley Mark Haselgrove Source Type: research

The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors
Neurobiol Learn Mem. 2023 Jun 21;203:107793. doi: 10.1016/j.nlm.2023.107793. Online ahead of print.ABSTRACTThe orbitofrontal cortex (OFC) is regarded as one of the core brain areas in a variety of value-based behaviors. Over the past two decades, tremendous knowledge about the OFC function was gained from studying the behaviors of single subjects. As a result, our previous understanding of the OFC's function of encoding decision variables, such as the value and identity of choices, has evolved to the idea that the OFC encodes a more complex representation of the task space as a cognitive map. Accumulating evidence also ind...
Source: Neurobiology of Learning and Memory - June 23, 2023 Category: Neurology Authors: Weikang Shi Olivia C Meisner Sylvia Blackmore Monika P Jadi Anirvan S Nandy Steve W C Chang Source Type: research

The orbitofrontal cortex: a goal-directed cognitive map framework for social and non-social behaviors
Neurobiol Learn Mem. 2023 Jun 21:107793. doi: 10.1016/j.nlm.2023.107793. Online ahead of print.ABSTRACTThe orbitofrontal cortex (OFC) is regarded as one of the core brain areas in a variety of value-based behaviors. Over the past two decades, tremendous knowledge about the OFC function was gained from studying the behaviors of single subjects. As a result, our previous understanding of the OFC's function of encoding decision variables, such as the value and identity of choices, has evolved to the idea that the OFC encodes a more complex representation of the task space as a cognitive map. Accumulating evidence also indicat...
Source: Neurobiology of Learning and Memory - June 23, 2023 Category: Neurology Authors: Weikang Shi Olivia C Meisner Sylvia Blackmore Monika P Jadi Anirvan S Nandy Steve W C Chang Source Type: research

Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex
Neurobiol Learn Mem. 2023 Jun 15;203:107789. doi: 10.1016/j.nlm.2023.107789. Online ahead of print.ABSTRACTPI3-kinase (PI3K) is an intracellular signaling complex that is stimulated upon cocaine exposure and linked with the behavioral consequences of cocaine. We recently genetically silenced the PI3K p110β subunit in the medial prefrontal cortex following repeated cocaine in mice, reinstating the capacity of these mice to engage in prospective goal-seeking behavior. In the present short report, we address two follow-up hypotheses: 1) The control of decision-making behavior by PI3K p110β is attributable to neuronal signal...
Source: Neurobiology of Learning and Memory - June 16, 2023 Category: Neurology Authors: Rachel A Davies Britton R Barbee Yesenia Garcia-Sifuentes Laura M Butkovich Shannon L Gourley Source Type: research

Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex
Neurobiol Learn Mem. 2023 Jun 14:107789. doi: 10.1016/j.nlm.2023.107789. Online ahead of print.ABSTRACTPI3-kinase (PI3K) is an intracellular signaling complex that is stimulated upon cocaine exposure and linked with the behavioral consequences of cocaine. We recently genetically silenced the PI3K p110β subunit in the medial prefrontal cortex following repeated cocaine in mice, reinstating the capacity of these mice to engage in prospective goal-seeking behavior. In the present short report, we address two follow-up hypotheses: 1) The control of decision-making behavior by PI3K p110β is attributable to neuronal signaling,...
Source: Neurobiology of Learning and Memory - June 16, 2023 Category: Neurology Authors: Rachel A Davies Britton R Barbee Yesenia Garcia-Sifuentes Laura M Butkovich Shannon L Gourley Source Type: research