Neurobiology of Learning and Memory 
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Neurobiol Learn Mem. 2023 Nov 21:107865. doi: 10.1016/j.nlm.2023.107865. Online ahead of print.ABSTRACTPreclinical studies show that inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory in male and female adult and adolescent rodents. The effect is highly selective, as NMII inhibition has no effect in other relevant brain regions (e.g., dorsal hippocampus [dPHC], nucleus accumbens [NAc]), nor does it interfere with associations for o...
Source: Neurobiology of Learning and Memory - November 23, 2023 Category: Neurology Authors: Madalyn Hafenbreidel Surya Pandey Sherri B Briggs Meghana Arza Shalakha Bonthu Cadence Fisher Annika Tiller Alice B Hall Shayna Reed Natasha Mayorga Li Lin Susan Khan Michael D Cameron Gavin Rumbaugh Courtney A Miller Source Type: research
The emergence of task-relevant representations in a nonlinear decision-making task
Neurobiol Learn Mem. 2023 Nov 10;206:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that ...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The emergence of task-relevant representations in a nonlinear decision-making task
Neurobiol Learn Mem. 2023 Nov 10;206:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that ...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The Emergence of Task-Relevant Representations in a Nonlinear Decision-Making Task
Neurobiol Learn Mem. 2023 Nov 10:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that part...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The Emergence of Task-Relevant Representations in a Nonlinear Decision-Making Task
Neurobiol Learn Mem. 2023 Nov 10:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that part...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The Emergence of Task-Relevant Representations in a Nonlinear Decision-Making Task
Neurobiol Learn Mem. 2023 Nov 10:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that part...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The Emergence of Task-Relevant Representations in a Nonlinear Decision-Making Task
Neurobiol Learn Mem. 2023 Nov 10:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that part...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The Emergence of Task-Relevant Representations in a Nonlinear Decision-Making Task
Neurobiol Learn Mem. 2023 Nov 10:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that part...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The Emergence of Task-Relevant Representations in a Nonlinear Decision-Making Task
Neurobiol Learn Mem. 2023 Nov 10:107860. doi: 10.1016/j.nlm.2023.107860. Online ahead of print.ABSTRACTThis paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers based on their overall classification rate and computed behavioural accuracy for each feature value. We found that part...
Source: Neurobiology of Learning and Memory - November 12, 2023 Category: Neurology Authors: N Menghi F Silvestrin L Pascolini W Penny Source Type: research
The anterior medial hippocampus contributes to both recall and familiarity-based memory for scenes
Neurobiol Learn Mem. 2023 Nov 7:107859. doi: 10.1016/j.nlm.2023.107859. Online ahead of print.ABSTRACTThe hippocampus is usually associated with recall memory, whereas its contribution to familiarity-based memory is debated. Growing evidence support the idea that this structure participates to any cognitive process performed on scene representations. In parallel, differences in functional specialisation and cortical connectivity were found across the longitudinal and transverse axes of the hippocampus. Here we reanalysed functional MRI data from 51 participants showing stronger engagement of the hippocampus in recall, fami...
Source: Neurobiology of Learning and Memory - November 9, 2023 Category: Neurology Authors: J Gardette E Cousin P Hot Source Type: research
Differential effects of acute stress on spatial learning and memory in the open-field tower maze across the female estrous cycle
Neurobiol Learn Mem. 2023 Nov 7:107862. doi: 10.1016/j.nlm.2023.107862. Online ahead of print.ABSTRACTThe purpose of the present investigation was to test how acute stress and levels of circulating estrogens together influence acquisition and retention of spatial learning, as well as explorative behaviors in female rats. We used the hippocampus-dependent Open-field Tower Maze (OFTM) task to assess acquisition followed by a retention test (reacquisition) that was given 48 hours later. Immediately prior to acquisition, experimental rats were exposed to an acute restraint stress and were trained under bright lights. Female ra...
Source: Neurobiology of Learning and Memory - November 9, 2023 Category: Neurology Authors: Olga Lipatova Matthew M Campolattaro Blakely K Lockhart Mariam B Hammad Source Type: research
Reminder-dependent alterations in long-term declarative memory expression
Neurobiol Learn Mem. 2023 Nov 7;206:107858. doi: 10.1016/j.nlm.2023.107858. Online ahead of print.ABSTRACTThe reminder of a previously-learned memory can render that memory vulnerable to disruption or change in expression. Such memory alterations have been viewed as supportive of the framework of memory reconsolidation. However, alternative interpretations and inconsistencies in the replication of fundamental findings have raised questions particularly in the domain of human declarative memory. Here we present a series of related experiments, all of which involve the learning of a declarative memory, followed 1-2 days late...
Source: Neurobiology of Learning and Memory - November 9, 2023 Category: Neurology Authors: Kai Rong Tay Francesca Bolt Hei Ting Wong Svetlina Vasileva Jonathan Lee Source Type: research
Electrophysiological evidence for context reinstatement effects on object recognition memory
Neurobiol Learn Mem. 2023 Nov 7:107861. doi: 10.1016/j.nlm.2023.107861. Online ahead of print.ABSTRACTReinstating the context present at encoding during the test phase generally enhances recognition memory compared with changing the context when specific item-context associations are established during encoding. However, it remains unclear whether context reinstatement improves the performance in differentiating between old and similar items in recognition memory tests and what underlying cognitive processes are involved. Using the context reinstatement paradigm together with event-related potentials (ERP), we examined the...
Source: Neurobiology of Learning and Memory - November 9, 2023 Category: Neurology Authors: Jingwen Miao Michael Weigl Nuo Kong Min-Fang Zhao Axel Mecklinger Zhiwei Zheng Juan Li Source Type: research
The anterior medial hippocampus contributes to both recall and familiarity-based memory for scenes
Neurobiol Learn Mem. 2023 Nov 7:107859. doi: 10.1016/j.nlm.2023.107859. Online ahead of print.ABSTRACTThe hippocampus is usually associated with recall memory, whereas its contribution to familiarity-based memory is debated. Growing evidence support the idea that this structure participates to any cognitive process performed on scene representations. In parallel, differences in functional specialisation and cortical connectivity were found across the longitudinal and transverse axes of the hippocampus. Here we reanalysed functional MRI data from 51 participants showing stronger engagement of the hippocampus in recall, fami...
Source: Neurobiology of Learning and Memory - November 9, 2023 Category: Neurology Authors: J Gardette E Cousin P Hot Source Type: research
Differential effects of acute stress on spatial learning and memory in the open-field tower maze across the female estrous cycle
Neurobiol Learn Mem. 2023 Nov 7:107862. doi: 10.1016/j.nlm.2023.107862. Online ahead of print.ABSTRACTThe purpose of the present investigation was to test how acute stress and levels of circulating estrogens together influence acquisition and retention of spatial learning, as well as explorative behaviors in female rats. We used the hippocampus-dependent Open-field Tower Maze (OFTM) task to assess acquisition followed by a retention test (reacquisition) that was given 48 hours later. Immediately prior to acquisition, experimental rats were exposed to an acute restraint stress and were trained under bright lights. Female ra...
Source: Neurobiology of Learning and Memory - November 9, 2023 Category: Neurology Authors: Olga Lipatova Matthew M Campolattaro Blakely K Lockhart Mariam B Hammad Source Type: research
