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Social Evaluative Stress Enhances Central Detail Memory, Reduces False Memory, and Results in Intrusive Memories that Last for Days
Neurobiol Learn Mem. 2024 Feb 24:107906. doi: 10.1016/j.nlm.2024.107906. Online ahead of print.ABSTRACTFew studies have quantified what an individual remembers about a laboratory-controlled stressor. Here, we aimed to replicate previous work by using a modified version of the Trier Social Stress Test (TSST) to quantify participant memory for a stressful experience. We also aimed to extend this work by quantifying false and intrusive memories that ensued. One hundred and seven participants were exposed to the TSST (stress) or the friendly TSST (f-TSST; no stress). The TSST required participants to deliver a ten-minute speec...
Source: Neurobiology of Learning and Memory - February 26, 2024 Category: Neurology Authors: Mercedes L Stanek Kayla M Boaz Chloe N Cordes Taylor D Niese Kristen E Long Matthew S Risner John G Blasco Koen N Suzelis Kelsey M Siereveld Boyd R Rorabaugh Phillip R Zoladz Source Type: research

Social Evaluative Stress Enhances Central Detail Memory, Reduces False Memory, and Results in Intrusive Memories that Last for Days
Neurobiol Learn Mem. 2024 Feb 24:107906. doi: 10.1016/j.nlm.2024.107906. Online ahead of print.ABSTRACTFew studies have quantified what an individual remembers about a laboratory-controlled stressor. Here, we aimed to replicate previous work by using a modified version of the Trier Social Stress Test (TSST) to quantify participant memory for a stressful experience. We also aimed to extend this work by quantifying false and intrusive memories that ensued. One hundred and seven participants were exposed to the TSST (stress) or the friendly TSST (f-TSST; no stress). The TSST required participants to deliver a ten-minute speec...
Source: Neurobiology of Learning and Memory - February 26, 2024 Category: Neurology Authors: Mercedes L Stanek Kayla M Boaz Chloe N Cordes Taylor D Niese Kristen E Long Matthew S Risner John G Blasco Koen N Suzelis Kelsey M Siereveld Boyd R Rorabaugh Phillip R Zoladz Source Type: research

tDCS of right-hemispheric Wernicke's area homologue affects contextual learning of novel lexicon
Neurobiol Learn Mem. 2024 Feb 23:107905. doi: 10.1016/j.nlm.2024.107905. Online ahead of print.ABSTRACTNumerous studies have shown robust evidence of the right hemisphere's involvement in language comprehension, for instance in the processing of intonation, grammar, prelexical processing stages, novel metaphor comprehension, etc. However, its role in lexicon acquisition remains obscure. We applied transcranial direct current stimulation (tDCS) over the right-hemispheric homologue of Wernicke's area to assess its putative involvement in processing different types of novel semantics. After receiving 15 min of anodal, cathoda...
Source: Neurobiology of Learning and Memory - February 25, 2024 Category: Neurology Authors: Daria Gnedykh Diana Tsvetova Nadezhda Mkrtychian Evgeny Blagovechtchenski Svetlana Kostromina Yury Shtyrov Source Type: research

The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice
Neurobiol Learn Mem. 2024 Feb 23:107903. doi: 10.1016/j.nlm.2024.107903. Online ahead of print.ABSTRACTFormation of long-term memories requires learning-induced changes in both transcription and translation. Epitranscriptomic modifications of RNA recently emerged as critical regulators of RNA dynamics, whereby adenosine methylation (m6A) regulates translation, mRNA stability, mRNA localization, and memory formation. Prior work demonstrated a pro-memory phenotype of m6A, as loss of m6A impairs and loss of the m6A/m demethylase FTO improves memory formation. Critically, these experiments focused exclusively on aversive memor...
Source: Neurobiology of Learning and Memory - February 25, 2024 Category: Neurology Authors: A M Leonetti I R Galluzzo T McLean G Stefanelli F Ramnaraign S Holm S M Winston I L Reeves M A Brimble B J Walters Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of dna oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of dna oxidative stress in hippocampal dentate gyrus
In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902 (Source: Neurobiology of Learning and Memory)
Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research

Dynamic regulation of corticostriatal glutamatergic synaptic expression during reversal learning in male mice
Neurobiol Learn Mem. 2024 Feb;208:107892. doi: 10.1016/j.nlm.2024.107892. Epub 2024 Jan 17.ABSTRACTBehavioral flexibility, one of the core executive functions of the brain, has been shown to be an essential skill for survival across species. Corticostriatal circuits play a critical role in mediating behavioral flexibility. The molecular mechanisms underlying these processes are still unclear. Here, we measured how synaptic glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and N-methyl-D-aspartic acid receptor (NMDAR) expression dynamically changed during specific stages of learning and re...
Source: Neurobiology of Learning and Memory - January 19, 2024 Category: Neurology Authors: Jayapriya Chandrasekaran Kevin K Caldwell Jonathan L Brigman Source Type: research

BDNF-dependent signaling in the olfactory bulb modulates social recognition memory in mice
Neurobiol Learn Mem. 2024 Feb;208:107891. doi: 10.1016/j.nlm.2024.107891. Epub 2024 Jan 17.ABSTRACTAn operative olfactory bulb (OB) is critical to social recognition memory (SRM) in rodents, which involves identifying conspecifics. Furthermore, OB also allocates synaptic plasticity events related to olfactory memories in their intricate neural circuit. Here, we asked whether the OB is a target for brain-derived neurotrophic factor (BDNF), a well-known mediator of plasticity and memory. Adult ICR-CD1 male mice had their SRM evaluated under the inhibition of BDNF-dependent signaling directly in the OB. We also quantified the...
Source: Neurobiology of Learning and Memory - January 18, 2024 Category: Neurology Authors: Caio M de Castro Ana F Almeida-Santos Lara M Z Mansk Laura F Jaimes Mart ín Cammarota Grace S Pereira Source Type: research