Neurobiology of Learning and Memory 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex
Neurobiol Learn Mem. 2023 Jun 14:107789. doi: 10.1016/j.nlm.2023.107789. Online ahead of print.ABSTRACTPI3-kinase (PI3K) is an intracellular signaling complex that is stimulated upon cocaine exposure and linked with the behavioral consequences of cocaine. We recently genetically silenced the PI3K p110β subunit in the medial prefrontal cortex following repeated cocaine in mice, reinstating the capacity of these mice to engage in prospective goal-seeking behavior. In the present short report, we address two follow-up hypotheses: 1) The control of decision-making behavior by PI3K p110β is attributable to neuronal signaling,...
Source: Neurobiology of Learning and Memory - June 16, 2023 Category: Neurology Authors: Rachel A Davies Britton R Barbee Yesenia Garcia-Sifuentes Laura M Butkovich Shannon L Gourley Source Type: research
Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex
Neurobiol Learn Mem. 2023 Jun 14:107789. doi: 10.1016/j.nlm.2023.107789. Online ahead of print.ABSTRACTPI3-kinase (PI3K) is an intracellular signaling complex that is stimulated upon cocaine exposure and linked with the behavioral consequences of cocaine. We recently genetically silenced the PI3K p110β subunit in the medial prefrontal cortex following repeated cocaine in mice, reinstating the capacity of these mice to engage in prospective goal-seeking behavior. In the present short report, we address two follow-up hypotheses: 1) The control of decision-making behavior by PI3K p110β is attributable to neuronal signaling,...
Source: Neurobiology of Learning and Memory - June 16, 2023 Category: Neurology Authors: Rachel A Davies Britton R Barbee Yesenia Garcia-Sifuentes Laura M Butkovich Shannon L Gourley Source Type: research
Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex
Neurobiol Learn Mem. 2023 Jun 14:107789. doi: 10.1016/j.nlm.2023.107789. Online ahead of print.ABSTRACTPI3-kinase (PI3K) is an intracellular signaling complex that is stimulated upon cocaine exposure and linked with the behavioral consequences of cocaine. We recently genetically silenced the PI3K p110β subunit in the medial prefrontal cortex following repeated cocaine in mice, reinstating the capacity of these mice to engage in prospective goal-seeking behavior. In the present short report, we address two follow-up hypotheses: 1) The control of decision-making behavior by PI3K p110β is attributable to neuronal signaling,...
Source: Neurobiology of Learning and Memory - June 16, 2023 Category: Neurology Authors: Rachel A Davies Britton R Barbee Yesenia Garcia-Sifuentes Laura M Butkovich Shannon L Gourley Source Type: research
Impaired fear memory in a rat model of the brain-derived neurotrophic factor Val66Met polymorphism is reversed by chronic exercise
Neurobiol Learn Mem. 2023 Jun 1;203:107779. doi: 10.1016/j.nlm.2023.107779. Online ahead of print.ABSTRACTThe brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release in the brain and has been implicated in fear and anxiety disorders, including post-traumatic stress disorder. Exercise has been shown to have benefits in affective disorders but the role of BDNF Val66Met remains unclear. Male and female BDNF Val66Met rats were housed in automated running-wheel cages from weaning while controls were housed in standard cages. During adulthood, all rats underwent s...
Source: Neurobiology of Learning and Memory - June 3, 2023 Category: Neurology Authors: Emily J Jaehne Emily J Antolasic Kerstin C Creutzberg Veronica Begni Marco A Riva Maarten van den Buuse Source Type: research
Impaired fear memory in a rat model of the brain-derived neurotrophic factor Val66Met polymorphism is reversed by chronic exercise
Neurobiol Learn Mem. 2023 Jun 1;203:107779. doi: 10.1016/j.nlm.2023.107779. Online ahead of print.ABSTRACTThe brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release in the brain and has been implicated in fear and anxiety disorders, including post-traumatic stress disorder. Exercise has been shown to have benefits in affective disorders but the role of BDNF Val66Met remains unclear. Male and female BDNF Val66Met rats were housed in automated running-wheel cages from weaning while controls were housed in standard cages. During adulthood, all rats underwent s...
Source: Neurobiology of Learning and Memory - June 3, 2023 Category: Neurology Authors: Emily J Jaehne Emily J Antolasic Kerstin C Creutzberg Veronica Begni Marco A Riva Maarten van den Buuse Source Type: research
