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Specialty: Geriatrics
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Total 1481 results found since Jan 2013.
Management of Hypertension in the Elderly and Frail Patient
AbstractHypertension is a frequent finding in elderly patients. Hypertension in older age can be both associated with frailty and represent a risk factor for frailty. Hypertension is recognized as a main risk factor for cardiovascular diseases such as heart failure, atrial fibrillation, and stroke and the occurrence of these diseases may provoke a decline in health status and/or worsen the degree of frailty. Blood pressure targets in hypertensive older and frail patients are not completely defined. However, specific evaluations of individual patients and their co-morbidities and assessment of domains and components of frai...
Source: Drugs and Aging - July 29, 2022 Category: Geriatrics Source Type: research
Association of Arterial Spin Labeling Parameters With Cognitive Decline, Vascular Events, and Mortality in a Memory-Clinic Sample
CONCLUSIONS: Higher baseline GM-sCoV of ASL was associated with a decline in memory and risk of cerebrovascular disease and vascular events, suggesting that cerebrovascular insufficiency may contribute to accelerated cognitive decline and worse clinical outcomes in memory clinic participants.PMID:35871110 | DOI:10.1016/j.jagp.2022.06.007
Source: Am J Geriatr Psychia... - July 23, 2022 Category: Geriatrics Authors: Bibek Gyanwali Henk Jmm Mutsaerts Chuen Seng Tan Omar Rajab Kaweilh Jan Petr Christopher Chen Saima Hilal Source Type: research
Assessing Delirium at Hospital Discharge
For more than forty years, delirium (defined as an acute confusional state) and post-operative cognitive dysfunction (POCD) have been observed in over 20% of hospitalized older adults, especially following acute trauma, cardiac surgery, TIA, stroke, and the use of anesthesia [1]. Delirium often goes unrecognized, increasing risk for poor outcome and post-discharge complications including injury and death [2]. These risks can be mitigated by utilizing brief cognitive screening instruments prior to hospital discharge [3].
Source: The American Journal of Geriatric Psychiatry - July 16, 2022 Category: Geriatrics Authors: Charles M. Lepkowsky, Herbert M. Janklow Tags: Letter to the Editor Source Type: research
Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment
Neurobiol Aging. 2022 Jun 16;118:1-8. doi: 10.1016/j.neurobiolaging.2022.06.002. Online ahead of print.ABSTRACTWhite matter hyperintensities (WMH), a marker of small vessel cerebrovascular disease, increase risk of developing mild cognitive impairment (MCI) and Alzheimer's disease (AD). Less is known about the extent and pattern of WMH in pre-MCI stages, such as among those with objectively-defined subtle cognitive decline (Obj-SCD). Five hundred and fifty-nine Alzheimer's Disease Neuroimaging Initiative participants (170 cognitively unimpaired [CU]; 83 Obj-SCD; 306 MCI) free of clinical dementia or stroke completed neurop...
Source: Neurobiology of Aging - July 9, 2022 Category: Geriatrics Authors: Amanda T Calcetas Kelsey R Thomas Emily C Edmonds Sophia L Holmqvist Lauren Edwards Maria Bordyug Lisa Delano-Wood Adam M Brickman Mark W Bondi Katherine J Bangen None For The Alzheimer's Disease Neuroimaging Initiative Source Type: research
The association between fatigue severity and risk of falls among middle-aged and older Australian stroke survivors
CONCLUSION: This study revealed an association between an increasing risk of falls with increasing severity of post stroke fatigue. Accurate detection and management of fatigue may help reduce the risk of falls and should be the focus of future research.PMID:35796976 | DOI:10.1007/s40520-022-02179-9
Source: Aging Clinical and Experimental Research - July 7, 2022 Category: Geriatrics Authors: David Sibbritt Jessica Bayes Wenbo Peng Jane Maguire Suzy Ladanyi Jon Adams Source Type: research
Prognosis of Ischemic Stroke Patients Undergoing Endovascular Thrombectomy is Influenced by Systemic Inflammatory Index Through Malignant Brain Edema
Source: Clinical Interventions in Aging - July 1, 2022 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research
NIH ’s vaunted program for solving puzzling medical cases is running out of money
Ten years ago, an athletic 12-year-old from Affton, Missouri, named Mitchell Herndon began to experience muscle weakness that eventually led to him using a wheelchair. After years of visits to specialists failed to diagnose his neurological symptoms, he enrolled in a National Institutes of Health (NIH)-funded program that studies patients with debilitating mystery diseases. Researchers eventually found an explanation for Mitchell’s condition: a mutated gene that causes certain brain cells to produce an overactive protein that leads to neuron damage.
Mitchell died 3 years ago at age 19. Since then, 14 more people hav...
Source: Science of Aging Knowledge Environment - June 27, 2022 Category: Geriatrics Source Type: research
Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study
Biogerontology. 2022 Jun 24. doi: 10.1007/s10522-022-09969-8. Online ahead of print.ABSTRACTTo find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy and unhealthy older individuals. Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn's disease, malabsorption or kidney disease. Six single nucleotide polymorphisms (SNPs) with unknown function associated with ten human genes were identified as candidate healths...
Source: Biogerontology - June 24, 2022 Category: Geriatrics Authors: Nadine Saul Ineke Dhondt Mikko Kuokkanen Markus Perola Clara Verschuuren Brecht Wouters Henrik von Chrzanowski Winnok H De Vos Liesbet Temmerman Walter Luyten Aleksandra Ze čić Tim Loier Christian Schmitz-Linneweber Bart P Braeckman Source Type: research
Electrical stimulation of the brain may help people who stutter
When Guillermo Mejias was 7 years old, his parents sent him out to buy bread during a family holiday in southern Spain. Mejias still remembers his growing anxiety as he walked to the bakery, repeating what he would say over and over in his head. But when the moment arrived, he was unable to produce a single word. He recalls returning empty-handed, ashamed, and wondering what to tell his parents. “I was so tense that I had been inadvertently biting my cheeks and tongue and my mouth was bleeding,” he says.
Mejias still stutters, but today, as a brain researcher at the Complutense University of Madrid, he investigate...
Source: Science of Aging Knowledge Environment - June 22, 2022 Category: Geriatrics Source Type: research
