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Specialty: Geriatrics

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Total 1481 results found since Jan 2013.

Antidepressants and the Risk of Ischemic Stroke in Older Adults According to the Degree of Serotonin Reuptake Inhibition: A Retrospective Cohort Study
CONCLUSION: The use of strong and intermediate SRIs should be considered carefully in older adult patients, especially when high-dose antidepressants are prescribed even for a short duration.PMID:37562992 | DOI:10.1016/j.jagp.2023.07.013
Source: Am J Geriatr Psychia... - August 10, 2023 Category: Geriatrics Authors: Kyoung-Eun Kwon Bo Ram Yang Mi-Sook Kim Byung-Joo Park Joongyub Lee Sun-Young Jung Source Type: research

Frailty in relation to the risk of carotid atherosclerosis and cardiovascular events in Chinese community-dwelling older adults: A five-year prospective cohort study
CONCLUSION: Deficit accumulation was closely associated with carotid atherosclerosis risks and strongly predicted five-year CVD events. The frailty index can be used to help identify older adults at high risks of CVD for improved preventive healthcare.PMID:37536575 | DOI:10.1016/j.exger.2023.112266
Source: Experimental Gerontology - August 3, 2023 Category: Geriatrics Authors: Chunxiu Wang Xianghua Fang Zhe Tang Yang Hua Zhongying Zhang Xiang Gu Beibei Liu Kun Yang Xunming Ji Xiaowei Song Source Type: research

Will unpredictable side effects dim the promise of new Alzheimer ’s drugs?
A sea change is underway in the treatment of Alzheimer’s disease, where for the first time a drug that targets the disease’s pathology and clearly slows cognitive decline has hit the U.S. market. A related therapy will likely be approved in the coming months. As many neurologists, patients, and brain scientists celebrate, they’re also nervously eyeing complications from treatment: brain swelling and bleeding, which in clinical trials affected up to about one-third of patients and ranged from asymptomatic to fatal. The side effect—amyloid-related imaging abnormalities, or ARIA—remains mysterious. “We don’...
Source: Science of Aging Knowledge Environment - August 2, 2023 Category: Geriatrics Source Type: research

Correlation Between MMP9 Promoter Methylation and Transient Ischemic Attack/Mild Ischemic Stroke with Early Cognitive Impairment
Source: Clinical Interventions in Aging - August 1, 2023 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research

Antidepressants and the risk of ischemic stroke in older adults according to the degree of serotonin reuptake inhibition: a retrospective cohort study
Antidepressants are a widely used drug class with an increasing trend in use, and an increasing consumption rate has been reported especially in older adults.(1) Many studies have reported a positive relationship between age and the prevalence of antidepressant prescription, attributing it to complicated health problems, worsening of various chronic diseases, and related disabilities that occur with age.(2) However, in prescribing antidepressants to older adults, more attention to the potential adverse reactions for each drug is needed because of considerations such as polypharmacy and physiological changes affecting drug ...
Source: The American Journal of Geriatric Psychiatry - July 27, 2023 Category: Geriatrics Authors: Kyoung-Eun Kwon, Bo Ram Yang, Mi-Sook Kim, Byung-Joo Park, Joongyub Lee, Sun-Young Jung Tags: Regular Research Article Source Type: research

These ants are ballooning with microbe-killing honey
Buried deep underneath the red, sunbaked soil of Australia’s deserts are hidden treasure troves of honey. It’s not the delicacy produced by bees, but rather the only type of honey made by ants. It’s also, a new study confirms, a potentially powerful medicine with antimicrobial properties. Australia’s Indigenous peoples have long used honey from honeypot ants ( Camponotus inflatus ) to treat a variety of maladies, from sore throats to infected wounds. Now, Western scientists are finally getting up to speed. In a study published today in PeerJ , researchers show that the honeypot ant’s honey has...
Source: Science of Aging Knowledge Environment - July 26, 2023 Category: Geriatrics Source Type: research

Moderate elevation of serum uric acid levels improves short-term functional outcomes of ischemic stroke in patients with type 2 diabetes mellitus
Serum uric acid (SUA), an end-product of purine catabolism diffused in the blood, is positively associated with the risk of type 2 diabetes mellitus (T2DM). However, in the T2DM population, the association of ...
Source: BMC Geriatrics - July 19, 2023 Category: Geriatrics Authors: Yalun Dai, Yingyu Jiang, Luping Zhang, Xin Qiu, Hongqiu Gu, Yong Jiang, Xia Meng, Zixiao Li and Yongjun Wang Tags: Research Source Type: research

Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi ’an Stroke Registry Study of China
In this study, we aimed to investigate the relationship between...
Source: BMC Geriatrics - July 5, 2023 Category: Geriatrics Authors: Zhongzhong Liu, Xuemei Lin, Lingxia Zeng, Huan Zhang, Weiyan Guo, Qingli Lu, Congli Huang, Jing Wang, Pei Liu, Qiaoqiao Chang, Mi Zhang, Yan Huo, Yan Wang, Fang Wang and Songdi Wu Tags: Research Source Type: research

Appendicular Skeletal Muscle Mass Associated with Sarcopenia as a Predictor of Poor Functional Outcomes in Ischemic Stroke
Source: Clinical Interventions in Aging - July 4, 2023 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research

Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment
Neurobiol Aging. 2023 May 5;129:168-177. doi: 10.1016/j.neurobiolaging.2023.05.001. Online ahead of print.ABSTRACTStroke is a major cause of death and disability worldwide and is also a leading cause of vascular dementia and Alzheimer's disease, with older women experiencing accelerated decline. Our previous studies show that intravenous (iv) injections of miR-20a-3p, a small noncoding RNA (miRNA) delivered after stroke improves acute stroke outcomes in middle-aged male and female rats. The present study tested whether mir-20a-3p treatment would also ameliorate stroke-induced cognitive decline in the chronic phase. Acyclic...
Source: Neurobiology of Aging - June 19, 2023 Category: Geriatrics Authors: Dayalan Sampath Taylor E Branyan Kylee G Markowsky Rithvik Gunda Nadia Samiya Andre Obenaus Farida Sohrabji Source Type: research