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Specialty: Geriatrics

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Total 1481 results found since Jan 2013.

Brain and Cognition Signature Fingerprinting Vascular Health in Diabetic Individuals: An International Multi-Cohort Study
CONCLUSION: Cognitive decline significantly elevates the risk of diabetic vascular complications and is correlated with retinal and renal microcirculation damage. Cognitive screening tests are strongly recommended as routine tools for management of diabetes.PMID:37230837 | DOI:10.1016/j.jagp.2023.04.010
Source: Am J Geriatr Psychia... - May 25, 2023 Category: Geriatrics Authors: Pingting Zhong Shaoying Tan Zhuoting Zhu Junyao Zhang Shida Chen Wenyong Huang Mingguang He Wei Wang Source Type: research

Neuron-specific enolase in hypertension patients with acute ischemic stroke and its value forecasting long-term functional outcomes
Neuron Specific Enolase (NSE), a neuro-biochemical protein marker, may correlate with the prognosis of stroke patients. Moreover, hypertension is the most common comorbidities in patients with acute ischemic s...
Source: BMC Geriatrics - May 15, 2023 Category: Geriatrics Authors: Lingfei Gao, Jiali Xie, Haiqin Zhang, Hangqi Zheng, Wanjun Zheng, Chunyang Pang, Yunlei Cai and Binbin Deng Tags: Research Source Type: research

Early versus late delayed percutaneous coronary intervention in elderly patients with ST-segment elevation myocardial infarction
CONCLUSION: Early delayed PCI (12-48 h from symptom onset), for elderly patients with STEMI who present > 12 h after symptom onset is not associated with better long-term clinical outcomes compared with late delayed PCI (48 h-28 days).PMID:37171538 | DOI:10.1007/s40520-023-02417-8
Source: Aging Clinical and Experimental Research - May 12, 2023 Category: Geriatrics Authors: Jiachun Lang Chen Wang Jingxia Zhang Yuecheng Hu Lin Wang Yin Liu Rongdi Xu Jikun Wu Wei Qi Chunwei Liu Wenyu Li Tingting Li Dongxia Jin Ao Wei Le Wang Hongliang Cong Source Type: research

Enlarged perivascular spaces and plasma A β42/Aβ40 ratio in older adults without dementia
Neurobiol Aging. 2023 Apr 14;128:43-48. doi: 10.1016/j.neurobiolaging.2023.04.004. Online ahead of print.ABSTRACTDilation of perivascular spaces (PVS) in the brain may indicate poor fluid drainage due to the accumulation of perivascular cell debris, waste, and proteins, including amyloid-beta (Aβ). No prior study has assessed whether plasma Aβ levels are related to PVS in older adults without dementia. Independently living older adults (N = 56, mean age = 68.2 years; Standard deviation (SD) = 6.5; 30.4% male) free of dementia or clinical stroke were recruited from the community and underwent brain MRI and venipuncture. P...
Source: Neurobiology of Aging - May 8, 2023 Category: Geriatrics Authors: Arunima Kapoor Aim ée Gaubert Belinda Yew Jung Yun Jang Shubir Dutt Yanrong Li John Paul M Alitin Amy Nguyen Jean K Ho Anna E Blanken Isabel J Sible Anisa Marshall Fatemah Shenasa Kathleen E Rodgers Alessandra C Martini Elizabeth Head Daniel A Nation Source Type: research

Development and validation of a nomogram for predicting dysphagia in long-term care facility residents
CONCLUSIONS: The nomogram may help long-term care facility staff identify older adults at high risk for dysphagia.PMID:37148466 | DOI:10.1007/s40520-023-02413-y
Source: Aging Clinical and Experimental Research - May 6, 2023 Category: Geriatrics Authors: Jinmei Liu Mingshu Liao Hui Yang Xiaofang Chen Yang Peng Jing Zeng Source Type: research

Handgrip strength is associated with risks of new-onset stroke and heart disease: results from 3 prospective cohorts
Stroke and heart disease are two major contributors to the global disease burden. We aimed to evaluate and compare the roles of different handgrip strength (HGS) expressions in predicting stroke and heart dise...
Source: BMC Geriatrics - May 4, 2023 Category: Geriatrics Authors: Guochen Li, Yanqiang Lu, Liping Shao, Luying Wu, Yanan Qiao, Yi Ding and Chaofu Ke Tags: Research Source Type: research

Scientists use AI to decipher words and sentences from brain scans
A technique based on artificial intelligence (AI) can translate brain scans into words and sentences, a team of computational neuroscientists reports. Although in the early stages and far from perfect, the new technology might eventually help individuals with brain injuries or paralysis regain the ability to communicate, researchers say. The study “shows that, using the right methods and better models, we can actually decode what the subject is thinking,” says Martin Schrimpf, a computational neuroscientist at the Massachusetts Institute of Technology who was not involved in the work. Other research teams hav...
Source: Science of Aging Knowledge Environment - May 1, 2023 Category: Geriatrics Source Type: research

Relationships between stroke prevalence, health literacy, and oral health-related quality of life in middle-aged and older adults: a national survey study
Stroke may cause debilitating neurological deficiencies that result in motor, sensory, and cognitive deficits and poorer psychosocial functioning. Prior studies have provided some initial evidence for the sign...
Source: BMC Geriatrics - April 18, 2023 Category: Geriatrics Authors: Li-Chung Pien, Wan-Ju Cheng, Wen-Pei Chang, Su-Ru Chen, Kuei-Ru Chou and Chia-Hui Wang Tags: Research Source Type: research

Clinical trial participant ’s autopsy and brain exam stoke Alzheimer’s drug fears
A full autopsy and detailed examination of the brain of a 79-year-old Florida woman who died after receiving lecanemab, an experimental Alzheimer’s therapy, in a pivotal clinical trial has deepened some researchers’ concerns that it poses serious risks for patients who share the woman’s hard-to-diagnose, preexisting condition. The patient’s history and autopsy “strongly suggests that lecanemab infusions were a catalyst leading to the events resulting in her death,” says Vanderbilt University pathologist Hannah Harmsen, co-author of a recently completed case report, which Science has obtained. The aut...
Source: Science of Aging Knowledge Environment - April 13, 2023 Category: Geriatrics Source Type: research

Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study
Neurobiol Aging. 2023 Mar 6;127:12-22. doi: 10.1016/j.neurobiolaging.2023.03.001. Online ahead of print.ABSTRACTWe studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated. We related biomarkers representing various inflammatory mechanisms to PVS burden using multivariable ordinal l...
Source: Neurobiology of Aging - April 5, 2023 Category: Geriatrics Authors: Oluchi Ekenze Adlin Pinheiro Serkalem Demissie Andreas Charidimou Alexa S Beiser Ramachandran S Vasan Emelia J Benjamin Charles DeCarli Sudha Seshadri Jose R Romero Source Type: research