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Total 384 results found since Jan 2013.
Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke
Conclusion: Direct inhibition of smooth muscle myosin by AmBleb in pre-capillary SMCs significantly contribute to the improvement of cerebral blood reperfusion and brain functions suggesting that smooth muscle myosin inhibition may have promising potential in stroke therapies as a follow-up treatment of physical or chemical removal of the occluding thrombus.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: M á t é P é nzes, Demeter T ú r ó s, Domokos M á th é , Kriszti á n Szigeti, Nikolett Heged ű s, Anna Á gnes Rauscher, P é ter T ó th, Ivan Ivic, Parasuraman Padmanabhan, Gabriella P á l, Á rp á d Dobolyi, M á t é Gyimesi, Andr á s M Tags: Research Paper Source Type: research
PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2- 18 FFluoro- d -Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke
ConclusionsAccumulation of FGA correlated well with the perfusion defect and inflammatory injury. As a PET agent, FGA has potential to image infarcted core in the brain stroke injury with high sensitivity, resolution, and specificity.
Source: Molecular Imaging and Biology - June 15, 2020 Category: Molecular Biology Source Type: research
Value of SPECT/CT over planar imaging during Tc-99m MDP triple phase bone scintigraphy for detection of osteomyelitis in patients with stage IV pressure ulcers
Conclusion: SPECT/CT imaging has a significant added diagnostic value over planar imaging in accurately detecting osseous involvement with stage IV pressure ulcers. It significantly reduced equivocal results by accurate uptake localization, reducing false positive results due to other associated pathologies and reducing false negative results due to overlap by other structures or difficult patient positioning.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Nasr, H., Alfawzan, T., Alqarni, A., Farghaly, H. Tags: Infection/Pulmonary/Outcomes (Poster Session) Source Type: research
A Case of Delayed Intraparenchymal Hemorrhage Due to Hyperperfusion After Flow Diverter Treatment
We present the case of a 54-year-old woman with a partially thrombosed large internal carotid artery aneurysm. She presented intraparenchymal hemorrhage in the right parietal lobe three days after the successful FD treatment. We performed endoscopic hematoma removal, and then her consciousness disturbance was fully recovered. IMP single-photon emission computed tomography showed significant increase of cerebral blood flow in the right hemisphere.
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Takaaki Itazu, Yukiko Enomoto, Keita Yamauchi, Yusuke Egashira, Toru Iwama Tags: Case Report Source Type: research
Impact of cortical hemodynamic failure on both subsequent hemorrhagic stroke and effect of bypass surgery in hemorrhagic moyamoya disease: a supplementary analysis of the Japan Adult Moyamoya Trial.
CONCLUSIONS: Hemodynamic failure is an independent risk factor for subsequent hemorrhage in hemorrhagic moyamoya disease. Direct bypass surgery showed a significant preventive effect in the hemodynamically impaired hemispheres. Thus, hemodynamic failure, as well as previously proposed factors such as choroidal anastomosis, should be considered for the surgical indication in hemorrhagic moyamoya disease.Clinical trial registration no.: C000000166 (umin.ac.jp).
PMID: 32168484 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - March 12, 2020 Category: Neurosurgery Authors: Takahashi JC, Funaki T, Houkin K, Kuroda S, Fujimura M, Tomata Y, Miyamoto S Tags: J Neurosurg Source Type: research
Examining the evidence for PFO closure and novel oral anticoagulants for treatment of cryptogenic stroke.
Authors: Khan R
Abstract
Introduction: There has been considerable study assessing the treatment of cryptogenic stroke (CS) recently. This review examines the role of patent foramen ovale (PFO) closure in CS, while also discussing the evidence for alternative medical therapies in disease treatment.Areas Covered: PFO closure for treatment of CS has been assessed in 6 randomized controlled trials (RCTs). This review summarizes the background, results and limitations of these trials. Methodological and treatment-related differences in RCTs provide potential explanations for the discordance in outcomes observed between...
Source: Expert Review of Cardiovascular Therapy - February 23, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.
Authors: Heo GS, Sultan D, Liu Y
Abstract
Cardiovascular disease (CVD) remains the leading cause of death worldwide despite advances in diagnostic technologies and treatment strategies. The underlying cause of most CVD is atherosclerosis, a chronic disease driven by inflammatory reactions. Atherosclerotic plaque rupture could cause arterial occlusion leading to ischemic tissue injuries such as myocardial infarction (MI) and stroke. Clinically, most imaging modalities are based on anatomy and provide limited information about the on-going molecular activities affecting the vulnerability of atherosclerotic lesion for...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Clinical imaging of cardiovascular inflammation.
Authors: Calcagno C, Fayad ZA
Abstract
Cardiovascular disease due to atherosclerosis is the number one cause of morbidity and mortality worldwide. In the past twenty years, compelling preclinical and clinical data have indicated that a maladaptive inflammatory response plays a crucial role in the development of atherosclerosis initiation and progression in the vasculature, all the way to the onset of life-threatening cardiovascular events. Furthermore, inflammation is key to heart and brain damage and healing after myocardial infarction or stroke. Recent evidence indicates that this interplay between the vasculatur...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Left thalamus infarction in the thalamotuberal artery perfusion area causing subcortical diaschisis and transcortical sensory aphasia
The thalamus is related to language function, and some thalamic stroke cases can cause aphasia [1]. However, most previous cases reporting thalamic damage-induced ipsilateral subcortical diaschisis and aphasia were hemorrhagic stroke [1,2]. Only a few left thalamus infarction cases showed cortical hypoperfusion concerned with the aphasia, but no single-photon emission computed tomography (SPECT) or thalamic nucleus data were available [3]. Thus, aphasia pathology due to cortical hypoperfusion following thalamus infarction, especially with respect to thalamic nuclei, is still unknown.
Source: Journal of the Neurological Sciences - January 24, 2020 Category: Neurology Authors: Kosuke Matsuzono, Kohei Furuya, Azusa Karube, Akie Horikiri, Tadashi Ozawa, Takafumi Mashiko, Haruo Shimazaki, Reiji Koide, Ryota Tanaka, Shigeru Fujimoto Tags: Letter to the Editor Source Type: research
Prognostic value of 99m Tc-ECD brain perfusion SPECT in patients with atrial fibrillation and dementia
ConclusionThis study demonstrated that decreased cerebral blood flow in the temporo-parieto-occipital lobe could be a potential prognostic value in patients with both AF and dementia.
Source: EJNMMI Research - January 9, 2020 Category: Radiology Source Type: research
Remote ischemic conditioning for the treatment of ischemic moyamoya disease.
CONCLUSIONS: Remote ischemic conditioning may be beneficial on controlling iMMD-induced ischemic events, relieving symptoms, and improving cerebral perfusion, without incidence of complications in this case series.
PMID: 31814317 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 7, 2019 Category: Neuroscience Authors: Ding JY, Shang SL, Sun ZS, Asmaro K, Li WL, Yang Q, Ding YC, Ji XM, Meng R Tags: CNS Neurosci Ther Source Type: research
Optimized sampling for high resolution multi-pinhole brain SPECT with stationary detectors.
Abstract
Brain perfusion SPECT can be used in the diagnosis of various neurologic or psychiatric disorders, e.g. stroke, epilepsy, dementia and posttraumatic stress disorder. As traditional SPECT provides limited resolution and sensitivity, we recently proposed a high resolution focusing multi-pinhole clinical SPECT scanner dubbed G-SPECT-I (Beekman et al 2015). G-SPECT-I achieves data completeness in the scan region of interest by making small translations of the patient bed while using projections from all bed positions together for image reconstruction. A strategy to restrict the number of bed translations is d...
Source: Physics in Medicine and Biology - November 25, 2019 Category: Physics Authors: Chen Y, Goorden MC, Vastenhouw B, Beekman FJ Tags: Phys Med Biol Source Type: research
Retropharyngeal ectopic parathyroid adenoma versus lymph node: Problem solving with CT neck angiogram
PP Batchala, PK RehmJournal of Postgraduate Medicine 2019 65(4):237-240
A 66-year-old female underwent preoperative evaluation for primary hyperparathyroidism. Ultrasound (US) neck and technetium (Tc)-99m-sestamibi planar scintigraphy were negative, but single photon emission computed tomography/computed tomography (SPECT/CT) demonstrated a tracer-avid retropharyngeal nodule compatible with parathyroid adenoma (PTA). A retrospective review of CT neck angiogram (CTA) and neck magnetic resonance imaging (MRI) performed 4 months earlier for stroke evaluation revealed arterial phase hyperenhancing retropharyngeal tissue, whic...
Source: Journal of Postgraduate Medicine - October 13, 2019 Category: Internal Medicine Authors: PP Batchala PK Rehm Source Type: research
Role of Gallium-SPECT-CT in the Management of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
Implantable left ventricular assist device (LVAD) has dramatically improved the prognosis of patients with advanced heart failure.1 With ongoing technological innovation, patient survival and quality of life are further improving,2,3 and major complications related to LVAD such as pump thrombosis and stroke have decreased3; however, these complications have not been completely overcome. Infection remains a major complication in up to 60% of VAD patients and worsens prognosis and quality of life.
Source: Journal of Cardiac Failure - August 23, 2019 Category: Cardiology Authors: Yuki Kimura, Osamu Seguchi, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Kensuke Kuroda, Seiko Nakajima, Emi Tateishi, Takuya Watanabe, Yorihiko Matsumoto, Satsuki Fukushima, Keisuke Kiso, Masanobu Yanase, Tomoyuki Fujita, Junjiro Kobayas Source Type: research
Moyamoya disease with epileptic nystagmus: A case report
We report a case of moyamoya disease with epileptic nystagmus. A 23-year-old woman presented with a headache and transient hemiparesis on her left side. Magnetic resonance imaging showed no ischemic or hemorrhagic stroke lesions. Digital subtraction angiography confirmed stenosis of the terminal portion of the right internal carotid artery and the formation of moyamoya vessels on the right side. 123I-N-isopropyl-iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) showed decreased uptake in the right basal ganglia, frontal, and parietal regions. After electroencephalography (EEG) and a hyperventila...
Source: Journal of Clinical Neuroscience - August 20, 2019 Category: Neuroscience Source Type: research
