Optimized sampling for high resolution multi-pinhole brain SPECT with stationary detectors.

Optimized sampling for high resolution multi-pinhole brain SPECT with stationary detectors. Phys Med Biol. 2019 Nov 26;: Authors: Chen Y, Goorden MC, Vastenhouw B, Beekman FJ Abstract Brain perfusion SPECT can be used in the diagnosis of various neurologic or psychiatric disorders, e.g. stroke, epilepsy, dementia and posttraumatic stress disorder. As traditional SPECT provides limited resolution and sensitivity, we recently proposed a high resolution focusing multi-pinhole clinical SPECT scanner dubbed G-SPECT-I (Beekman et al 2015). G-SPECT-I achieves data completeness in the scan region of interest by making small translations of the patient bed while using projections from all bed positions together for image reconstruction. A strategy to restrict the number of bed translations is desired to minimize overhead time. Previously we presented optimized bed translation paths for focused partial brain imaging, while here we focus on whole brain imaging which is the common procedure in perfusion studies. Thus, a series of noise-free scans using a reduced number of bed positions were simulated and compared to an oversampled reference scan acquired with 128 bed positions. Noisy simulations were included to validate the utility of the optimized sequences in more realistic situations. Brain Uptake Ratios (BURs) and left-right Asymmetry Indices (AIs) in 51 selected Regions of Interest (ROIs) were calculated for assessment. Results show that i...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research