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Specialty: Neurology
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Total 1309 results found since Jan 2013.

A Mirror Therapy-Based Action Observation Protocol to Improve Motor Learning After Stroke
Conclusion. The present study showed that a mirror therapy–based AO protocol contributes to motor learning after stroke.
Source: Neurorehabilitation and Neural Repair - June 25, 2015 Category: Neurology Authors: Harmsen, W. J., Bussmann, J. B. J., Selles, R. W., Hurkmans, H. L. P., Ribbers, G. M. Tags: Clinical Research Articles Source Type: research

Depressive symptoms influence use of feedback for motor learning and recovery in chronic stroke.
CONCLUSION: The presence of PSD diminished the ability to use auditory feedback for arm motor recovery and motor learning. PMID: 26444639 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Procedural learning as a measure of functional impairment in a mouse model of ischemic stroke.
Abstract Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a murine model of stroke (30min. right MCAO), we submitted C57Bl/6J mice to various sensorimotor tests, then to an operant procedure (Serial Order Learning) specifically assessing the ability to learn a simple motor sequence. Results showed that MCAO affected the performance in some of the sensorimotor tests (accelerated rotating rod and amphetamine rotation test) and the way animals learned a motor sequence. Th...
Source: Behavioural Brain Research - March 17, 2016 Category: Neurology Authors: Linden J, Beeck LV, Plumier JC, Ferrara A Tags: Behav Brain Res Source Type: research

Kinematic and Kinetic Outcome of Robot Assisted Neurorehabilitation in Chronic Moderate-to-Severe Hemiparetic Stroke (P3.298)
Conclusions: RT+TTT was not significantly different from RT alone, suggesting that TTT did not interfere with motor learning conferred by RT. Study Supported by: American Academy of Neurology (AAN) and the VA Department of Research and Development VA Merit Award B6935RDisclosure: Dr. Iqbal has nothing to disclose. Dr. Conroy has nothing to disclose. Dr. Roy has nothing to disclose. Dr. Bever has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Iqbal, T., Conroy, S., Roy, A., Bever, C. Tags: Neurorehabilitation Source Type: research

The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after ischemic stroke.
Abstract Ischemic stroke is a devastating condition with few therapeutic interventions available. The neuroprotective compound P7C3-A20 inhibits mature neuronal cell death while also increasing the net magnitude of postnatal neurogenesis in models of neurodegeneration and acute injury. P7C3 compounds enhance flux of nicotinamide adenine dinucleotide (NAD) in mammalian cells, a proposed therapeutic approach to treating cerebral ischemia. The effectiveness of P7C3-A20 treatment on chronic histopathological and behavioral outcomes and neurogenesis after ischemic stroke has not previously been established. Here, a tra...
Source: Experimental Neurology - January 7, 2017 Category: Neurology Authors: Loris ZB, Pieper AA, Dalton Dietrich W Tags: Exp Neurol Source Type: research

Treatment of Acute Ischemic Stroke
This article provides an update on the state of the art of the emergency treatment of acute ischemic stroke with particular emphasis on the alternatives for reperfusion therapy. Recent Findings: The results of several randomized controlled trials consistently and conclusively demonstrating that previously functional patients with disabling strokes from a proximal intracranial artery occlusion benefit from prompt recanalization with mechanical thrombectomy using a retrievable stent have changed the landscape of acute stroke therapy. Mechanical thrombectomy within 6 hours of symptom onset should now be considered the prefer...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2017 Category: Neurology Tags: Review Articles Source Type: research

Remote Evaluation of the Patient With Acute Stroke
This article describes advances related to the successful remote evaluation of the patient with acute stroke. Telestroke is a connected care approach that brings expert stroke care to remote, neurologically underserved urban or rural locations. Recent findings reveal strong evidence showing that telestroke is equivalent to in-person care. Time is critical in treating patients with acute stroke, and telestroke networks must assure that technology improves—not delays—delivery of care. The stroke center and the spoke site must work collaboratively to develop and institute protocols and policies to ensure that eligible pat...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2017 Category: Neurology Tags: Practice Issues Source Type: research

The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke.
CONCLUSIONS: Unilateral tDCS is effective for improving JTT performance, but not motor sequence learning. SIGNIFICANCE: This has implications for the design of future clinical trials. PMID: 28410884 [PubMed - as supplied by publisher]
Source: Clinical Neurophysiology - March 31, 2017 Category: Neurology Authors: Fleming MK, Rothwell JC, Sztriha L, Teo JT, Newham DJ Tags: Clin Neurophysiol Source Type: research

Transcranial direct current stimulation combined with visuo-motor training as treatment for chronic stroke patients.
CONCLUSION: Four-week visuo-motor training combined with tDCS showed no difference between the Active and Sham groups in the total UE FMA score, which may be explained by heterogeneity of the degree of recovery in the Active group. However, the shoulder-elbow FMA sub-score improved significantly more in the Active compared to the Sham group, which deserves further study. PMID: 28506002 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - May 17, 2017 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

BDNF Val66Met but not transcranial direct current stimulation affects motor learning after stroke
Conclusion BDNF Val66Met is a determinant of motor skill learning after stroke and could be important for prognostic models. tDCS does not modulate motor skill learning in our study and might be less effective than previously assumed.
Source: Brain Stimulation - July 13, 2017 Category: Neurology Source Type: research

Changes in spectroscopic biomarkers after transcranial direct current stimulation in children with perinatal stroke
Conclusions MRS metabolite levels and changes may reflect mechanisms of tDCS-related M1 plasticity and response biomarkers in hemiparetic children with perinatal stroke undergoing intensive neurorehabilitation.
Source: Brain Stimulation - September 13, 2017 Category: Neurology Source Type: research

Motor imagery: a systematic review of its effectiveness in the rehabilitation of the upper limb following a stroke.
CONCLUSIONS: Motor imagery, combined with conventional therapy (physiotherapy or occupational therapy), seems to have positive effects on the motor rehabilitation of the upper limb following a stroke. Further research is needed to improve the heterogeneity of the interventions and to evaluate their effectiveness in the long term. PMID: 29480509 [PubMed - in process]
Source: Revista de Neurologia - February 27, 2018 Category: Neurology Authors: Fernandez-Gomez E, Sanchez-Cabeza A Tags: Rev Neurol Source Type: research

Sex Differences in the Effects of Parp Inhibition on Microglial Phenotypes Following Neonatal Stroke.
This study aims to examine the effects of PJ34, a PARP inhibitor, on microglial phenotypes at 3 and 8 days and on neurobehavioral disorders in adulthood for both male and female P9 mice subjected to permanent middle cerebral artery occlusion (pMCAo). PJ34 significantly reduced the lesion size by 78% and reduced the density of CX3CR1gfp-labeled microglial cells by 46% when examined 3 days after pMCAo in male but not in female mice. Eight days after pMCAo, the number of Iba1+/Cox-2+ cells did not differ between male and female mice in the cortical peri-infarct region. In the amygdala, Iba1+/Cox-2+ (M1-like) cell numbers were...
Source: Brain, Behavior, and Immunity - May 28, 2018 Category: Neurology Authors: Charriaut-Marlangue C, Leconte C, Csaba Z, Chafa L, Pansiot J, Talatizi M, Simon K, Moretti R, Marchand-Leroux C, Baud O, Besson VC Tags: Brain Behav Immun Source Type: research

White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study.
Abstract Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects...
Source: Neural Plasticity - March 15, 2019 Category: Neurology Authors: Wadden KP, Peters S, Borich MR, Neva JL, Hayward KS, Mang CS, Snow NJ, Brown KE, Woodward TS, Meehan SK, Boyd LA Tags: Neural Plast Source Type: research

The effects of five sessions of continuous theta burst stimulation over contralesional sensorimotor cortex paired with paretic skilled motor practice in people with chronic stroke.
CONCLUSIONS: Multiple sessions of STT practice can improve paretic arm function and decrease TCI bilaterally, with no additional benefit of prior cTBS. Our results suggest that improvement in STT practice following M1c cTBS scaled with change in paretic arm function in some individuals. Our results highlight the need for a better understanding of the mechanisms of cTBS to effectively identify who may benefit from this form of brain stimulation. PMID: 31227676 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - June 23, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research