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Total 1309 results found since Jan 2013.

Machine Learning Analysis of MicroRNA Expression Data Reveals Novel Diagnostic Biomarker for Ischemic Stroke
In this study, we sought to use different machine learning algorithms to identify an optimal model of microRNA by integrating the expression data of pre-selected microRNAs for discriminating patients with IS from controls.
Source: Journal of Stroke and Cerebrovascular Diseases - May 19, 2021 Category: Neurology Authors: Xinyi Zhao, Xingmei Chen, Xulong Wu, Lulu Zhu, Jianxiong Long, Li Su, Lian Gu Source Type: research

A Deep Learning-Based Automatic Collateral Assessment in Patients with Acute Ischemic Stroke
This study aimed to develop a supervised deep learning (DL) model for grading collateral status from dynamic susceptibility contrast magnetic resonance perfusion (DSC-MRP) images from patients with large vessel occlusion (LVO) acute ischemic stroke (AIS) and compare its performance against experts ’ manual grading. Among consecutive LVO-AIS at three medical center sites, DSC-MRP data were processed to generate collateral flow maps consisting of arterial, capillary, and venous phases. With the use of expert readings as a reference, a DL model was developed to analyze collateral status with o utput classified into good and...
Source: Translational Stroke Research - May 21, 2022 Category: Neurology Source Type: research

The mucormycosis and Stroke: the learning curve during the second COVID-19 pandemic
Background The Angio-invasive Rhino-orbito-cerebral mucormycosis (ROCM) producing strokes is a less explored entity. Our hospital, a stroke-ready one, had an opportunity to manage mucormycosis when it was identified as the nodal center for mucormycosis management. We are sharing our experiences and mistakes in managing the cerebrovascular manifestations of ROCM.Methods We conducted a prospective observational study during the second wave of the COVID-19 pandemic from 1st May 2021 to 30th September 2021, where consecutive patients aged more than 18 years with microbiologically confirmed cases of ROCM were included.
Source: Journal of Stroke and Cerebrovascular Diseases - October 12, 2022 Category: Neurology Authors: Dileep Ramachandran, Aravind R, Praveen Panicker, Jayaprabha S, MC Sathyabhama, Abhilash Nair, Raj S. Chandran, Simon George, Chintha S, Thomas Iype Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (I9-4B)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (S53.005)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Sleep Source Type: research

Evaluation and Acute Management of Ischemic Stroke in Infants and Children
This article provides an overview of stroke in neonates, infants, and children.RECENT FINDINGSArterial ischemic stroke and cerebral venous sinus thrombosis are increasingly recognized in childhood as important causes of lifelong morbidity and mortality. Diagnosis of arterial ischemic stroke is frequently delayed, as acute neurologic deficits can be challenging to detect in the young child, and stroke is often not considered in the differential diagnosis. Neurologic sequelae following stroke are common, and strategies to minimize stroke size and optimize recovery are being developed. Recurrent arterial ischemic stroke is no...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2018 Category: Neurology Tags: Review Articles Source Type: research

Memory decline in young stroke survivors during a 9-year follow-up: A cohort study
ConclusionYoung stroke survivors might be at risk of memory decline over the decade following the stroke.
Source: Frontiers in Neurology - November 25, 2022 Category: Neurology Source Type: research

Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
ConclusionA fast and fully automatic method can be used for stroke subtype risk assessment and classification based on fundus photographs alone.
Source: Frontiers in Neurology - August 22, 2022 Category: Neurology Source Type: research

The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients.
We present the current data on the role of BDNF and polymorphisms of the BDNF gene in stroke patients, concentrating on human studies. PMID: 28291539 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - March 5, 2017 Category: Neurology Authors: Kotlęga D, Peda B, Zembroń-Łacny A, Gołąb-Janowska M, Nowacki P Tags: Neurol Neurochir Pol Source Type: research

Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice.
Abstract Stroke remains a leading cause of disability worldwide. Recently, we have established an animal model of stroke that results in delayed impairment in spatial memory, allowing us to better investigate cognitive deficits. Young and aged brains show different recovery profiles after stroke; therefore, we assessed aged-related differences in poststroke cognition. As neurotrophic support diminishes with age, we also investigated the involvement of brain-derived neurotrophic factor (BDNF) in these differences. Young (3-6 months old) and aged (16-21 months old) mice were trained in operant touchscreen chambers t...
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Houlton J, Zhou LYY, Barwick D, Gowing EK, Clarkson AN Tags: Neural Plast Source Type: research

The Evolving Concept of Cryptogenic Stroke
This article discusses cryptogenic stroke and the results of recent randomized trials that can inform its evaluation and management. RECENT FINDINGS Most cryptogenic strokes appear embolic, leading to the term embolic stroke of undetermined source. It was previously thought that embolic stroke of undetermined source was a single, therapeutically relevant entity, the underlying sources of which would respond to anticoagulant therapy; however, two large randomized trials found no benefit with anticoagulation compared to antiplatelet therapy for secondary stroke prevention after embolic stroke of undetermined source. A sin...
Source: CONTINUUM: Lifelong Learning in Neurology - April 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

IgA natural antibodies are produced following T-cell independent B-cell activation following stroke.
Abstract Up to 30% of stroke patients experience cognitive decline within one year of their stroke. There are currently no FDA-approved drugs that can prevent post-stroke cognitive decline, in part due to a poor understanding of the mechanisms involved. We have previously demonstrated that a B-lymphocyte response to stroke, marked by IgA+ cells, can cause delayed cognitive dysfunction in mice and that a similar adaptive immune response occurs in the brains of some human stroke patients that suffer from vascular dementia. The stimuli which trigger B-lymphocyte activation following stroke, and their target antigens,...
Source: Brain, Behavior, and Immunity - September 17, 2020 Category: Neurology Authors: Zbesko JC, Frye JB, Becktel DA, Gerardo DK, Stokes J, Calderon K, Nguyen TV, Bhattacharya D, Doyle KP Tags: Brain Behav Immun Source Type: research

Data lake-driven analytics identify nocturnal non-dipping of heart rate as predictor of unfavorable stroke outcome at discharge
ConclusionsOur data suggest that a lack of circadian HR modulation, specifically nocturnal non-dipping, is associated with short-term unfavorable functional outcome after stroke, and that including HR into machine learning-based prediction models may lead to improved stroke outcome prediction.
Source: Journal of Neurology - April 20, 2023 Category: Neurology Source Type: research

Ipsilateral hippocampal atrophy is associated with long‐term memory dysfunction after ischemic stroke in young adults
Abstract Memory impairment after stroke in young adults is poorly understood. In elderly stroke survivors memory impairments and the concomitant loss of hippocampal volume are usually explained by coexisting neurodegenerative disease (e.g., amyloid pathology) in interaction with stroke. However, neurodegenerative disease, such as amyloid pathology, is generally absent at young age. Accumulating evidence suggests that infarction itself may cause secondary neurodegeneration in remote areas. Therefore, we investigated the relation between long‐term memory performance and hippocampal volume in young patients with first‐eve...
Source: Human Brain Mapping - March 1, 2015 Category: Neurology Authors: Pauline Schaapsmeerders, Inge W.M. van Uden, Anil M. Tuladhar, Noortje A.M. Maaijwee, Ewoud J. van Dijk, Loes C.A. Rutten‐Jacobs, Renate M. Arntz, Hennie C. Schoonderwaldt, Lucille D.A. Dorresteijn, Frank‐Erik de Leeuw, Roy P.C. Kessels Tags: Research Article Source Type: research

Knowledge Translation in Right Brain Rehabilitation: A Feasibility Study of Prism Treatment After Acute Stroke (P6.210)
Conclusions:Fewer patients had spatial neglect than expected, but we demonstrated feasible knowledge translation for spatial neglect care in an underserved setting. An active-learning approach may be key to clinician engagement. Future research in stroke centers will help clarify the impact of neglect assessment and treatment on quality outcomes.Disclosure: Dr. Barrett has received personal compensation for activities with Kessler Foundation as an employee. Dr. Barrett has received research support from SPR therapeutics. Dr. Chen has nothing to disclose. Dr. Hreha has received personal compensation for activities with Kess...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Barrett, A., Chen, P., Hreha, K., Alban, F., Gocon, C., Santos, C., Lawless, K., LaRosa, J. Tags: Behavioral and Cognitive Neurology: Brain-behavior Correlations Source Type: research