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Total 1309 results found since Jan 2013.

Co-morbid beta-amyloid toxicity and stroke produce impairments in an ambiguous context task in rats without any impairment in spatial working memory.
This study examined the combined effects of beta-amyloid administration and unilateral stroke in an animal model of AD. Adult rats were given a sham surgery, bilateral intraventricular infusion of 10μL of 50nmol Aβ25-35, a unilateral injection of endothelin-1 into the right striatum, or Aβ and endothelin-1 administration in combination. Following a recovery period, rats were tested in the 1-trial place learning variant of the Morris water task followed by an ambiguous discriminative fear-conditioning to context task. After behavioural assessment, rats were euthanized, and representative sections of the medial septum wer...
Source: Neurobiology of Learning and Memory - January 7, 2015 Category: Neurology Authors: Keeley RJ, Hong NS, Fisher A, McDonald RJ Tags: Neurobiol Learn Mem Source Type: research

Varied Overground Walking Training Versus Body-Weight-Supported Treadmill Training in Adults Within 1 Year of Stroke: A Randomized Controlled Trial
Conclusions: In this sample of community-dwelling adults within 1 year of stroke, a 15-session program of varied overground walking-focused training was not superior to a BWSTT program of equal frequency, duration, and in-session step activity.
Source: Neurorehabilitation and Neural Repair - March 25, 2015 Category: Neurology Authors: DePaul, V. G., Wishart, L. R., Richardson, J., Thabane, L., Ma, J., Lee, T. D. Tags: Clinical Research Articles Source Type: research

Using swing resistance and assistance to improve gait symmetry in individuals post-stroke.
Abstract A major characteristic of hemiplegic gait observed in individuals post-stroke is spatial and temporal asymmetry, which may increase energy expenditure and the risk of falls. The purpose of this study was to examine the effects of swing resistance/assistance applied to the affected leg on gait symmetry in individuals post-stroke. We recruited 10 subjects with chronic stroke who demonstrated a shorter step length with their affected leg in comparison to the non-affected leg during walking. They participated in two test sessions for swing resistance and swing assistance, respectively. During the adaptation p...
Source: Human Movement Science - June 8, 2015 Category: Neurology Authors: Yen SC, Schmit BD, Wu M Tags: Hum Mov Sci Source Type: research

Spatial-Motor Flexibility (SMF) and Post-Stroke Cognitive Recovery (P6.014)
Conclusions:The ability to direct movement flexibly in the side of body-centered space near impaired limbs may be needed for optimal functional stroke recovery. The clicker test provides an easy way to assess this ability and its performance may also reflect functioning of executive-action systems. Further studies examining whether SMF deficits predict cognitive recovery in stroke survivors more generally are needed.Disclosure: Dr. Barrett has received personal compensation for activities with Kessler Foundation as an employee. Dr. Barrett has received research support from SPR therapeutics. Dr. Zhang has nothing to disclo...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Barrett, A., Zhang, R., Frey, S., Oh-Park, M. Tags: Cerebrovascular Disease and Interventional Neurology ePoster Session Source Type: research

The Zürich Maxi Mental Status Inventory (ZüMAX): Test-Retest Reliability and Discriminant Validity in Stroke Survivors
Conclusion: The ZüMAX has moderate to good test-retest reliability. Furthermore, the tool might discriminate between healthy persons and chronic stroke survivors on three of five subscales. The ZüMAX shows promise in measuring neuropsychological disturbances in stroke survivors; however, further trials are required with larger samples.
Source: Cognitive and Behavioral Neurology - June 1, 2016 Category: Neurology Tags: Original Studies Source Type: research

Predicting Motor Sequence Learning in Individuals With Chronic Stroke
Conclusion. Nonlinear information extracted from multiple time points across practice, specifically the rate of motor skill acquisition during practice, relates strongly with changes in motor behavior at the retention test following practice and could be used to predict optimal doses of practice on an individual basis.
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Wadden, K. P., Asis, K. D., Mang, C. S., Neva, J. L., Peters, S., Lakhani, B., Boyd, L. A. Tags: Original Research Articles Source Type: research

Domain-general subregions of the medial prefrontal cortex contribute to recovery of language after stroke
AbstractWe hypothesized that the recovery of speech production after left hemisphere stroke not only depends on the integrity of language-specialized brain systems, but also on ‘domain-general’ brain systems that have much broader functional roles. The presupplementary motor area/dorsal anterior cingulate forms part of the cingular-opercular network, which has a broad role in cognition and learning. Consequently, we have previously suggested that variability in the rec overy of speech production after aphasic stroke may relate in part to differences in patients’ abilities to engage this domain-general brain region. T...
Source: Brain - June 27, 2017 Category: Neurology Source Type: research

Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats
AbstractDespite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion after a 90-min middle cerebral artery occlusion (MCAO). In the present study, we investigated a more clinically relevant therapeutic window for P7C3-A20 treatment after ischemic stroke. MCAO rats were administered P7C3-A20 for 1  week, beginning immediately or at a delayed point, 6 h post-reperfusio...
Source: Translational Stroke Research - August 25, 2017 Category: Neurology Source Type: research

Timing independent spatial motor sequence learning is preserved in left hemisphere stroke
Publication date: Available online 28 September 2017 Source:Neuropsychologia Author(s): Anna Dovern, Eva Niessen, Jana M. Ant, Jochen Saliger, Hans Karbe, Gereon R. Fink, Iring Koch, Peter H. Weiss During neurorehabilitation, the re-learning of motor sequences is crucial for patients with motor deficits, enabling them to master again complex movements. A recent study showed that patients with left hemisphere (LH) stroke exhibited preserved motor sequence learning (as assessed by the serial reaction time (SRT) task) when the timing of the stimuli was comparable in the training and later test phase. However, patients showed...
Source: Neuropsychologia - September 28, 2017 Category: Neurology Source Type: research

Targeted Neuromodulation of Abnormal Interhemispheric Connectivity to Promote Neural Plasticity and Recovery of Arm Function after Stroke: A Randomized Crossover Clinical Trial Study Protocol.
Conclusion: The findings from this single-site early stage clinical trial will provide foundational results to inform the design of larger-scale, multisite clinical trials to evaluate the therapeutic potential of ihPAS-based neuromodulation for upper limb recovery after stroke. This trial is registered with NCT02465034. PMID: 29721010 [PubMed - in process]
Source: Neural Plasticity - May 4, 2018 Category: Neurology Authors: Borich MR, Wolf SL, Tan AQ, Palmer JA Tags: Neural Plast Source Type: research

Brain ‐State Dependent Stimulation boosts functional recovery following stroke
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Natalie Mrachacz ‐Kersting, Andrew J.T. Stevenson, Helle R. M. Jørgensen, Kåre Eg Severinsen, Susan Aliakbaryhosseinabadi, Ning Jiang, Dario Farina Tags: Research Article Source Type: research

Effects and safety of combined rTMS and action observation for recovery of function in the upper extremities in stroke patients: A randomized controlled trial.
CONCLUSIONS: Distal upper extremity function, as measured by MFT and grip power, was improved after rTMS and AO in combination. The combination of rTMS with AO may be applied safely to improve upper extremity function after stroke. PMID: 31177248 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - June 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Evaluation of sex differences in acid/base and electrolyte concentrations in acute large vessel stroke.
CONCLUSION: Acid/base and electrolyte response to ischemic conditions differ between men and women, and these early changes could be used to predict local acid/base changes and how they develop differently in men and women during ischemia. These findings provide a novel insight into the pathology of large vessel stroke in humans, particularly potential variations based on sex. PMID: 31697942 [PubMed - as supplied by publisher]
Source: Experimental Neurology - November 3, 2019 Category: Neurology Authors: Martha SR, Collier LA, Davis SM, Erol A, Lukins D, Pennypacker KR, Fraser JF Tags: Exp Neurol Source Type: research

Preserved motor skill learning in acute stroke patients
AbstractRecovery is dynamic during acute stroke, but whether new motor skills can be acquired with the paretic upper limb (UL) during this recovery period is unknown. Clarifying this unknown is important, because neurorehabilitation largely relies on motor learning. The aim was to investigate whether, during acute stroke, patients achieved motor skill learning and retention with the paretic UL. Over 3 consecutive days (D1 –D3), 14 patients practiced with their paretic UL the CIRCUIT, a motor skill learning task with a speed/accuracy trade-off (SAT). A Learning Index (LI) was used to quantify normalised SAT changes in com...
Source: Acta Neurologica Belgica - March 8, 2020 Category: Neurology Source Type: research