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Condition: Hypertension
Procedure: Perfusion
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Total 203 results found since Jan 2013.
Commentary on “Post-carotid Endarterectomy Hypertension. Part 2: Association with Peri-operative Clinical, Anaesthetic, and Transcranial Doppler Derived Parameters”
Guidance on peri-operative haemodynamics is crucial to prevent procedural stroke in carotid endarterectomy (CEA) by preserving cerebral perfusion.1,2 Newman et al. suggest a one size fits all post-operative systolic blood pressure (BP) policy treating > 170 mmHg or > 160 mmHg in patients with symptoms.3 This policy causes significant overtreatment, as two in five CEA patients will undergo in hospital BP lowering treatment for several days, leading to a high workload, increased in hospital costs, and bed occupancy.
Source: European Journal of Vascular and Endovascular Surgery - February 28, 2018 Category: Surgery Authors: Leonie M.M. Fassaert, Gert J. de Borst Tags: Correspondence Source Type: research
Effects of Riociguat on Right Ventricular Remodeling in Chronic Thromboembolic Pulmonary Hypertension Patients: A Prospective Study
Conclusions Riociguat treatment was associated with increased RVSVI and trends for improvement in myocardial remodeling in CTEPH patients. A larger clinical study is warranted to observe the therapeutic benefits of riociguat on RV remodeling. Teaser Riociguat is an approved medical treatment for chronic thromboembolic pulmonary hypertension (CTEPH) patients. We studied the effects of riociguat treatment on right ventricular (RV) remodeling by means of magnetic resonance imaging (MRI) and positron emission tomography (PET). After 6 months of riociguat treatment in 6 CTEPH patients, RV function increased, fibrosis decreased ...
Source: Canadian Journal of Cardiology - June 26, 2018 Category: Cardiology Source Type: research
Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging
ObjectiveRecent availability of amyloid and tau positron emission tomography (PET) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of Alzheimer disease (AD) pathologies. We wanted to quantify early cerebrovascular health –related magnetic resonance imaging brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health.MethodsWe used 2 independent samples (discovery, n = 390; validation, n = 1,035) of individuals, aged ≥ 60 years, along the...
Source: Annals of Neurology - October 25, 2018 Category: Neurology Authors: Prashanthi Vemuri,
Timothy G. Lesnick,
Scott A. Przybelski,
Jonathan Graff ‐Radford,
Robert I. Reid,
Val J. Lowe,
Samantha M. Zuk,
Matthew L. Senjem,
Christopher G. Schwarz,
Jeffrey L. Gunter,
Kejal Kantarci,
Mary M. Machulda,
Michelle M. Mi Tags: Research Article Source Type: research
Fool Me Once: An Uncommon Presentation of PE
BY FREDDIE IRIZARRY-DELGADO; VAROON KAKAIYA; & AHMED RAZIUDDIN, MDAn 86-year-old African-American woman was brought to the ED by her daughter after two days of nutritional neglect, abdominal pain, and altered mental status. Her daughter said her mother felt lightheaded, appeared dehydrated, and vomited nonbilious watery fluid once. The patient had a history of diabetes mellitus type 2, DVT/PE, dementia, and early signs of parkinsonism.Her vital signs were remarkable only for tachypnea (24 bpm). Her troponin I was markedly elevated at 1.7 ng/mL. A D-dimer was ordered because of her history of unprovoked DVT/PE, and i...
Source: The Case Files - November 27, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Thrombolytic therapy for pulmonary embolism.
CONCLUSIONS: Low-quality evidence suggests that thrombolytics reduce death following acute pulmonary embolism compared with heparin. The included studies used a variety of thrombolytic drugs. Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause major and minor haemorrhagic events and stroke. More high-quality, blinded randomised controlled trials assessing safety and cost-effectiveness of therapies for pulmonary embolism are required.
PMID: 30560579 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 18, 2018 Category: General Medicine Authors: Hao Q, Dong BR, Yue J, Wu T, Liu GJ Tags: Cochrane Database Syst Rev Source Type: research
Effects of Normothermic Machine Perfusion Conditions on Mesenchymal Stromal Cells
In this study the effect of NMP perfusion fluid on survival, metabolism and function of thawed cryopreserved human (h)MSC and porcine (p)MSC in suspension conditions was studied. Suspension conditions reduced the viability of pMSC by 40% in both perfusion fluid and culture medium. Viability of hMSC was reduced by suspension conditions by 15% in perfusion fluid, whilst no differences were found in survival in culture medium. Under adherent conditions, survival of the cells was not affected by perfusion fluid. The perfusion fluid did not affect survival of fresh MSC in suspension compared to the control culture medium. The f...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research
History of Hypertension Is Associated With MR Hypoperfusion in Chinese Inpatients With DWI-Negative TIA
Conclusion: Our results suggest that the prevalence of perfusion abnormality is high as assessed by RAPID using the parametric Tmax 4 s. History of hypertension is a strong predictor of focal perfusion abnormality as calculated by RAPID on Tmax map of TIA patients with negative DWI findings.
Source: Frontiers in Neurology - August 13, 2019 Category: Neurology Source Type: research
Alzheimer's dementia: pathogenesis and impact of cardiovascular risk factors on cognitive decline.
Authors: Wanleenuwat P, Iwanowski P, Kozubski W
Abstract
Alzheimer's disease (AD) is the most common form of dementia manifesting as alterations in cognitive abilities, behavior and deterioration in memory which is progressive, leading to gradual worsening of symptoms. Major pathological features of AD are accumulations of neuronal amyloid plaques and neurofibrillary tangles, with early lesions appearing primarily in the hippocampus, the area of the brain involved in memory and learning. Cardiovascular related risk factors are believed to play a crucial role in disease development and the acceleration of cognitive ...
Source: Postgraduate Medicine - August 21, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research
Effect of sildenafil on maternal hemodynamics in pregnancies complicated by severe early-onset fetal growth restriction: planned subgroup analysis from a multicenter randomized placebo-controlled double-blind trial.
CONCLUSIONS: Sildenafil in a dose of 25 mg three times daily increases HR, reduces BP and reduces arterial stiffness in pregnancies complicated by FGR. These changes are modest, consistent with the anticipated vasodilatory effect and their clinical impact on the mother and baby, in both the short- and long-term, remains uncertain. This article is protected by copyright. All rights reserved.
PMID: 31432556 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - August 19, 2019 Category: Radiology Authors: Khalil A, Sharp A, Cornforth C, Jackson R, Mousa H, Stock S, Harrold J, Turner MA, Kenny LC, Baker PN, Johnstone ED, von Dadelszen P, Magee L, Papageorghiou AT, Alfirevic Z Tags: Ultrasound Obstet Gynecol Source Type: research
Impact of hypertension on cerebral microvascular structure in CPAP-treated obstructive sleep apnoea patients: a diffusion magnetic resonance imaging study
ConclusionBased on IVIM analysis, cerebral microvascular structure and function showed no difference between hypertensive and normotensive patients with moderate-to-severe OSA treated with CPAP. Treatment adherence with antihypertensive drug regime and, in turn, controlled hypertension seems not to affect microvascular structure and perfusion of the brain.Trial registrationClinicalTrials.gov Identifier: NCT02493673
Source: Neuroradiology - September 15, 2019 Category: Radiology Source Type: research
Postoperative hemorrhage during the acute phase after direct or combined revascularization for moyamoya disease: risk factors, prognosis, and literature review.
CONCLUSIONS: Preoperative hypertension, CTP stage > III, and posterior circulation involvement are independent risk factors for postoperative ICH after direct or combined revascularization for MMD. After appropriate perioperative management, postoperative ICH has no significant correlations with the postoperative short-term and long-term neurofunctional status.
PMID: 31628285 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - October 17, 2019 Category: Neurosurgery Authors: Chen Y, Ma L, Lu J, Chen X, Ye X, Zhang D, Zhang Y, Wang R, Zhao Y Tags: J Neurosurg Source Type: research
Inducing ketogenesis via an enteral formulation in patients with acute brain injury:a phase II study.
Conclusion: In patients with acute brain injury, an enterally administered ketogenic formulation increased plasma ketone concentrations, was well tolerated, did not impact on cerebral hemodynamics and can be safely administered.Clinical trial registered at the Australian New Zealand Clinical Trials Registry (ACTRN12616000332426)Abbreviations: BHB: betahydroxybutyrate; AcAc: acetoacetate; ABI: acute brain injury; TBI: traumatic brain injury; CSF: cerebrospinal fluid; SAH: subarachnoid injury; CVA: cerebrovascular accidents; ICP: intracranial pressure; CPP: cerebral perfusion pressure; ICU: intensive care unit; EVD: external...
Source: Neurological Research - February 28, 2020 Category: Neurology Tags: Neurol Res Source Type: research
Potential applications of FDG-PET/MRI in detecting vascular dementia
Conclusions: FDG-PET/MRI may be a valuable tool in the diagnosis of VaD. However, the paucity of data in the field necessitates a further analysis of its similarity to FDG-PET/CT in results. Novel studies should be conducted to explore various scanners, patient populations, and MRI protocols to better inform the identification of VaD.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Bhattaru, A., Zhang, V., Hancin, E., Borja, A., Rojulpote, K. V., Werner, T., Revheim, M.-E., Alavi, A. Tags: Educational Exhibits Poster Session I Source Type: research
