Effects of Riociguat on Right Ventricular Remodeling in Chronic Thromboembolic Pulmonary Hypertension Patients: A Prospective Study

Conclusions Riociguat treatment was associated with increased RVSVI and trends for improvement in myocardial remodeling in CTEPH patients. A larger clinical study is warranted to observe the therapeutic benefits of riociguat on RV remodeling. Teaser Riociguat is an approved medical treatment for chronic thromboembolic pulmonary hypertension (CTEPH) patients. We studied the effects of riociguat treatment on right ventricular (RV) remodeling by means of magnetic resonance imaging (MRI) and positron emission tomography (PET). After 6 months of riociguat treatment in 6 CTEPH patients, RV function increased, fibrosis decreased (detected by MRI) and the ratio between myocardial metabolism and perfusion improved (detected by PET). These results suggest improved RV remodeling with riociguat.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research