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Condition: Hypertension
Procedure: Perfusion
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Total 203 results found since Jan 2013.
Abstract P136: Ischemic Evaluation in Patients With Hypertensive Emergency / Urgency and Acute Systolic Heart Failure: Is Coronary Angiography Required for All? Session Title: Onsite Poster Competition I With Reception
Conclusions: Our results suggest that only a minority of patients with HU/E and S-HF have obstructive CAD. It may be possible to stratify patients using demographic and non-invasive tests to direct only those with high likelihood of O-CAD for coronary angiography. These results should be validated in large registry populations.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jared W Davis, Muhannad Almubarak, Samuel K McElwee, Amrita Mukherjee, Firas Al-Solaiman, Mark F Sasse, Massoud A Leesar, Arka Chatterjee Tags: Poster Abstract Presentations Source Type: research
Abstract 142: Angiotensin II Type 1 Receptor Autoantibody Inhibition Improves Blood Pressure and Markers of Neurological Damage and Oxidative Stress in Brains of Placental Ischemic Rats During Pregnancy Session Title: Developmental Programming and Pregnancy Induced Hypertension
In conclusion, our preliminary data suggests that AT1-AA inhibition could be a potential therapy to improve peripheral and neurological complications during PE. Research Supported by T32HL105324 (Cunningham), RO1HD067541-06 (LaMarca), DK-104184 (Roman), 050049 (Fan), P20-GM-104357 (cores B and C-Roman; Pilot-Fan) and AHA 16GRNT31200036 (Fan).
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Mark W Cunningham, Venkata Ramana Vaka, Lorena Amaral, Fan Fan, Tarek Ibrahim, Richard R Roman, Babbette LaMarca Tags: Oral Abstract Presentations Source Type: research
Abstract P446: Sestrin2 Suppresses Age-related Hypertrophy by Inhibiting mTORC1 Signaling Pathway Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Introduction: The mechanistic target of rapamycin complex 1 (mTORC1) plays a critical role in the regulation of cell growth and energy state. A novel stress-inducible protein, Sestrin2 was recognized as a sensor for mTORC1 pathway.Hypothesis: The cardiac mTORC1 activation modulated by Sestrin2 is impaired in aging that sensitizes heart to hypertrophy.Methods: C57BL/6J young WT (4-6 months) and aged WT mice (24-26 months), and young Sestrin2 knockout mice (4-6 months) were subjected to transverse aortic constriction (TAC) for pressure overload. The ex vivo working heart perfusion was used for measuring substrate metabolism....
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nanhu Quan, Courtney Cates, Thomas Rousselle, Ji Li Tags: Poster Abstract Presentations Source Type: research
Abstract P450: AT2 Receptor Stimulation Reduces Ischemic Brain Damage Through AT2 Receptor-interacting Protein Signal Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusions: These results suggested that ATIP could enhance the cerebral protective effects of AT2 receptor stimulation at least in part due to the increase of CBF and MMS2 expression after ischemia.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Akinori Higaki, Masanori Kukida, Hirotomo Nakaoka, Toshifumi Yamauchi, Hui-Yu Bai, Bao-Shuai Shan, Li-Juan Min, Masatsugu Horiuchi Tags: Poster Abstract Presentations Source Type: research
Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced HypertensionNovelty and Significance Brain
The brain is highly susceptible to injury caused by hypertension because the increased blood pressure causes artery remodeling that can limit cerebral perfusion. Mineralocorticoid receptor (MR) antagonism prevents hypertensive cerebral artery remodeling, but the vascular cell types involved have not been defined. In the periphery, the endothelial MR mediates hypertension-induced vascular injury, but cerebral and peripheral arteries are anatomically distinct; thus, these findings cannot be extrapolated to the brain. The parenchymal arterioles determine cerebrovascular resistance. Determining the effects of hypertension and ...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Janice M. Diaz-Otero, Courtney Fisher, Kelsey Downs, M. Elizabeth Moss, Iris Z. Jaffe, William F. Jackson, Anne M. Dorrance Tags: Hypertension, Vascular Disease Original Articles Source Type: research
Outcomes of Unrelated Donor Stem Cell Transplant with Post-Transplant Cyclophosphamide for Graft-versus-Host Disease Prophylaxis in Patients with Severe Sickle Cell Disease
Sickle cell disease (SCD) is a hemoglobinopathy affecting 1 in every 500 African American newborns and an estimated 100,000 persons in the United States [1]. Vascular occlusion caused by the sickled RBCs leads to decreased perfusion in target organs and manifests clinically as vaso-occlusive pain crisis, stroke (cerebral infarction), pulmonary restrictive disease, and pulmonary hypertension [2]. Despite advances in supportive care, including the use of hydroxyurea (HU), RBC transfusion, and iron chelation therapy, patients with SCD continue to experience considerable morbidity and mortality in their lifetime.
Source: Biology of Blood and Marrow Transplantation - October 20, 2017 Category: Hematology Authors: Hemalatha G. Rangarajan, Rolla Abu-Arja, Vinita Pai, Gregory M.T. Guilcher, Sandeep Soni Source Type: research
Outcomes of Unrelated Donor Stem Cell Transplantion with Post-Transplant Cyclophosphamide for Graft-versus-Host Disease Prophylaxis in Patients with Severe Sickle Cell Disease
Sickle cell disease (SCD) is a hemoglobinopathy affecting 1 in every 500 African American newborns and an estimated 100,000 persons in the United States [1]. Vascular occlusion caused by the sickled RBCs leads to decreased perfusion in target organs and manifests clinically as vaso-occlusive pain crisis, stroke (cerebral infarction), pulmonary restrictive disease, and pulmonary hypertension [2]. Despite advances in supportive care, including the use of hydroxyurea (HU), RBC transfusion, and iron chelation therapy, patients with SCD continue to experience considerable morbidity and mortality in their lifetime.
Source: Biology of Blood and Marrow Transplantation - October 20, 2017 Category: Hematology Authors: Hemalatha G. Rangarajan, Rolla Abu-Arja, Vinita Pai, Gregory M.T. Guilcher, Sandeep Soni Source Type: research
Semi-quantitative assessment of pulmonary arterial hypertension associated with congenital heart disease through myocardial perfusion imaging.
CONCLUSION: Semi-quantitative MPI has high diagnostic value in evaluating the severity level of pulmonary arterial hypertension in patients with congenital heart disease. The diagnostic performance of MPI at pre-treatment patients was superior to that at post-treatment. More cases need to be included for further study.
PMID: 29177254 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Plasma microparticles in Alzheimer ’s disease: The role of vascular dysfunction
We examined the plasma changes of endothelial MPs (EMPs) and platelet MPs (PMPs) in AD patients with vascular risk factors. The plasma Annexin V+ CD 41a− CD144+ EMPs and Annexin V+ CD41a+ CD144− PMPs of 37 patients with AD, with or without vascular risk factors (hypertension, diabetes, dyslipidemia, stroke, coronary artery disease, and smoking), and 10 age-matched controls were quantified by flow cytometry. Pearson correlation analysis used to evaluate the linear relationship between variables. Significantly higher plasma levels of EMPs were observed in AD patients with vascular risk factors as compared to the patients...
Source: Metabolic Brain Disease - December 5, 2017 Category: Neurology Source Type: research
What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease?
Authors: Willen SM, Gladwin MT
Abstract
Patient case: An 18-year-old male patient with homozygous hemoglobin SS disease was evaluated for progressive dyspnea and elevated tricuspid regurgitant jet velocity (TRV) on echocardiography. The patient's case is described in detail in Lancet1 He had been treated with regular transfusions since childhood for stroke, had rare episodes of vaso-occlusive pain episodes, and did not take narcotic pain medications. He presented with progressive severe dyspnea on exertion and lower extremity edema. His laboratory tests were notable for a total hemoglobin level of 11.8 g/dL and hem...
Source: Hematology ASH Education Program - December 10, 2017 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Right Ventricular Perfusion Physiology and Clinical Implications
Regulation of blood flow to the right ventricle differs significantly from that to the left ventricle. The right ventricle develops a lower systolic pressure than the left ventricle, resulting in reduced extravascular compressive forces and myocardial oxygen demand. Right ventricular perfusion has eight major characteristics that distinguish it from left ventricular perfusion: (1) appreciable perfusion throughout the entire cardiac cycle; (2) reduced myocardial oxygen uptake, blood flow, and oxygen extraction; (3) an oxygen extraction reserve that can be recruited to at least partially offset a reduction in coronary blood ...
Source: Anesthesiology - December 12, 2017 Category: Anesthesiology Source Type: research
Cerebral Perfusion Monitoring in Adult Patients Following Cardiac Surgery: An Observational Study.
CONCLUSIONS: The prevalence of low cerebral oximetry values underscores the importance of increasing the sensitivity of monitoring tools. Further evaluation is required to assess the value of this modality and the role of nurses in optimizing neurocognitive outcomes.
PMID: 29284341 [PubMed - as supplied by publisher]
Source: Contemporary Nurse - December 30, 2017 Category: Nursing Tags: Contemp Nurse Source Type: research
Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database
ConclusionsThese data describe contemporary patient characteristics, operative strategies, and outcomes for AAAD in North America. Mortality and morbidity for AAAD remain high.
Source: Journal of Cardiac Surgery - December 1, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Teng C. Lee, Zachary Kon, Faisal H. Cheema, Maria V. Grau ‐Sepulveda, Brian Englum, Sunghee Kim, Paramita S. Chaudhuri, Vinod H. Thourani, Gorav Ailawadi, G. Chad Hughes, Matthew L. Williams, J. Matthew Brennan, Lars Svensson, James S. Gammie Tags: ORIGINAL ARTICLE Source Type: research
Commentary on “Post-carotid Endarterectomy Hypertension. Part 2: Association with Peri-operative Clinical, Anaesthetic, and Transcranial Doppler Derived Parameters”
Guidance on peri-operative haemodynamics is crucial to prevent procedural stroke in carotid endarterectomy (CEA) by preserving cerebral perfusion.1,2 Newman et al. suggest a one size fits all post-operative systolic blood pressure (BP) policy treating > 170 mmHg or > 160 mmHg in patients with symptoms.3 This policy causes significant overtreatment, as two in five CEA patients will undergo in hospital BP lowering treatment for several days, leading to a high workload, increased in hospital costs, and bed occupancy.
Source: European Journal of Vascular and Endovascular Surgery - February 28, 2018 Category: Surgery Authors: Leonie M.M. Fassaert, Gert J. de Borst Tags: Correspondence Source Type: research
Cerebral Haemodynamics: Effects of Systemic Arterial Pulsatile Function and Hypertension
AbstractPurpose of ReviewConcepts of pulsatile arterial haemodynamics, including relationships between oscillatory blood pressure and flow in systemic arteries, arterial stiffness and wave propagation phenomena have provided basic understanding of underlying haemodynamic mechanisms associated with elevated arterial blood pressure as a major factor of cardiovascular risk, particularly the deleterious effects of isolated systolic hypertension in the elderly. This topical review assesses the effects of pulsatility of blood pressure and flow in the systemic arteries on the brain. The review builds on the emerging notion of the...
Source: Current Hypertension Reports - March 19, 2018 Category: Primary Care Source Type: research
