Inducing ketogenesis via an enteral formulation in patients with acute brain injury:a phase II study.

Inducing ketogenesis via an enteral formulation in patients with acute brain injury:a phase II study. Neurol Res. 2020 Feb 26;:1-11 Authors: White H, Venkatesh B, Jones M, Kruger PS, Walsham J, Fuentes H Abstract Objective: Although extensively studied in children, the safety and tolerability of ketone supplementation in adults is unclear, particularly in the acute brain injury population. The purpose of this study was to examine the feasibility and safety of inducing ketosis using an enteric ketogenic formulation and determine its impact on intracranial and cerebral perfusion pressures and metabolic parameters.Methods: Prospective interventional Phase II trial of ventilated critically ill patients with acute brain injury administered a ketogenic feed over a 6 day period.Results: 20 patients were recruited, 5 females and 15 males, 3 with stroke, 2 with subarachnoid haemorrhage and 15 with traumatic brain injury. Feeds were well tolerated with 19 patients completing study. There was a significant increase in both plasma beta-hydroxybutyrate and acetoacetate from 0.24± 0.31 mmol/l and 0.19 ± 0.16 mmol/l to 0.61 ± 0.53 mmol/l (p =0.0005) and 0.52 ± 0.40 mmol/l (p
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research

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