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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Abstract P451: Cerebrovasuclular Events in Patients With Primary Aldosteronism: Results of the PA Sendai Study Registry Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Background: Hyperaldosteronism is associated with the risk of cardio-and cerebrovascular events (CVE) that is independent of blood pressure levels and Primary aldosteronism (PA) display a higher risk of CVE compared with essential hypertension (EH).Objective: Our objective was to elucidate the prevalence of symptomatic stroke in PA patients and to characterize their clinical features.Design and Setting: This was a retrospective cross-sectional single center study (PA Sendai Study registry) between 2007 and 2016 in Japan.Patient: 807 patients with PA were registered and analyzed. The all patients were performed adrenal veno...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Masataka Kudo, Ryo Morimoto, Syuji Mugikura, Yuta Tezuka, Kei Omata, Mashiro Nezu, Yasuhiro Igarashi, Kazumasa Seiji, Kei Takase, Sadayoshi Ito, Fumitoshi Satoh Tags: Poster Abstract Presentations Source Type: research
Abstract P521: Relationship Between Carotid Arterial Elastic Properties and Central Aortic Hemodynamics in Patients with Stroke Session Title: Vascular
This study aims to investigate the association between carotid artery parameters and central aortic hemodynamics in patients with ischemic stroke.Methods: A total of 101 consecutive patients with ischemic stroke who underwent clinically indicated transesophageal echocardiography (TEE) were performed carotid ultrasonography to assess vascular elastic properties. Using velocity-vector imaging (VVI), instantaneous vessel area (cm2) and deformation as fractional area change (FAC, %) and circumferential strain (%) were obtained in both cross-sectional image of common carotid artery (CA) and descending thoracic aorta (DTA) durin...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sung-ai Kim, Sang-Ho Jo, Kyung-Ha Park, Hyun-Sook Kim Tags: Poster Abstract Presentations Source Type: research
Abstract P012: Mycophenolate Mofetil Prevents Cerebrovascular Injury in Stroke-prone Spontaneously Hypertensive Rats Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
The stroke-prone spontaneously hypertensive rat strain (SHR-A3) develops hypertensive end-organ injury, including strokes and progressive kidney disease, as a result of naturally occurring genetic variations. Our recent work identifies genetic variants in immune signaling pathways that contribute to susceptibility to end organ injury. These variants are present in SHR-A3 animals, but absent in SHR lines that resist end organ injury. To test the hypothesis that a dysregulated immune response promotes stroke susceptibility, 20-week old male SHR-A3 rats were salt loaded (1% NaCl in drinking water) and treated daily with the i...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Dhande, I. S., Zhu, Y., Doris, P. A. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research
Abstract P396: The Stroke Belt: Forged in the Heat of the Buckle? A Hypothesis Session Title: Epidemiology
The “stroke belt”(SB) in the SE USA has significantly higher stroke rates in whites (W) and African Americans (AA). HTN is the major driving force. The “Buckle” (B) of the SB, with even higher rates, lies along the costal “low country” plains of the Carolinas. Being born in the B is a powerful exposure that increases risk. Forty percent of all US slaves came thru, slaved and many died in the B of the SB. While reading the scholarly review “Slavery, Disease and Suffering in the Southern Low Country”, by Dr. Peter McCandless, (Cambridge U Press, 2011) I was stuck with the effect of the hot, humid weather with...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Clarence Grim Tags: Poster Abstract Presentations Source Type: research
Abstract P454: Does Intensive Pulse Pressure control results in lower rates of cardiovascular events? An Analysis of Systolic BP Intervention Trial (SPRINT) database Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusion: In the SPRINT database of 9347 participants, we found that higher PP conferred an increased risk for multiple adverse cardiovascular event. Our study is among the largest US studies of PP and adds further support to the prognostic utility of PP. In addition, the SPRINT database offers a contemporary analysis of the relationship between PP and DBP, which is important given that nature pathophysiology of blood pressure. Current study also strengthen the possibility that DBP
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Quan Tran Tags: Poster Abstract Presentations Source Type: research
Common Carotid Artery Diameter and Risk of Cardiovascular Events and MortalityNovelty and Significance Epidemiology/Population
Carotid arterial diameter enlargement is a manifestation of arterial remodeling and may be a risk factor for cardiovascular disease (CVD). We evaluated the association between carotid artery diameter and risk of stroke, coronary heart disease, CVD, and all-cause mortality and explored whether the associations could be explained by processes involved in arterial remodeling, that is, blood pressure–related media thickening, arterial stiffness, arterial wall stress, and atherosclerosis. We included 4887 participants (mean age 67±9 years; 54% women) from 4 cohort studies: Rotterdam Study, NEPHROTEST, Hoorn Study, and a stud...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Sanaz Sedaghat, Thomas T. van Sloten, Stephane Laurent, Gerard M. London, Bruno Pannier, Maryam Kavousi, Francesco Mattace–Raso, Oscar H. Franco, Pierre Boutouyrie, M. Arfan Ikram, Coen D.A. Stehouwer Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Ultrasound, Cerebrovascular Disease/Stroke Original Articles Source Type: research
Modeling Superimposed Preeclampsia Using Ang II (Angiotensin II) Infusion in Pregnant Stroke-Prone Spontaneously Hypertensive RatsNovelty and Significance Preeclampsia
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and developing treatment options are crucial. The pregnant stroke-prone spontaneously hypertensive rat has impaired uteroplacental blood flow and abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats to mimic the increased cardiovascular stress associated with superimposed preeclampsia and examine ...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Hannah L. Morgan, Elaine Butler, Shona Ritchie, Florian Herse, Ralf Dechend, Elisabeth Beattie, Martin W. McBride, Delyth Graham Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Animal Models of Human Disease, Hypertension, Preeclampsia Original Articles Source Type: research
Interaction Between Chromosome 2 and 3 Regulates Pulse Pressure in the Stroke-Prone Spontaneously Hypertensive Rat Genetics
In an F2 cross between stroke-prone spontaneously hypertensive (SHRSP) and Wistar Kyoto (WKY) rats, we previously identified blood pressure quantitative trait loci (QTL) on rat chromosome (RNO) 2 and a pulse pressure QTL on RNO3. The aims of this study were to confirm the QTL on RNO3 and to investigate interaction between RNO2 and RNO3 loci through the generation and phenotypic assessment of single RNO3 congenic (SP.WKYGla3a) and bicongenic (SP.WKYGla2a/3a) strains. Hemodynamic profiling, vascular function, and renal histology were examined in these newly generated strains along with the previously reported RNO2 congenic s...
Source: Hypertension - June 12, 2013 Category: Cardiology Authors: Koh-Tan, H. H. C., McBride, M. W., McClure, J. D., Beattie, E., Young, B., Dominiczak, A. F., Graham, D. Tags: Animal models of human disease, Peripheral vascular disease Genetics Source Type: research
Circulating Endothelin-1 Alters Critical Mechanisms Regulating Cerebral Microcirculation Endothelin
Endothelin-1 (ET1) is a potent vasoconstrictor peptide implicated in the cerebrovascular alterations occurring in stroke, subarachnoid hemorrhage, and brain trauma. Brain or circulating levels of ET1 are elevated in these conditions and in risk factors for cerebrovascular diseases. Most studies on the cerebrovascular effects of ET1 have focused on vascular smooth muscle constriction, and little is known about the effect of the peptide on cerebrovascular regulation. We tested the hypothesis that ET1 increases cerebrovascular risk by disrupting critical mechanisms regulating cerebral blood flow. Male C57Bl6/J mice equipped w...
Source: Hypertension - September 11, 2013 Category: Cardiology Authors: Faraco, G., Moraga, A., Moore, J., Anrather, J., Pickel, V. M., Iadecola, C. Tags: Cerebrovascular disease/stroke, Brain Circulation and Metabolism, Endothelium/vascular type/nitric oxide Endothelin Source Type: research
Hypertension: A Harbinger of Stroke and Dementia Brief Review
Source: Hypertension - October 16, 2013 Category: Cardiology Authors: Faraco, G., Iadecola, C. Tags: Cerebrovascular disease/stroke Brief Review Source Type: research
Abstract 567: Combined Treatment With Irbesartan and Vitamin D Retards Renal Injury in Salt-loaded Uni-nephrectomized Stroke-prone Spontaneously Hypertensive Rats Poster Session II
Vitamin D diminishes renin expression. In addition, we previously reported that vitamin D increased renal expression of klotho in rats with normal kidney function. In the present study, effects of vitamin D on renal injury was assessed in four groups of rats (n=6-8 for each group); uni-nephrectomized stroke-prone spontaneously hypertensive rats fed high salt (6%) diet as a control (C), those treated with irbesartan (100 mg/kg/day) (I), rats treated with calcitriol (30 ng/kg/day) (V), and rats treated with both irbesartan and calcitriol (I+V). Six weeks later, rats were killed with over-anesthesia, and harvested right kidne...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Takenaka, T., Inoue, T., Ohno, Y., Miyazaki, T., Nishiyama, A., Ishii, N., Suzuki, H. Tags: Poster Session II Source Type: research
Optimum Blood Pressure Target After Lacunar Stroke: Pro Side of the Argument Controversies in Hypertension
Source: Hypertension - April 9, 2014 Category: Cardiology Authors: Hankey, G. J., Lacey, B. Tags: Other hypertension, Other Stroke Treatment - Medical Controversies in Hypertension Source Type: research
Healthy Lifestyle Factors and Risk of Cardiovascular Events and Mortality in Treatment-Resistant Hypertension: The Reasons for Geographic and Racial Differences in Stroke Study Epidemiology/Population
In conclusion, healthy lifestyle factors, particularly physical activity and nonsmoking, are associated with a lower risk for cardiovascular events and mortality among individuals with apparent treatment-resistant hypertension.
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Diaz, K. M., Booth, J. N., Calhoun, D. A., Irvin, M. R., Howard, G., Safford, M. M., Muntner, P., Shimbo, D. Tags: Other hypertension, Epidemiology Epidemiology/Population Source Type: research
Origin of the Y Chromosome Influences Intrarenal Vascular Responsiveness to Angiotensin I and Angiotensin (1-7) in Stroke-Prone Spontaneously Hypertensive Rats Renin-Angiotensin System and Y Chromosome
This study demonstrates that the origin of the Y chromosome significantly impacts the renal vascular responsiveness and therefore may influence the long-term renal regulation of blood pressure.
Source: Hypertension - November 12, 2014 Category: Cardiology Authors: Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Head, G. A., Thomas, M. C., Chin-Dusting, J. P. F., Dominiczak, A. F., Jennings, G. L. Tags: Cardio-renal physiology/pathophysiology, ACE/Angiotension receptors, Animal models of human disease, Other hypertension, Functional genomics, Genetics of cardiovascular disease Renin-Angiotensin System and Y Chromosome Source Type: research
Epidermal Growth Factor Receptor Is Critical For Angiotensin II-Mediated Hypertrophy in Cerebral Arterioles Renin-Angiotensin System
We examined the molecular mechanism of Ang II–mediated cerebrovascular remodeling that involves the epidermal growth factor receptor (EGFR) pathway. Mutant EGFR mice (waved-2), their heterozygous control (wild-type [WT]), and C57BL/6J mice were infused with Ang II (1000 ng kg–1 min–1) or saline via osmotic minipumps for 28 days (n=8 per group). Eight of the Ang II–infused C57BL/6J mice were cotreated with AG1478 (12 mg/kg per day, IP), a specific EGFR tyrosine kinase inhibitor. Systolic arterial pressure was measured by a tail-cuff method. Pressure and diameter of cerebral arterioles were measured t...
Source: Hypertension - March 11, 2015 Category: Cardiology Authors: Chan, S.-L., Umesalma, S., Baumbach, G. L. Tags: Cerebrovascular disease/stroke, Hypertrophy, Other Vascular biology Renin-Angiotensin System Source Type: research
