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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Stages in Discovery: Angiotensin-Converting Enzyme Type 2 and Stroke Editorial Commentaries
Source: Hypertension - June 10, 2015 Category: Cardiology Authors: Pena-Silva, R. A., Heistad, D. D. Tags: ACE/Angiotension receptors, Cerebrovascular disease/stroke, Other hypertension, Acute Cerebral Infarction, Neuroprotectors Editorial Commentaries Source Type: research
Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With Brachydactyly Genetics
Autosomal-dominant hypertension with brachydactyly is a salt-independent Mendelian syndrome caused by activating mutations in the gene encoding phosphodiesterase 3A. These mutations increase the protein kinase A–mediated phosphorylation of phosphodiesterase 3A resulting in enhanced cAMP-hydrolytic affinity and accelerated cell proliferation. The phosphorylated vasodilator-stimulated phosphoprotein is diminished, and parathyroid hormone-related peptide is dysregulated, potentially accounting for all phenotypic features. Untreated patients die prematurely of stroke; however, hypertension-induced target-organ damage is ...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Toka, O., Tank, J., Schachterle, C., Aydin, A., Maass, P. G., Elitok, S., Bartels-Klein, E., Hollfinger, I., Lindschau, C., Mai, K., Boschmann, M., Rahn, G., Movsesian, M. A., Muller, T., Doescher, A., Gnoth, S., Muhl, A., Toka, H. R., Wefeld-Neuenfeld, Y Tags: Cerebrovascular disease/stroke, Clinical Studies Genetics Source Type: research
Abstract P075: Stroke Volume and Visceral Fat Drive Differences in Blood Pressure Between Two Generations: A Population-Based Study of Adolescents and Their Parents Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Excess total body fat (TBF) and visceral fat (VF) are major risk factors of hypertension. Blood pressure (BP) increases with age, as do TBF and VF. Here we investigated whether TBF and VF contribute to BP differences between adolescents and adults. A population-based sample of adolescents (n=933, 12-18 years) and their parents (n=429, 38-65 years) was studied as part of the Saguenay Youth Study. In all participants, beat-by-beat values of SBP, DBP and underlying hemodynamic parameters (heart rate, stroke volume [SV] and total peripheral resistance) were obtained with a Finometer during a 52-minute protocol mimicking daily ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Syme, C. A., Abrahamowicz, M., Leonard, G., Perron, M., Richer, L., Veillette, S., Gaudet, D., Paus, T., Pausova, Z. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research
Abstract P157: Tractography of White Matter Connections Predicts for Vascular Cognitive Impairment in Hypertensive Patients Session Title: Cerebrovascular Disease and Stroke
In this study, we used DTI and cognitive assessment (CA), in order to identify a regional pattern of fractional anisotropy (FA) changes that could predict for VCI in hypertensive patients (HT).We have examined 15 HT (moderate to severe, with antihypertensive medications) vs 15 normotensive (NT), subjecting them to DTI and CA. HT had significant higher SBP (138±4 vs 118±3 in NT) and DBP (87±2 vs 75±2 in NT) (p<0.001), displayed a significant LV hypertrophic remodeling (LVM/BSA 112±5 vs 83±3 for NT) (p<0.0001), with a significant moderate increase in albuminuria (15.7±2....
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Carnevale, L., Selvetella, G., Cugino, D., Grillea, G., Lembo, G., Carnevale, D. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P158: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure Session Title: Cerebrovascular Disease and Stroke
Conclusions: These data indicate that elevated levels of CatK are closely associated with the presence of CHF and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of cardiac remodeling and dysfunction in patients with CHF.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Cheng, X. W., Zhao, G., Han, X., Fang, E., Li, X., Zhou, D., Jiang, H., Li, Y., Cui, L. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P159: Effect of Pharmacological Kinin Receptor Activation on Brain Damage and Mortality in Experimental Cerebral Ischemia in Non-diabetic and Diabetic Mice Session Title: Cerebrovascular Disease and Stroke
Brain ischemia is a major complication of arterial diseases and has a poorer prognosis in diabetic patients. As activation of the kallikrein-kinin system has been shown to enhance cardiac and renal tolerance to ischemia we tested effect of kinin receptor activation by pharmacological agonists, selective B1R or B2R, in a mouse model of transient middle cerebral artery occlusion [C57bl6 male, 10 week-old, anaesthesia, occlusion 60 min (MCAO)]. Treatment with the B1R agonist NG29 (B1Rago) or the B2R agonist NG291 (B2Rago) was started at reperfusion using osmotic micropumps. Neurological deficit (ND) was evaluated at 1 and 2 d...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Desposito, D., Taveau, C., Zadigue, G., Adam, C., Bouby, N., Alhenc-Gelas, F., Roussel, R. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P161: Angiotensin Receptor Blockade Decreases Glutamate-induced Brain Inflammation Session Title: Cerebrovascular Disease and Stroke
Chronic Kidney Disease (CKD) is very frequently associated with brain inflammation and cell injury leading to cognitive loss. At present a combined treatment of related kidney and brain injury has never been proposed. We focused on glutamate-induced excitotoxicity and neuronal inflammation, and on the effects of candesartan, a renoprotective Angiotensin Receptor Blocker (ARB) ameliorating hypertension and diabetes-induced kidney damage, and with accompanying neuroprotective efficacy. Primary cerebellar granule cells (CGC) were exposed to 100 μM glutamate and pre-treated for one hour with candesartan at neuroprotective c...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Saavedra, J., Elkahloun, A. G., Hafko, R. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Medication Adherence and the Risk of Cardiovascular Mortality and Hospitalization Among Patients With Newly Prescribed Antihypertensive Medications Epidemiology/Population
This study evaluated the effect of antihypertensive medication adherence on specific cardiovascular disease mortality (ischemic heart disease [IHD], cerebral hemorrhage, and cerebral infarction). Our study used data from a 3% sample cohort that was randomly extracted from enrollees of Korean National Health Insurance. Study subjects were aged ≥20 years, were diagnosed with hypertension, and started newly prescribed antihypertensive medication in 2003 to 2004. Adherence to antihypertensive medication was estimated as the cumulative medication adherence. Subjects were divided into good (cumulative medication adherence, &g...
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Kim, S., Shin, D. W., Yun, J. M., Hwang, Y., Park, S. K., Ko, Y.-J., Cho, B. Tags: Cardiovascular Disease, Primary Prevention, Compliance/Adherence, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research
Role of Tumor Necrosis Factor-{alpha} and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive RatNovelty and Significance Pregnancy and Hypertension
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse pregnancy outcome compared with the control Wistar–Kyoto. The activation of the immune system plays a role in hypertension and adverse pregnancy outcome. Therefore, we investigated the role of tumor necrosis factor-α in the SHRSP phenotype in an intervention study using etanercept (0.8 mg/kg SC) at gestational days 0, 6, 12, and 18 in pregnant SHRSP compared with vehicle-tre...
Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T. J., Graham, D., Delles, C. Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Hypertension, Preeclampsia Original Articles Source Type: research
Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive RatNovelty and Significance Uromodulin in Hypertensive Pregnancy
The kidney is centrally involved in blood pressure regulation and undergoes extensive changes during pregnancy. Hypertension during pregnancy may result in an altered urinary peptidome that could be used to indicate new targets of therapeutic or diagnostic interest. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of maternal chronic hypertension. Capillary electrophoresis-mass spectrometry was conducted to interrogate the urinary peptidome in SHRSP and the control Wistar–Kyoto strain at three time points: prepregnancy and gestational days 12 and 18. The comparison within and between the Wistar–Kyoto ...
Source: Hypertension - April 12, 2017 Category: Cardiology Authors: Sheon Mary, Heather Yvonne Small, Justyna Siwy, William Mullen, Ashok Giri, Christian Delles Tags: Animal Models of Human Disease, Proteomics, Hypertension Original Articles Source Type: research
Vitamin D, Hypertension, and Ischemic Stroke Editorial Commentary
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Ronen Levi-Vardi, Yoram Yagil Tags: Epidemiology, Genetic, Association Studies, High Blood Pressure, Ischemic Stroke Editorial Commentaries Source Type: research
Abstract P257: Investigating Angiotensin II Infusion as a Model of Superimposed Preeclampsia in Pregnant Stroke Prone Spontaneously Hypertensive Rats Session Title: Onsite Poster Competition II
Background: Hypertensive disorders of pregnancy are a leading cause of maternal mortality worldwide. Chronic hypertension with superimposed preeclampsia is becoming more prevalent in modern society. Animal models are vital for understanding this condition. Our aim was to induce a preeclamptic phenotype in pregnant stroke prone spontaneously hypertensive (SHRSP) rats by angiotensin II (AngII) infusion.Methods: AngII, at a dose of 500ng/kg/min or 1000ng/kg/min, was administered by minipump in pregnant SHRSP rats from gestational day (GD)10. Cardiovascular and renal changes were monitored using radiotelemetry, echocardiograph...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hannah L Morgan, Elaine Butler, Elisabeth Beattie, Martin W McBride, Delyth Graham Tags: Poster Abstract Presentations Source Type: research
Abstract P401: The Progress of Carotid Atherosclerosis is Associated With Incident Stroke and Coronary Heart Disease: The Suita Study Session Title: Epidemiology
Conclusions: The novel finding of this study is that CIMT-plaque progression could be a good predictor of new-onset CVD in a general population.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Yoshihiro Kokubo, Makoto Watanabe, Aya Higashiyama, Yoko M Nakao, Fumiaki Nakamura, Yoshihiro Miyamoto Tags: Poster Abstract Presentations Source Type: research
Abstract P444: Surveillance, Control, and Prevention Systems and Community Engagement Process of Hypertension in Singburi, Thailand Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
This study was to convert disease oriented to health promotion approach to primary health care, using “ VICHAI’s 7 Color Balls Model”, which was used for primary screening of hypertension. The target population aged 15-65 which covering more than 90% of Singburi population. The screening result was classified by types and levels of severity of hypertension (blood pressure).The 7 colors are referred to normal
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Vichai Tiienthavorn Tags: Poster Abstract Presentations Source Type: research
Left Ventricular Wall Stress-Mass-Heart Rate Product and Cardiovascular Events in Treated Hypertensive Patients: LIFE Study Clinical Trial
In the Losartan Intervention for End Point Reduction in Hypertension (LIFE) study, 4.8 years’ losartan- versus atenolol-based antihypertensive treatment reduced left ventricular hypertrophy and cardiovascular end points, including cardiovascular death and stroke. However, there was no difference in myocardial infarction (MI), possibly related to greater reduction in myocardial oxygen demand by atenolol-based treatment. Myocardial oxygen demand was assessed indirectly by the left ventricular massxwall stressxheart rate (triple product) in 905 LIFE participants. The triple product was included as time-varying covariate...
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: Devereux, R. B., Bang, C. N., Roman, M. J., Palmieri, V., Boman, K., Gerdts, E., Nieminen, M. S., Papademetriou, V., Wachtell, K., Hille, D. A., Dahlof, B. Tags: Hypertrophy, Other etiology Clinical Trial Source Type: research
