Filtered By:
Source: Hypertension
Condition: Hypertension
This page shows you your search results in order of relevance. This is page number 16.
Order by Relevance | Date
Total 260 results found since Jan 2013.
Abstract P279: Mapping of Chromosome 2 Differentially Expressed Aortic Genes Linked to Vascular Inflammation Using Congenic Rats Fed a High-salt Diet Session Title: Onsite Poster Competition II
Background: Three congenic rat strains (SB2a, SB2b and SB2e) were created by chromosome (Chr) 2 fragment introgression from normotensive Brown Norway (BN) rats into hypertensive Dahl salt sensitive (SS) background. SB2a and SB2b rats fed a normal-salt diet presented reduced blood pressure (BP) and inflammation when compared to SS rats. We hypothesized that BN-Chr2 contains antihypertensive and anti-inflammatory genes that could prevent high-salt diet (HSD)-induced BP elevation and vascular injury in SB2a and SB2b rats. These genes will be identified using microRNA (miRNA) and total RNA expression profiling analysis in aort...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Olga Berillo, Sofiane Ouerd, Ku-Geng Huo, Chantal Richer, Daniel Sinnett, Anne E Kwitek, Pierre Paradis, Ernesto L Schiffrin Tags: Poster Abstract Presentations Source Type: research
Abstract P304: Motivia(R), a Cardiovascular Disease Prevention Program, Decreases Hospitalization Length in Patients With High Risk for Developing Cardiovascular Event. Retrospective Analysis From 2010-2015 Session Title: Pregnancy and Preeclampsia and Developmental Programming of Cardiovascular Disease
Conclusions: Motivia® program, based on intensive treatment using TPA determination may benefit patients and health insurance by decreasing hospitality length.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hernan A Perez, Natalia Jorgensen, Santiago Torales, Andres Chianalino, Luis J Armando Tags: Poster Abstract Presentations Source Type: research
Abstract P334: Persistent Adrenomedullin Derivative Inhibits Development of Hypertension Session Title: Salt and Hypertension
Human adrenomedullin (hAM) consists of a 52 amino acid peptide that is amidated and has a disulfide bond. The bioactive peptide hAM has a variety of physiological functions, such as vasodilatation, hormone secretion, neurotransmission, embryogenesis, wound healing and immunoregulation. hAM has shown several therapeutic effects in experimental models of various diseases, including ischemic heart disease, inflammatory bowel disease, stroke and retinochoroidal disease. However, these therapies required continuous administration of hAM as the half-life of native hAM is quite short in blood. To resolve these issues, the aim of ...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sayaka Nagata, Motoo Yamasaki, Kazuo Kitamura Tags: Poster Abstract Presentations Source Type: research
Abstract P346: Diurnal Variation of Serum Uric Acid Levels and Corresponding Variations of Oxidative Stress Makers in Patients With Hypertension and Stable Coronary Artery Disease Session Title: Inflammation, Immunity and Cytokines, Endothelial Factors, and Oxidative Stress
Discussion: Serum UA levels showed diurnal variation even in patients with hypertension and CAD. Considering the fact that oxidative stress makers showed corresponding diurnal variations, diurnal variation of serum UA level may play a role in the pathogenesis of CAD.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Megumi Shimizu, Takatoshi Kasai, Shoichiro Yatsu, Azusa Murata, Hiroki Matsumoto, Jun Shitara, Takao Kato, Shoko Suda, Masaru Hiki, Ryo Naito, Kazunori Shimada, Hiroyuki Daida Tags: Poster Abstract Presentations Source Type: research
Abstract P351: Cornell Product in Electrocardiogram is More Strongly Related to LV Regional Wall Motion Than Sokolow-Lyon Voltage Session Title: Cardiac Hypertrophy and Dysfunction and Coronary Artery Disease and Hypertension
Backgrounds: Left ventricular hypertrophy (LVH) evaluated by Cornell product in electrocardiogram predicted future stroke events greater than LVH by Sokolow-Lyon voltage. Therefore, we evaluated whether Cornell product was related to regional myocardial wall motion greater than Sokolow-Lyon voltage.Methods: We enrolled 288 hypertensive patients who were performed echocardiography for evaluating target organ damage. Cornell product was calculated as follows; R in aVL lead + S in V3 lead (0.6 mV added in female)хQRS duration; Sokolow-Lyon voltage, R in V5 lead + S in lead V1. We evaluated left ventricular mass index (LVMI),...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Joji Ishikawa, Yuko Yamanaka, Shintaro Watanabe, Kazumasa Harada Tags: Poster Abstract Presentations Source Type: research
Abstract P378: Current Progress of Antihypertensive Medication Use According to Healthy People 2020 Goals Among Adults With Hypertension- the National Health Interview Survey 2014-2015 Session Title: Blood Pressure Control and Adherence to Treatment
Conclusion: To control hypertension, most patients require antihypertensive medications to achieve control. Understanding disparities in antihypertensive medication utilization is needed for all population to achieve Healthy People 2020 targets by the end of the decade.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jing Fang, Carma Ayala, Fleetwood Loustalot Tags: Poster Abstract Presentations Source Type: research
Abstract P392: Autonomic Reflexes Mask the Hemodynamic Effects of Continuous Positive Airway Pressure Session Title: Neurogenic Mechanisms
Continuous positive airway pressure (CPAP) improves cardiac function and blood pressure (BP) in patients with sleep-breathing disorders by reducing increased sympathetic tone. The direct hemodynamic effects of increased intrathoracic pressure with CPAP, however, are not known and are likely masked by baroreflex buffering. To determine the acute hemodynamic effects of CPAP in the absence of autonomic modulation, we applied 5 levels of CPAP (0, 4, 8, 12 and 16 cm H2O, each for 2 min) to 7 healthy normotensive (NTN, 33±3 years, BMI 29±3, 4 females) and 12 hypertensive subjects (HTN, 50±2 years, BMI 30±2, 8 females) before...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Luis E Okamoto, Alfredo Gamboa, Jorge E Celedonio, Andre Diedrich, Sachin Y Paranjape, Italo Biaggioni Tags: Poster Abstract Presentations Source Type: research
Abstract P421: The Effects of Dual Angiotensin Receptor and Neprilysin Inhibitor on Organoprotection in Experimental Model of Chronic Heart Failure Session Title: Renin-Angiotensin System
The cardiac effects of dual angiotensin receptor and neprilysin inhibitor (LCZ696) as a novel therapeutic approach for inhibition of renin-angiotensin system was assessed in volume overload-induced chronic heart failure (CHF) in hypertensive Ren2 transgenic rats (TGR) with aorto-caval fistula (ACF) and compared with valsartan (VAL). CHF model was induced by ACF in male TGR at 8 weeks of age. After 5 weeks of ACF induction, LCZ696 was administered in standard dosing at 68 mg/kg/day and VAL at 31 mg/kg/day for next 15 weeks to assess the effect on mortality. In second series, 12 weeks after ACF, the animals were anaesthetize...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Libor Kopkan, Lenka Hoskova, Voȷtech Melenovsky, Zuzana Huskova, Ludek Cervenka Tags: Poster Abstract Presentations Source Type: research
Abstract P440: Renin-angiotensin Signal Develops Arterial Senescence and Atherosclerosis via Modulation of Mitochondrial Dynamics Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusion: Mitochondrial fusion plays a crucial role to retard arterial senescence and atherosclerosis by RAS-inhibition.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Yoshiyuki Ikeda, Masaaki Iwabayashi, Yuichi Sasaki, Yuichi Akasaki, Koji Higuchi, Masaaki Miyata, Mitsuru Ohishi Tags: Poster Abstract Presentations Source Type: research
Abstract P441: Accelerated Age-dependent Cardiovascular and Cognitive Decline in Dahl-S Rats is Associated with Elevated Levels of an Endogenous Na/K-ATPase Inhibitor Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Age-associated central arterial stiffening contributes to both cerebral arterial fibrosis and to cognitive impairment. Accelerated aging, accompanied by a gradual increase in blood pressure (BP) and aortic remodeling, occurs in Dahl-S rats (DSS) vs. normotensive Sprague-Dawley rats (S-D) counterparts even in the absence of a high salt intake. A novel pro-hypertensive factor marinobufagenin (MBG) is implicated in DSS hypertension. Here we determined whether an increase in MBG is also implicated in age-associated arterial remodeling in DSS.Methods: Life span was measured in 60 S-D and 78 DSS. BP, pulse wave velocity (PWV), b...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Olga V Fedorova, Yulia N Grigorova, Jeffrey M Long, Rebecca L McPherson, Ondrej Juhasz, Wen Wei, Valentina Zernetkina, Natalia Petrashevskaya, Kenneth W Fishbein, Richard G Spencer, Peter R Rapp, Edward G Lakatta Tags: Poster Abstract Presentations Source Type: research
Abstract P442: Estradiol Treatment Attenuates the Ovariectomy-induced Increase in Blood Pressure in the Middle Aged Dahl Salt Sensitive Rat as Long as Treatment is Initiated Immediately After Ovariectomy Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Introduction: Several studies have shown that ovariectomy increases blood pressure and that 17beta-estradiol (E2) treatment can attenuate this effect; however, the majority of these studies were conducted in young animals in which E2 replacement was initiated soon after ovariectomy. Since most women who experience ovarian hormone loss are middle aged rather than young, this study investigated the effect of E2 replacement in middle aged Dahl salt-sensitive (DS) rats. In addition, the time at which E2 replacement was initiated was examined.Methods: DS rats were ovariectomized (OVX) at 4.5 months (mo) (DS-OVXY) and 7mo (DS-OV...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hong Ji, Crystal A West, Xie Wu, Amrita Pai, Aline Souza, Parnika Kadam, David A West, Michelle J Zhu, Kathryn Sandberg Tags: Poster Abstract Presentations Source Type: research
Abstract P443: Multiple Chronic Conditions in Older Adults: Implications for Clinical Trials & Guidelines in Hypertension Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusions: HTN impacts ~82% of older adults with a higher burden of MCC, and ~75% (27,324/36,533) of Medicare beneficiaries with HTN have a large burden of MCCs. Behavioral health diagnosis, associated with adverse outcomes and costs, are common with MCCs. Clinical care, outcomes and costs for older adults with HTN and MCCs could improve with more representative inclusion in clinical trials and translation through integrated clinical guidelines developed by multi-specialty/disciplinary teams.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Brent M Egan, Susan E Sutherland, Valinda Rutledge, Robert A Davis, Peter L Tilkemeier, Angelo Sinopoli Tags: Poster Abstract Presentations Source Type: research
Abstract P445: Sympathetic and Renal Mechanisms of Age-related Hypertension Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Hypothesis: Sympathoexcitation and sodium retention contribute to age-related hypertension (HTN).Methods: Three, 8, and 16 month old male SD rats underwent an IV volume expansion (VE; 5% BW) and MAP, HR, urine output and paraventricular nucleus (PVN) neuronal activation (c-Fos expression) were assessed. In separate groups of rats fed a 21 day normal (NS; 0.6% NaCl) or high salt (HS; 4% NaCl) diet, measures of 1) ex vivo afferent renal nerve (ARN) activity (norepinephrine (NE)-evoked substance P release) or 2) MAP, HR, NCC activity (ΔUNaV to IV HCTZ, 2mg/kg) and sympathetic tone (plasma and renal NE content, ΔMAP to IV he...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Richard D Wainford, Alissa A Frame Tags: Poster Abstract Presentations Source Type: research
Abstract P446: Sestrin2 Suppresses Age-related Hypertrophy by Inhibiting mTORC1 Signaling Pathway Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Introduction: The mechanistic target of rapamycin complex 1 (mTORC1) plays a critical role in the regulation of cell growth and energy state. A novel stress-inducible protein, Sestrin2 was recognized as a sensor for mTORC1 pathway.Hypothesis: The cardiac mTORC1 activation modulated by Sestrin2 is impaired in aging that sensitizes heart to hypertrophy.Methods: C57BL/6J young WT (4-6 months) and aged WT mice (24-26 months), and young Sestrin2 knockout mice (4-6 months) were subjected to transverse aortic constriction (TAC) for pressure overload. The ex vivo working heart perfusion was used for measuring substrate metabolism....
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nanhu Quan, Courtney Cates, Thomas Rousselle, Ji Li Tags: Poster Abstract Presentations Source Type: research
Abstract P447: Hesperidin, Ingredient of Citrus Fruits Juice, Attenuates Cognitive Impairment Induced by Ischemic Brain Damage Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusion: Taken together, these results suggest that the intake of hesperidin in CI should prevent cognitive decline after brain ischemia at least in part due to reduction of oxidative stress and an increase in CBF.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Moe Kawakami, Jun Iwanami, Kana Tsukuda, Akinori Higaki, Li-Juan Min, Masaki Mogi, Masatsugu Horiuchi Tags: Poster Abstract Presentations Source Type: research
