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Source: Hypertension
Condition: Hypertension

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Total 260 results found since Jan 2013.

Abstract P532: Hypertension and Gender Differences in Acute Ischemic Stroke Patients Treated With Rtpa Session Title: Genetics and Epigenetics
Conclusion: The important factor for the poorer outcome and gender differences in hypertensive patients with acute ischemic stroke is mainly due to stroke severity and thrombolysis may play a major role in neutralizing this effect.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Thomas I Nathaniel, Jordan Gainey, Leah Wormack, Chibueze Ubah, Leanne Brechtel, Amber Frazier Tags: Poster Abstract Presentations Source Type: research

Abstract P452: Evaluation of Pathological Basis of a Shrsp-based Congenic Strain Characterized by Early Stroke Occurrence Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Objectives: The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-known model for essential hypertension and cerebral stroke. In the previous studies, we have identified a major blood pressure (BP) QTL on chromosome (chr) 1 of SHRSP and have explored gene(s) on the BP QTL responsible for hypertensive phenotypes of this strain through physiological analyses using reciprocal congenic strains between SHRSP and a normotensive control (Wistar-Kyoto rat, WKY). In a recent observation, we unexpectedly found that a SHRSP-based congenic strain, harboring a 0.3-Mbp fragment of the chr1 QTL, has developed stroke earlier t...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hiroki Ohara, Davis L Ngarashi, Toru Nabika Tags: Poster Abstract Presentations Source Type: research

Evidence to Maintain the Systolic Blood Pressure Treatment Threshold at 140 mm Hg for Stroke Prevention: The Northern Manhattan Study Epidemiology/Population
In 2014, the Eighth Joint National Committee revised the target maximum systolic blood pressure (SBP) from 140 to 150 mm Hg in patients aged ≥60 years without diabetes mellitus or chronic kidney disease. The evidence from cohort studies supporting this change was sparse, particularly among US minority populations. In the Northern Manhattan Study, 1750 participants aged ≥60 years and free of stroke, diabetes mellitus, and chronic kidney disease had SBP measured at baseline and were annually followed up for incident stroke. Mean age at baseline was 72±8 years, 63% were women, 48% Hispanic, 25% non-Hispanic white...
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Dong, C., Della-Morte, D., Rundek, T., Wright, C. B., Elkind, M. S. V., Sacco, R. L. Tags: Epidemiology Epidemiology/Population Source Type: research

Differential Modulation of Uncoupling Protein 2 in Kidneys of Stroke-Prone Spontaneously Hypertensive Rats Under High-Salt/Low-Potassium Diet Original Articles
In conclusion, high-salt diet downregulates the antioxidant UCP2-dependent mechanism in kidneys of SHRsp, but not of stroke-resistant SHR. A parallel differential kidney miR regulation under high-salt diet in the 2 strains may contribute to the differential UCP2 modulation. UCP2 is a critical protein to prevent oxidative stress damage in renal mesangial cells in vitro.
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Di Castro, S., Scarpino, S., Marchitti, S., Bianchi, F., Stanzione, R., Cotugno, M., Sironi, L., Gelosa, P., Duranti, E., Ruco, L., Volpe, M., Rubattu, S. Tags: Original Articles Source Type: research

Prolonged Corrected QT Interval Is Predictive of Future Stroke Events Even in Subjects Without ECG-Diagnosed Left Ventricular Hypertrophy Heart
In conclusion, prolonged QTc interval was associated with stroke risk even among patients without ECG-LVH in the general population.
Source: Hypertension - February 11, 2015 Category: Cardiology Authors: Ishikawa, J., Ishikawa, S., Kario, K. Tags: Risk Factors, Hypertrophy, Electrocardiology, Epidemiology Heart Source Type: research

Morning and Evening Home Blood Pressure and Risks of Incident Stroke and Coronary Artery Disease in the Japanese General Practice Population: The Japan Morning Surge-Home Blood Pressure Study Epidemiology/Population
Our aim is to determine the optimal time schedule for home blood pressure (BP) monitoring that best predicts stroke and coronary artery disease in general practice. The Japan Morning Surge-Home Blood Pressure (J-HOP) study is a nationwide practice-based study that included 4310 Japanese with a history of or risk factors for cardiovascular disease, or both (mean age, 65 years; 79% used antihypertensive medication). Home BP measures were taken twice daily (morning and evening) over 14 days at baseline. During a mean follow-up of 4 years (16 929 person-years), 74 stroke and 77 coronary artery disease events occurred. Morning ...
Source: Hypertension - June 7, 2016 Category: Cardiology Authors: Hoshide, S., Yano, Y., Haimoto, H., Yamagiwa, K., Uchiba, K., Nagasaka, S., Matsui, Y., Nakamura, A., Fukutomi, M., Eguchi, K., Ishikawa, J., Kario, K., on behalf of the J-HOP Study Group Tags: Hypertension Epidemiology/Population Source Type: research

Vitamin D, Hypertension, and Ischemic Stroke in 116 655 Individuals From the General PopulationNovelty and Significance Epidemiology/Population
Observational studies indicate that low concentrations of plasma 25-hydroxyvitamin D (25(OH)D) are associated with high blood pressure, hypertension, and ischemic stroke. However, whether these associations are causal remain unknown. A total of 116 655 white individuals of Danish descent from the general population were genotyped for genetic variants in DHCR7 and CYP2R1 affecting plasma 25(OH)D concentrations; 35 517 had plasma 25(OH)D measurements. Primary outcomes were blood pressure, hypertension, and ischemic stroke. Median follow-up for incident ischemic stroke was 9.3 years (range, 1 day–33.6 years). DHCR7/CYP2R1 a...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Shoaib Afzal, Borge G. Nordestgaard Tags: Risk Factors, Genetic, Association Studies, High Blood Pressure, Hypertension Original Articles Source Type: research

Abstract P114: White Coat Effect is Common Among Stroke Survivors Session Title: Onsite Poster Competition I With Reception
Background and Purpose: Among stroke survivors, uncontrolled hypertension is a major risk factor for recurrent stroke. Blood pressure (BP) medication titration often relies on office BP measures, which may be inaccurate due to the white coat effect (WCE). We sought to determine the prevalence of the WCE in stroke survivors and to determine whether clinical and demographic factors were associated with WCE.Methods: We followed ischemic and hemorrhagic stroke and transient ischemic attack patients with prior hypertension presenting to our stroke clinic for a BP study. Sitting BP was obtained by a medical assistant using an of...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Adriana Morell, Munachi Okpala, Sean Savitz, Anjail Z Sharrief Tags: Poster Abstract Presentations Source Type: research

Effect of Adherence to Antihypertensive Medication on the Long-Term Outcome After Hemorrhagic Stroke in KoreaNovelty and Significance Hemorrhagic Stroke
Hypertension is the single most important risk factor for hemorrhagic stroke, a leading cause of mortality and disability worldwide. Adherence to antihypertensive medication is essential to achieving strict blood pressure control, but poor adherence is common in clinical practice. We evaluated adherence to antihypertensive medication in patients with acute hemorrhagic stroke and its effects on long-term outcome. This was a retrospective cohort study based on a nationwide health insurance claims database in South Korea. We included 1872 hypertensive patients who were admitted with acute hemorrhagic stroke during 2002 to 201...
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Jinkwon Kim, Cheryl D. Bushnell, Hye Sun Lee, Sang Won Han Tags: Secondary Prevention, Hypertension, Compliance/Adherence, Intracranial Hemorrhage Original Articles Source Type: research

Acetaminophen Use and Risk of Myocardial Infarction and Stroke in a Hypertensive Cohort Epidemiology/Population
Recent data suggest that self-reported acetaminophen use is associated with increased risk of cardiovascular events and that acetaminophen causes a modest blood pressure rise. There are no randomized trials or studies using verified prescription data of this relationship. We aimed to assess the relationship between verified acetaminophen prescription data and risk of myocardial infarction or stroke in patients with hypertension. We performed a retrospective data analysis using information contained within the UK Clinical Research Practice Datalink. Multivariable Cox proportional hazard models were used to estimate hazard r...
Source: Hypertension - April 8, 2015 Category: Cardiology Authors: Fulton, R. L., Walters, M. R., Morton, R., Touyz, R. M., Dominiczak, A. F., Morrison, D. S., Padmanabhan, S., Meredith, P. A., McInnes, G. T., Dawson, J. Tags: Clinical Studies Epidemiology/Population Source Type: research

Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke Nervous System
Neuronal death after ischemic stroke involves multiple pathophysiological events, as well as a complex molecular mechanism. Inhibiting a single therapeutic target that is involved in several ischemic signaling cascades may be a promising strategy for stroke management. Here, we report the versatile biological roles of tumor necrosis factor receptor–associated factor 3 (TRAF3) in ischemic stroke. Using several genetically manipulated mouse strains, we also demonstrated that TRAF3 inhibition can be neuroprotective. TRAF3 expression, which is robustly induced in response to ischemia/reperfusion (I/R) injury, was detecte...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Gong, J., Li, Z.-Z., Guo, S., Zhang, X.-J., Zhang, P., Zhao, G.-N., Gao, L., Zhang, Y., Zheng, A., Zhang, X.-F., Xiang, M., Li, H. Tags: Apoptosis, Ischemic biology - basic studies, Acute Cerebral Infarction, Oxidant stress Nervous System Source Type: research

Abstract P013: Meta-analysis of Poor Outcomes and Permissive Hypertension after Acute Ischemic Stroke Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Conclusion: Use of antihypertensive therapy in acute period of ischemic stroke does not have an effect on disability or all-cause mortality.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Ivanov, A., Mohamed, A., Korniyenko, A. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research

Allopurinol and Cardiovascular Outcomes in Adults With Hypertension Epidemiology/Population
Allopurinol lowers blood pressure in adolescents and has other vasoprotective effects. Whether similar benefits occur in older individuals remains unclear. We hypothesized that allopurinol is associated with improved cardiovascular outcomes in older adults with hypertension. Data from the United Kingdom Clinical Research Practice Datalink were used. Multivariate Cox-proportional hazard models were applied to estimate hazard ratios for stroke and cardiac events (defined as myocardial infarction or acute coronary syndrome) associated with allopurinol use over a 10-year period in adults aged >65 years with hypertension. A ...
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: MacIsaac, R. L., Salatzki, J., Higgins, P., Walters, M. R., Padmanabhan, S., Dominiczak, A. F., Touyz, R. M., Dawson, J. Tags: Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research

Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged
Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population–based cohort studies evaluating CIMT measurements. Information...
Source: Hypertension - March 11, 2015 Category: Cardiology Authors: Eikendal, A. L. M., Groenewegen, K. A., Anderson, T. J., Britton, A. R., Engstrom, G., Evans, G. W., de Graaf, J., Grobbee, D. E., Hedblad, B., Holewijn, S., Ikeda, A., Kitagawa, K., Kitamura, A., Lonn, E. M., Lorenz, M. W., Mathiesen, E. B., Nijpels, G., Tags: Risk Factors, Imaging, Acute myocardial infarction, Acute Stroke Syndromes, Epidemiology Epidemiology/Population Source Type: research

Achieved Blood Pressure and Outcomes in the Secondary Prevention of Small Subcortical Strokes Trial Clinical Trial
Abstract— Studies suggest a J-shaped association between blood pressure and cardiovascular events in the setting of intensive systolic blood pressure control; whether there is a similar association with stroke remains less well established. The Secondary Prevention of Small Subcortical Strokes was a randomized trial to evaluate higher (130–149 mm Hg) versus lower (<130 mm Hg) systolic blood pressure targets in participants with recent lacunar infarcts. We evaluated the association of mean achieved blood pressure, 6 months after randomization, and recurrent stroke, major vascular events, and all-cause mortali...
Source: Hypertension - December 9, 2015 Category: Cardiology Authors: Odden, M. C., McClure, L. A., Sawaya, B. P., White, C. L., Peralta, C. A., Field, T. S., Hart, R. G., Benavente, O. R., Pergola, P. E. Tags: Clinical Studies, Cerebrovascular Disease/Stroke Clinical Trial Source Type: research