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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
High Blood Pressure and Cerebral White Matter Lesion Progression in the General Population White Matter Lesions
High blood pressure is considered an important risk factor for cerebral white matter lesions (WMLs) in the aging population. In a longitudinal population-based study of 665 nondemented persons, we investigated the longitudinal relationship of systolic blood pressure, diastolic blood pressure, and pulse pressure with annual progression of WMLs. Means of blood pressure were calculated over a 5-year period before longitudinal MRI scanning. WML progression was subsequently measured on 2 scans 3.5 years apart. We performed analyses with linear regression models and evaluated adjustments for age, sex, cardiovascular risk factors...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Verhaaren, B. F. J., Vernooij, M. W., de Boer, R., Hofman, A., Niessen, W. J., van der Lugt, A., Ikram, M. A. Tags: Cerebrovascular disease/stroke, Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke, Epidemiology White Matter Lesions Source Type: research
Activation of Neuronal Transient Receptor Potential Vanilloid 1 Channel Underlies 20-Hydroxyeicosatetraenoic Acid-Induced Vasoactivity: Role for Protein Kinase A Inflammation and Hypertension
A rise in intraluminal pressure triggers vasoconstriction in resistance arteries, which is associated with local generation of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE). Importantly, dysregulation of 20-HETE synthesis and activity has been implicated in several cardiovascular disease states, including ischemic disease, hypertension, and stroke; however, the exact molecular pathways involved in mediating 20-HETE bioactivity are uncertain. We investigated whether 20-HETE activates the transient receptor potential vanilloid 1 (TRPV1) and thereby regulates vascular function and blood pressure. We demonstrat...
Source: Hypertension - July 17, 2013 Category: Cardiology Authors: Bubb, K. J., Wen, H., Panayiotou, C. M., Finsterbusch, M., Khan, F. J., Chan, M. V., Priestley, J. V., Baker, M. D., Ahluwalia, A. Tags: Animal models of human disease, Other Vascular biology Inflammation and Hypertension Source Type: research
Retinal Vasculature: A Window on the Brain Editorial Commentaries
Source: Hypertension - September 11, 2013 Category: Cardiology Authors: Spence, J. D., Fraser, J. A. Tags: Cerebrovascular disease/stroke, Risk Factors for Stroke Editorial Commentaries Source Type: research
Abstract 351: Mineralocorticoid Receptor Antagonism During the Development of Hypertension Improves Cerebral Artery Endothelium Dependent Dilation Even After Treatment Withdrawal Poster Session II
Hypertension causes cerebral artery remodeling and increases the risk of stroke. Renin angiotensin system blockade during the development of hypertension has therapeutic effects even after treatment withdrawal. Mineralocorticoid receptor (MR) activation has been implicated in artery remodeling and impaired endothelial function. The possibility that there is a critical therapeutic window for MR antagonism has not been investigated. We hypothesized that temporary MR antagonism while hypertension develops would improve endothelium dependent dilation even after treatment withdrawal. Six-week-old male stroke prone spontaneously...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: McClain, J. L., Dorrance, A. M. Tags: Poster Session II Source Type: research
Abstract 616: The Population Impact and Cost-Effectiveness of Blood Pressure Treatment in U.S. Adults Age 75 and Older Poster Session II
Conclusions: Treatment of systolic blood pressure to a target of 140 mmHg would prevent the most cardiovascular events and result in the greatest QALYs gained. The presence of side effects, polypharmacy-related cognitive impairment, fractures, or frailty could substantially offset this benefit. Treatment strategies that are tailored to the health status of older adults are warranted.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Odden, M. C., Coxson, P., Moran, A., Guzman, D., Goldman, L., Bibbins-Domingo, K. Tags: Poster Session II Source Type: research
Abstract 620: Angiotensin AT2 Receptor Exerts an Anti-inflammatory Response in Lipopolysaccharide-activated THP-1 Macrophages Poster Session II
In conclusion, AT2R stimulation may potentially suppress the inflammatory response of macrophages to LPS by shifting the balance from pro- to anti-inflammatory cytokine production and may prove to be beneficial in the control of the inflammatory component of stroke and hypertension.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Dhande, I. S., Hussain, T. Tags: Poster Session II Source Type: research
Association Between Ambulatory Systolic Blood Pressure During the Day and Asymptomatic Intracranial Arterial Stenosis Cerebrovascular Atherosclerosis
In conclusion, the present study showed a significant association between early morning SBP and asymptomatic ICAS in patients with hypertension after accounting for conventional cardiovascular risk factors. Our findings highlight the importance of morning SBP as a cardiovascular risk factor and should be validated in prospective studies.
Source: Hypertension - December 11, 2013 Category: Cardiology Authors: Chen, C.-T., Li, Y., Zhang, J., Wang, Y., Ling, H.-W., Chen, K.-M., Gao, P.-J., Zhu, D.-L. Tags: Cerebrovascular disease/stroke, Angiography, Risk Factors for Stroke Cerebrovascular Atherosclerosis Source Type: research
Common Carotid Intima-Media Thickness Measurements Do Not Improve Cardiovascular Risk Prediction in Individuals With Elevated Blood Pressure: The USE-IMT Collaboration Epidemiology/Population
Carotid intima-media thickness (CIMT) is a marker of cardiovascular risk. It is unclear whether measurement of mean common CIMT improves 10-year risk prediction of first-time myocardial infarction or stroke in individuals with elevated blood pressure. We performed an analysis among individuals with elevated blood pressure (ie, a systolic blood pressure ≥140 mm Hg and a diastolic blood pressure ≥ 90 mm Hg) in USE-IMT, a large ongoing individual participant data meta-analysis. We refitted the risk factors of the Framingham Risk Score on asymptomatic individuals (baseline model) and expanded this model with mean common ...
Source: Hypertension - May 7, 2014 Category: Cardiology Authors: Bots, M. L., Groenewegen, K. A., Anderson, T. J., Britton, A. R., Dekker, J. M., Engstrom, G., Evans, G. W., de Graaf, J., Grobbee, D. E., Hedblad, B., Hofman, A., Holewijn, S., Ikeda, A., Kavousi, M., Kitagawa, K., Kitamura, A., Ikram, M. A., Lonn, E. M. Tags: Imaging Epidemiology/Population Source Type: research
Prevalence and Associated Factors of Silent Brain Infarcts in a Mediterranean Cohort of Hypertensives Brain and Cognition
Silent brain infarcts (SBIs) are detected by neuroimaging in approximately 20% of elderly patients in population-based studies. Limited evidence is available for hypertensives at low cardiovascular risk countries. Investigating Silent Strokes in Hypertensives: a Magnetic Resonance Imaging Study (ISSYS) is aimed to assess the prevalence and risk factors of SBIs in a hypertensive Mediterranean population. This is a cohort study in randomly selected hypertensives, aged 50 to 70 years old, and free of clinical stroke and dementia. On baseline, all participants underwent a brain magnetic resonance imaging to assess prevalence a...
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Delgado, P., Riba-Llena, I., Tovar, J. L., Jarca, C. I., Mundet, X., Lopez-Rueda, A., Orfila, F., Llussa, J., Manresa, J. M., Alvarez-Sabin, J., Nafria, C., Fernandez, J. L., Maisterra, O., Montaner, J., on behalf of ISSYS Investigators* Tags: Cerebral Lacunes Brain and Cognition Source Type: research
Critical Blood Pressure Threshold Dependence of Hypertensive Injury and Repair in a Malignant Nephrosclerosis Model Kidney
Most patients with essential hypertension do not exhibit substantial renal damage. Renal autoregulation by preventing glomerular transmission of systemic pressures has been postulated to mediate this resistance. Conversely, malignant nephrosclerosis (MN) has been postulated to develop when severe hypertension exceeds a critical ceiling. If the concept is valid, even modest blood pressure (BP) reductions to below this threshold regardless of antihypertensive class (1) should prevent MN and (2) lead to the healing of the already developed MN lesions. Both predicates were tested using BP radiotelemetry in the stroke-prone spo...
Source: Hypertension - September 10, 2014 Category: Cardiology Authors: Griffin, K. A., Polichnowski, A., Litbarg, N., Picken, M., Venkatachalam, M. A., Bidani, A. K. Tags: Animal models of human disease Kidney Source Type: research
Visit-to-Visit Variability of Blood Pressure and Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis Epidemiology/Population
Visit-to-visit variability of blood pressure (BP) has been associated with cardiovascular disease (CVD) and mortality in some but not all studies. We conducted a systematic review and meta-analysis to examine the association between visit-to-visit variability of BP and CVD and all-cause mortality. Medical databases were searched through June 4, 2014, for studies meeting the following eligibility criteria: adult participants; BP measurements at ≥3 visits; follow-up for CVD, coronary heart disease, stroke, or mortality outcomes; events confirmed via database, death certificate, or event ascertainment committee; and adjust...
Source: Hypertension - October 8, 2014 Category: Cardiology Authors: Diaz, K. M., Tanner, R. M., Falzon, L., Levitan, E. B., Reynolds, K., Shimbo, D., Muntner, P. Tags: Risk Factors, Other hypertension, Epidemiology Epidemiology/Population Source Type: research
Treatment-Resistant Hypertension and the Incidence of Cardiovascular Disease and End-Stage Renal Disease: Results From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Clinical Trial
Apparent treatment-resistant hypertension (aTRH) is defined as uncontrolled hypertension despite the use of ≥3 antihypertensive medication classes or controlled hypertension while treated with ≥4 antihypertensive medication classes. Although a high prevalence of aTRH has been reported, few data are available on its association with cardiovascular and renal outcomes. We analyzed data on 14 684 Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants to determine the association between aTRH (n=1870) with coronary heart disease, stroke, all-cause mortality, heart failure, periph...
Source: Hypertension - October 8, 2014 Category: Cardiology Authors: Muntner, P., Davis, B. R., Cushman, W. C., Bangalore, S., Calhoun, D. A., Pressel, S. L., Black, H. R., Kostis, J. B., Probstfield, J. L., Whelton, P. K., Rahman, M., for the ALLHAT Collaborative Research Group* Tags: Clinical Studies Clinical Trial Source Type: research
Brachial-Ankle Pulse Wave Velocity as a Predictor of Mortality in Elderly Chinese Pulse Wave Analysis
In conclusion, brachial-ankle PWV predicts mortality in elderly Chinese on the conditions of markedly increased PWV and hypertension.
Source: Hypertension - October 8, 2014 Category: Cardiology Authors: Sheng, C.-S., Li, Y., Li, L.-H., Huang, Q.-F., Zeng, W.-F., Kang, Y.-Y., Zhang, L., Liu, M., Wei, F.-F., Li, G.-L., Song, J., Wang, S., Wang, J.-G. Tags: Clinical Studies Pulse Wave Analysis Source Type: research
High-Sensitivity Troponin T and Cardiovascular Events in Systolic Blood Pressure Categories: Atherosclerosis Risk in Communities Study Epidemiology/Population
Based on observational studies, there is a linear increase in cardiovascular risk with higher systolic blood pressure (SBP), yet clinical trials have not shown benefit across all SBP categories. We assessed whether troponin T measured using high-sensitivity assay was associated with cardiovascular disease within SBP categories in 11 191 Atherosclerosis Risk in Communities study participants. Rested sitting SBP by 10-mm Hg increments and troponin categories were identified. Incident heart failure hospitalization, coronary heart disease, and stroke were ascertained for a median of 12 years after excluding individuals with co...
Source: Hypertension - December 10, 2014 Category: Cardiology Authors: Pokharel, Y., Sun, W., de Lemos, J. A., Taffet, G. E., Virani, S. S., Ndumele, C. E., Mosley, T. H., Hoogeveen, R. C., Coresh, J., Wright, J. D., Heiss, G., Boerwinkle, E. A., Bozkurt, B., Solomon, S. D., Ballantyne, C. M., Nambi, V. Tags: Other heart failure, Primary prevention, Other etiology, Other diagnostic testing Epidemiology/Population Source Type: research
Prevalence and Prognostic Significance of Apparent Treatment Resistant Hypertension in Chronic Kidney Disease: Report From the Chronic Renal Insufficiency Cohort Study Resistant Hypertension
The association between apparent treatment resistant hypertension (ATRH) and clinical outcomes is not well studied in chronic kidney disease. We analyzed data on 3367 hypertensive participants in the Chronic Renal Insufficiency Cohort (CRIC) to determine prevalence, associations, and clinical outcomes of ATRH in nondialysis chronic kidney disease patients. ATRH was defined as blood pressure ≥140/90 mm Hg on ≥3 antihypertensives, or use of ≥4 antihypertensives with blood pressure at goal at baseline visit. Prevalence of ATRH was 40.4%. Older age, male sex, black race, diabetes mellitus, and higher body mass index w...
Source: Hypertension - January 13, 2016 Category: Cardiology Authors: Thomas, G., Xie, D., Chen, H.-Y., Anderson, A. H., Appel, L. J., Bodana, S., Brecklin, C. S., Drawz, P., Flack, J. M., Miller, E. R., Steigerwalt, S. P., Townsend, R. R., Weir, M. R., Wright, J. T., Rahman, M., CRIC Study Investigators Tags: Cardiovascular Disease, Heart Failure, High Blood Pressure, Hypertension, Mortality/Survival Resistant Hypertension Source Type: research
