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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Refractory Hypertension: Determination of Prevalence, Risk Factors, and Comorbidities in a Large, Population-Based Cohort Epidemiology/Population
Refractory hypertension is an extreme phenotype of antihypertensive treatment failure. Participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, a large (n=30 239), population-based cohort were evaluated to determine the prevalence of refractory hypertension and associated cardiovascular risk factors and comorbidities. Refractory hypertension was defined as uncontrolled blood pressure (systolic/diastolic, ≥140/90 mm Hg) on ≥5 antihypertensive drug classes. Participants with resistant hypertension (systolic/diastolic, ≥140/90 mm Hg on ≥3 or <140/90 mm Hg on ≥4 antihyperte...
Source: Hypertension - February 12, 2014 Category: Cardiology Authors: Calhoun, D. A., Booth, J. N., Oparil, S., Irvin, M. R., Shimbo, D., Lackland, D. T., Howard, G., Safford, M. M., Muntner, P. Tags: Cardiovascular Pharmacology, Other hypertension Epidemiology/Population Source Type: research
Rho-Associated Kinase Activity Is a Predictor of Cardiovascular Outcomes Cardiovascular Outcomes
Cardiovascular diseases are associated with chronic activation of Rho-associated kinase. Rho-associated kinase activity is significantly correlated with endothelial function and Framingham risk score. However, there is no information on the prognostic value of Rho-associated kinase activity. We evaluated Rho-associated kinase activity in peripheral leukocytes by Western blot analysis in 633 subjects who underwent health-screening examination at Hiroshima University Hospital. We assessed the associations between Rho-associated kinase activity and first major cardiovascular events (death from cardiovascular causes, myocardia...
Source: Hypertension - March 12, 2014 Category: Cardiology Authors: Kajikawa, M., Noma, K., Maruhashi, T., Mikami, S., Iwamoto, Y., Iwamoto, A., Matsumoto, T., Hidaka, T., Kihara, Y., Chayama, K., Nakashima, A., Goto, C., Liao, J. K., Higashi, Y. Tags: Risk Factors Cardiovascular Outcomes Source Type: research
Cardiovascular Risk With and Without Antihypertensive Drug Treatment in the Japanese General Population: Participant-Level Meta-Analysis Epidemiology/Population
To evaluate the cardiovascular mortality risk in association with blood pressure level among people with and without antihypertensive treatment, we performed the participant-level meta-analysis that included 39 705 Japanese from 6 cohorts (58.4% women; mean age, 60.1 years; 20.4% treated). Multivariable-adjusted Cox models were used to analyze the risk of cardiovascular mortality and its subtypes among 6 blood pressure levels according to recent guidelines, optimal to Grade 3 hypertension, and the usage of antihypertensive medication at baseline. During median 10.0 years of follow-up, there were 2032 cardiovascular deaths ...
Source: Hypertension - May 7, 2014 Category: Cardiology Authors: Asayama, K., Satoh, M., Murakami, Y., Ohkubo, T., Nagasawa, S.-y., Tsuji, I., Nakayama, T., Okayama, A., Miura, K., Imai, Y., Ueshima, H., Okamura, T., on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPA Tags: Epidemiology Epidemiology/Population Source Type: research
Combined Effect of Blood Pressure and Total Cholesterol Levels on Long-Term Risks of Subtypes of Cardiovascular Death: Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Epidemiology/Population
No large-scale, longitudinal studies have examined the combined effects of blood pressure (BP) and total cholesterol levels on long-term risks for subtypes of cardiovascular death in an Asian population. To investigate these relationships, a meta-analysis of individual participant data, which included 73 916 Japanese subjects (age, 57.7 years; men, 41.1%) from 11 cohorts, was conducted. During a mean follow-up of 15.0 years, deaths from coronary heart disease, ischemic stroke, and intraparenchymal hemorrhage occurred in 770, 724, and 345 cases, respectively. Cohort-stratified Cox proportional hazard models were used. After...
Source: Hypertension - February 11, 2015 Category: Cardiology Authors: Satoh, M., Ohkubo, T., Asayama, K., Murakami, Y., Sakurai, M., Nakagawa, H., Iso, H., Okayama, A., Miura, K., Imai, Y., Ueshima, H., Okamura, T., on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Res Tags: Lipids, Epidemiology Epidemiology/Population Source Type: research
Selective Heart Rate Reduction With Ivabradine Increases Central Blood Pressure in Stable Coronary Artery Disease Clinical Trials
In conclusion, the decrease in HR with ivabradine was associated with an increase in central systolic pressure, which may have antagonized possible benefits of HR lowering in coronary artery disease patients.
Clinical Trials—URL:
http://www.clinicaltrials.gov. Unique identifier NCT01039389.
Source: Hypertension - May 10, 2016 Category: Cardiology Authors: Rimoldi, S. F., Messerli, F. H., Cerny, D., Gloekler, S., Traupe, T., Laurent, S., Seiler, C. Tags: Hemodynamics, Hypertension, Coronary Artery Disease Clinical Trials Source Type: research
Abstract P480: Effects Of Long And Intermediate Acting Dihydropyridine Calcium Channel Blockers In Hypertension: A Systematic Review And Aeta-analysis Of 18 Prospective, Actively Controlled, Randomized Clinical Trials Session Title: Antihypertensive Drugs and Pharmacology, Patient-Provider-Healthcare System Issues, and Pediatric and Adolescent Hypertension
Conclusions: This study suggests that Amlodipine offers greater protection against major complications of hypertension compared to intermediate acting dihydropyridine calcium channel blockers.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sandip Chaugai, Hisatomi Arima, Lhamo Yangchen Sherpa, Amir Sepehry Tags: Poster Abstract Presentations Source Type: research
Angiotensin-Converting Enzyme 2 Priming Enhances the Function of Endothelial Progenitor Cells and Their Therapeutic Efficacy Original Articles Part 2
Angiotensin-converting enzyme 2 (ACE2) is a lately discovered enzyme catalyzing Angiotensin II into Angiotensin 1-7. Angiotensin II has been reported to impair endothelial progenitor cell (EPC) function and is detrimental to stroke. Here, we studied the role of ACE2 in regulating EPC function in vitro and in vivo. EPCs were cultured from human renin and angiotensinogen transgenic (R+A+) mice and their controls (R–A–). In in vitro experiments, EPCs were transduced with lentivirus-ACE2 or lentivirus-green fluorescence protein. The effects of ACE2 overexpression on EPC function and endothelial NO synthase (eNOS)/n...
Source: Hypertension - February 13, 2013 Category: Cardiology Authors: Chen, J., Xiao, X., Chen, S., Zhang, C., Chen, J., Yi, D., Shenoy, V., Raizada, M. K., Zhao, B., Chen, Y. Tags: ACE/Angiotension receptors, Angiogenesis, Animal models of human disease Original Articles Part 2 Source Type: research
Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: Results by Sex Clinical Trial - ALLHAT
To determine whether an angiotensin-converting enzyme inhibitor (lisinopril) or calcium channel blocker (amlodipine) is superior to a diuretic (chlorthalidone) in reducing cardiovascular disease incidence in sex subgroups, we carried out a prespecified subgroup analysis of 15 638 women and 17 719 men in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Total follow-up (active treatment + passive surveillance using national administrative databases to ascertain deaths and hospitalizations) was 8 to 13 years. The primary outcome was fatal coronary heart disease or nonfatal myocardial i...
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Oparil, S., Davis, B. R., Cushman, W. C., Ford, C. E., Furberg, C. D., Habib, G. B., Haywood, L. J., Margolis, K., Probstfield, J. L., Whelton, P. K., Wright, J. T., for the ALLHAT Collaborative Research Group Tags: Primary prevention, Secondary prevention, Clinical Studies Clinical Trial - ALLHAT Source Type: research
Skeletal Muscle Signaling and the Heart Rate and Blood Pressure Response to Exercise: Insight From Heart Rate Pacing During Exercise With a Trained and a Deconditioned Muscle Group Exercise and Blood Pressure
Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was 15 bpm lower during...
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Mortensen, S. P., Svendsen, J. H., Ersboll, M., Hellsten, Y., Secher, N. H., Saltin, B. Tags: Exercise/exercise testing/rehabilitation, Other Vascular biology Exercise and Blood Pressure Source Type: research
Differential Influence of Distinct Components of Increased Blood Pressure on Cardiovascular Outcomes: From the Atherosclerosis Risk in Communities Study Epidemiology/Population
Elevation in blood pressure (BP) increases risk for all cardiovascular events. Nevertheless, the extent to which different indices of BP elevation may be associated to varying degrees with different cardiovascular outcomes remains unclear. We studied 13 340 participants (aged 54±6 years, 56% women and 27% black) of the Atherosclerosis Risk in Communities Study who were free of baseline cardiovascular disease. We used Cox proportional hazards models to compare the relative contributions of systolic BP, diastolic BP, pulse pressure, and mean arterial pressure to risk for coronary heart disease, heart failure, stroke, ...
Source: Hypertension - August 14, 2013 Category: Cardiology Authors: Cheng, S., Gupta, D. K., Claggett, B., Sharrett, A. R., Shah, A. M., Skali, H., Takeuchi, M., Ni, H., Solomon, S. D. Tags: Clinical Studies Epidemiology/Population Source Type: research
Abstract 522: HEALS Program Implementation in African American Churches for Hypertension Control and Prevention Poster Session II
Conclusion: If successful, the findings from this study will provide much-needed information on the translation and sustainability of evidence-based lifestyle modification in HTN members in community-based settings, particularly within churches, which represent the most influential institution in the community lives of AA
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Dodani, S., Arora, S., Mahin, C., Butterfield, R. Tags: Poster Session II Source Type: research
Abstract 090: Outcomes of Hypertensive Crises as Predicted by Red Cell Distribution Width Session Title: Concurrent XV C: Clinical Hypertension
Conclusions: Elevated RDW level in patients with hypertensive crisis was an independent predictor of all-cause mortality and new-onset heart failure in patients with hypertensive crisis.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Raheja, S., Patel, K., Patel, R., Mawri, S., Michaels, A., Gibbs, J., McCord, J. Tags: Session Title: Concurrent XV C: Clinical Hypertension Source Type: research
More Versus Less Intensive Blood Pressure-Lowering Strategy: Cumulative Evidence and Trial Sequential Analysis Intensive Blood Pressure Reduction and Outcome
Several randomized trials compared a more versus less intensive blood pressure–lowering strategy on the risk of major cardiovascular events and death. Cumulative meta-analyses and trial sequential analyses can establish whether and when firm evidence favoring a specific intervention has been reached from accrued literature. Therefore, we conducted a cumulative trial sequential analysis of 18 trials that randomly allocated 53 405 patients to a more or less intensive blood pressure–lowering strategy. We sought to ascertain the extent to which trial evidence added to previously accrued data. Outcome measures were ...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Verdecchia, P., Angeli, F., Gentile, G., Reboldi, G. Tags: Cardiovascular Disease, Hypertension, Meta Analysis, Mortality/Survival, Quality and Outcomes Intensive Blood Pressure Reduction and Outcome Source Type: research
More Versus Less Intensive Blood Pressure-Lowering StrategyNovelty and Significance Intensive Blood Pressure Reduction and Outcome
Several randomized trials compared a more versus less intensive blood pressure–lowering strategy on the risk of major cardiovascular events and death. Cumulative meta-analyses and trial sequential analyses can establish whether and when firm evidence favoring a specific intervention has been reached from accrued literature. Therefore, we conducted a cumulative trial sequential analysis of 18 trials that randomly allocated 53 405 patients to a more or less intensive blood pressure–lowering strategy. We sought to ascertain the extent to which trial evidence added to previously accrued data. Outcome measures were stroke...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Verdecchia, P., Angeli, F., Gentile, G., Reboldi, G. Tags: Cardiovascular Disease, Hypertension, Meta Analysis, Mortality/Survival, Quality and Outcomes Original Articles Source Type: research
Prevalence of Cardiovascular Disease and Its Risk Factors in Primary AldosteronismNovelty and Significance Primary Aldosteronism
There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) in patients with primary aldosteronism (PA); however, their results have left it unclear whether CVD is affected by the plasma aldosterone concentration or hypokalemia. We assessed the PA database established by the multicenter JPAS (Japan Primary Aldosteronism Study) and compared the prevalence of CVD among patients with PA with that among age-, sex-, and blood pressure-matched essential hypertension patients and participants with hypertension in a general population cohort. We also performed binary logistic regress...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Toshinari Yamasaki, Osamu Ogawa, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichiȷo, Takuyuki Katabami, Yasushi Tanaka, Norio Wada, Yui Shibayama, Takanobu Yosh Tags: Cardiovascular Disease, Risk Factors, Hypertension, Vascular Disease Original Articles Source Type: research
