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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Trends in Antihypertensive Medication Discontinuation and Low Adherence Among Medicare Beneficiaries Initiating Treatment From 2007 to 2012 Epidemiology/Population
In conclusion, low adherence to antihypertensive medication has decreased among Medicare beneficiaries; however, rates of discontinuation and low adherence remain high.
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Tajeu, G. S., Kent, S. T., Kronish, I. M., Huang, L., Krousel-Wood, M., Bress, A. P., Shimbo, D., Muntner, P. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Hypertension Epidemiology/Population Source Type: research
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase ActivityNovelty and Significance Heart
In conclusion, this study provides the first evidence that Klotho deficiency downregulates SIRT1 activity in arterial endothelial and smooth muscle cells. Pharmacological activation of SIRT1 may be an effective therapeutic strategy for arterial stiffness and hypertension.
Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Gao, D., Zuo, Z., Tian, J., Ali, Q., Lin, Y., Lei, H., Sun, Z. Tags: Animal Models of Human Disease, Physiology, Hypertension Original Articles Source Type: research
Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral ArteriesNovelty and Significance Vessels
In this study, we investigated the contribution of TIMP3 and Notch3 signaling to the impairment of maximal vasodilator capacity caused by the archetypal R169C mutation. Maximally dilated cerebral arteries in TgNotch3R169C mice exhibited a decrease in lumen diameter over a range of physiological pressures that occurred before myogenic tone deficits. This defect was not prevented by genetic reduction of TIMP3 in TgNotch3R169C mice and was not observed in mice overexpressing TIMP3. Knock-in mice with the R169C mutation (Notch3R170C/R170C) exhibited similar reductions in arterial lumen, and both TgNotch3R169C and Notch3R170C/R...
Source: Hypertension - December 6, 2016 Category: Cardiology Authors: Celine Baron–Menguy, Valerie Domenga–Denier, Lamia Ghezali, Frank M. Faraci, Anne Joutel Tags: Animal Models of Human Disease, Pathophysiology, Genetically Altered and Transgenic Models, Vascular Disease Original Articles Source Type: research
Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in HypertensionNovelty and Significance Endothelium
Endothelium-dependent hyperpolarization (EDH)–mediated responses are impaired in hypertension, but the underlying mechanisms have not yet been determined. The activation of small- and intermediate-conductance of Ca2+-activated K+ channels (SKCa and IKCa) underpins EDH-mediated responses. It was recently reported that Ca2+ influx through endothelial transient receptor potential vanilloid type 4 channel (TRPV4) is a prerequisite for the activation of SKCa/IKCa in endothelial cells in specific beds. Here, we attempted to determine whether the impairment of EDH in hypertension is attributable to the dysfunction of TRPV4 and ...
Source: Hypertension - December 6, 2016 Category: Cardiology Authors: Takunori Seki, Kenichi Goto, Kanako Kiyohara, Yasuo Kansui, Noboru Murakami, Yoshie Haga, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono Tags: Endothelium/Vascular Type/Nitric Oxide, Hypertension Original Articles Source Type: research
Case of Asymptomatic Carotid Artery Stenosis in a Hypertensive Patient Clinical-Pathological Conference
Source: Hypertension - May 10, 2017 Category: Cardiology Authors: David Calvet, Laurence Amar, Gian Paolo Rossi, Stephane Laurent, Anna F. Dominiczak, Guillaume Turc, Garry Jennings, Tomasz Guzik, Rhian M. Touyz Tags: Clinical Studies, Hypertension, Revascularization, Cerebrovascular Procedures, Ischemic Stroke – Pathological Conference Source Type: research
Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes MellitusNovelty and Significance Epidemiology/Population
Despite adequate glycemic and blood pressure control, treated type 2 diabetic hypertensive subjects have a significantly elevated overall/cardiovascular risk. We studied 244 816 normotensive and 99 720 hypertensive subjects (including 7480 type 2 diabetics) attending medical checkups between 1992 and 2011. We sought to identify significant differences in overall/cardiovascular risk between hypertension with and without diabetes mellitus. Mean follow-up was 12.7 years; 14 050 all-cause deaths were reported. From normotensive to hypertensive populations, a significant progression in overall/cardiovascular mortality was...
Source: Hypertension - May 10, 2017 Category: Cardiology Authors: Michel E. Safar, Jean–Barthelemy Gnakamene, Sola Aoun Bahous, Alexandra Yannoutsos, Frederique Thomas Tags: Clinical Studies, Hypertension Original Articles Source Type: research
Systolic Blood Pressure and Vascular Disease in Men Aged 65 Years and OverNovelty and Significance Epidemiology/Population
There is uncertainty about the relation between blood pressure and vascular disease at older age. We assessed the association of systolic blood pressure (SBP) and major vascular events in a prospective cohort study of 7564 men aged 65 to 94 years, recruited in 1996–1999 from the general population in Perth, Western Australia. SBP was measured at baseline and again at resurvey in 2001–2004. Participants were monitored for fatal and nonfatal vascular events. To limit the effect of reverse causality, analyses were restricted to men without previous vascular disease at baseline. Hazard ratios were estimated by Cox regressi...
Source: Hypertension - May 10, 2017 Category: Cardiology Authors: Ben Lacey, Jonathan Golledge, Bu B. Yeap, Sarah Lewington, Kieran A. McCaul, Paul E. Norman, Leon Flicker, Osvaldo P. Almeida, Graeme J. Hankey Tags: Aging, Cardiovascular Disease, Epidemiology, High Blood Pressure Original Articles Source Type: research
Angiogenic Markers and Cardiovascular Indices in the Prediction of Hypertensive Disorders of PregnancyNovelty and Significance Preeclampsia
We examined a cohort of 110 pregnant women with uneventful pregnancy outcome (controls) and 129 with hypertensive pregnancy disorders, including 77 with preeclampsia and 52 with pregnancy-induced hypertension. Cardiac indices were obtained with a USCOM-1A monitor, and soluble fms-like tyrosin kinase 1, placental growth factor, and NT-proBNP were measured in serum samples on automated platforms. Logistic regression, as well as Cox proportional hazard analysis, was performed. There were significant contributions from all variables tested, except for heart rate, stroke volume index, and cardiac index to the prediction model. ...
Source: Hypertension - May 10, 2017 Category: Cardiology Authors: Stefan Verlohren, Frank H. Perschel, Baskaran Thilaganathan, Lisa Antonia Droge, Wolfgang Henrich, Andreas Busȷahn, Asma Khalil Tags: Hypertension, Preeclampsia, Echocardiography, Ultrasound Original Articles Source Type: research
Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)Novelty and Significance Clinical Trials
Randomized trials of hypertension have seldom examined heterogeneity in response to treatments over time and the implications for cardiovascular outcomes. Understanding this heterogeneity, however, is a necessary step toward personalizing antihypertensive therapy. We applied trajectory-based modeling to data on 39 763 study participants of the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) to identify distinct patterns of systolic blood pressure (SBP) response to randomized medications during the first 6 months of the trial. Two trajectory patterns were identified: immediate responde...
Source: Hypertension - June 7, 2017 Category: Cardiology Authors: Sanket S. Dhruva, Chenxi Huang, Erica S. Spatz, Andreas C. Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Xiao Xu, Curt D. Furberg, Barry R. Davis, Sara L. Pressel, Ronald R. Coifman, Harlan M. Krumholz Tags: Cardiovascular Disease, Hypertension, Quality and Outcomes Original Articles Source Type: research
Risk of Cardiovascular Events in Patients With Diabetes Mellitus on {beta}-BlockersNovelty and Significance Clinical Trials
This study aimed to evaluate whether the use of β-blockers is effective in patients with diabetes mellitus and whether its use is associated with the occurrence of severe hypoglycemia. Using the ACCORD trial (Action to Control Cardiovascular Risk in Diabetes) data, we performed Cox proportional hazards analyses with a propensity score adjustment. The primary outcome was the first occurrence of a cardiovascular event during the study period, which included nonfatal myocardial infarction, unstable angina, nonfatal stroke, and cardiovascular death. The mean follow-up periods (±SD) were 4.6±1.6 years in patients on β-block...
Source: Hypertension - June 7, 2017 Category: Cardiology Authors: Tetsuro Tsujimoto, Takehiro Sugiyama, Martin F. Shapiro, Mitsuhiko Noda, Hiroshi Kajio Tags: Cardiovascular Disease, Diabetes, Type 2, Chronic Ischemic Heart Disease, Heart Failure Original Articles Source Type: research
Blood Pressure, Antihypertensive Polypharmacy, Frailty, and Risk for Serious Fall Injuries Among Older Treated Adults With HypertensionNovelty and Significance Epidemiology/Population
In conclusion, indicators of frailty, but not BP or number of antihypertensive medication classes, were associated with increased risk for serious fall injuries among older adults taking antihypertensive medication.
Source: Hypertension - July 12, 2017 Category: Cardiology Authors: Samantha G. Bromfield, Cedric-Anthony Ngameni, Lisandro D. Colantonio, C. Barrett Bowling, Daichi Shimbo, Kristi Reynolds, Monika M. Safford, Maciej Banach, Peter P. Toth, Paul Muntner Tags: Hypertension Original Articles Source Type: research
Effects of Folic Acid Therapy on the New-Onset Proteinuria in Chinese Hypertensive PatientsNovelty and Significance Clinical Trials
In conclusion, enalapril–folic acid therapy, compared with enalapril alone, significantly reduced the development of proteinuria in diabetic patients with hypertension.Clinical Trial Registration—URL: http://www.ClinicalTrials.gov. Unique identifier: NCT00794885.
Source: Hypertension - July 12, 2017 Category: Cardiology Authors: Youbao Li, Min Liang, Guobao Wang, Binyan Wang, Mingli He, Genfu Tang, Delu Yin, Xin Xu, Yong Huo, Yimin Cui, Fan Fan Hou, Xianhui Qin Tags: Clinical Studies, Diabetes, Type 1, Diet and Nutrition, Hypertension Original Articles Source Type: research
Blood Pressure and Risk of Cardiovascular Events in Patients on Chronic HemodialysisNovelty and Significance Dialysis and Blood Pressure
In conclusion, among hemodialysis patients, although there is a U-shaped (paradoxical) association of dialysis-unit-SBP and risk of cardiovascular disease, there is a linear association of out-of-dialysis-unit-SBP with risk of cardiovascular disease. Out-of-dialysis-unit blood pressure provides key information and may be an important therapeutic target.
Source: Hypertension - July 12, 2017 Category: Cardiology Authors: Nisha Bansal, Charles E. McCulloch, Feng Lin, Arnold Alper, Amanda H. Anderson, Magda Cuevas, Alan S. Go, Radhakrishna Kallem, John W. Kusek, Claudia M. Lora, Eva Lustigova, Akinlolu Ojo, Mahboob Rahman, Cassianne Robinson-Cohen, Raymond R. Townsend, Jack Tags: Epidemiology, Cardiorenal Syndrome Original Articles Source Type: research
Prognostic Value of Variability in Systolic Blood Pressure Related to Vascular Events and Premature Death in Type 2 Diabetes MellitusNovelty and Significance Visit-to-Visit Variability
Visit-to-visit variability in systolic blood pressure (SBP) is a risk factor for cardiovascular events. However, whether it provides additional predictive information beyond traditional risk factors, including mean SBP, in the long term is unclear. The ADVANCE trial (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) was a randomized controlled trial in patients with type 2 diabetes mellitus; ADVANCE-ON (ADVANCE-Observational) followed-up patients subsequently. In these analyses, 9114 patients without major macrovascular or renal events or death during the first 24 month...
Source: Hypertension - July 12, 2017 Category: Cardiology Authors: Toshiaki Ohkuma, Mark Woodward, Min Jun, Paul Muntner, Jun Hata, Stephen Colagiuri, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Peter Rothwell, John Chalmers Tags: High Blood Pressure, Hypertension, Cerebrovascular Disease/Stroke, Coronary Artery Disease, Vascular Disease Original Articles Source Type: research
Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular EventsNovelty and Significance Arterial Stiffness
The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA (Multi-Ethnic Study of Atherosclerosis). Aortic arch PWV was measured using magnetic resonance imaging at baseline in 3527 MESA participants (mean age, 62±10 years at baseline; 47% men) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in rel...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Yoshiaki Ohyama, Bharath Ambale-Venkatesh, Chikara Noda, Jang-Young Kim, Yutaka Tanami, Gisela Teixido-Tura, Atul R. Chugh, Alban Redheuil, Chia-Ying Liu, Colin O. Wu, W. Gregory Hundley, David A. Bluemke, Eliseo Guallar, Joao A.C. Lima Tags: Epidemiology, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research
