Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase ActivityNovelty and Significance [Heart]

In conclusion, this study provides the first evidence that Klotho deficiency downregulates SIRT1 activity in arterial endothelial and smooth muscle cells. Pharmacological activation of SIRT1 may be an effective therapeutic strategy for arterial stiffness and hypertension.

Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Gao, D., Zuo, Z., Tian, J., Ali, Q., Lin, Y., Lei, H., Sun, Z. Tags: Animal Models of Human Disease, Physiology, Hypertension Original Articles Source Type: research