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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Maternal Cardiovascular Function in Normal Pregnancy: Evidence of Maladaptation to Chronic Volume Overload Pregnancy and Hypertension
The aim of this study was to investigate cardiac functional status in pregnancy using a comprehensive approach taking into account the simultaneous changes in loading and geometry, as well as maternal age and anthropometric indices. This was a prospective cross-sectional study of 559 nulliparous pregnant women assessed at 4 time points during pregnancy and at 1 year postpartum. All women underwent conventional echocardiography and tissue Doppler velocities and strain rate analysis at multiple cardiac sites. Mean arterial pressure and total vascular resistance index significantly decreased (both P<0.001) during the first...
Source: Hypertension - March 9, 2016 Category: Cardiology Authors: Melchiorre, K., Sharma, R., Khalil, A., Thilaganathan, B. Tags: Heart Failure, Remodeling, Preeclampsia, Echocardiography Pregnancy and Hypertension Source Type: research
Angiotensin-Converting Enzyme Inhibitor Use and Major Cardiovascular Outcomes in Type 2 Diabetes Mellitus Treated With the Dipeptidyl Peptidase 4 Inhibitor Alogliptin Cardiovascular Outcomes in the EXAMINE Trial
Activation of the sympathetic nervous system when there is dipeptidyl peptidase 4 inhibition in the presence of high-dose angiotensin-converting enzyme (ACE) inhibition has led to concerns of potential increases in cardiovascular events when the 2 classes of drugs are coadministered. We evaluated cardiovascular outcomes from the EXAMINE (Examination of Cardiovascular Outcomes With Alogliptin versus Standard of Care) trial according to ACE inhibitor use. Patients with type 2 diabetes mellitus and a recent acute coronary syndrome were randomly assigned to receive the dipeptidyl peptidase 4 inhibitor alogliptin or placebo add...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: White, W. B., Wilson, C. A., Bakris, G. L., Bergenstal, R. M., Cannon, C. P., Cushman, W. C., Heller, S. K., Mehta, C. R., Nissen, S. E., Zannad, F., Kupfer, S., for the EXAMINE Investigators Tags: Heart Failure, Myocardial Infarction, Complications, Mortality/Survival Cardiovascular Outcomes in the EXAMINE Trial Source Type: research
Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk Assessment: A Prospective Cohort Study Aortic Blood Pressure and Cardiovascular Risk
In conclusion, invasively measured aortic systolic BP does not add prognostic information about cardiovascular outcomes and all-cause mortality compared with office BP in patients with stable angina pectoris, either with or without diabetes mellitus.
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Laugesen, E., Knudsen, S. T., Hansen, K. W., Rossen, N. B., Jensen, L. O., Hansen, M. G., Munkholm, H., Thomsen, K. K., Sondergaard, H., Bottcher, M., Raungaard, B., Madsen, M., Hulman, A., Witte, D., Botker, H. E., Poulsen, P. L. Tags: Myocardial Infarction, Hypertension, Mortality/Survival Aortic Blood Pressure and Cardiovascular Risk Source Type: research
Orthostatic Hypotension in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) Blood Pressure Trial: Prevalence, Incidence, and Prognostic Significance Clinical Trial
Orthostatic hypotension (OH) is associated with hypertension and diabetes mellitus. However, in populations with both hypertension and diabetes mellitus, its prevalence, the effect of intensive versus standard systolic blood pressure (BP) targets on incident OH, and its prognostic significance are unclear. In 4266 participants in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial, seated BP was measured 3x, followed by readings every minute for 3 minutes after standing. Orthostatic BP change, calculated as the minimum standing minus the mean seated systolic BP and diastolic BP, was assessed at baseline...
Source: Hypertension - September 6, 2016 Category: Cardiology Authors: Fleg, J. L., Evans, G. W., Margolis, K. L., Barzilay, J., Basile, J. N., Bigger, J. T., Cutler, J. A., Grimm, R., Pedley, C., Peterson, K., Pop-Busui, R., Sperl-Hillen, J., Cushman, W. C. Tags: Hypertension Clinical Trial Source Type: research
Orthostatic Hypotension in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) Blood Pressure TrialNovelty and Significance Clinical Trial
Orthostatic hypotension (OH) is associated with hypertension and diabetes mellitus. However, in populations with both hypertension and diabetes mellitus, its prevalence, the effect of intensive versus standard systolic blood pressure (BP) targets on incident OH, and its prognostic significance are unclear. In 4266 participants in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial, seated BP was measured 3×, followed by readings every minute for 3 minutes after standing. Orthostatic BP change, calculated as the minimum standing minus the mean seated systolic BP and diastolic BP, was assessed at baselin...
Source: Hypertension - September 6, 2016 Category: Cardiology Authors: Fleg, J. L., Evans, G. W., Margolis, K. L., Barzilay, J., Basile, J. N., Bigger, J. T., Cutler, J. A., Grimm, R., Pedley, C., Peterson, K., Pop-Busui, R., Sperl-Hillen, J., Cushman, W. C. Tags: Hypertension Original Articles Source Type: research
Angiotensin-Converting Enzyme Inhibitor Use and Major Cardiovascular Outcomes in Type 2 Diabetes Mellitus Treated With the Dipeptidyl Peptidase 4 Inhibitor AlogliptinNovelty and Significance Cardiovascular Outcomes in the EXAMINE Trial
Activation of the sympathetic nervous system when there is dipeptidyl peptidase 4 inhibition in the presence of high-dose angiotensin-converting enzyme (ACE) inhibition has led to concerns of potential increases in cardiovascular events when the 2 classes of drugs are coadministered. We evaluated cardiovascular outcomes from the EXAMINE (Examination of Cardiovascular Outcomes With Alogliptin versus Standard of Care) trial according to ACE inhibitor use. Patients with type 2 diabetes mellitus and a recent acute coronary syndrome were randomly assigned to receive the dipeptidyl peptidase 4 inhibitor alogliptin or placebo add...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: White, W. B., Wilson, C. A., Bakris, G. L., Bergenstal, R. M., Cannon, C. P., Cushman, W. C., Heller, S. K., Mehta, C. R., Nissen, S. E., Zannad, F., Kupfer, S. Tags: Heart Failure, Myocardial Infarction, Complications, Mortality/Survival Original Articles Source Type: research
Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk AssessmentNovelty and Significance Aortic Blood Pressure and Cardiovascular Risk
In conclusion, invasively measured aortic systolic BP does not add prognostic information about cardiovascular outcomes and all-cause mortality compared with office BP in patients with stable angina pectoris, either with or without diabetes mellitus.
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Laugesen, E., Knudsen, S. T., Hansen, K. W., Rossen, N. B., Jensen, L. O., Hansen, M. G., Munkholm, H., Thomsen, K. K., Sondergaard, H., Bottcher, M., Raungaard, B., Madsen, M., Hulman, A., Witte, D., Botker, H. E., Poulsen, P. L. Tags: Myocardial Infarction, Hypertension, Mortality/Survival Original Articles Source Type: research
Ambulatory Pulse Wave Velocity Is a Stronger Predictor of Cardiovascular Events and All-Cause Mortality Than Office and Ambulatory Blood Pressure in Hemodialysis PatientsNovelty and Significance Arterial Stiffness
This study examines the prognostic significance of ambulatory brachial BP, central BP, pulse wave velocity (PWV), and heart rate–adjusted augmentation index [AIx(75)] in this population. A total of 170 hemodialysis patients underwent 48-hour ambulatory monitoring with Mobil-O-Graph-NG during a standard interdialytic interval and followed-up for 28.1±11.2 months. The primary end point was a combination of all-cause death, nonfatal myocardial infarction, and nonfatal stroke. Secondary end points included: (1) all-cause mortality; (2) cardiovascular mortality; and (3) a combination of cardiovascular death, nonfatal myocard...
Source: Hypertension - June 7, 2017 Category: Cardiology Authors: Pantelis A. Sarafidis, Charalampos Loutradis, Antonios Karpetas, Georgios Tzanis, Alexia Piperidou, Georgios Koutroumpas, Vasilios Raptis, Christos Syrgkanis, Vasilios Liakopoulos, Georgios Efstratiadis, Gerard London, Carmine Zoccali Tags: Nephrology and Kidney, Cardiovascular Disease, Hypertension, Mortality/Survival Original Articles Source Type: research
Blood Pressure Trajectories and the Risk of Intracerebral Hemorrhage and Cerebral InfarctionNovelty and Significance Epidemiology/Population
The association between long-term blood pressure (BP) patterns in community-dwelling adults and risk of intracerebral hemorrhage and cerebral infarction is not well characterized. This prospective study included 79 385 participants, free of stroke, myocardial infarction, and cancer in or before 2010 (baseline). Systolic BP trajectories were identified using latent mixture modeling with data from 2006, 2008, and 2010. Incident cases of intracerebral hemorrhage and cerebral infarction occurred during 2010 to 2014, confirmed by review of medical records, by 3 physicians. We identified 5 distinct systolic BP trajectories durin...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Weijuan Li, Cheng Jin, Anand Vaidya, Yuntao Wu, Kathryn Rexrode, Xiaoming Zheng, Mahmut E. Gurol, Chaoran Ma, Shouling Wu, Xiang Gao Tags: Cardiovascular Disease, Epidemiology, High Blood Pressure Original Articles Source Type: research
Abstract P104: Oxygen Drastically Increases Cardiac Output Without Changing Mean Pulmonary Arterial Pressure in a Patient With Severe, Progressive Pulmonary Hypertension Session Title: Onsite Poster Competition I With Reception
Conclusion: Our patient had no significant change in mPAP facing oxygen-induced decrease in PVR. Instead, there was a marked increase in RV CO explainable only by an increase in RV SV facing decreased RV afterload, as HR decreased with oxygen. These findings are consistent with the patient’s class 1 exercise capacity despite having severe PH, indicating an ability to increase CO with activity and suggesting a positive response to medications and better prognosis. Our case shows the importance of assessing hemodynamic data in the workup and management of PH. We propose using TTE assessment of CO coupled with 100% oxygen a...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Dan Zheng, Thomas Roe Tags: Poster Abstract Presentations Source Type: research
Abstract P400: Relative Contributions of Systolic and Diastolic Blood Pressure to Adverse Cardiovascular Outcomes in an Outpatient Cohort of 1.3 Million Adults Session Title: Epidemiology
We examined the impact of systolic and diastolic pressures in multivariable survival analysis controlling for age, sex, race, and comorbidities using two different approaches. We first used the burden of systolic (SBP>=140) and diastolic (DBP>=90) hypertension as predictors. Both systolic burden (hazard ratio [HR] 1.17 for z-score, 95% CI 1.16 to 1.18, P78). Again, both SBP (HR 1.39 for z-score, 95% CI 1.37 to 1.41, P
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Alexander C Flint, Carol Conell, Xiushui Ren, Nader Banki, Sheila L Chan, Vivek A Rao, Ron B Melles, Deepak L Bhatt Tags: Poster Abstract Presentations Source Type: research
Abstract P427: Inhibition of the Regulator of G Protein Signaling 14, a Novel Anti-Hypertensive Mechanism Session Title: Renin-Angiotensin System
The Regulator of G Protein Signaling 14 (RGS14) knockout (KO) mouse is unique in that it not only extends longevity, but also enhances several aspects of healthful aging. The RGS14 KO mouse, compared with wild type (WT), is protected against obesity and diabetes, and has increased exercise capacity, similar to levels achieved with chronic exercise training, all potentially important anti-hypertensive mechanisms. The goal of this investigation was to test more directly that the RGS14 KO mouse is protected against hypertension. Accordingly, we chronically infused angiotensin II (1.44 mg/kg/day) by implanted osmotic pump for ...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jie Zhang, John J Guers, Marko Oydanich, Dorothy E Vatner, Stephen F Vatner Tags: Poster Abstract Presentations Source Type: research
Abstract P438: Cardio-Renal Anemia Syndrome in acute heart failure patients: An Observational data from “Gulf-CARE” Heart Failure Registry Session Title: Chronic Kidney Disease
Conclusions: In the setting of acute heart failure in CRAS patients LV function has no significant role in the incidence of in-hospital stroke, major bleeding and death.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Mohammed Al Jarallah, Rajesh Rajan, Ahmed R. Al-Saber, Raja Dashti, Bassam Bulbanat, Mustafa Ridha, Khadhim Sulaiman, Prashanth Panduranga, Alawi Alshekh-Ali, Khalid Al Habib, Jassim Al Suwaidi, Wael Al Mahmeed, Hussam Al Faleh, Abdelfatah Elasfar, Ahmed Tags: Poster Abstract Presentations Source Type: research
Abstract P486: Effects of Isometric Leg Training on Ambulatory Blood Pressure and Morning Blood Pressure Surge in Young Normotensive Men and Women Session Title: Non-Pharmacological Therapy and Nutrition and Hypertension
Conclusion: These results support previous research showing that IRT is effective in lowering ambulatory BP. Furthermore, the significant reductions in the MBPS offer the potential for clinically meaningful CVD and stroke risk reduction, provided these effects can be demonstrated in those who are at risk.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Anthony W Baross, Kevin J Milne, Cheri L McGowan, Ian L Swaine Tags: Poster Abstract Presentations Source Type: research
Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in HypertensionNovelty and Significance Oxidative Stress
Vascular Nox (NADPH oxidase)-derived reactive oxygen species and endoplasmic reticulum (ER) stress have been implicated in hypertension. However, relationships between these processes are unclear. We hypothesized that Nox isoforms localize in a subcellular compartment-specific manner, contributing to oxidative and ER stress, which influence the oxidative proteome and vascular function in hypertension. Nox compartmentalization (cell fractionation), O2− (lucigenin), H2O2 (amplex red), reversible protein oxidation (sulfenylation), irreversible protein oxidation (protein tyrosine phosphatase, peroxiredoxin oxidation), and ER...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Livia L. Camargo, Adam P. Harvey, Francisco J. Rios, Sofia Tsiropoulou, Renee de Nazare Oliveira Da Silva, Zhenbo Cao, Delyth Graham, Claire McMaster, Richard J. Burchmore, Richard C. Hartley, Neil Bulleid, Augusto C. Montezano, Rhian M. Touyz Tags: Hypertension Original Articles Source Type: research
