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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Relationship Between Stroke Subtypes and Morning Surge or Dipping Pattern Letters to the Editors
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Hosaka, M., Asayama, K., Imai, Y., Ohkubo, T. Tags: Letters to the Editors Source Type: research
Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients: A Matched Cohort Study Original Articles
This study evaluated the effects of initial versus delayed treatment with a drug combination on blood pressure (BP) control and the risk of cardiovascular (CV) events in hypertensive patients. Clinical trials suggest that the time to BP control is an important determinant of long-term outcomes, but real-world evidence is scarce. Using electronic medical charts (2005–2009), we retrospectively analyzed 1762 adult patients with BP elevation initiating combination therapy matched 1:1 with similar patients initiating monotherapy and later switched to combination therapy. Incidence rate ratios of CV events (myocardial infa...
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Gradman, A. H., Parise, H., Lefebvre, P., Falvey, H., Lafeuille, M.-H., Duh, M. S. Tags: Original Articles Source Type: research
Loss of Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells and Cardiomyocytes Causes Arterial Hypotension and Cardiac Hypertrophy Original Articles
The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, contributes to parainflammatory dysregulation, possibly causing cardiovascular dysfunction and remodeling. The physiological role of cardiovascular EGFR is not completely understood. To investigate the physiological importance of EGFR in vascular smooth muscle cells and cardiomyocytes, we generated a mouse model with targeted deletion of the EGFR using the SM22 (smooth muscle-specific protein 22) promoter. While the reproduction of knockout animals was not impaired, life span was significantly reduced. Systolic blood pressure was not different between...
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Schreier, B., Rabe, S., Schneider, B., Bretschneider, M., Rupp, S., Ruhs, S., Neumann, J., Rueckschloss, U., Sibilia, M., Gotthardt, M., Grossmann, C., Gekle, M. Tags: Original Articles Source Type: research
Left Ventricular Global Function Index by Magnetic Resonance Imaging--A Novel Marker for Assessment of Cardiac Performance for the Prediction of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology/Population Science
Left ventricular (LV) function is generally assessed independent of structural remodeling and vice versa. The purpose of this study was to evaluate a novel LV global function index (LVGFI) that integrates LV structure with global function and to assess its predictive value for cardiovascular (CV) events throughout adult life in a multiethnic population of men and women without history of CV diseases at baseline. A total of 5004 participants in the Multi-Ethnic Study of Atherosclerosis underwent a cardiac magnetic resonance study and were followed up for a median of 7.2 years. The LVGFI by cardiac magnetic resonance was def...
Source: Hypertension - March 13, 2013 Category: Cardiology Authors: Mewton, N., Opdahl, A., Choi, E.-Y., Almeida, A. L. C., Kawel, N., Wu, C. O., Burke, G. L., Liu, S., Liu, K., Bluemke, D. A., Lima, J. A. C. Tags: Congestive, Risk Factors, Hypertrophy, CT and MRI Epidemiology/Population Science Source Type: research
A Blood Pressure Genetic Risk Score Is a Significant Predictor of Incident Cardiovascular Events in 32 669 Individuals Genetics
In conclusion, BP findings from genome-wide association studies are strongly replicated. GRSs comprising bona fide BP-single nucleotide polymorphisms predicted CVD risk, consistent with a lifelong effect on BP of these variants collectively.
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Havulinna, A. S., Kettunen, J., Ukkola, O., Osmond, C., Eriksson, J. G., Kesaniemi, Y. A., Jula, A., Peltonen, L., Kontula, K., Salomaa, V., Newton-Cheh, C. Tags: Other hypertension, Epidemiology Genetics Source Type: research
Angiotensin-Converting Enzyme 2 Activation Improves Endothelial Function Renin-Angiotensin System
Diminished release and function of endothelium-derived nitric oxide coupled with increases in reactive oxygen species production is critical in endothelial dysfunction. Recent evidences have shown that activation of the protective axis of the renin–angiotensin system composed by angiotensin-converting enzyme 2, angiotensin-(1–7), and Mas receptor promotes many beneficial vascular effects. This has led us to postulate that activation of intrinsic angiotensin-converting enzyme 2 would improve endothelial function by decreasing the reactive oxygen species production. In the present study, we tested 1-[[2-(dimetila...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Fraga-Silva, R. A., Costa-Fraga, F. P., Murca, T. M., Moraes, P. L., Martins Lima, A., Lautner, R. Q., Castro, C. H., Soares, C. M. A., Borges, C. L., Nadu, A. P., Oliveira, M. L., Shenoy, V., Katovich, M. J., Santos, R. A. S., Raizada, M. K., Ferreira, A Tags: ACE/Angiotension receptors, Cerebrovascular disease/stroke, Type 1 diabetes, Endothelium/vascular type/nitric oxide Renin-Angiotensin System Source Type: research
Intensive Blood Pressure Lowering Increases Cerebral Blood Flow in Older Subjects With Hypertension Blood Pressure Lowering and Cerebral Blood Flow
Hypertension is associated with reduced cerebral blood flow (CBF). Intensive (<130/80 mm Hg) blood pressure (BP) lowering in older people might give greater reduction in cardiovascular risk, but there are concerns that this might produce hypoperfusion which may precipitate falls and possibly stroke. We determined the effect of intensive compared with usual BP lowering on CBF in hypertensive older subjects. Individuals aged >70 years with a history of systolic hypertension on 1 or no BP lowering drugs were recruited from primary care (n=37; age, 75±4 years; systolic BP, >150 mm Hg) and randomized to receive ...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Tryambake, D., He, J., Firbank, M. J., O'Brien, J. T., Blamire, A. M., Ford, G. A. Tags: Clinical Studies Blood Pressure Lowering and Cerebral Blood Flow Source Type: research
Central Pulse Pressure Is an Independent Determinant of Vascular Remodeling in the Retinal Circulation Retinal Vessels
Pulse pressure has been recognized as a risk factor for stroke. Moreover, it was shown that central pulse pressure relates more strongly to vascular disease and outcome than (peripheral) brachial pulse pressure. Because vascular remodeling in the retinal circulation mirrors the 1 in the cerebral circulation and represents an easy, noninvasive possibility to assess microvascular changes in humans, we analyzed the impact of central pulse pressure on retinal vascular structure in humans. The study cohort comprised 135 nondiabetic patients across a wide range of blood pressure values. Parameter of retinal arteriolar remodeling...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Ott, C., Raff, U., Harazny, J. M., Michelson, G., Schmieder, R. E. Tags: Remodeling Retinal Vessels Source Type: research
Impact of Atrial Fibrillation on the Accuracy of Oscillometric Blood Pressure Monitoring Atrial Fibrillation
In conclusion, atrial fibrillation did not significantly affect the accuracy of oscillometric measurements, if 3 repeated measurements were performed.
Source: Hypertension - August 14, 2013 Category: Cardiology Authors: Pagonas, N., Schmidt, S., Eysel, J., Compton, F., Hoffmann, C., Seibert, F., Hilpert, J., Tschope, C., Zidek, W., Westhoff, T. H. Tags: Clinical Studies Atrial Fibrillation Source Type: research
Abstract 5: Intrarenal Responses to Angiotensin I and Angiotensin (1-7) in the Stroke-Prone Spontaneously Hypertensive Rat Are Y Chromosome Dependent Oral Session I: Concurrent A Angiotensin Action and Signaling
This study provides novel evidence that the Y chromosome influences the vasodilatory arm of the RAS and intrarenal vascular function.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Chin-Dusting, J. P., Dominiczak, A., Jennings, G. L. Tags: Oral Session I: Concurrent A Angiotensin Action and Signaling Source Type: research
Abstract 70: Eplerenone Increases Dilation and the Diameter of Cerebral Penetrating Arterioles in Rats with Sustained Hypertension Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones
Hypertension is linked to dementia in humans, as well as remodeling and dysfunction in large cerebral arteries. The effects of hypertension on cerebral microvessels, such as penetrating arterioles (PenA), are still unknown. These arterioles are the bottlenecks bridging the pial circulation to the deep parenchymal microcirculation, and they are vital for neurovascular coupling and functional hyperemia. Mineralocorticoid receptor (MR) antagonism reverses hypertension-induced changes in large cerebral arteries. Thus, we hypothesized that MR antagonism will improve PenA dilation and structure in adult rats with sustained hyper...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Pires, P. W., Jackson, W. F., Dorrance, A. M. Tags: Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones Source Type: research
Abstract 208: Augmented Cerebrovascular Responses to Diazoxide, an Opener of MitokAtp Channels, Following Middle Cerebral Artery (MCA) Occlusion in Rats Poster Session I
Previous research has not examined the effects of ischemia on cerebral vascular responses to mitochondrial activation in experimental strokes caused by occlusion of the MCA (MCAO). We investigated the role and mechanisms of mitochondrial derived vasoreactivity in the MCA of male SD rats following 90 min ischemia/48 h reperfusion injury. Ischemia was induced ipsilaterally (I) and the contralateral (C) side was non-ischemic. Electron microscopy showed disrupted mitochondrial morphology on the I side. Western blots for expression of mitochondrial proteins (Mean±SEM of immunoband intensity normalized to β-actin and...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Rutkai, I., Dutta, S., Liu, D., Katakam, P. V., Busija, D. W. Tags: Poster Session I Source Type: research
Abstract 241: Splenic T Regulatory Lymphocytes Are Reduced in Genetically Hypertensive Rats Associated with Central Sympathoexcitation Poster Session I
Conclusion: Our findings indicate that splenic Tregs are reduced in SHRSP at both prehypertensive and established hypertensive stages. These alterations may contribute to the development and maintenance of hypertension. Central sympathoinhibition increases the reduced splenic Tregs in SHRSP suggesting interaction between sympathetic hyperactivity and Tregs.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Katsuki, M., Hirooka, Y., Kishi, T., Sunagawa, K. Tags: Poster Session I Source Type: research
Abstract 364: Maternal History of Hypertension and Incident Atrial Fibrillation According to Blood Pressure Category in a General Urban Population: The Suita Study Poster Session II
Conclusions: A maternal history of hypertension is a predictor of incident AF. For persons with a maternal history of hypertension, BP control would be under normal BP for AF prevention.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Kokubo, Y., Watanbe, M., Kobayashi, T., Kamakura, S., Kawanishi, K., Miyamoto, Y. Tags: Poster Session II Source Type: research
Abstract 614: Premenopausal Women May Not Be Protected Against Early Vascular Disease In The Presence Of Diabetes. Poster Session II
CONCLUSION: In our population, diabetic women after age 40 should be considered at possibly high risk of cardiovascular events compared with a non-diabetic group. Direct assessment of atherosclerotic burden, such as TPA, should be used early in this population, even in the presence of menstrual cycles, instead of relying on traditional risk scores.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Garcia, N. H., Perez, H. A., Spence, J. D., Armando, L. J. Tags: Poster Session II Source Type: research
