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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 and Acute Ischemic Stroke Editorial Commentaries
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Ojeda, N. B. Tags: Other hypertension, Neuroprotectors Editorial Commentaries Source Type: research
Use of Nonsteroidal Anti-Inflammatory Drugs and Risk of Chronic Kidney Disease in Subjects With Hypertension: Nationwide Longitudinal Cohort Study Kidney
Limited studies have examined the effects of nonsteroidal anti-inflammatory drug (NSAID) use on the risk of chronic kidney disease (CKD), especially in subjects with hypertension. Using National Health Insurance claims data in Taiwan, we conducted a propensity score–matched cohort study to investigate the relationship between NSAID use and CKD in subjects with hypertension. A total of 31976 subjects were included in this study: subjects not taking any NSAIDs in 2007 (n=10782); subjects taking NSAIDs for 1 to 89 days in 2007 (n=10605); and subjects taking NSAIDs for ≥90 days in 2007 (n=10589). We performed multivar...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Hsu, C.-C., Wang, H., Hsu, Y.-H., Chuang, S.-Y., Huang, Y.-W., Chang, Y.-K., Liu, J.-S., Hsiung, C. A., Tsai, H.-J. Tags: Clinical Studies Kidney Source Type: research
Short-Term Blood Pressure Variability Relates to the Presence of Subclinical Brain Small Vessel Disease in Primary Hypertension Cerebral Small Vessel Disease
Blood pressure (BP) variability is associated with stroke risk, but less is known about subclinical cerebral small vessel disease (CSVD). We aimed to determine whether CSVD relates to short-term BP variability independently of BP levels and also, whether they improve CSVD discrimination beyond clinical variables and office BP levels. This was a cohort study on asymptomatic hypertensives who underwent brain magnetic resonance imaging and 24-hour ambulatory BP monitoring. Office and average 24-hour, daytime and nighttime BP levels, and several metrics of BP variability (SD, weighted SD, coefficient of variation, and average ...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Filomena, J., Riba-Llena, I., Vinyoles, E., Tovar, J. L., Mundet, X., Castane, X., Vilar, A., Lopez-Rueda, A., Jimenez-Balado, J., Cartanya, A., Montaner, J., Delgado, P., on behalf of ISSYS Investigators Tags: Clinical Studies, Cerebral Lacunes Cerebral Small Vessel Disease Source Type: research
Amino-Terminal Pro-B-Type Natriuretic Peptide Improves Discrimination for Incident Atherosclerotic Cardiovascular Disease Beyond Ambulatory Blood Pressure in Elderly Men NT-proBNP and Cardiovascular Risk
Improvement of risk prediction for atherosclerotic cardiovascular disease (ASCVD) is needed. Both ambulatory blood pressure (ABP) and biomarkers amino-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein and cystatin C improve risk prediction but they have not been evaluated in relation to each other. We analyzed whether NT-proBNP, high-sensitivity C-reactive protein, or cystatin C improved risk prediction beyond traditional ASCVD risk factors combined with 24-hour systolic BP (SBP). Secondary aim was to evaluate whether ABP improved risk prediction when compared with models with the bio...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Skoglund, P. H., Hoijer, J., Arnlov, J., Zethelius, B., Svensson, P. Tags: Risk Factors NT-proBNP and Cardiovascular Risk Source Type: research
High Salt Intake: Independent Risk Factor for Obesity? Salt Intake
High salt intake is the major cause of raised blood pressure and accordingly leads to cardiovascular diseases. Recently, it has been shown that high salt intake is associated with an increased risk of obesity through sugar-sweetened beverage consumption. Increasing evidence also suggests a direct link. Our study aimed to determine whether there was a direct association between salt intake and obesity independent of energy intake. We analyzed the data from the rolling cross-sectional study–the UK National Diet and Nutrition Survey 2008/2009 to 2011/2012. We included 458 children (52% boys; age, 10±4 years) and ...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Ma, Y., He, F. J., MacGregor, G. A. Tags: Cerebrovascular disease/stroke, Other hypertension Salt Intake Source Type: research
Rho-Associated Kinase Activity Is an Independent Predictor of Cardiovascular Events in Acute Coronary Syndrome Acute Coronary Syndrome
Rho-associated kinases play an important role in a variety of cellular functions. Although Rho-associated kinase activity has been shown to be an independent predictor for future cardiovascular events in a general population, there is no information on Rho-associated kinase activity in patients with acute coronary syndrome. We evaluated leukocyte Rho-associated kinase activity by Western blot analysis in 73 patients with acute coronary syndrome and 73 age- and gender-matched control subjects. Rho-associated kinase activity within 2 hours of acute coronary syndrome onset was higher in patients with acute coronary syndrome t...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Kajikawa, M., Noma, K., Nakashima, A., Maruhashi, T., Iwamoto, Y., Matsumoto, T., Iwamoto, A., Oda, N., Hidaka, T., Kihara, Y., Aibara, Y., Chayama, K., Sasaki, S., Kato, M., Dote, K., Goto, C., Liao, J. K., Higashi, Y. Tags: Risk Factors, Other arteriosclerosis Acute Coronary Syndrome Source Type: research
Pathological Effects of Obstructive Apneas During the Sleep Cycle in an Animal Model of Cerebral Small Vessel Disease Obstructive Sleep Apnea
We tested the hypothesis that apneas during the sleep cycle exacerbate hypertension and accelerate changes that occur with cerebral small vessel disease. Obstructive sleep apnea was modeled by intermittent inflations of a chronically implanted tracheal balloon to occlude the airway during the sleep cycle (termed OSA) in spontaneously hypertensive stroke-prone (SHRSP) rats, a model of cerebral small vessel disease. SHRSP rats and their parent strain, Wistar Kyoto (WKY) rats, were exposed to OSA for 2 weeks (from 9 to 11 or from 18 to 20 weeks). At 9 weeks, hypertension was developing in the SHRSP rats and was firmly establi...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Lloyd, E. E., Durgan, D. J., Martini, S. R., Bryan, R. M. Tags: Animal models of human disease, Hypertension - basic studies Obstructive Sleep Apnea Source Type: research
Angiotensin-II, the Brain, and Hypertension: An Update Recent Advances in Hypertension
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: Young, C. N., Davisson, R. L. Tags: Cerebrovascular disease/stroke, Other hypertension, Hypertension - basic studies, Autonomic, reflex, and neurohumoral control of circulation, Oxidant stress Recent Advances in Hypertension Source Type: research
High B-Type Natriuretic Peptide Hypertensives at Target Blood Pressure: Potential Role of {beta}-Blockers to Reduce Their Elevated Risk Brief Review
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: Struthers, A. D., George, J. Tags: Cardiovascular Pharmacology, Primary prevention, Cerebrovascular disease/stroke, Other hypertension, Clinical Studies Brief Review Source Type: research
Prevalence of Apparent Therapy-Resistant Hypertension and Its Effect on Outcome in Patients With Chronic Kidney Disease Kidney
New options recently became available for treatment of uncontrolled blood pressure. Information on the prevalence of therapy-resistant hypertension (TRH) in patients with chronic kidney disease and its consequences is relevant to balance risks and benefits of potential new therapies. Data of 788 patients with chronic kidney disease came from a multicenter study investigating the effect on outcome of an integrated multifactorial approach delivered by nurse practitioners added to usual care versus usual care alone. Blood pressure was measured at the office and during 30 minutes using an automated oscillometric device. Appare...
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: de Beus, E., Bots, M. L., van Zuilen, A. D., Wetzels, J. F. M., Blankestijn, P. J., on behalf of the MASTERPLAN Study Group* Tags: Other hypertension Kidney Source Type: research
Abstract P015: Bilateral Common Carotid Artery Stenosis in Hypertensive Rats Impairs Dilation in Penetrating Arterioles and Posterior Communicating Arteries Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Hypertension and chronic cerebral hypoperfusion (CCH) are leading risk factors for cognitive impairment. We induced hypoperfusion in stroke prone spontaneously hypertensive rats (SHRSP) by bilateral carotid artery stenosis (BCAS) to create a novel, physiologically relevant model of cognitive impairment. We hypothesized that BCAS in SHRSP would impair endothelium dependent dilation and lead to outward remodeling of the penetrating arterioles (PAs) and posterior cerebral arteries (PCAs). The PAs are critical for maintaining parenchymal perfusion and controlling blood flow to the neurovascular unit, and the PCAs are integral ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Matin, N., Fisher, C., Jackson, W. F., Dorrance, A. M. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research
Abstract 097: Vascular Aging in Aldosterone Associated Hypertension: Role of NADPH Oxidase 1 Session Title: Concurrent XVI A: Oxidative Stress I
In conclusion, endothelial dysfunction and vascular remodelling in hypertension are associated with increased aldo-mediated activation of pro-inflammatory and redox-sensitive pathways. These processes involve Nox1. Our findings identify an important role for aldo/Nox1/ROS in molecular processes underlying vascular changes of ageing in hypertension.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Harvey, A., Montezano, A. C., Hood, K. Y., Lopes, R. A., Graham, D., Touyz, R. M. Tags: Session Title: Concurrent XVI A: Oxidative Stress I Source Type: research
Abstract P114: Mas Receptor Deficiency Increases Diastolic Blood Pressure and Reduces Cardiac Function in Obese Female Mice Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Conclusion: These results demonstrate that MasR deficiency promotes elevated diastolic blood pressures and reduced cardiac function in obese female mice, suggesting that the Ang-(1-7)/MasR axis protects females from obesity-hypertension. Moreover, these results suggest that MasR agonists may be effective therapies for obesity-associated cardiovascular conditions.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Wang, Y., Shoemaker, R., Thatcher, S., Cassis, L. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research
Abstract P229: Is a Multidisciplinary Approach to Hypertension Better Than Traditional Care in Female Hypertensive Patients? Session Title: Clinical/Blood Pressure/Therapeutic/Other 2
Conclusion: The multidisciplinary approach had better BP control in female hypertensive pts. Prospective studies comparing MDA to standard practice may help to assess improved quality of life, compliance and outcomes.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Weber, J. A., Shah, S. C., Turley, S., Braun, L. T., Kent, E. R., Volgman, A. S. Tags: Session Title: Clinical/Blood Pressure/Therapeutic/Other 2 Source Type: research
Abstract P254: Hypertension: A proposed Mechanistic Pathway for Arterial System Remodeling Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors
Conclusion: Reliable and accessible markers that indicate changes in arterial pressure, flow & volume, are: PP and AC (SV/PP), and AC (Tau /TPR). These variables detected increases in the heart-load and alterations in pressure-flow patterns that impair cardiovascular-function resulting in HTN-CVD; input and characteristic impedance, also provides remodeling information about the arterial system but are not readily available to clinicians.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Randall, O. S., Lee, D., Retta, T., Haddad, G., Ketete, M., Kwagyan, J., Xu, S. Tags: Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors Source Type: research
