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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Genetic Interference With Endothelial PPAR–{gamma} (Peroxisome Proliferator–Activated Receptor–{gamma}) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1–7Novelty and Significance Renin-Angiotensin System
Pharmacological activation of PPAR-γ (peroxisome proliferator–activated receptor-γ) protects the vasculature. Much less is known on the cell-specific impact of PPAR-γ when driven by endogenous ligands. Recently, we found that endothelial PPAR-γ protects against angiotensin II–induced endothelial dysfunction. Here, we explored that concept further examining whether effects were sex dependent along with underlying mechanisms. We studied mice expressing a human dominant–negative mutation in PPAR-γ driven by the endothelial-specific vascular cadherin promoter (E-V290M), using nontransgenic littermates as controls. A...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: T. Michael De Silva, Chunyan Hu, Dale A. Kinzenbaw, Mary L. Modrick, Curt D. Sigmund, Frank M. Faraci Tags: Cerebrovascular Disease/Stroke, Vascular Disease Original Articles Source Type: research
High Prevalence of Multiple Arterial Bed Lesions in Patients With Fibromuscular DysplasiaNovelty and Significance Fibromuscular Dysplasia
In conclusion, FMD is a systemic arterial disease. At least 2 vascular beds were affected by dysplastic stenoses in 48.0% of cases and by dysplastic stenoses, aneurysms, and dissections in 66.1% of cases. RA imaging should be proposed to hypertensive patients with a cerebrovascular presentation. Cervical artery imaging should be considered in patients with a renal presentation and bilateral RA lesions.Clinical Trial Registration—URL: www.Clinicaltrials.gov. Unique identifier: NCT02884141.
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Pierre–Francois Plouin, Jean–Philippe Baguet, Frederic Thony, Olivier Ormezzano, Arshid Azarine, Francois Silhol, Catherine Oppenheim, Beatrice Bouhanick, Louis Boyer, Alexandre Persu, Frank Hammer, Philippe Gosse, Claire Mounier–Vehier, Tags: Hypertension, Cerebrovascular Disease/Stroke, Vascular Disease Original Articles Source Type: research
Transcriptome-Wide Analysis Identifies Novel Associations With Blood PressureNovelty and Significance Genomics
Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely understood. Transcriptome profiling offers possibilities to uncover genetics effects on BP. Based on 2 populations including 2549 individuals, a meta-analyses of monocytic transcriptome-wide profiles were performed to identify transcripts associated with BP. Replication was performed in 2 independent studies of whole-blood transcriptome data including 1990 individuals. For identified candidate genes, a direct link between long-term changes in BP and gene expression over time and by treatmen...
Source: Hypertension - September 13, 2017 Category: Cardiology Authors: Tanȷa Zeller, Claudia Schurmann, Katharina Schramm, Christian Muller, Soonil Kwon, Philipp S. Wild, Alexander Teumer, David Herrington, Arne Schillert, Licia Iacoviello, Adelheid Kratzer, Annika Jagodzinski, Mahir Karakas, Jingzhong Ding, Johannes Tags: Cardiovascular Disease, Gene Expression & Regulation, Genetic, Association Studies, Hypertension Original Articles Source Type: research
Abstract 031: Diastolic Blood Pressure, Coronary Artery Calcium, and Cardiac Outcomes in the Multi-ethnic Study of Atherosclerosis Session Title: Cardiac Hypertrophy and Dysfunction
Diastolic blood pressure (BP) has a J-curve relationship with coronary heart disease and death. Because this association is thought to reflect reduced coronary perfusion at low diastolic BP, our objective was to test whether the J-curve is most pronounced among persons with coronary artery calcium. Among 6,811 participants from the Multi-Ethnic Study of Atherosclerosis, we used Cox models to examine if diastolic BP category is associated with coronary heart disease events, stroke, and mortality. Analyses were conducted in the sample overall and after stratification by coronary artery calcium score. In multivariable-adjuste...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: John W McEvoy, Faisal Rahman, Mahmoud Al Rifai, Michael Blaha, Khurram Nasir, Matthew Budoff, Bruce Psaty, Wendy Post, Roger Blumenthal Tags: Oral Abstract Presentations Source Type: research
Abstract 044: Sex Differences in Relative Contributions of Hemodynamic Parameters to Blood Pressure: A Population-based Study of Adolescents and Middle-aged Adults Session Title: Gender Differences and Sex Hormones
Hypertension is a leading cause of death. Sex differences in blood pressure (BP) and hypertension prevalence emerge during adolescence and remain throughout reproductive age. Sex differences in BP-underlying hemodynamics, i.e., in the relative contributions of stroke volume (SV), total peripheral resistance (TPR) and heart rate (HR) to BP, have not been investigated in these age categories in a population-based setting. We studied a cohort of 1,347 individuals, including 911 adolescents (12-18 years, 52 % female) and 426 young to middle-aged adults (36-65 years, 56 % female). Beat-by-beat systolic BP (SBP) and diastolic BP...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Catriona A Syme, Jean Shin, Michal Abrahamowicz, Gabriel Leonard, Michel Perron, Louis Richer, Suzanne Veillette, Daniel Gaudet, Tomas Paus, Zdenka Pausova Tags: Oral Abstract Presentations Source Type: research
Abstract 104: Cerebrovascular and Cognitive Dysfunction in DOCA-Salt Hypertension is Mediated by Perivascular Macrophages Session Title: Salt and Hypertension
Hypertension (HTN) and high-salt diets are important risk factors for stroke and dementia. DOCA-salt is a recognized model of HTN driven by sodium retention and brain renin-angiotensin system (RAS) activation. However, it is unknown whether essential mechanisms regulating the cerebral circulation are altered in DOCA-salt mice, and, if so, whether these alterations are associated with cognitive impairment. To this end, C57BL/6 mice were implanted with 50mg DOCA pellets SQ and received 0.9% NaCl drinking water for 3 weeks. Cerebral blood flow (CBF) was measured in the somatosensory cortex by laser-Doppler flowmetry through a...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Monica M Santisteban, Giuseppe Faraco, Gianfranco Racchumi, Josef Anrather, Costantino Iadecola Tags: Oral Abstract Presentations Source Type: research
Abstract P136: Ischemic Evaluation in Patients With Hypertensive Emergency / Urgency and Acute Systolic Heart Failure: Is Coronary Angiography Required for All? Session Title: Onsite Poster Competition I With Reception
Conclusions: Our results suggest that only a minority of patients with HU/E and S-HF have obstructive CAD. It may be possible to stratify patients using demographic and non-invasive tests to direct only those with high likelihood of O-CAD for coronary angiography. These results should be validated in large registry populations.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jared W Davis, Muhannad Almubarak, Samuel K McElwee, Amrita Mukherjee, Firas Al-Solaiman, Mark F Sasse, Massoud A Leesar, Arka Chatterjee Tags: Poster Abstract Presentations Source Type: research
Abstract 137: Sox6 Regulates Renin Expression During Juxtaglomerular Cell Expansion Session Title: Renin Angiotensin System II
Introduction: Hypertension, a common condition that affects 33% of the US population, is a major risk factor for heart disease and stroke. Treatments for hypertension are limited and there is a critical need to develop new therapies. The Renin Angiotensin Aldosterone System (RAAS) plays a key role in regulating blood pressure, and renin controls its rate-limiting step. In adults, renin is produced and stored by renal Juxtaglomerular (JG) cells. During sodium restriction and other pathophysiological stresses that require an increase in renin expression and release, the adult kidney increases the number of cells expressing r...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jason D Foss, Liang Xiao, Kandi D Horton, Mohammad Saleem, Conrad P Hodgkinson, David G Harrison, Jose A Gomez Tags: Oral Abstract Presentations Source Type: research
Abstract 142: Angiotensin II Type 1 Receptor Autoantibody Inhibition Improves Blood Pressure and Markers of Neurological Damage and Oxidative Stress in Brains of Placental Ischemic Rats During Pregnancy Session Title: Developmental Programming and Pregnancy Induced Hypertension
In conclusion, our preliminary data suggests that AT1-AA inhibition could be a potential therapy to improve peripheral and neurological complications during PE. Research Supported by T32HL105324 (Cunningham), RO1HD067541-06 (LaMarca), DK-104184 (Roman), 050049 (Fan), P20-GM-104357 (cores B and C-Roman; Pilot-Fan) and AHA 16GRNT31200036 (Fan).
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Mark W Cunningham, Venkata Ramana Vaka, Lorena Amaral, Fan Fan, Tarek Ibrahim, Richard R Roman, Babbette LaMarca Tags: Oral Abstract Presentations Source Type: research
Abstract 143: Pregnancy Dependant Transcriptomic Changes in Uterine Arteries From Hypertensive and Normotensive Rat Models Session Title: Developmental Programming and Pregnancy Induced Hypertension
This study investigated early gene expression changes in the uterine arteries (UA) of pregnant SHRSP and normotensive Wistar Kyoto (WKY) rats.Methods: SHRSP and WKY females were time mated and UA isolated at gestational day (GD)6 (n=3). Non-pregnant (NP) UA were isolated from virgin aged matched controls (n=3). UA RNAseq (Illumina platform) was performed. Transcript level gene changes were interpreted using Ingenuity Pathway Analysis (FDR 1.0). Quantitative RT-PCR was used to validate significantly differentially expressed genes.Results: There was a greater number of differentially expressed transcripts NP v GD6 in SHRSP c...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hannah L Morgan, Elisabeth Beattie, Martin W McBride, Delyth Graham Tags: Oral Abstract Presentations Source Type: research
Abstract P146: Uric Acid is an Independent Risk Factor for Developing Hypertension From Prehypertension: A 5-year Japanese Cohort Study Session Title: Onsite Poster Competition I With Reception
This study is conducted to clarify the risks.Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Masanari Kuwabara, Shigeko Hara, Koichiro Niwa, Minoru Ohno, Ichiro Hisatome Tags: Poster Abstract Presentations Source Type: research
Abstract P173: Target Blood Pressure in Elderly Hypertensive Patients: A Korean National Health Insurance Service Health Examinee Cohort Study Session Title: Onsite Poster Competition I With Reception
This study used the National Health Insurance Service Health examinee Sample Cohort. We selected subjects who were over the age of 60 years and who had received a newly diagnosis of hypertension (Korean Classification of Disease [KCD] codes I10–I13) from 2003 to 2006. Subjects who had previous major cardiovascular (CV) events, such as heart failure, ischemic heart disease, stroke, or end stage renal disease (ESRD) were excluded. The remaining 25,858 individuals were divided into three groups; 1) mean systolic blood pressure (SBP)
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jiwon Seo, Sungha Park, Chan Joo Lee, Jinseub Hwang Tags: Poster Abstract Presentations Source Type: research
Abstract P201: Prevalence of Metabolic Syndrome in Hypertensive Patients Session Title: Onsite Poster Competition I With Reception
This study was done to find out the prevalence of metabolic syndrome among newly diagnosed hypertensive patients in a tertiary care hospital of northern India, Guru Nanak Dev hospital, attached to Government Medical College, Amritsar, India.Methods: It is a hospital based cross sectional study involving one hundred newly diagnosed subjects with hypertension above the age 20 years. High blood pressure was defined according to Joint National committe-7 (JNC-7) guidelines, taking systolic BP> 140 and diastolic BP>90 as hypertension. Exclusion criteria included secondary hypertension, secondary cause of obesity, pregnancy, acu...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nirankar Singh Neki, Jaswinder Singh Tags: Poster Abstract Presentations Source Type: research
Abstract P242: Nicotinic Acetylcholine Receptor Subunit {alpha}7 is Protective Against Angiotensin II-induced Aneurysm and Hypertension Session Title: Onsite Poster Competition I With Reception
We report for the first time that the α7 nAChR-/- deficient mouse serves as a novel model of hypertension and aneurysm formation. Seven month old male WT and α7 nAChR-/- mice weighing 28-33g were infused with low dose Ang II (350 ng/kg/min) or high dose (700 ng/kg/min) or vehicle for 15 days using mini-osmotic pumps (Alzet, model 2004) implanted subcutaneously. Blood pressure (BP) was recorded on day 0,3,7,10 and 14. Mice were euthanized on day 15. Heart and body weights were measured, histological analysis was performed on the aortas and immune profile of peripheral blood was analyzed by flow cytometry. High dose Ang II...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nayaab S Khan, Spyros Mavropoulos, Kaie Ojamaa Tags: Poster Abstract Presentations Source Type: research
Abstract P253: Relation Between Microvascular Function and Large Artery Stiffness in African American Diabetic Patients Session Title: Onsite Poster Competition I With Reception
Conclusions: Among African Americans with diabetes, subclinical microvascular dysfunction is significantly correlated to large artery stiffness and possibly to glycemic control. Further study is needed to clarify mediating factors of these relationships.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Ajibola M Adedayo, Ayobami Eluwole, Fasika Tedla, Arye Kremer, Nicole Mastrogiovanni, Mohammed Afzal, Carl Rosenberg, Paul Dreizen, John LaRosa, Mohamed Boutjdir, MaryAnn Banerji, Clinton Brown, Moro Salifu, Ahmed Bakillah, Jason Lazar Tags: Poster Abstract Presentations Source Type: research
