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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Abstract P160: Role of Uncoupling Protein 2 in Stroke Susceptibility of Stroke-prone Spontaneously Hypertensive Rat Session Title: Cerebrovascular Disease and Stroke
Mitochondrial dysfunction causes severe cellular derangements potentially underlying tissue injury and consequent diseases. Evidence of a direct involvement of mitochondrial dysfunction in hypertensive target organ damage is still poor.The gene encoding Uncoupling Protein 2 (UCP2), a inner mitochondrial membrane protein, maps inside stroke QTL/STR1 in stroke prone spontaneously hypertensive rat (SHRSP). We explored the role of UCP2 in stroke pathogenesis of SHRSP. Male SHRSP, stroke resistant SHR (SHRSR) and reciprocal STR1/congenic rats were fed with stroke permissive Japanese style diet (JD). A group of SHRSP received JD...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Rubattu, S., Cotugno, M., Bianchi, F., Di Castro, S., Stanzione, R., Busceti, C., Marchitti, S., Nicoletti, F., Volpe, M. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Hypertensive Retinopathy and Risk of Stroke Hypertensive Retinopathy
In this study, we examine whether hypertensive retinopathy predicts the long-term risk of stroke in those with hypertension. A total of 2907 participants with hypertension aged 50 to 73 years at the 1993 to 1995 examination, who had gradable retinal photographs, no history of diabetes mellitus, stroke, and coronary heart disease at baseline and data on incident stroke, were included from the Atherosclerosis Risk in Communities (ARIC) Study. Retinal photographs were assessed for hypertensive retinopathy signs and classified as none, mild, and moderate/severe. Incident events of any stroke, cerebral infarction, and hemorrhag...
Source: Hypertension - September 11, 2013 Category: Cardiology Authors: Ong, Y.-T., Wong, T. Y., Klein, R., Klein, B. E. K., Mitchell, P., Sharrett, A. R., Couper, D. J., Ikram, M. K. Tags: Cerebrovascular disease/stroke, Acute Cerebral Infarction, Risk Factors for Stroke Hypertensive Retinopathy Source Type: research
Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults Epidemiology/Population
This report included 3310 hypertensive adults, a subset of the China Stroke Primary Prevention Trial (CSPPT) with baseline measurements for baPWV. During a median follow-up of 4.5 years, 111 participants developed first stroke. The risk of stroke was higher among participants with baPWV in the highest quartile than among those in the lower quartiles (6.3% versus 2.4%; hazard ratio, 1.66; 95% confidence interval, 1.06–2.60). Similarly, the participants with inadequate hypertension control had a higher risk of stroke than those with adequate control (5.1% versus 1.8%; hazard ratio, 2.32; 95% confidence interval, 1.49&n...
Source: Hypertension - June 7, 2016 Category: Cardiology Authors: Song, Y., Xu, B., Xu, R., Tung, R., Frank, E., Tromble, W., Fu, T., Zhang, W., Yu, T., Zhang, C., Fan, F., Zhang, Y., Li, J., Bao, H., Cheng, X., Qin, X., Tang, G., Chen, Y., Yang, T., Sun, N., Li, X., Zhao, L., Hou, F. F., Ge, J., Dong, Q., Wang, B., Xu, Tags: Hypertension, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research
Two Genomic Regions of Chromosomes 1 and 18 Explain Most of the Stroke Susceptibility Under Salt Loading in Stroke-Prone Spontaneously Hypertensive Rat/Izm Genetics
This study indicated a major role for 2 QTLs on chr 1 and 18 in stroke susceptibility in SHRSP under salt loading. The salt-sensitive blood pressure increase was implied to play a key role in the stroke susceptibility.
Source: Hypertension - June 12, 2013 Category: Cardiology Authors: Gandolgor, T.-A., Ohara, H., Cui, Z.-H., Hirashima, T., Ogawa, T., Saar, K., Hubner, N., Watanabe, T., Isomura, M., Nabika, T. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Genetics of Stroke Source Type: research
Cardiovascular Disease Is the Main Cause of Long-Term Excess Mortality After Ischemic Stroke in Young Adults Ischemic Stroke in Young Adults
Adults with stroke at a young age (18–50 years) remain at an increased risk of death for decades. It is unclear what cause underlies this long-term excess mortality and whether this is sex and time specific. Therefore, we investigated sex-specific temporal changes in cause of death after transient ischemic attack or ischemic stroke in young adults aged 18 to 50 years. We included all 845 consecutive 30-day survivors, of a first-ever transient ischemic attack (n=261) or ischemic stroke (n=584), admitted to our hospital between 1980 and 2010. Survival status was assessed at April 1, 2013. Observed cause-specific mortal...
Source: Hypertension - February 11, 2015 Category: Cardiology Authors: Rutten-Jacobs, L. C. A., Arntz, R. M., Maaijwee, N. A. M., Schoonderwaldt, H. C., Dorresteijn, L. D., van Dijk, E. J., de Leeuw, F.-E. Tags: Acute Cerebral Infarction Ischemic Stroke in Young Adults Source Type: research
Mid- to Late-Life Trajectories of Blood Pressure and the Risk of Stroke: The Rotterdam Study Epidemiology/Population
Hypertension is a major modifiable risk factor for stroke. Associations of blood pressure with incident stroke are mostly based on single or average blood pressure levels. However, this approach does not take into account long-term trajectories of blood pressure, which can vary considerably in the elderly. Within the population-based Rotterdam Study, we examined trajectories of systolic blood pressure in 6745 participants (60.0% women) over an age-range from 55 to 106 years and jointly modeled their risk of stroke and competing causes of death using joint latent class mixed modeling. Four trajectories were identified. Clas...
Source: Hypertension - May 10, 2016 Category: Cardiology Authors: Portegies, M. L. P., Mirza, S. S., Verlinden, V. J. A., Hofman, A., Koudstaal, P. J., Swanson, S. A., Ikram, M. A. Tags: Epidemiology, High Blood Pressure, Mortality/Survival, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research
High Blood Pressure After Acute Ischemic Stroke Is Associated With Poor Clinical Outcomes: Fukuoka Stroke Registry Stroke and Blood Pressure
The relationship between the poststroke blood pressure (BP) and functional outcomes in patients with acute ischemic stroke is still controversial. The aim of the present study was to elucidate the impact of the poststroke BP on the clinical outcomes of acute ischemic stroke. Among the patients in the Fukuoka Stroke Registry, 1874 patients with first-ever acute ischemic stroke (within 24 hours of onset) who had been functionally independent before onset were prospectively enrolled in the present study. The poststroke BP levels were defined as the average values during the 48 hours after onset. The study outcomes were a good...
Source: Hypertension - December 11, 2013 Category: Cardiology Authors: Ishitsuka, K., Kamouchi, M., Hata, J., Fukuda, K., Matsuo, R., Kuroda, J., Ago, T., Kuwashiro, T., Sugimori, H., Nakane, H., Kitazono, T., on behalf of the FSR Investigators Tags: Stroke and Blood Pressure Source Type: research
Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men Epidemiology/Population
We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988–1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for a...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Eastwood, S. V., Tillin, T., Chaturvedi, N., Hughes, A. D. Tags: Cerebrovascular disease/stroke, Risk Factors, Epidemiology Epidemiology/Population Source Type: research
Systolic and Diastolic Blood Pressure Changes in Relation With Myocardial Infarction and Stroke in Patients With Coronary Artery Disease Clinical Trials
In conclusion, in patients with coronary artery disease and initially free from congestive heart failure, a BP reduction from baseline over the examined BP range had little effect on the risk of MI and predicted a lower risk of stroke. An increase in systolic BP from baseline increased the risk of stroke and MI. The relationships of BP with risk were much steeper for stroke than for MI. A treatment-induced BP reduction over the explored range seems to be safe in patients with coronary artery disease.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00153101.
Source: Hypertension - December 10, 2014 Category: Cardiology Authors: Verdecchia, P., Reboldi, G., Angeli, F., Trimarco, B., Mancia, G., Pogue, J., Gao, P., Sleight, P., Teo, K., Yusuf, S. Tags: Secondary prevention, Clinical Studies, Other Stroke Treatment - Medical Clinical Trials Source Type: research
Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements: The Ohasama Study Epidemiology/Population
In conclusion, impacts of partial WCHT as well as partial masked hypertension for long-term stroke risk were comparable to those of complete masked hypertension or sustained hypertension. We need both home and 24-h ambulatory blood pressure measurements to evaluate stroke risk accurately.
Source: Hypertension - December 9, 2015 Category: Cardiology Authors: Satoh, M., Asayama, K., Kikuya, M., Inoue, R., Metoki, H., Hosaka, M., Tsubota-Utsugi, M., Obara, T., Ishiguro, A., Murakami, K., Matsuda, A., Yasui, D., Murakami, T., Mano, N., Imai, Y., Ohkubo, T. Tags: Epidemiology, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research
Continuing or Temporarily Stopping Prestroke Antihypertensive Medication in Acute StrokeNovelty and Significance Stroke
Over 50% of patients are already taking blood pressure–lowering therapy on hospital admission for acute stroke. An individual patient data meta-analysis from randomized controlled trials was undertaken to determine the effect of continuation versus temporarily stopping preexisting antihypertensive medication in acute stroke. Key databases were searched for trials against the following inclusion criteria: randomized design; stroke onset ≤48 hours; investigating the effect of continuation versus stopping prestroke antihypertensive medication; and follow-up of ≥2 weeks. Two randomized controlled trials were identified a...
Source: Hypertension - April 12, 2017 Category: Cardiology Authors: Lisa J. Woodhouse, Lisa Manning, John F. Potter, Eivind Berge, Nikola Sprigg, Joanna Wardlaw, Kennedy R. Lees, Philip M. Bath, Thompson G. Robinson Tags: High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Original Articles Source Type: research
Brachial-Ankle Pulse Wave Velocity Is a Strong Predictor for Mortality in Patients With Acute Stroke Epidemiology/Population
This study suggested that measurement of baPWV during the acute phase of stroke might be useful in identifying patients at a higher risk for mortality.
Source: Hypertension - July 9, 2014 Category: Cardiology Authors: Kim, J., Song, T.-J., Song, D., Lee, K. J., Kim, E. H., Lee, H. S., Nam, C. M., Nam, H. S., Kim, Y. D., Heo, J. H. Tags: Cerebrovascular disease/stroke, Pathophysiology, Other diagnostic testing, Acute Cerebral Infarction Epidemiology/Population Source Type: research
Aortic Stiffness Determines Diastolic Blood Flow Reversal in the Descending Thoracic Aorta: Potential Implication for Retrograde Embolic Stroke in Hypertension Arterial Stiffness
In conclusion, aortic stiffness determines the extent of flow reversal from the descending aorta to the aortic arch, which contributes to the diastolic antegrade flow into the carotid artery. This hemodynamic relationship constitutes a potential mechanism linking increased aortic stiffness, altered flow dynamics, and increased stroke risk in hypertension.
Source: Hypertension - August 14, 2013 Category: Cardiology Authors: Hashimoto, J., Ito, S. Tags: Pathophysiology, Embolic stroke Arterial Stiffness Source Type: research
Abstract P119: Hypertension Trends in Florida Stroke Patients. The Florida Puerto Rico Collaboration to Reduce Stroke Disparities Session Title: Onsite Poster Competition I With Reception
Conclusions: In our large Stroke Registry we observed higher prevalence of HTN in women, blacks and AIS. We also observe a decreasing trend over the past 7 years, especially among women and minorities (blacks and Hispanics). These findings provide an opportunity to design and implement interventions to reduce disparities in HTN and improve stroke outcome.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Marialaura Simonetto, Nirav H Shah, Kefeng Wang, Maria A Ciliberti–Vargas, Carolina Gutierrez, Chuanhui Dong, Jorge Sanchez, Dianne Foster, Jose’ G Romano, Ralp L Sacco, Tatȷana Rundek Tags: Poster Abstract Presentations Source Type: research
Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke Renin-Angiotensin System
The angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis represents a promising target for inducing stroke neuroprotection. Here, we explored stroke-induced changes in expression and activity of endogenous angiotensin-converting enzyme 2 and other system components in Sprague–Dawley rats. To evaluate the clinical feasibility of treatments that target this axis and that may act in synergy with stroke-induced changes, we also tested the neuroprotective effects of diminazene aceturate, an angiotensin-converting enzyme 2 activator, administered systemically post stroke. Among rats that underwent experimental ...
Source: Hypertension - June 10, 2015 Category: Cardiology Authors: Bennion, D. M., Haltigan, E. A., Irwin, A. J., Donnangelo, L. L., Regenhardt, R. W., Pioquinto, D. J., Purich, D. L., Sumners, C. Tags: ACE/Angiotension receptors, Animal models of human disease, Other Treatment, Acute Cerebral Infarction, Neuroprotectors Renin-Angiotensin System Source Type: research
