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Source: Hypertension
Condition: Hypertension
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Total 260 results found since Jan 2013.
Abstract P256: Structural Alterations of Subcutaneous Small Resistance Arteries in Resistant Hypertension Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors
Conclusion: Hypertensive patients with true resistant hypertension have greater microvascular structural alterations compared with non-resistant hypertensive patients. This could partly explain the resistance to treatment and the high cardiovascular risk observed in these patients.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: De Ciuceis, C., Rossini, C., Muiesan, M. L., Salvetti, M., Porteri, E., Gavazzi, A., Paini, A., Pileri, P., Agabiti Rosei, E., Rizzoni, D. Tags: Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors Source Type: research
Abstract P636: Sex Differences in Cardioprotective AT2R Expression in Diabetic Rats and Its Correlation with Myocardial Damage Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome
Diabetes mellitus (DM) is an independent risk factor for cardiovascular disease (CVD). Healthy, young women are protected from CVD, while diabetic women are more susceptible to CVD compared to age-matched diabetic men and non-diabetic women. Underlying mechanisms for this sex difference in CVD are not fully elucidated. The angiotensin II type 2 receptor (AT2R) is a member of the protective, vasodilative arm of the renin angiotensin system. The Agtr2 gene that codes for AT2R is X-linked, and increased Agtr2 expression is reported in female vasculature of rodent models. We hypothesized that a sex difference might exist in DM...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Lum-Naihe, K., Mahmood, A., Bajwa, J., Emter, C. A., Pulakat, L. Tags: Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome Source Type: research
Abstract P638: Investigating Gene Pleiotropy in the Metabolic Syndrome in Lyon Hypertensive Rats Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome
The metabolic syndrome (MetS) - hypertension, obesity, dyslipidemia, and insulin resistance - is a major risk factor for cardiovascular disease and stroke. Our overall goal is to identify novel genes and pathways causing MetS. Our previous work determined that rat chromosome 17 (RNO17) contributes to several MetS-defining traits (including high blood pressure, obesity, and dyslipidemia) in the Lyon Hypertensive (LH) rat, a genetically determined MetS rat model. We hypothesized that at least some of the traits on RNO17 are controlled by a single gene with pleiotropic effects. To address this hypothesis, we generated congeni...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Kwitek, A. E., Pettus, J., Jakoubek, J., Ma, J. Tags: Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome Source Type: research
Earlier Age of Onset of Chronic Hypertension and Type 2 Diabetes Mellitus After a Hypertensive Disorder of Pregnancy or Gestational Diabetes Mellitus Epidemiology/Population
A prospective cohort study was conducted to assess the impact of a history of hypertensive disorder of pregnancy (HDP) or gestational diabetes mellitus (GDM) on the risk and age of onset of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease (CVD) later in life, independent of hypertension and T2D. Between 1993 and 1997, 22 265 ever-pregnant women were included from the European Prospective Investigation into Cancer and Nutrition-NL study, aged 20 to 70 years at baseline. Details on complications of pregnancy and known hypertension were obtained by questionnaire. Blood pressure was measured at enrollme...
Source: Hypertension - November 11, 2015 Category: Cardiology Authors: Heida, K. Y., Franx, A., van Rijn, B. B., Eijkemans, M. J. C., Boer, J. M. A., Verschuren, M. W. M., Oudijk, M. A., Bots, M. L., van der Schouw, Y. T. Tags: Cardiovascular Disease, Diabetes, Type 2, Epidemiology, Primary Prevention, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research
Hypertensive Target Organ Damage and Longitudinal Changes in Brain Structure and Function: The Second Manifestations of Arterial Disease-Magnetic Resonance Study Cognitive Decline and Blood Pressure
We examined the association of hypertensive target organ damage with longitudinal changes in brain structure and function within the Second Manifestations of Arterial Disease–Magnetic Resonance (SMART-MR) study. Renal function, albuminuria, and left ventricular hypertrophy on electrocardiography were measured in 663 patients with manifest arterial disease (mean age, 57±9 years; 81% men). Automated brain segmentation was used to quantify progression of global brain atrophy (change in brain parenchymal fraction) and progression of cerebral small vessel disease on 1.5T magnetic resonance imaging, and memory and e...
Source: Hypertension - November 11, 2015 Category: Cardiology Authors: van der Veen, P. H., Geerlings, M. I., Visseren, F. L. J., Nathoe, H. M., Mali, W. P. T. M., van der Graaf, Y., Muller, M., for the SMART Study Group* Tags: Risk Factors, Hypertension, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Vascular Disease Cognitive Decline and Blood Pressure Source Type: research
Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension Oxidative Stress
Oxidative stress is implicated in vascular dysfunction in hypertension. Although mechanisms regulating vascular pro-oxidants are emerging, there is a paucity of information on antioxidant systems, particularly nuclear factor erythroid 2–related factor (Nrf2), a master regulator of antioxidants enzymes. We evaluated the vascular regulatory role of Nrf2 in hypertension and examined molecular mechanisms, whereby Nrf2 influences redox signaling in small arteries and vascular smooth muscle cells from Wistar Kyoto (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Cells were stimulated with angiotensin II in t...
Source: Hypertension - November 11, 2015 Category: Cardiology Authors: Lopes, R. A., Neves, K. B., Tostes, R. C., Montezano, A. C., Touyz, R. M. Tags: Hypertension Oxidative Stress Source Type: research
Retinal Microvasculature Is Associated With Long-Term Survival in the General Adult Dutch Population Epidemiology/Population
Retinal vascular diameters are associated with (sub)clinical cardiovascular disease and short-term cardiovascular mortality, but their association with long-term mortality is uncertain. We studied the association of retinal vascular diameters with cause-specific mortality in the general adult Dutch population during 25 years of follow-up. From 1990 to 1993, arteriolar and venular diameters were measured semiautomatically on digitized images in 5674 persons (mean age 68.0 years, 59% women) from the population-based Rotterdam study. Follow-up for mortality was complete till March 2015. Associations between vascular diameters...
Source: Hypertension - January 13, 2016 Category: Cardiology Authors: Mutlu, U., Ikram, M. K., Wolters, F. J., Hofman, A., Klaver, C. C. W., Ikram, M. A. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Mortality/Survival, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research
Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study Epidemiology/Population
In conclusion, aortic stiffness was associated with cognitive function and markers of subclinical brain injury in young to middle-aged adults. Prospective studies are needed to examine whether aortic stiffening in young adulthood is associated with vascular cognitive impairment later in life.
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Pase, M. P., Himali, J. J., Mitchell, G. F., Beiser, A., Maillard, P., Tsao, C., Larson, M. G., DeCarli, C., Vasan, R. S., Seshadri, S. Tags: Aging, Risk Factors, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Cognitive Impairment Epidemiology/Population Source Type: research
Roles of Caveolin-1 in Angiotensin II-Induced Hypertrophy and Inward Remodeling of Cerebral Pial Arterioles Vessel Remodeling
In conclusion, Cav-1 is essential in Ang II–mediated inward remodeling and hypertrophy in pial arterioles. Cav-1–induced MMP9 is exclusively involved in inward remodeling, not hypertrophy. Further studies are needed to determine the role of Akt in Ang II–mediated hypertrophy.
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Umesalma, S., Houwen, F. K., Baumbach, G. L., Chan, S.-L. Tags: Hypertension, Vascular Disease Vessel Remodeling Source Type: research
Persistent Maternal Cardiac Dysfunction After Preeclampsia Identifies Patients at Risk for Recurrent Preeclampsia Preeclampsia
The purpose of our study was to assess cardiac function in nonpregnant women with previous early preeclampsia before a second pregnancy to highlight the cardiovascular pattern, which may take a risk for recurrent preeclampsia. Seventy-five normotensive patients with previous preeclampsia and 147 controls with a previous uneventful pregnancy were enrolled in a case-control study and submitted to echocardiographic examination in the nonpregnant state 12 to 18 months after the first delivery. All patients included in the study had pregnancy within 24 months from the echocardiographic examination and were followed until term. ...
Source: Hypertension - March 9, 2016 Category: Cardiology Authors: Valensise, H., Lo Presti, D., Gagliardi, G., Tiralongo, G. M., Pisani, I., Novelli, G. P., Vasapollo, B. Tags: Preeclampsia, Echocardiography, Complications Source Type: research
Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events Flow-Mediated Vasodilation and Cardiovascular Events
Measurement of nitroglycerine-induced vasodilation has been performed to differentiate endothelium-dependent vasodilation from endothelium-independent vasodilation as a control test for flow-mediated vasodilation (FMD). Recently, nitroglycerine-induced vasodilation per se has been reported to be a useful marker of the grade of atherosclerosis. The present study aimed to evaluate the prognostic value of FMD combined with nitroglycerine-induced vasodilation for future cardiovascular events. We measured FMD and nitroglycerine-induced vasodilation in 402 subjects, including patients with cardiovascular diseases. During a media...
Source: Hypertension - April 12, 2016 Category: Cardiology Authors: Kajikawa, M., Maruhashi, T., Hida, E., Iwamoto, Y., Matsumoto, T., Iwamoto, A., Oda, N., Kishimoto, S., Matsui, S., Hidaka, T., Kihara, Y., Chayama, K., Goto, C., Aibara, Y., Nakashima, A., Noma, K., Higashi, Y. Tags: Quality and Outcomes, Atherosclerosis Flow-Mediated Vasodilation and Cardiovascular Events Source Type: research
Association Between Protein Intake and Mortality in Hypertensive Patients Without Chronic Kidney Disease in the OLD-HTA Cohort Epidemiology/Population
The objective of this study was to test the prognostic value of protein intake assessed by 24-hour urinary urea in a cohort of hypertensive patients with preserved renal function. A total of 1128 hypertensive patients were followed according to tertile of protein intake adjusted for ideal body weight: <0.70, 0.70 to 0.93, and >0.93 g/kg. Baseline characteristics (mean±standard deviation) were age 45.1±13.2 years, systolic/diastolic blood pressure 185±32/107±20 mm Hg, and estimated glomerular filtration rate 82±32 mL/min. After 10 years of follow-up, 289 deaths occurred, 202 of which...
Source: Hypertension - May 10, 2016 Category: Cardiology Authors: Courand, P.-Y., Lesiuk, C., Milon, H., Defforges, A., Fouque, D., Harbaoui, B., Lantelme, P. Tags: Diet and Nutrition, Epidemiology, Hypertension Epidemiology/Population Source Type: research
Longitudinal Patterns of Change in Systolic Blood Pressure and Incidence of Cardiovascular Disease: The Atherosclerosis Risk in Communities Study Epidemiology/Population
Elevated blood pressure in midlife contributes significantly to the risk of cardiovascular disease. However, patterns of blood pressure increase may differ among individuals and may result in differential risk. Our goal was to examine the contribution of longitudinal patterns of blood pressure change to incidence of heart failure, coronary heart disease, stroke, and cardiovascular disease mortality. Latent class growth models were used to identify patterns of change in blood pressure across 4 clinical examinations (1987–1998) among 9845 Atherosclerosis Risk in Communities (ARIC) cohort participants (mean age, 53.7 [S...
Source: Hypertension - May 10, 2016 Category: Cardiology Authors: Petruski-Ivleva, N., Viera, A. J., Shimbo, D., Muntner, P., Avery, C. L., Schneider, A. L. C., Couper, D., Kucharska-Newton, A. Tags: Cardiovascular Disease, Risk Factors, Hypertension Epidemiology/Population Source Type: research
The Association Between Antihypertensive Medication Nonadherence and Visit-to-Visit Variability of Blood Pressure: Findings From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Epidemiology/Population
In conclusion, improving medication adherence may lower VVV of BP. However, VVV of BP is associated with cardiovascular outcomes independent of medication adherence.
Source: Hypertension - June 7, 2016 Category: Cardiology Authors: Kronish, I. M., Lynch, A. I., Oparil, S., Whittle, J., Davis, B. R., Simpson, L. M., Krousel-Wood, M., Cushman, W. C., Chang, T. I., Muntner, P. Tags: Hypertension Epidemiology/Population Source Type: research
Masked Hypertension and Cardiovascular Disease Events in a Prospective Cohort of Blacks: The Jackson Heart Study Masked Hypertension
Masked hypertension, defined as nonelevated clinic blood pressure (BP) with elevated out-of-clinic BP, has been associated with increased cardiovascular disease (CVD) risk in Europeans and Asians. Few data are available on masked hypertension and CVD and mortality risk among blacks. We analyzed data from the Jackson Heart Study, a prospective cohort study of blacks. Analyses included participants with clinic-measured systolic/diastolic BP <140/90 mm Hg who completed ambulatory BP monitoring after the baseline examination in 2000 to 2004 (n=738). Masked daytime (10:00 am–8:00 pm) hypertension was defined as mean am...
Source: Hypertension - July 12, 2016 Category: Cardiology Authors: Booth, J. N., Diaz, K. M., Seals, S. R., Sims, M., Ravenell, J., Muntner, P., Shimbo, D. Tags: Cardiovascular Disease, Epidemiology, Hypertension Masked Hypertension Source Type: research
