Abstract 137: Sox6 Regulates Renin Expression During Juxtaglomerular Cell Expansion [Session Title: Renin Angiotensin System II]

Introduction: Hypertension, a common condition that affects 33% of the US population, is a major risk factor for heart disease and stroke. Treatments for hypertension are limited and there is a critical need to develop new therapies. The Renin Angiotensin Aldosterone System (RAAS) plays a key role in regulating blood pressure, and renin controls its rate-limiting step. In adults, renin is produced and stored by renal Juxtaglomerular (JG) cells. During sodium restriction and other pathophysiological stresses that require an increase in renin expression and release, the adult kidney increases the number of cells expressing renin, in a process known as JG cell expansion. JG cells formation mechanisms remain unclear. Our aim is to determine new regulators of renin and blood pressure control.Methods: In vivo: JG cell expansion was induced by 10 days of low sodium diet (0.01% Na) and furosemide (0.1 mg/g body weight). In vitro: primary renal Mesenchymal Stromal Cells (MSC) were isolated from wild type mice and used until passage 5. MSC were differentiated into renin expressing cells by 7 days I modulating renin expression during pathological conditions. These findings suggest that Sox6 may become a new target for blood pressure control.
Source: Hypertension - Category: Cardiology Authors: Tags: Oral Abstract Presentations Source Type: research